메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMOYL PHOSPHATE SYNTHASE; GLUCAGON; GLUCOSE BLOOD LEVEL; ORNITHINE CARBAMOYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PPARGC1A PROTEIN, MOUSE; SIRT3 PROTEIN, MOUSE; SIRT5 PROTEIN, MOUSE; SIRTUIN; SIRTUIN 3; UREA;

EID: 84963701001     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24156     Document Type: Article
Times cited : (34)

References (48)
  • 1
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel, A. R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529 (2001).
    • (2001) Cell , vol.104 , pp. 517-529
    • Saltiel, A.R.1
  • 2
    • 2442701392 scopus 로고    scopus 로고
    • PGC-1 promotes insulin resistance in liver through PPAR-?-dependent induction of TRB-3
    • Koo, S. H. et al. PGC-1 promotes insulin resistance in liver through PPAR-?-dependent induction of TRB-3. Nat. Med. 10, 530-534 (2004).
    • (2004) Nat. Med , vol.10 , pp. 530-534
    • Koo, S.H.1
  • 3
    • 65249087389 scopus 로고    scopus 로고
    • SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    • Nakagawa, T., Lomb, D. J., Haigis, M. C., Guarente, L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570 (2009).
    • (2009) Cell , vol.137 , pp. 560-570
    • Nakagawa, T.1    Lomb, D.J.2    Haigis, M.C.3    Guarente, L.4
  • 4
    • 0019133275 scopus 로고
    • L-leucine and a nonmetabolized analogue activate Pancreatic islet glutamate dehydrogenase
    • Sener, A., Malaisse, W. J. L-leucine and a nonmetabolized analogue activate Pancreatic islet glutamate dehydrogenase. Nature 288, 187-189 (1980).
    • (1980) Nature , vol.288 , pp. 187-189
    • Sener, A.1    Malaisse, W.J.2
  • 5
    • 33748316536 scopus 로고    scopus 로고
    • SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic ' cells
    • Haigis, M. C. et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic ? cells. Cell 126, 941-954 (2006).
    • (2006) Cell , vol.126 , pp. 941-954
    • Haigis, M.C.1
  • 6
    • 0025361955 scopus 로고
    • Nitrogen metabolism and ornithine cycle function
    • Meijer, A. J., Lamers,W. H., Chamuleau, R. Nitrogen metabolism and ornithine cycle function. Physiol. Rev. 70, 701-748 (1990).
    • (1990) Physiol. Rev , vol.70 , pp. 701-748
    • Meijer, A.J.1    Lamers, W.H.2    Chamuleau, R.3
  • 7
    • 0036402941 scopus 로고    scopus 로고
    • Regulation of enzymes of the urea cycle and arginine metabolism
    • Morris, S. M. Regulation of enzymes of the urea cycle and arginine metabolism. Annu. Rev. Nutr. 22, 87-105 (2002).
    • (2002) Annu. Rev. Nutr , vol.22 , pp. 87-105
    • Morris, S.M.1
  • 8
    • 84876736793 scopus 로고    scopus 로고
    • Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels
    • Soria, L. R., Marrone, J., Calamita, G., Marinelli, R. A. Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels. Hepatology 57, 2061-2071 (2013).
    • (2013) Hepatology , vol.57 , pp. 2061-2071
    • Soria, L.R.1    Marrone, J.2    Calamita, G.3    Marinelli, R.A.4
  • 9
    • 0036988606 scopus 로고    scopus 로고
    • Pathophysiology of hepatic encephalopathy: A new look at ammonia
    • Butterworth, R. F. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metab. Brain. Dis. 17, 221-227 (2002).
    • (2002) Metab. Brain. Dis , vol.17 , pp. 221-227
    • Butterworth, R.F.1
  • 11
    • 84876566528 scopus 로고    scopus 로고
    • UCP2 regulates the glucagon response to fasting and starvation
    • Allister, E. M. et al. UCP2 regulates the glucagon response to fasting and starvation. Diabetes 62, 1623-1633 (2013).
    • (2013) Diabetes , vol.62 , pp. 1623-1633
    • Allister, E.M.1
  • 12
    • 33744534726 scopus 로고    scopus 로고
    • GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1?
    • Lerin, C. et al. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1? . Cell. Metab. 3, 429-438 (2006).
