Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 775-776, Issue , 2014, Pages 69-80

  Kirkland, David ^a   Zeiger, Errol ^b   Madia, Federica ^c   Corvi, Raffaella ^c  

^a Kirkland Consulting   (United Kingdom)

^b Errol Zeiger Consulting   (United States)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Carcinogenicity; Database; Genotoxicity in vitro; Genotoxicity in vivo; Mammalian cell tests; Positive Ames tests

Indexed keywords

AMES TEST; ARTICLE; CARCINOGEN TESTING; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CHROMOSOME DAMAGE; CYTOTOXICITY; DNA STRAND BREAKAGE; GENE MUTATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MICRONUCLEUS; MUTAGENICITY; NONHUMAN; PREDICTION; PREDICTIVE VALUE; TASK PERFORMANCE; ANIMAL; CHEMICAL DATABASE; DNA DAMAGE; DRUG EFFECTS; ITALY; RODENT; TOXICITY; TOXICITY TESTING;

MAMMALIA;

CARCINOGEN; MUTAGENIC AGENT;

ANIMALS; CARCINOGENS; DATABASES, CHEMICAL; DNA DAMAGE; HUMANS; IN VITRO TECHNIQUES; ITALY; MUTAGENS; RODENTIA; TOXICITY TESTS;

EID: 84911997512     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2014.10.006     Document Type: Article

References (18)

1. Zeiger E. Identification of rodent carcinogens and non-carcinogens using genetic toxicity tests: premises, promises, and performance. Regul. Toxicol. Pharmacol. 1998, 28:85-95.
2. Kirkland D., Zeiger E., Madia F., Gooderham N., Kasper P., Lynch A., Morita T., Ouedrago-Arras G., Parra Morte J.M., Pfuhler S., Rogiers V., Schulz M., Thybaud V., van Benthem J., Vanparys P., Worth A., Corvi R. Do in vitro mammalian cell genotoxicity test results predict in vivo carcinogenic or genotoxic activity with compounds positive in the Ames test? I. Reports of individual databases presented at an EURL ECVAM Workshop. Mutat. Res. 2014, (in this issue).
3. Kirkland D., Aardema M., Henderson L., Müller L. Evaluation of the ability of a battery of 3 in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity. Mutat. Res. 2005, 584:1-256.
4. Schisler M.R., Gollapudi B.B., Moore M.M. Evaluation of the mouse lymphoma mutation assay (MLA) data of the U.S. National Toxicology Program (NTP) using International Workshop on Genotoxicity Tests (IWGT) criteria. Environ. Mol. Mutagen. 2010, 51:732.
5. Shephard S.E., Gunz D., Schlatter C. Genotoxicity of agaritine in the lacI transgenic mouse mutation assay: evaluation of the health risk of mushroom consumption. Food Chem. Toxicol. 1995, 33:257-264.
6. OECD (Organization for Economic Co-operation and Development), OECD Guideline for the Testing of Chemicals. Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays. TR 488, Adopted 28 July 2011.
7. NTP (National Toxicology Program), Toxicology and Carcinogenesis Studies of C.I. Acid 114 (CAS NO. 6459-94-5) in F344/N Rats (Drinking Water Studies), National Toxicology Program Technical Report Series No. 405, (1991), 236 pp.
8. Mirsalis J., Tyson K., Beck J., Loh E., Steinmetz K., Contreras C., Austere L., Martin S., Spalding J. Induction of Unscheduled DNA Synthesis (UDS) in hepatocytes following in vitro and in vivo treatment. Environ. Mutagen. 1983, 5:482.
9. NCI (National Cancer Institute), Bioassay of Trifluralin for Possible Carcinogenicity. CAS No. 1582-09-8. NCI-CG-TR-34. National Cancer Institute Technical Report Series No. 34, (1979) 112 pp.
10. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., Zeiger E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals. Environ. Mutagen. 1986, 8(Suppl. 7):1-119.
11. NTP (National Toxicology Program), NTP Technical Report on the Toxicology and Carcinogenesis Studies of Urethane, Ethanol, and Urethane/Ethanol (Urethane, CAS NO. 51-79-6; Ethanol, CAS NO. 64-17-5) in B6C3F1 Mice (Drinking Water Studies). NTP TR 510, August 2004, 351 pp.
12. Ishidate M., Harnois M.C., Sofuni T. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures. Mutat. Res. 1988, 195:151-213.
13. Ishidate M., Odashima S. Chromosome tests with 134 compounds on Chinese hamster cells in vitro - a screening for chemical carcinogens. Mutat. Res. 1977, 48:337-353.
14. Tweats D.J., Blakey D., Heflich R.H., Jacobs A., Jacobsen S.D., Morita T., Nohmi T., O'Donovan M.R., Sasaki Y.F., Sofuni T., Tice R. Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests. II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test. Mutat. Res. 2007, 627:92-105. IWGT Working Group.
15. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K. Salmonella mutagenicity tests. V. Results from the testing of 311 chemicals. Environ. Mol. Mutagen. 1992, 19(Suppl. 21):2-141.
16. Burke D.A., Wedd D.J., Herriott D., Bayliss M.K., Spalding D.J., Wilcox P. Evaluation of pyrazole and ethanol induced S9 fraction in bacterial mutagenicity testing. Mutagenesis 1994, 9:23-29.
17. Corvi R., Albertini S., Hartung T., Hoffmann S., Maurici D., Pfuhler S., van Benthem J., Vanparys P. ECVAM retrospective validation of in vitro micronucleus test (MNT). Mutagenesis 2008, 23:271-283.
18. Zeiger E., Haseman J.K., Shelby M.D., Margolin B.H., Tennant R.W. Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen. 1990, 16(Suppl. 18):1-14.