메뉴 건너뛰기




Volumn 43, Issue 1, 2016, Pages 19-28

Recent advances in animal models of systemic sclerosis

Author keywords

Fli1+ mice; Fra2 transgenic mice; Klf5 + ; new genetic animal models; systemic sclerosis; urokinase type plasminogen activator receptor deficient mice

Indexed keywords

BETA CATENIN; BLOOM SYNDROME HELICASE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; HLA ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; KRUPPEL LIKE FACTOR 5; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR FRA 2; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; FLI1 PROTEIN, MOUSE; FOSL2 PROTEIN, MOUSE; KLF5 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; PLAUR PROTEIN, MOUSE; UROKINASE RECEPTOR;

EID: 84962424898     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/1346-8138.13185     Document Type: Review
Times cited : (18)

References (109)
  • 2
    • 84940889699 scopus 로고    scopus 로고
    • Vasculopathy in scleroderma
    • Asano Y, Sato S,. Vasculopathy in scleroderma. Semin Immunopathol 2015; 37: 489-500.
    • (2015) Semin Immunopathol , vol.37 , pp. 489-500
    • Asano, Y.1    Sato, S.2
  • 4
    • 80051600437 scopus 로고    scopus 로고
    • Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: Reversal by caveolin-1 scaffolding domain peptide
    • Tourkina E, Bonner M, Oates J, et al,. Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide. Fibrogenesis Tissue Repair 2011; 4: 15.
    • (2011) Fibrogenesis Tissue Repair , vol.4 , pp. 15
    • Tourkina, E.1    Bonner, M.2    Oates, J.3
  • 5
    • 84941985446 scopus 로고    scopus 로고
    • Partially evoked epithelial-mesenchymal transition (EMT) is associated with increased TGFβ signaling within lesional scleroderma skin
    • Nikitorowicz-Buniak J, Denton CP, Abraham D, Stratton R,. Partially evoked epithelial-mesenchymal transition (EMT) is associated with increased TGFβ signaling within lesional scleroderma skin. PLoS ONE 2015; 10: e0134092.
    • (2015) PLoS ONE , vol.10 , pp. e0134092
    • Nikitorowicz-Buniak, J.1    Denton, C.P.2    Abraham, D.3    Stratton, R.4
  • 6
    • 84904854851 scopus 로고    scopus 로고
    • Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis
    • Jimenez SA,. Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol 2013; 2013: 835948.
    • (2013) ISRN Rheumatol , vol.2013 , pp. 835948
    • Jimenez, S.A.1
  • 7
    • 0023885251 scopus 로고
    • Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization
    • Scharffetter K, Lankat-Buttgereit B, Krieg T,. Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur J Clin Invest 1988; 18: 9-17.
    • (1988) Eur J Clin Invest , vol.18 , pp. 9-17
    • Scharffetter, K.1    Lankat-Buttgereit, B.2    Krieg, T.3
  • 8
    • 0025092082 scopus 로고
    • Transcription and expression of transforming growth factor type β in the skin of progressive systemic sclerosis: A mediator of fibrosis?
    • Gruschwitz M, Müller PU, Sepp N, Hofer E, Fontana A, Wick G,. Transcription and expression of transforming growth factor type β in the skin of progressive systemic sclerosis: a mediator of fibrosis? J Invest Dermatol 1990; 94: 197-203.
    • (1990) J Invest Dermatol , vol.94 , pp. 197-203
    • Gruschwitz, M.1    Müller, P.U.2    Sepp, N.3    Hofer, E.4    Fontana, A.5    Wick, G.6
  • 9
    • 0032769817 scopus 로고    scopus 로고
    • Expression of TGF- β1, - β2 and - β3 in localized and systemic scleroderma
    • Querfeld C, Eckes B, Huerkamp C, Krieg T, Sollberg S,. Expression of TGF- β1,-β2 and-β3 in localized and systemic scleroderma. J Dermatol Sci 1999; 21: 13-22.