    • (2006) Cell. Metab , vol.3 , pp. 429-438
    • Lerin, C.1
  • 13
    • 77953292242 scopus 로고    scopus 로고
    • Nutrient-dependent regulation of PGC-1? 's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
    • Dominy, J. E., Lee, Y., Gerhart-Hines, Z., Puigserver, P. Nutrient-dependent regulation of PGC-1? 's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim. Biophys. Acta. 1804, 1676-1683 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1804 , pp. 1676-1683
    • Dominy, J.E.1    Lee, Y.2    Gerhart-Hines, Z.3    Puigserver, P.4
  • 14
    • 84871107379 scopus 로고    scopus 로고
    • Mitochondrial protein acylation and intermediary metabolism: Regulation by sirtuins and implications for metabolic disease
    • Newman, J. C., He, W.,Verdin, E. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J. Biol. Chem. 287, 42436-42443 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 42436-42443
    • Newman, J.C.1    He, W.2    Verdin, E.3
  • 15
    • 84903697938 scopus 로고    scopus 로고
    • SIRT5 is under the control of PGC-1? and AMPK and is involved in regulation of mitochondrial energy metabolism
    • Buler, M., Aatsinki, S. M., Izzi, V., Uusimaa, J., Hakkola, J. SIRT5 is under the control of PGC-1? and AMPK and is involved in regulation of mitochondrial energy metabolism. FASEB J. 28, 3225-3237 (2014).
    • (2014) FASEB J , vol.28 , pp. 3225-3237
    • Buler, M.1    Aatsinki, S.M.2    Izzi, V.3    Uusimaa, J.4    Hakkola, J.5
  • 16
    • 79951497866 scopus 로고    scopus 로고
    • Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
    • Hallows, W. C. et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol. Cell. 41, 139-149 (2011).
    • (2011) Mol. Cell , vol.41 , pp. 139-149
    • Hallows, W.C.1
  • 17
    • 77953933813 scopus 로고    scopus 로고
    • Urea cycle regulation by mitochondrial sirtuin
    • Nakagawa, T., Guarente, L. Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging 1, 578-581 (2009).
    • (2009) SIRT5. Aging , vol.1 , pp. 578-581
    • Nakagawa, T.1    Guarente, L.2
  • 18
    • 77249128352 scopus 로고    scopus 로고
    • Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1
    • Ogura, M. et al. Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1. Biochem. Biophys. Res. Commun. 393, 73-78 (2010).
    • (2010) Biochem. Biophys. Res. Commun , vol.393 , pp. 73-78
    • Ogura, M.1
  • 19
    • 84869221105 scopus 로고    scopus 로고
    • Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism
    • Buler, M., Aatsinki, S. M., Izzi, V., Hakkola, J. Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PloS one 7, e49863 (2012).
    • (2012) PloS One , vol.7 , pp. e49863
    • Buler, M.1    Aatsinki, S.M.2    Izzi, V.3    Hakkola, J.4
  • 20
    • 78651429899 scopus 로고    scopus 로고
    • Transcription dynamics in a physiological process: ?-catenin signaling directs liver metabolic zonation
    • Torre, C., Perret, C., Colnot, S. Transcription dynamics in a physiological process: ?-catenin signaling directs liver metabolic zonation. Int. J. Biochem. Cell. Biol. 43, 271-278 (2011).
    • (2011) Int. J. Biochem. Cell. Biol , vol.43 , pp. 271-278
    • Torre, C.1    Perret, C.2    Colnot, S.3
  • 21
    • 33750536032 scopus 로고    scopus 로고
    • Differential gene expression in periportal and perivenous mouse hepatocytes
    • Braeuning, A. et al. Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J. 273, 5051-5061 (2006).
    • (2006) FEBS J , vol.273 , pp. 5051-5061
    • Braeuning, A.1
  • 22
    • 0017754365 scopus 로고
    • Heterogeneous reciprocal localization of fructose-1, 6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue
    • Katz, N., Teutsch, H. F., Jungermann, K., Sasse, D. Heterogeneous reciprocal localization of fructose-1, 6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue. FEBS Lett. 83, 272-276 (1977).
