Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue

Biochemical Pharmacology

Volumn 100, Issue , 2016, Pages 86-97

  Mcilroy, George D ^a   Tammireddy, Seshu R ^b   Maskrey, Benjamin H ^b   Grant, Louise ^a   Doherty, Mary K ^b   Watson, David G ^c   Delibegović, Mirela ^a   Whitfield, Phillip D ^b   Mody, Nimesh ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Adipocytes; Dihydroceramide; Fenretinide; Lipidomics; Metabolomics; Retinoic acid

Indexed keywords

4 OXO N (4 HYDROXYPHENYL)RETINAMIDE; ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CELLULAR RETINOL BINDING PROTEIN 1; CERAMIDE; FATTY ACID BINDING PROTEIN 4; FENRETINIDE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; CITRIC ACID CYCLE; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; LIPIDOMICS; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MITOCHONDRION; MOUSE; NONHUMAN; NUTRIENT; OBESITY; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WESTERN BLOTTING; 3T3-L1 CELL LINE; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; LIPOGENESIS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; CERAMIDES; DIET, HIGH-FAT; FENRETINIDE; LIPOGENESIS; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MITOCHONDRIA; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION;

EID: 84963690368     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.11.017     Document Type: Article

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