    • (1999) J Dermatol Sci , vol.21 , pp. 13-22
    • Querfeld, C.1    Eckes, B.2    Huerkamp, C.3    Krieg, T.4    Sollberg, S.5
  • 10
    • 0025145174 scopus 로고
    • Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis
    • Kulozik M, Hogg A, Lankat-Buttgereit B, Krieg T,. Co-localization of transforming growth factor β2 with α1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis. J Clin Invest 1990; 86: 917-922.
    • (1990) J Clin Invest , vol.86 , pp. 917-922
    • Kulozik, M.1    Hogg, A.2    Lankat-Buttgereit, B.3    Krieg, T.4
  • 11
    • 84871284466 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling augments transforming growth factor-β responses: A novel mechanism for maintaining and amplifying fibrosis in scleroderma
    • Bhattacharyya S, Kelley K, Melichian DS, et al,. Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 2013; 182: 192-205.
    • (2013) Am J Pathol , vol.182 , pp. 192-205
    • Bhattacharyya, S.1    Kelley, K.2    Melichian, D.S.3
  • 12
    • 84899051032 scopus 로고    scopus 로고
    • FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling
    • Bhattacharyya S, Tamaki Z, Wang W, et al,. FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling. Sci Transl Med 2014; 6: 232ra50.
    • (2014) Sci Transl Med , vol.6 , pp. 232ra50
    • Bhattacharyya, S.1    Tamaki, Z.2    Wang, W.3
  • 13
    • 84919919841 scopus 로고    scopus 로고
    • Amelioration of tissue fibrosis by toll-like receptor 4 knockout in murine models of systemic sclerosis
    • Takahashi T, Asano Y, Ichimura Y, et al,. Amelioration of tissue fibrosis by toll-like receptor 4 knockout in murine models of systemic sclerosis. Arthritis Rheumatol 2015; 67: 254-265.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 254-265
    • Takahashi, T.1    Asano, Y.2    Ichimura, Y.3
  • 14
    • 84921841338 scopus 로고    scopus 로고
    • Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis
    • Bhattacharyya S, Varga J,. Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis. Curr Rheumatol Rep 2015; 17: 474.
    • (2015) Curr Rheumatol Rep , vol.17 , pp. 474
    • Bhattacharyya, S.1    Varga, J.2
  • 15
    • 75649110070 scopus 로고    scopus 로고
    • Animal model of systemic sclerosis
    • Yamamoto T,. Animal model of systemic sclerosis. J Dermatol 2010; 37: 26-41.
    • (2010) J Dermatol , vol.37 , pp. 26-41
    • Yamamoto, T.1
  • 16
    • 77957668307 scopus 로고    scopus 로고
    • Animal models of systemic sclerosis: Prospects and limitations
    • Beyer C, Schett G, Distler O, Distler JH,. Animal models of systemic sclerosis: prospects and limitations. Arthritis Rheum 2010; 62: 2831-2844.
    • (2010) Arthritis Rheum , vol.62 , pp. 2831-2844
    • Beyer, C.1    Schett, G.2    Distler, O.3    Distler, J.H.4
  • 17
    • 84885737407 scopus 로고    scopus 로고
    • Animal models of scleroderma: Current state and recent development
    • Asano Y, Sato S,. Animal models of scleroderma: current state and recent development. Curr Rheumatol Rep 2013; 15: 382.
    • (2013) Curr Rheumatol Rep , vol.15 , pp. 382
    • Asano, Y.1    Sato, S.2
  • 18
    • 66949168883 scopus 로고    scopus 로고
    • Selective oxidation of DNA topoisomerase 1 induces systemic sclerosis in the mouse
    • Servettaz A, Goulvestre C, Kavian N, et al,. Selective oxidation of DNA topoisomerase 1 induces systemic sclerosis in the mouse. J Immunol 2009; 182: 5855-5864.
