Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats

Toxicology and Industrial Health

Volumn 32, Issue 4, 2016, Pages 730-740

  Unsal, Cuneyt ^a   Oran, Mustafa ^a   Albayrak, Yakup ^a   Aktas, Cevat ^a   Erboga, Mustafa ^a   Topcu, Birol ^a   Uygur, Ramazan ^a   Tulubas, Feti ^a   Yanartas, Omer ^b   Ates, Ozkan ^a   Ozen, Oguz Aslan ^a  

^a NAMIK KEMAL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

ebselen; Intracerebroventricular streptozotocin; neuronal apoptosis; neuronal damage; oxidative stress; rats

Indexed keywords

EBSELEN; GLUTATHIONE PEROXIDASE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT; ORGANOSELENIUM DERIVATIVE; PYRROLE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFICACY; FRONTAL CORTEX; HISTOPATHOLOGY; MALE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; TUNEL ASSAY; ANIMAL; BRAIN; CYTOLOGY; DRUG EFFECTS; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; AZOLES; BRAIN; IN SITU NICK-END LABELING; MALE; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

EID: 84962467431     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713509429     Document Type: Article

References (68)

1. Agrawala R, Mishraa B, Tyagia E, Nathb C, Shuklaa R, (2010) Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Pharmacological Research 61: 247-252.
2. Aliev G, Smith MA, de la Torre JC, Perry G, (2004) Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. Mitochondrion 4 (5-6): 649-663.
3. Apel K, Hirt H, (2004) Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annual Review of Plant Physiology 55: 373-399.
4. Ashok BT, Ali R, (1999) The aging paradox: free radical theory of aging. Experimental Gerontology 34: 293-303.
5. Baldeiras I, Santana I, Proenca MT, Garrucho MH, Pascoal R, Rodrigues A, et al. (2008) Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease. Journal of Alzheimer Disease 15: 117-128.
6. Bursztajn SH, DeSouza R, McPhie DL, Berman SA, Shioi J, Robakis NK, et al. (1998) Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. Journal of Neuroscience 18: 9790-9799.
7. Butterfield DA, (2004) Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain. Brain Research 1000: 1-7.
8. Cakatay U, Kayali R, Uzun H, (2008) Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population. Clinical and Experimental Medicine 8: 51-57.
9. Centuriao FB, Corte CL, Paixao MW, Braga AL, Zeni G, Emanuelli T, et al. (2005) Effect of ebselen and organochalcogenides on excitotoxicity induced by glutamate in isolated chick retina. Brain Research 1039: 146-152.
10. Chonpathompikunlert P, Wattanathorn J, Muchimapura S, (2010) Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. Food and Chemical Toxicology 48: 798-802.
11. Cotgreave IA, Johansson U, Westergren G, Moldeus PW, Brattsand R, (1988) The anti-inflammatory activity of Ebselen but not thiols in experimental alveolitis and bronchiolitis. Agents and Actions 24: 313-319.
12. Deshmukh R, Sharma V, Mehan S, Sharma N, Bedi KL, (2009) Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine-a PDE1 inhibitor. European Journal of Pharmacology 620: 49-56.
13. Dringen R, (2000) Metabolism and functions of glutathione in brain (Review). Progress in Neurobiology 62: 649-671.
14. Dringen R, Gutterer JM, Hirrlinger J, (2000) Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. European Journal of Biochemistry 267: 4912-4916.
15. Dröge W, Kinscherf R, (2008) Aberrant insulin receptor signaling and amino acid homeostasis as amajor cause of oxidative stress in aging. Antioxidants and Redox Signaling 10: 661-678.
16. Duelli R, Schrock H, Kuschinsky W, Hoyer S, (1994) Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. International Journal of Developmental Neuroscience 12: 737-743.
17. Freude B, Masters TN, Robicsek F, Fokin A, Kostin S, Zimmermann R, et al. (2000) Apoptosis is initiated by myocardial ischemia and executed during reperfusion. Journal of Molecular and Cellular Cardiology 32: 197-208.
18. Garcia-Segura LM, (2009) Hormones and brain plasticity. New York, NY: Oxford University Press.
19. Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, et al. (1998) Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nature Medicine 4: 957-962.
20. Halliwell B, (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs and Aging 18: 685-716.
21. Hattori N, Kitagawa K, Higashida T, Yagyu K, Shimohama S, Wataya T, et al. (1998) Cl-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains. Neuroscience Letters 254: 141-144.
22. Hoyer S, Lannert H, (1999) Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats. Annals of the New York Academy of Sciences 893: 301-303.
23. Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM, (2001) Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke 32: 2149-2154.
24. Ishrat T, Hoda N, Khan MB, Yousuf S, Ahmad M, Khan M, et al. (2009a) Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). European Neuropsychopharmacology 19: 636-647.
25. Ishrat T, Parveen K, Khan M, Khuwaja G, Khan B, Yousuf S, et al. (2009b) Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Research 1281: 117-127.
26. Kalayci M, Coskun O, Cagavi F, Kanter M, Armutcu F, Gul S, et al. (2005) Neuroprotective effects of ebselen on experimental spinal cord injury in rats. Neurochemical Research 30 (3): 403-410.
27. Lannert H, Hoyer S, (1998) Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behavioral Neuroscience 112: 1199-1208.
28. Lee JM, Zipfel GJ, Choi DW, (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399: 7-14.
29. Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM, (2006) Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Journal of Alzheimer Disease 9: 13-33.
30. Long Z, Zheng M, Zhao L, Xie P, Song C, Chu Y, et al. (2013) Valproic acid attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer's disease mice model. Current Alzheimer Research 10 (3): 261-269.
31. Lowry OH, Rosebrough NJ, Farr AL, Randall RI, (1951) Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 193: 265-275.
32. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, Dekosky S, (2002) Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. Journal of the American Medical Association 288: 1475-1483.
33. Mariani E, Polidori MC, Cherubini A, Mecocci P, (2005) Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences 827: 65-75.
34. Markesbery WR, (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radical Biology and Medicine 23 (1): 134-147.
35. Maulik N, Yoshida T, Das DK, (1998) Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis. Free Radical Biology and Medicine 24: 869-875.
36. Meister A, (1988) Glutathione metabolism and its selective modification. Journal of Biological Chemistry 263: 17205-17208.
37. Moussaoui S, Obinu MC, Daniel N, Reibaud M, Blandchard V, Imperato A, et al. (2000) The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease. Experimental Neurology 166: 235-245.
38. Nelson VM, Dancik CM, Pan W, Jiang ZG, Lebowitz MS, Ghanbari HA, (2009) PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. Journal of Alzheimer Disease 17: 611-619.
39. Nita DA, Nita V, Spulber S, Moldovan M, Popa DP, Zagrean AM, et al. (2001) Oxidative damage following cerebral ischemia depends on reperfusion a biochemical study in rat. Journal of Cellular and Molecular Medicine 5: 163-170.
40. Nobakht M, Hoseini SM, Mortazavi P, Sohrabi I, Esmailzade B, Rooshandel NR, et al. (2011) Neuropathological changes in brain cortex and hippocampus in a rat model of Alzheimer's disease. Iranian Biomedical Journal 15 (1&2): 51-58.
41. Ohkawa H, Ohishi N, Yagi K, (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid rection. Analytical Biochemistry 95: 351-358.
42. Paglia DE, Valentine WN, (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158-169.
43. Parnham M, Sies H, (2000) Ebselen: prospective therapy for cerebral ischaemia. Expert Opinion on Investigational Drugs 9: 607-619.
44. Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, et al. (2002) Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology and Medicine 33 (11): 1475-1479.
45. Plaschke K, Hoyer S, (1993) Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus. International Journal of Developmental Neuroscience 11: 477-483.
46. Porciuncula LO, Rocha JB, Boeck CR, Vendite D, Souza DO, (2001) Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons. Neuroscience Letters 299: 217-220.
47. Porciuncula LO, Rocha JB, Cimarosti H, Vinade L, Ghisleni G, Salbego CG, et al. (2003) Neuroprotective effect of ebselen on rat hippocampal slices submitted to oxygen-glucose deprivation: correlation with immunocontent of inducible nitric oxide synthase. Neuroscience Letters 346: 101-104.
48. Ren X, Yang L, Liu J, Su D, You D, Liu C, et al. (2001) A novel glutathione peroxidase mimic with antioxidant activity. Archives of Biochemistry and Biophysics 387: 250-256.
49. Rossier BC, Geering K, Kraenbuhl JP, (1987) Regulation of the sodium pump: how and why? Trends in Biochemical Sciences 2: 483-487.
50. Saito I, Asano T, Sano K, Takakura K, Abe H, Yoshimoto T, et al. (1998) Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery 42: 269-278.
51. Satoh T, Ishige K, Sagara Y, (2004) Protective effects on neuronal cells of Mouse afforded by ebselen against oxidative stress at multiple steps. Neuroscience Letters 371: 1-5.
52. Sharma M, Gupta YK, (2001) Effect of chronic treatment of melatonin on learning, memory and oxidative deficiencies induced by intracerebroventricular streptozotocin in rats. Pharmacology Biochemistry and Behavior 70: 325-331.
53. Sharma N, Deshmukh R, Bedi KL, (2010) SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats. Pharmacology Biochemistry and Behavior 96: 386-394.
54. Sharma V, Bala A, Deshmukh R, Bedi KL, Sharma PL, (2012) Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacology Biochemistry and Behavior 101: 239-245.
55. Shoham S, Bejar C, Kovalev E, Schorer-Apelbaum D, Weinstock M, (2007) Ladostigil prevents gliosis, oxidative-nitrative stress and memory deficits induced by intracerebroventricular injection of streptozotocin in rats. Neuropharmacology 52: 836-843.
56. Sies H, (1993) Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Radical Biology and Medicine 14: 313-323.
57. Sies H, Arteel GE, (2000) Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics. Free Radical Biology and Medicine 28: 1451-1455.
58. Sies H, Masumoto H, (1997) Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. Advances in Pharmacology 38: 229-246.
59. Sun Y, (1990) Free radicals, antioxidant enzymes, and carcinogenesis. Free Radical Biology and Medicine 8: 583-599.
60. Sun Y, Oberley LW, Li Y, (1988) A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34: 497-500.
61. Szkudelski T, (2001) The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiological Research 50: 537-546.
62. Takasago T, Peters EE, Graham DI, Masayasu H, Macrae IM, (1997) Neuroprotective efficacy of ebselen an antioxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion. British Journal of Pharmacology 122: 1251-1256.
63. Yamagata K, Ichinose S, Miyashita A, Tagami M, (2008) Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience 153: 428-435.
64. Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, et al. (1998) Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical rial. Stroke 29: 12-17.
65. Yoshizumi M, Kogame T, Suzaki Y, Fujita Y, Kyaw M, Kirima K, et al. (2002) Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. British Journal of Pharmacology 136: 1023-1032.
66. Yu BP, Yang R, (1996) Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis. Annals of the New York Academy of Sciences 786: 1-11.
67. Zeng GF, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM, (2013) Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats. Rejuvenation Research 16 (2): 124-133.
68. Zhu X, Lee HG, Casadesus G, Avila J, Drew K, Perry G, et al. (2005) Oxidative imbalance in Alzheimer's disease (Review). Molecular Neurobiology 31: 205-217.