Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion

European Journal of Pharmacology

Volumn 762, Issue , 2015, Pages 136-149

  Impellizzeri, Daniela ^a   Bruschetta, Giuseppe ^a   Ahmad, Akbar ^b   Crupi, Rosalia ^a   Siracusa, Rosalba ^a   Di Paola, Rosanna ^a   Paterniti, Irene ^a   Prosdocimi, Marco ^c   Esposito, Emanuela ^a   Cuzzocrea, Salvatore ^a,d  

^a UNIVERSITY OF MESSINA   (Italy)

^b University of Texas Medical Branch School of Medicine   (United States)

^c Prismic Pharmaceuticals Inc Hayden Corporate Center   (United States)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Apoptosis; Cytokines; Inflammation; Oxidative stress; Renal disease

Indexed keywords

3 NITROTYROSINE; CATALASE; CHYMASE; COPPER ZINC SUPEROXIDE DISMUTASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MEMBRANE PROTEIN; MYELOPEROXIDASE; NITRATE; NITRITE; PADGEM PROTEIN; PALMIDROL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN PAR; SILYMARIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3-NITROTYROSINE; CYTOKINE; ETHANOLAMINE DERIVATIVE; NITRIC ACID DERIVATIVE; PALMITIC ACID DERIVATIVE; TYROSINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY ARTERY STENOSIS; KIDNEY DYSFUNCTION; KIDNEY ISCHEMIA; KIDNEY TUBULE DAMAGE; MALE; MOUSE; MOUSE MODEL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; CELL NUCLEUS; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; DRUG INTERACTION; GENE EXPRESSION REGULATION; INJURIES; KIDNEY; METABOLISM; PATHOLOGY; RISK FACTOR;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELL NUCLEUS; CHYMASES; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG INTERACTIONS; ETHANOLAMINES; GENE EXPRESSION REGULATION; KIDNEY; MALE; MICE; NITRATES; NITRITES; OXIDATIVE STRESS; PALMITIC ACIDS; REPERFUSION INJURY; RISK FACTORS; SILYMARIN; TRANSCRIPTION FACTOR RELA; TYROSINE;

EID: 84930686012     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.05.010     Document Type: Article

References (35)