    • (2009) J Immunol , vol.182 , pp. 5855-5864
    • Servettaz, A.1    Goulvestre, C.2    Kavian, N.3
  • 19
    • 80155206307 scopus 로고    scopus 로고
    • Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling
    • Yoshizaki A, Yanaba K, Ogawa A, Asano Y, Kadono T, Sato S,. Immunization with DNA topoisomerase I and Freund's complete adjuvant induces skin and lung fibrosis and autoimmunity via interleukin-6 signaling. Arthritis Rheum 2011; 63: 3575-3585.
    • (2011) Arthritis Rheum , vol.63 , pp. 3575-3585
    • Yoshizaki, A.1    Yanaba, K.2    Ogawa, A.3    Asano, Y.4    Kadono, T.5    Sato, S.6
  • 20
    • 84865186839 scopus 로고    scopus 로고
    • Angiotensin II induces skin fibrosis: A novel mouse model of dermal fibrosis
    • Stawski L, Han R, Bujor AM, Trojanowska M,. Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis. Arthritis Res Ther 2012; 14: R194.
    • (2012) Arthritis Res Ther , vol.14 , pp. R194
    • Stawski, L.1    Han, R.2    Bujor, A.M.3    Trojanowska, M.4
  • 21
    • 0029941445 scopus 로고    scopus 로고
    • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation
    • Siracusa LD, McGrath R, Ma Q, et al,. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res 1996; 6: 300-313.
    • (1996) Genome Res , vol.6 , pp. 300-313
    • Siracusa, L.D.1    McGrath, R.2    Ma, Q.3
  • 22
    • 0018876860 scopus 로고
    • The ultrastructure of collagen in the dermis of tight-skin (Tsk) mutant mice
    • Menton DN, Hess RA,. The ultrastructure of collagen in the dermis of tight-skin (Tsk) mutant mice. J Invest Dermatol 1980; 74: 139-147.
    • (1980) J Invest Dermatol , vol.74 , pp. 139-147
    • Menton, D.N.1    Hess, R.A.2
  • 25
    • 33846247466 scopus 로고    scopus 로고
    • Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma
    • Sonnylal S, Denton CP, Zheng B, et al,. Postnatal induction of transforming growth factor β signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 2007; 56: 334-344.
    • (2007) Arthritis Rheum , vol.56 , pp. 334-344
    • Sonnylal, S.1    Denton, C.P.2    Zheng, B.3
  • 26
    • 0042090396 scopus 로고    scopus 로고
    • Fibroblast-specific expression of a kinase-deficient type II transforming growth factor β (TGFβ) receptor leads to paradoxical activation of TGFβ signaling pathways with fibrosis in transgenic mice
    • Denton CP, Zheng B, Evans LA, et al,. Fibroblast-specific expression of a kinase-deficient type II transforming growth factor β (TGFβ) receptor leads to paradoxical activation of TGFβ signaling pathways with fibrosis in transgenic mice. J Biol Chem 2003; 278: 25109-25119.
    • (2003) J Biol Chem , vol.278 , pp. 25109-25119
    • Denton, C.P.1    Zheng, B.2    Evans, L.A.3
  • 27
    • 2342547687 scopus 로고    scopus 로고
    • An increased transforming growth factor β receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma
    • Pannu J, Gore-Hyer E, Yamanaka M, et al,. An increased transforming growth factor β receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma. Arthritis Rheum 2004; 50: 1566-1577.
    • (2004) Arthritis Rheum , vol.50 , pp. 1566-1577
    • Pannu, J.1    Gore-Hyer, E.2    Yamanaka, M.3
  • 28
    • 33749320619 scopus 로고    scopus 로고
    • Increased levels of transforming growth factor β receptor type I and up-regulation of matrix gene program: A model of scleroderma
    • Pannu J, Gardner H, Shearstone JR, Smith E, Trojanowska M,. Increased levels of transforming growth factor β receptor type I and up-regulation of matrix gene program: A model of scleroderma. Arthritis Rheum 2006; 54: 3011-3021.
