Valproic acid attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer's disease mice model

Current Alzheimer Research

Volumn 10, Issue 3, 2013, Pages 261-269

  Long, Zhimin ^a   Zheng, Min ^a   Zhao, Lei ^a   Xie, Peng ^a   Song, Cong ^b   Chu, Yalan ^a   Song, Weihong ^a   He, Guiqiong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease; Apoptosis; GSK 3 ; Valproic acid

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALCIUM ION; CASPASE 12; CASPASE 3; CASPASE 9; CYTOCHROME C; PRESENILIN 1; PROTEIN BAX; PROTEIN BCL 2; VALPROIC ACID;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; BRAIN CELL; CELL LOSS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEUROPIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, TRANSGENIC; NEURONS; NEUROPROTECTIVE AGENTS; VALPROIC ACID;

EID: 84876872086     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011310030005     Document Type: Article

References (32)

1. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 6(4): 487-98 (1991).
2. Prvulovic D, Hampel H. Amyloid beta (Abeta) and phospho-tau (ptau) as diagnostic biomarkers in Alzheimer's disease. Clin Chem Lab Med 49(3): 367-74 (2011).
3. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (New York, NY 297(5580): 353-6 (2002).
4. Yao M, Nguyen TV, Pike CJ. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci 25(5): 1149-58 (2005).
5. Luque FA, Jaffe SL. The molecular and cellular pathogenesis of dementia of the Alzheimer's type an overview. Int Rev Neurobiol 84:151-65 (2009).
6. Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci 26(22): 6011-8 (2006).
7. Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Int Med 140(8): 627-38 (2004).
8. Town T. Alzheimer's Disease Beyond Abeta. Expert Rev Neurother 10(5): 671-5 (2010).
9. Seabrook GR, Ray WJ, Shearman M, Hutton M. Beyond amyloid: the next generation of Alzheimer's disease therapeutics. Mol Interven 7(5): 261-70 (2007).
10. Golde TE, Schneider LS, Koo EH. Anti-abeta therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 69(2): 203-13 (2011).
11. Hooper C, Killick R, Lovestone S. The GSK3 hypothesis of Alzheimer's disease. Journal of neurochemistry. 2008 Mar; 104(6): 1433-9.
12. Alvarez AR, Godoy JA, Mullendorff K, Olivares GH, Bronfman M, Inestrosa NC. Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons. Exp Cell Res 297(1):186-96 (2004).
13. Kosik KS. Cellular aspects of Alzheimer neurofibrillary pathology. Prog Clin Biol Res 379:183-93 (1992).
14. Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423(6938): 435-9 (2003).
15. Liang MH, Chuang DM. Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 282(6): 3904-17 (2007).
16. Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. The EMBO J 20(1-2): 27-39 (2001).
17. Beurel E, Jope RS. The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79(4):173-89 (2006).
18. Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276(39): 36734-41 (2001).
19. Chen PS, Peng GS, Li G, Yang S, Wu X, Wang CC, et al. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry 11(12): 1116-25 (2006).
20. Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 321(3): 892-901 (2007).
21. Williams RS, Cheng L, Mudge AW, Harwood AJ. A common mechanism of action for three mood-stabilizing drugs. Nature 417(6886): 292-5 (2002).
22. Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, et al. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med 205(12): 2781-9 (2008).
23. Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nature Rev 2(1): 67-71 (2001).
24. Mines MA, Beurel E, Jope RS. Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3. Int J Alzheimer's Dis 861072 (2011).
25. Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A 101(7): 2173-8 (2004).
26. Medina M, Avila J. Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease. Curr Pharm Des 16(25): 2790-8 (2010).
27. Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol 55(6): 801-14 (2004).
28. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3(11): E255-63 (2001).
29. Chou JL, Shenoy DV, Thomas N, Choudhary PK, Laferla FM, Goodman SR, et al. Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. J Proteomics 74(4):466-79 (2011).
30. Cui N, Li S, Zhao X, Zhang T, Zhang C, Yu L, et al. Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione. Neurochem Res 32(9):1566-72 (2007).
31. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765): 98-103 (2000).
32. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399(6735): 483-7 (1999).