The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding

Toxicological Sciences

Volumn 150, Issue 1, 2016, Pages 190-203

  Hendriks, Giel ^a   Derr, Remco S ^a   Misovic, Branislav ^a   Morolli, Bruno ^a   Calléja, Fabienne M G R ^a   Vrieling, Harry ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DNA damage response; Genotoxicity; Mechanisms of toxicity; Qxidative stress; Reporter cell lines

Indexed keywords

DNA; GREEN FLUORESCENT PROTEIN; PROTEIN P53; BIOLOGICAL MARKER;

ANIMAL CELL; ARTICLE; CELL STRESS; COMPUTER PROGRAM; DNA DAMAGE; DNA REPLICATION; GENOTOXICITY ASSAY; NONHUMAN; OXIDATIVE STRESS; PROTEIN FOLDING; SENSITIVITY AND SPECIFICITY; TOXTRACKER ASSAY; ANIMAL; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; EMBRYONIC STEM CELL; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM; MOUSE; MUTAGEN TESTING; PATHOLOGY; PROCEDURES; REPORTER GENE; REPRODUCIBILITY;

ANIMALS; BIOMARKERS; CELL LINE; CELL SURVIVAL; DNA DAMAGE; EMBRYONIC STEM CELLS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; MICE; MUTAGENICITY TESTS; OXIDATIVE STRESS; PROTEIN FOLDING; REPRODUCIBILITY OF RESULTS;

EID: 84963796193     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv323     Document Type: Article

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