    • (2006) Arthritis Rheum , vol.54 , pp. 3011-3021
    • Pannu, J.1    Gardner, H.2    Shearstone, J.R.3    Smith, E.4    Trojanowska, M.5
  • 29
    • 34249845879 scopus 로고    scopus 로고
    • Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
    • Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M,. Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J Biol Chem 2007; 282: 10405-10413.
    • (2007) J Biol Chem , vol.282 , pp. 10405-10413
    • Pannu, J.1    Nakerakanti, S.2    Smith, E.3    Ten Dijke, P.4    Trojanowska, M.5
  • 30
    • 85047692249 scopus 로고    scopus 로고
    • Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts
    • Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K,. Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts. J Clin Invest 2004; 113: 253-264.
    • (2004) J Clin Invest , vol.113 , pp. 253-264
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Kubo, M.4    Tamaki, K.5
  • 31
    • 78751681095 scopus 로고    scopus 로고
    • Altered dynamics of transforming growth factor β(TGF-β) receptors in scleroderma fibroblasts
    • Asano Y, Ihn H, Jinnin M, Tamaki K, Sato S,. Altered dynamics of transforming growth factor β(TGF-β) receptors in scleroderma fibroblasts. Ann Rheum Dis 2011; 70: 384-387.
    • (2011) Ann Rheum Dis , vol.70 , pp. 384-387
    • Asano, Y.1    Ihn, H.2    Jinnin, M.3    Tamaki, K.4    Sato, S.5
  • 32
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL,. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat Cell Biol 2003; 5: 410-421.
    • (2003) Nat Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 33
    • 0035964954 scopus 로고    scopus 로고
    • Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    • Drab M, Verkade P, Elger M, et al,. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001; 293: 2449-2452.
    • (2001) Science , vol.293 , pp. 2449-2452
    • Drab, M.1    Verkade, P.2    Elger, M.3
  • 34
    • 0037143769 scopus 로고    scopus 로고
    • Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    • Zhao YY, Liu Y, Stan RV, et al,. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci USA 2002; 99: 11375-11380.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11375-11380
    • Zhao, Y.Y.1    Liu, Y.2    Stan, R.V.3
  • 35
    • 51849169053 scopus 로고    scopus 로고
    • Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis
    • Del Galdo F, Sotgia F, de Almeida CJ, et al,. Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum 2008; 58: 2854-2865.
    • (2008) Arthritis Rheum , vol.58 , pp. 2854-2865
    • Del Galdo, F.1    Sotgia, F.2    De Almeida, C.J.3
  • 36
    • 77951743012 scopus 로고    scopus 로고
    • Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis
    • Sonnylal S, Shi-Wen X, Leoni P, et al,. Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 2010; 62: 1523-1532.
    • (2010) Arthritis Rheum , vol.62 , pp. 1523-1532
    • Sonnylal, S.1    Shi-Wen, X.2    Leoni, P.3
  • 37
    • 76649142440 scopus 로고    scopus 로고
    • Transforming growth factor-β in systemic sclerosis (scleroderma)
    • Varga J, Whitfield ML,. Transforming growth factor-β in systemic sclerosis (scleroderma). Front Biosci (Schol Ed) 2009; 1: 226-235.
    • (2009) Front Biosci (Schol Ed) , vol.1 , pp. 226-235
    • Varga, J.1    Whitfield, M.L.2
  • 38
    • 79958036406 scopus 로고    scopus 로고
    • Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
    • Wei J, Melichian D, Komura K, et al,. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 2011; 63: 1707-1717.
    • (2011) Arthritis Rheum , vol.63 , pp. 1707-1717
    • Wei, J.1    Melichian, D.2    Komura, K.3
  • 39
    • 84859500585 scopus 로고    scopus 로고
    • β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
    • Beyer C, Schramm A, Akhmetshina A, et al,. β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2012; 71: 761-767.
    • (2012) Ann Rheum Dis , vol.71 , pp. 761-767
    • Beyer, C.1    Schramm, A.2    Akhmetshina, A.3
  • 40
    • 0019400724 scopus 로고
    • Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma)
    • Gershwin ME, Abplanalp H, Castles JJ, et al,. Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J Exp Med 1981; 153: 1640-1659.