    • (1977) FEBS Lett , vol.83 , pp. 272-276
    • Katz, N.1    Teutsch, H.F.2    Jungermann, K.3    Sasse, D.4
  • 23
    • 0027055347 scopus 로고
    • Hepatocyte heterogeneity in the metabolism of amino acids and ammonia
    • Haussinger, D., Lamers, W. H., Moorman, A. F. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme 46, 72-93 (1992).
    • (1992) Enzyme , vol.46 , pp. 72-93
    • Haussinger, D.1    Lamers, W.H.2    Moorman, A.F.3
  • 24
    • 33947139689 scopus 로고    scopus 로고
    • Hepatocellular expression of glutamine synthetase: An indicator of morphogen actions as master regulators of zonation in adult liver
    • Gebhardt, R., Baldysiak-Figiel, A., Krugel, V., Ueberham, E., Gaunitz, F. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog. Histochem. Cytochem. 41, 201-266 (2007).
    • (2007) Prog. Histochem. Cytochem , vol.41 , pp. 201-266
    • Gebhardt, R.1    Baldysiak-Figiel, A.2    Krugel, V.3    Ueberham, E.4    Gaunitz, F.5
  • 25
    • 0026320434 scopus 로고
    • Hepatocellular heterogeneity in ammonia metabolism: Demonstration of limited colocalization of carbamoylphosphate synthetase and glutamine synthetase
    • Gebhardt, R., Lindros, K., Lamers, W. H.,Moorman, A. F. Hepatocellular heterogeneity in ammonia metabolism: demonstration of limited colocalization of carbamoylphosphate synthetase and glutamine synthetase. Eur. J. Cell. Biol. 56, 464-467 (1991).
    • (1991) Eur. J. Cell. Biol , vol.56 , pp. 464-467
    • Gebhardt, R.1    Lindros, K.2    Lamers, W.H.3    Moorman, A.F.4
  • 26
    • 5344252327 scopus 로고    scopus 로고
    • Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1' null mice
    • Lin, J. et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1? null mice. Cell 119, 121-135 (2004).
    • (2004) Cell , vol.119 , pp. 121-135
    • Lin, J.1
  • 27
    • 0017869009 scopus 로고
    • The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems
    • Sies, H. The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods Enzymol. 52, 48-59 (1978).
    • (1978) Methods Enzymol , vol.52 , pp. 48-59
    • Sies, H.1
  • 28
    • 0035943684 scopus 로고    scopus 로고
    • Alanine metabolism in the perfused rat liver STUDIES with 15N
    • Brosnan, J. T. et al. Alanine Metabolism in the Perfused Rat Liver STUDIES WITH 15N. Biol. Chem. 276, 31876-31882 (2001).
    • (2001) Biol. Chem , vol.276 , pp. 31876-31882
    • Brosnan, J.T.1
  • 29
    • 2542615327 scopus 로고    scopus 로고
    • Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: Role for NO and Kupffer cell-derived oxidants
    • Taniai, H. et al. Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: Role for NO and Kupffer cell-derived oxidants. Hepatology 39, 1544-1552 (2004).
    • (2004) Hepatology , vol.39 , pp. 1544-1552
    • Taniai, H.1
  • 30
    • 51549103448 scopus 로고    scopus 로고
    • Coactivator PGC-1' regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes
    • Arpiainen, S. et al. Coactivator PGC-1? regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes. Toxicol. Appl. Pharmacol. 232, 135-141 (2008).
    • (2008) Toxicol. Appl. Pharmacol , vol.232 , pp. 135-141
    • Arpiainen, S.1
  • 31
    • 0029658493 scopus 로고    scopus 로고
    • Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate
    • Nissim, I., Yudkoff, M., Brosnan, J. T. Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate. J. Biol. Chem. 271, 31234-31242 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 31234-31242
    • Nissim, I.1    Yudkoff, M.2    Brosnan, J.T.3
  • 32
    • 0742288183 scopus 로고    scopus 로고
    • A window into cellular metabolism: Hepatic metabolism of (15)N-labelled substrates
    • Brosnan, J. T., Brosnan, M. E., Nissim, I. A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates. Metab. Eng. 6, 6-11 (2004).
