The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy

Gut Microbes

Volumn 7, Issue 3, 2016, Pages 246-261

  Whitfield Cargile, Canaan M ^a   Cohen, Noah D ^a   Chapkin, Robert S ^b,c   Weeks, Brad R ^a   Davidson, Laurie A ^b   Goldsby, Jennifer S ^b   Hunt, Carrie L ^c   Steinmeyer, Shelby H ^c   Menon, Rani ^d   Suchodolski, Jan S ^a   Jayaraman, Arul ^d   Alaniz, Robert C ^c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A M COLLEGE OF MEDICINE   (United States)

^d Texas AandM University   (United States)

Author keywords

Dysbiosis; Indole; microbial metabolites; Microbiota; non steroidal antiinflammatory drugs (NSAIDs); transcriptome

Indexed keywords

CALGRANULIN; INDOLE; INDOMETACIN; TRYPTOPHAN; ANTIINFLAMMATORY AGENT; GASTROINTESTINAL AGENT; INDOLE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA EXTRACTION; ENTEROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; FLOW CYTOMETRY; GENE SEQUENCE; HISTOLOGY; MESENTERY LYMPH NODE; METABOLITE; MICROFLORA; MOUSE; MUCOSA INFLAMMATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOLOGY; POLYMERASE CHAIN REACTION; RNA EXTRACTION; SMALL INTESTINAL TISSUE; SPLEEN; ANIMAL; BACTERIUM; BIOTA; CHEMICALLY INDUCED; CHEMISTRY; CLASSIFICATION; CYTOCHEMISTRY; DISEASE MODEL; ENTERITIS; FECES; IMMUNOLOGY; INFLAMMATION; ISOLATION AND PURIFICATION; LYMPH NODE; METABOLISM; MICROBIOLOGY; NEUTROPHIL; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BACTERIA; BIOTA; DISEASE MODELS, ANIMAL; ENTERITIS; FECES; GASTROINTESTINAL AGENTS; HISTOCYTOCHEMISTRY; INDOLES; INFLAMMATION; LEUKOCYTE L1 ANTIGEN COMPLEX; LYMPH NODES; MICE; NEUTROPHILS; SPLEEN; TREATMENT OUTCOME;

EID: 84963588764     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.1080/19490976.2016.1156827     Document Type: Article

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