    • (1981) J Exp Med , vol.153 , pp. 1640-1659
    • Gershwin, M.E.1    Abplanalp, H.2    Castles, J.J.3
  • 41
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • Sgonc R, Gruschwitz MS, Dietrich H, Recheis H, Gershwin ME, Wick G,. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J Clin Invest 1996; 98: 785-792.
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3    Recheis, H.4    Gershwin, M.E.5    Wick, G.6
  • 42
    • 48749092428 scopus 로고    scopus 로고
    • Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
    • Eferl R, Hasselblatt P, Rath M, et al,. Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci USA 2008; 105: 10525-10530.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10525-10530
    • Eferl, R.1    Hasselblatt, P.2    Rath, M.3
  • 43
    • 73449115656 scopus 로고    scopus 로고
    • Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis
    • Maurer B, Busch N, Jüngel A, et al,. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. Circulation 2009; 120: 2367-2376.
    • (2009) Circulation , vol.120 , pp. 2367-2376
    • Maurer, B.1    Busch, N.2    Jüngel, A.3
  • 44
    • 74849137794 scopus 로고    scopus 로고
    • The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis
    • Reich N, Maurer B, Akhmetshina A, et al,. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. Arthritis Rheum 2010; 62: 280-290.
    • (2010) Arthritis Rheum , vol.62 , pp. 280-290
    • Reich, N.1    Maurer, B.2    Akhmetshina, A.3
  • 45
    • 84863812038 scopus 로고    scopus 로고
    • Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis
    • Maurer B, Reich N, Juengel A, et al,. Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis. Ann Rheum Dis 2012; 71: 1382-1387.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1382-1387
    • Maurer, B.1    Reich, N.2    Juengel, A.3
  • 47
    • 84905158456 scopus 로고    scopus 로고
    • Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: A new model of experimental scleroderma?
    • Manetti M, Rosa I, Milia AF, et al,. Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma? Ann Rheum Dis 2014; 73: 1700-1709.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1700-1709
    • Manetti, M.1    Rosa, I.2    Milia, A.F.3
  • 48
    • 84954367716 scopus 로고    scopus 로고
    • Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice
    • Manetti M, Rosa I, Fazi M, et al,. Systemic sclerosis-like histopathological features in the myocardium of uPAR-deficient mice. Ann Rheum Dis 2015; doi: 10.1136/annrheumdis-2015-207803.
    • (2015) Ann Rheum Dis
    • Manetti, M.1    Rosa, I.2    Fazi, M.3
  • 49
    • 84923341300 scopus 로고    scopus 로고
    • Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
    • Noda S, Asano Y, Nishimura S, et al,. Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis. Nat Commun 2014; 5: 5797.
    • (2014) Nat Commun , vol.5 , pp. 5797
    • Noda, S.1    Asano, Y.2    Nishimura, S.3
  • 50
    • 84941421097 scopus 로고    scopus 로고
    • Double heterozygous mice for Klf5 and Fli1 genes: A new animal model of systemic sclerosis recapitulating its three cardinal pathological features
    • Asano Y,. Double heterozygous mice for Klf5 and Fli1 genes: a new animal model of systemic sclerosis recapitulating its three cardinal pathological features. Med Mol Morphol 2015; 48: 123-128.
    • (2015) Med Mol Morphol , vol.48 , pp. 123-128
    • Asano, Y.1
  • 51
    • 63449091795 scopus 로고    scopus 로고
    • Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension
    • ten Freyhaus H, Dumitrescu D, Bovenschulte H, Erdmann E, Rosenkranz S,. Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension. Clin Res Cardiol 2009; 98: 265-267.