    • (2004) Metab. Eng , vol.6 , pp. 6-11
    • Brosnan, J.T.1    Brosnan, M.E.2    Nissim, I.3
  • 33
    • 0032539673 scopus 로고    scopus 로고
    • Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating protonx
    • Shimizu, S. et al. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating protonx. Proc. Natl. Acad. Sci. USA 95, 1455-1459 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1455-1459
    • Shimizu, S.1
  • 34
    • 33745685054 scopus 로고    scopus 로고
    • Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
    • Cipolat, S. et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126, 163-175 (2006).
    • (2006) Cell , vol.126 , pp. 163-175
    • Cipolat, S.1
  • 36
    • 0001841295 scopus 로고
    • Multiple assays of the five urea-cycle enzymes in human liver homogenates
    • (eds Nuzum, C. T. et al.) Wiley New York
    • Nuzum, C. T. Multiple assays of the five urea-cycle enzymes in human liver homogenates. In The urea cycle (eds Nuzum, C. T. et al.) 325-349 (Wiley New York, 1976).
    • (1976) The Urea Cycle , pp. 325-349
    • Nuzum, C.T.1
  • 38
  • 39
    • 84961060835 scopus 로고
    • Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver
    • Schimke, R. T. Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver. J. Biol. Chem. 237, 1921-1924 (1962).
    • (1962) J. Biol. Chem , vol.237 , pp. 1921-1924
    • Schimke, R.T.1
  • 40
    • 0023631866 scopus 로고
    • Induction of the five urea-cycle enzymes by glucagon in cultured foetal rat hepatocytes
    • Husson, A., Buquet, C., Vaillant, R. Induction of the five urea-cycle enzymes by glucagon in cultured foetal rat hepatocytes. Differentiation 35, 212-218 (1987).
    • (1987) Differentiation , vol.35 , pp. 212-218
    • Husson, A.1    Buquet, C.2    Vaillant, R.3
  • 41
    • 67650242167 scopus 로고    scopus 로고
    • Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferatoractivated receptor-' coactivator-1' expression
    • Estall, J. L. et al. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferatoractivated receptor-' coactivator-1' expression. Diabetes 58, 1499-1508 (2009).
    • (2009) Diabetes , vol.58 , pp. 1499-1508
    • Estall, J.L.1
  • 42
    • 0018144057 scopus 로고
    • Induction of urea cycle enzymes of rat liver by glucagon
    • Snodgrass, P. J., Lin, R. C., Muller, W. A., Aoki, T. T. Induction of urea cycle enzymes of rat liver by glucagon. J. Biol. Chem. 253, 2748-2753 (1978).
    • (1978) J. Biol. Chem , vol.253 , pp. 2748-2753
    • Snodgrass, P.J.1    Lin, R.C.2    Muller, W.A.3    Aoki, T.T.4
  • 43
    • 0027234019 scopus 로고
    • Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms
    • Ulbrigt, C., Snodgrass, P. J. Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms. Arch. Biochem. Biophys. 301, 237-243 (1993).
    • (1993) Arch. Biochem. Biophys , vol.301 , pp. 237-243
    • Ulbrigt, C.1    Snodgrass, P.J.2
  • 44
    • 0035979492 scopus 로고    scopus 로고
    • Caloric restriction alters the feeding response of key metabolic enzyme genes
    • Dhahbi, J. M. et al. Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech Ageing Dev. 122, 1033-1048 (2001).
    • (2001) Mech Ageing Dev , vol.122 , pp. 1033-1048
    • Dhahbi, J.M.1
  • 45
    • 0016419551 scopus 로고
    • Amino acid metabolism in man
    • Felig, P. Amino acid metabolism in man. Annu. Rev. Biochem. 44, 933-955 (1975).
    • (1975) Annu. Rev. Biochem , vol.44 , pp. 933-955
    • Felig, P.1
  • 46
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115-124 (1999).
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1
  • 47
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon, J. C. et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131-138 (2001).
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1
  • 48
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1', a nodal regulator of Mitochondrial biogenesis
    • Fernandez-Marcos, P. J., Auwerx, J. Regulation of PGC-1', a nodal regulator of Mitochondrial biogenesis. Am. J. Clin. Nutr. 93, 884S-890S (2011).
    • (2011) Am. J. Clin. Nutr , vol.93 , pp. 884S-890S
    • Fernandez-Marcos, P.J.1    Auwerx, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.