Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9

Molecular Cell

Volumn 61, Issue 6, 2016, Pages 886-894

  Hirano, Seiichi ^a   Nishimasu, Hiroshi ^a,b   Ishitani, Ryuichiro ^a   Nureki, Osamu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENDONUCLEASE; ESTER; GUIDE RNA; PROTEIN CAS9; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; SPACER DNA;

ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; CRYSTAL STRUCTURE; GENE MUTATION; GENETIC ENGINEERING; GENETIC VARIABILITY; IN VITRO STUDY; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE MOTIF; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTOSPACER ADJACENT MOTIF; STREPTOCOCCUS PYOGENES; WILD TYPE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; MUTATION; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CRISPR-CAS SYSTEMS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, INTERGENIC; ENDONUCLEASES; GENETIC ENGINEERING; MUTATION; RNA, GUIDE; SUBSTRATE SPECIFICITY;

EID: 84962580403     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.02.018     Document Type: Article

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