    • (2009) Clin Res Cardiol , vol.98 , pp. 265-267
    • Ten Freyhaus, H.1    Dumitrescu, D.2    Bovenschulte, H.3    Erdmann, E.4    Rosenkranz, S.5
  • 52
    • 77955813534 scopus 로고    scopus 로고
    • Imatinib mesylate has the potential to exert its efficacy by down-regulating the plasma concentration of platelet-derived growth factor in patients with pulmonary arterial hypertension
    • Hatano M, Yao A, Shiga T, Kinugawa K, Hirata Y, Nagai R,. Imatinib mesylate has the potential to exert its efficacy by down-regulating the plasma concentration of platelet-derived growth factor in patients with pulmonary arterial hypertension. Int Heart J 2010; 51: 272-276.
    • (2010) Int Heart J , vol.51 , pp. 272-276
    • Hatano, M.1    Yao, A.2    Shiga, T.3    Kinugawa, K.4    Hirata, Y.5    Nagai, R.6
  • 53
    • 0036906177 scopus 로고    scopus 로고
    • UPAR: A versatile signalling orchestrator
    • Blasi F, Carmeliet P,. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3: 932-943.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 54
    • 57349182712 scopus 로고    scopus 로고
    • The absence of uPAR is associated with the progression of dermal fibrosis
    • Kanno Y, Kaneiwa A, Minamida M, et al,. The absence of uPAR is associated with the progression of dermal fibrosis. J Invest Dermatol 2008; 128: 2792-2797.
    • (2008) J Invest Dermatol , vol.128 , pp. 2792-2797
    • Kanno, Y.1    Kaneiwa, A.2    Minamida, M.3
  • 55
    • 34347384693 scopus 로고    scopus 로고
    • Urokinase receptor cleavage: A crucial step in fibroblast-to-myofibroblast differentiation
    • Bernstein AM, Twining SS, Warejcka DJ, Tall E, Masur SK,. Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation. Mol Biol Cell 2007; 18: 2716-2727.
    • (2007) Mol Biol Cell , vol.18 , pp. 2716-2727
    • Bernstein, A.M.1    Twining, S.S.2    Warejcka, D.J.3    Tall, E.4    Masur, S.K.5
  • 56
    • 5644277559 scopus 로고    scopus 로고
    • Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis
    • D'Alessio S, Fibbi G, Cinelli M, et al,. Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. Arthritis Rheum 2004; 50: 3275-3285.
    • (2004) Arthritis Rheum , vol.50 , pp. 3275-3285
    • D'Alessio, S.1    Fibbi, G.2    Cinelli, M.3
  • 57
    • 33845666597 scopus 로고    scopus 로고
    • Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, β2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: Failure of association in systemic sclerosis endothelial cells
    • Margheri F, Manetti M, Serratì S, et al,. Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, β2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: failure of association in systemic sclerosis endothelial cells. Arthritis Rheum 2006; 54: 3926-3938.
    • (2006) Arthritis Rheum , vol.54 , pp. 3926-3938
    • Margheri, F.1    Manetti, M.2    Serratì, S.3
  • 58
    • 0034965980 scopus 로고    scopus 로고
    • Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts
    • Arnett FC, Cho M, Chatterjee S, Aguilar MB, Reveille JD, Mayes MD,. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum 2001; 44: 1359-1362.
    • (2001) Arthritis Rheum , vol.44 , pp. 1359-1362
    • Arnett, F.C.1    Cho, M.2    Chatterjee, S.3    Aguilar, M.B.4    Reveille, J.D.5    Mayes, M.D.6
  • 59
    • 0038004795 scopus 로고    scopus 로고
    • Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies
    • Feghali-Bostwick C, Medsger TA, Wright TM,. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum 2003; 48: 1956-1963.
    • (2003) Arthritis Rheum , vol.48 , pp. 1956-1963
    • Feghali-Bostwick, C.1    Medsger, T.A.2    Wright, T.M.3
  • 60
    • 84908506366 scopus 로고    scopus 로고
    • The role of genetics and epigenetics in the pathogenesis of systemic sclerosis
    • Broen JC, Radstake TR, Rossato M,. The role of genetics and epigenetics in the pathogenesis of systemic sclerosis. Nat Rev Rheumatol 2014; 10: 671-681.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 671-681
    • Broen, J.C.1    Radstake, T.R.2    Rossato, M.3
  • 61
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • Wang Y, Fan PS, Kahaleh B,. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 2006; 54: 2271-2279.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 62
    • 84888341033 scopus 로고    scopus 로고
    • Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma
    • Wang Y, Kahaleh B,. Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. J Cell Mol Med 2013; 17: 1291-1299.