1. A. Ahmad, R. Crupi, D. Impellizzeri, M. Campolo, A. Marino, E. Esposito, and S. Cuzzocrea Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice Brain Behav. Immunol. 26 2012 1310 1321
2. J.V. Bonventre Mechanisms of ischemic acute renal failure Kidney Int. 43 1993 1160 1178
3. E. Bosisio, C. Benelli, and O. Pirola Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes Pharmacol. Res. 25 1992 147 154
4. F. Chamoun, M. Burne, M. O'Donnell, and H. Rabb Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury Front. Biosci. 5 2000 E103 E109
5. J.W. Chang, C.S. Kim, S.B. Kim, S.K. Park, J.S. Park, and S.K. Lee Proinflammatory cytokine-induced NF-kappaB activation in human mesangial cells is mediated through intracellular calcium but not ROS: effects of silymarin Nephron Exp. Nephrol. 103 2006 e156 e165
6. C.C. Chen, C.L. Rosenbloom, D.C. Anderson, and A.M. Manning Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation J. Immunol. 155 1995 3538 3545
7. H.H. Chen, T.W. Chen, and H. Lin Prostacyclin-induced peroxisome proliferator-activated receptor-alpha translocation attenuates NF-kappaB and TNF-alpha activation after renal ischemia-reperfusion injury Am. J. Physiol. Ren. Physiol. 297 2009 F1109 F1118
8. E.M. Conner, and M.B. Grisham Inflammation, free radicals, and antioxidants Nutrition 12 1996 274 277
9. R. Di Paola, T. Genovese, D. Impellizzeri, A. Ahmad, S. Cuzzocrea, and E. Esposito The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-alphaR1: a comparison with infliximab treatment Eur. J. pharmacol. 700 2013 134 146
10. R. Di Paola, D. Impellizzeri, P. Mondello, E. Velardi, C. Aloisi, A. Cappellani, E. Esposito, and S. Cuzzocrea Palmitoylethanolamide reduces early renal dysfunction and injury caused by experimental ischemia and reperfusion in mice Shock 38 2012 356 366
11. E. Esposito, and S. Cuzzocrea Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation Front. Biosci. 14 2009 263 296
12. M.K. Fallahzadeh, B. Dormanesh, M.M. Sagheb, J. Roozbeh, G. Vessal, M. Pakfetrat, Y. Daneshbod, E. Kamali-Sarvestani, and K.B. Lankarani Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: a randomized, double-blind, placebo-controlled trial Am. J. Kidney Dis. 60 2012 896 903
13. D. Impellizzeri, E. Esposito, J. Attley, and S. Cuzzocrea Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD) Pharmacol. Res. 81 2014 91 102
14. S.K. Katiyar Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (review) Int. J. Oncol. 26 2005 169 176
15. K. Khazim, Y. Gorin, R.C. Cavaglieri, H.E. Abboud, and P. Fanti The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo Am. J. Physiol. Ren. Physiol. 305 2013 F691 F700
16. J. Kim, H.S. Jang, and K.M. Park Reactive oxygen species generated by renal ischemia and reperfusion trigger protection against subsequent renal ischemia and reperfusion injury in mice Am. J. Physiol. Ren. Physiol. 298 2010 F158 F166
17. S.K. Manna, A. Mukhopadhyay, N.T. Van, and B.B. Aggarwal Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis J. Immunol. 163 1999 6800 6809
18. G. Mattace Raso, R. Simeoli, R. Russo, A. Santoro, C. Pirozzi, R. d'Emmanuele di Villa Bianca, E. Mitidieri, O. Paciello, T.B. Pagano, N.S. Orefice, R. Meli, and A. Calignano N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress Pharmacol. Res. 76 2013 67 76
19. C.M. Meyers, and J.P. Briggs Silymarin for diabetic nephropathy: the challenges of botanical product research Am. J. Kidney Dis. 60 2012 887 889
20. S. Mondello, M. Galuppo, E. Mazzon, I. Domenico, P. Mondello, A. Carmela, and S. Cuzzocrea Glutamine treatment attenuates the development of ischaemia/reperfusion injury of the gut Eur. J. Pharmacol. 643 2010 304 315
21. K.M. Mullane, R. Kraemer, and B. Smith Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium J. Pharmacol. Methods 14 1985 157 167
22. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
23. N.S. Patel, P.K. Chatterjee, R. Di Paola, E. Mazzon, D. Britti, A. De Sarro, S. Cuzzocrea, and C. Thiemermann Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion J. Pharmacol. Exp. Ther. 312 2005 1170 1178
24. N.S. Patel, U. Cortes, R. Di Poala, E. Mazzon, H. Mota-Filipe, S. Cuzzocrea, Z.Q. Wang, and C. Thiemermann Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury J. Am. Soc. Nephrol. 16 2005 712 719
25. N.S. Patel, E.J. Sharples, S. Cuzzocrea, P.K. Chatterjee, D. Britti, M.M. Yaqoob, and C. Thiemermann Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo Kidney Int. 66 2004 983 989
26. A.A. Pieper, T. Walles, G. Wei, E.E. Clements, A. Verma, S.H. Snyder, and J.L. Zweier Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption Mol. Med. 6 2000 271 282
27. H. Rabb, Y.M. O'Meara, P. Maderna, P. Coleman, and H.R. Brady Leukocytes, cell adhesion molecules and ischemic acute renal failure Kidney Int. 51 1997 1463 1468
28. G. Ramakrishnan, S. Jagan, S. Kamaraj, P. Anandakumar, and T. Devaki Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis Investig. New Drugs 27 2009 233 240
29. J. Roozbeh, B. Shahriyari, M. Akmali, G. Vessal, M. Pakfetrat, G.A. Raees Jalali, R. Afshariani, M. Hasheminasab, and N. Ghahramani Comparative effects of silymarin and vitamin E supplementation on oxidative stress markers, and hemoglobin levels among patients on hemodialysis Ren. Fail. 33 2011 118 123
30. P.S. Satyanarayana, D. Singh, and K. Chopra Quercetin, a bioflavonoid, protects against oxidative stress-related renal dysfunction by cyclosporine in rats Methods Find. Exp. Clin. Pharmacol. 23 2001 175 181
31. A.M. Sheridan, and J.V. Bonventre Cell biology and molecular mechanisms of injury in ischemic acute renal failure Curr. Opin. Nephrol. Hypertens. 9 2000 427 434
32. L. Stogdale Correlation of changes in blood chemistry with pathological changes in the animal's body: II. Electrolytes, kidney function tests, serum enzymes, and liver function tests J. S. Afr. Vet. Assoc. 52 1981 155 164
33. H.Z. Toklu, T. Tunali Akbay, A. Velioglu-Ogunc, F. Ercan, N. Gedik, M. Keyer-Uysal, and G. Sener Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury J. Surg. Res. 145 2008 214 222
34. F. Turgut, O. Bayrak, F. Catal, R. Bayrak, A.F. Atmaca, A. Koc, A. Akbas, A. Akcay, and D. Unal Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats Int. Urol. Nephrol. 40 2008 453 460
35. M.Y. Zuidema, and C. Zhang Ischemia/reperfusion injury: the role of immune cells World J. Cardiol. 2 2010 325 332