A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation

European Journal of Pharmacology

Volumn 782, Issue , 2016, Pages 107-118

  Esposito, E ^a   Impellizzeri, D ^a   Bruschetta, G ^a   Cordaro, M ^a   Siracusa, R ^a   Gugliandolo, E ^a   Crupi, R ^a   Cuzzocrea, S ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inflammation; Pain; Peroxynitrite; Reactive oxygen species

Indexed keywords

3 NITROTYROSINE; CARRAGEENAN; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; PALMIDROL; PICEID; 3-NITROTYROSINE; CYTOKINE; ETHANOLAMINE DERIVATIVE; GLUCOSIDE; I KAPPA B KINASE ALPHA; PALMITIC ACID DERIVATIVE; STILBENE DERIVATIVE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TYROSINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG INTERACTION; EDEMA; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; NEUTROPHIL CHEMOTAXIS; ORAL DRUG ADMINISTRATION; PROTEIN DEGRADATION; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADMINISTRATION, ORAL; ANIMALS; CARRAGEENAN; CELL LINE, TUMOR; CELL NUCLEUS; CYCLOOXYGENASE 2; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG INTERACTIONS; EDEMA; ETHANOLAMINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSIDES; HYPERALGESIA; INFLAMMATION; MALE; NEUTROPHIL INFILTRATION; NF-KAPPAB INHIBITOR ALPHA; NITRIC OXIDE SYNTHASE TYPE II; PALMITIC ACIDS; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; STILBENES; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TYROSINE;

EID: 84963940245     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.03.033     Document Type: Article

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