    • (2013) J Cell Mol Med , vol.17 , pp. 1291-1299
    • Wang, Y.1    Kahaleh, B.2
  • 63
    • 79953665837 scopus 로고    scopus 로고
    • Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis
    • Hu B, Gharaee-Kermani M, Wu Z, Phan SH,. Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis. Am J Pathol 2011; 178: 1500-1508.
    • (2011) Am J Pathol , vol.178 , pp. 1500-1508
    • Hu, B.1    Gharaee-Kermani, M.2    Wu, Z.3    Phan, S.H.4
  • 64
    • 84858074879 scopus 로고    scopus 로고
    • DNA demethylation of CD40 l in CD4 + T cells from women with systemic sclerosis: A possible explanation for female susceptibility
    • Lian X, Xiao R, Hu X, et al,. DNA demethylation of CD40 l in CD4 + T cells from women with systemic sclerosis: a possible explanation for female susceptibility. Arthritis Rheum 2012; 64: 2338-2345.
    • (2012) Arthritis Rheum , vol.64 , pp. 2338-2345
    • Lian, X.1    Xiao, R.2    Hu, X.3
  • 65
    • 84862777126 scopus 로고    scopus 로고
    • Demethylation of TNFSF7 contributes to CD70 overexpression in CD4 + T cells from patients with systemic sclerosis
    • Jiang H, Xiao R, Lian X, et al,. Demethylation of TNFSF7 contributes to CD70 overexpression in CD4 + T cells from patients with systemic sclerosis. Clin Immunol 2012; 143: 39-44.
    • (2012) Clin Immunol , vol.143 , pp. 39-44
    • Jiang, H.1    Xiao, R.2    Lian, X.3
  • 66
    • 84927514937 scopus 로고    scopus 로고
    • Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis
    • Wang Y, Shu Y, Xiao Y, et al,. Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis. Clin Epigenetics 2014; 6: 25.
    • (2014) Clin Epigenetics , vol.6 , pp. 25
    • Wang, Y.1    Shu, Y.2    Xiao, Y.3
  • 67
    • 84940368260 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies
    • Altorok N, Tsou PS, Coit P, Khanna D, Sawalha AH,. Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies. Ann Rheum Dis 2015; 74: 1612-1620.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1612-1620
    • Altorok, N.1    Tsou, P.S.2    Coit, P.3    Khanna, D.4    Sawalha, A.H.5
  • 68
    • 0025138488 scopus 로고
    • Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus
    • Ben-David Y, Giddens EB, Bernstein A,. Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci USA 1990; 87: 1332-1336.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1332-1336
    • Ben-David, Y.1    Giddens, E.B.2    Bernstein, A.3
  • 69
    • 0025736350 scopus 로고
    • Erythroleukemia induction by Friend murine leukemia virus: Insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1
    • Ben-David Y, Giddens EB, Letwin K, Bernstein A,. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev 1991; 5: 908-918.
    • (1991) Genes Dev , vol.5 , pp. 908-918
    • Ben-David, Y.1    Giddens, E.B.2    Letwin, K.3    Bernstein, A.4
  • 70
    • 0026686674 scopus 로고
    • Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
    • Delattre O, Zucman J, Plougastel B, et al,. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-165.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3
  • 71
    • 7444252292 scopus 로고    scopus 로고
    • Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors
    • Hollenhorst PC, Jones DA, Graves BJ,. Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res 2004; 32: 5693-5702.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5693-5702
    • Hollenhorst, P.C.1    Jones, D.A.2    Graves, B.J.3
  • 72
    • 0035877684 scopus 로고    scopus 로고
    • Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway
    • Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M,. Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 2001; 276: 20839-20848.
    • (2001) J Biol Chem , vol.276 , pp. 20839-20848
    • Czuwara-Ladykowska, J.1    Shirasaki, F.2    Jackers, P.3    Watson, D.K.4    Trojanowska, M.5
  • 73
    • 0042846026 scopus 로고    scopus 로고
    • Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin
    • Kubo M, Czuwara-Ladykowska J, Moussa O, et al,. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 2003; 163: 571-581.
    • (2003) Am J Pathol , vol.163 , pp. 571-581
    • Kubo, M.1    Czuwara-Ladykowska, J.2    Moussa, O.3
  • 74
    • 0033912227 scopus 로고    scopus 로고
    • Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor
    • Spyropoulos DD, Pharr PN, Lavenburg KR, et al,. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol 2000; 20: 5643-5652.
    • (2000) Mol Cell Biol , vol.20 , pp. 5643-5652
    • Spyropoulos, D.D.1    Pharr, P.N.2    Lavenburg, K.R.3
  • 75
    • 11144221224 scopus 로고    scopus 로고
    • Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice
    • Masuya M, Moussa O, Abe T, et al,. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood 2005; 105: 95-102.
    • (2005) Blood , vol.105 , pp. 95-102
    • Masuya, M.1    Moussa, O.2    Abe, T.3
  • 76
    • 36849091820 scopus 로고    scopus 로고
    • Transforming growth factor-β regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation
    • Asano Y, Czuwara J, Trojanowska M,. Transforming growth factor-β regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation. J Biol Chem 2007; 282: 34672-34683.
    • (2007) J Biol Chem , vol.282 , pp. 34672-34683
    • Asano, Y.1    Czuwara, J.2    Trojanowska, M.3
  • 77
    • 63049102007 scopus 로고    scopus 로고
    • Phosphorylation of Fli1 at threonine 312 by protein kinase C δ promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor β
    • Asano Y, Trojanowska M,. Phosphorylation of Fli1 at threonine 312 by protein kinase C δ promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor β. Mol Cell Biol 2009; 29: 1882-1894.
    • (2009) Mol Cell Biol , vol.29 , pp. 1882-1894
    • Asano, Y.1    Trojanowska, M.2
  • 79
    • 77950560433 scopus 로고    scopus 로고
    • Endothelial Fli1 deficiency impairs vascular homeostasis: A role in scleroderma vasculopathy
    • Asano Y, Stawski L, Hant F, et al,. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol 2010; 176: 1983-1998.
    • (2010) Am J Pathol , vol.176 , pp. 1983-1998
    • Asano, Y.1    Stawski, L.2    Hant, F.3
  • 80
    • 0033576676 scopus 로고    scopus 로고
    • Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter
    • Shirasaki F, Makhluf HA, LeRoy C, Watson DK, Trojanowska M,. Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter. Oncogene 1999; 18: 7755-7764.
    • (1999) Oncogene , vol.18 , pp. 7755-7764
    • Shirasaki, F.1    Makhluf, H.A.2    LeRoy, C.3    Watson, D.K.4    Trojanowska, M.5
  • 81
    • 68549104124 scopus 로고    scopus 로고
    • Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
    • Dong JT, Chen C,. Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci 2009; 66: 2691-2706.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2691-2706
    • Dong, J.T.1    Chen, C.2
  • 82
    • 74949131620 scopus 로고    scopus 로고
    • Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
    • Takeda N, Manabe I, Uchino Y, et al,. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 2010; 120: 254-265.
    • (2010) J Clin Invest , vol.120 , pp. 254-265
    • Takeda, N.1    Manabe, I.2    Uchino, Y.3
  • 83
    • 80052359505 scopus 로고    scopus 로고
    • Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice
    • Fujiu K, Manabe I, Nagai R,. Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice. J Clin Invest 2011; 121: 3425-3441.
    • (2011) J Clin Invest , vol.121 , pp. 3425-3441
    • Fujiu, K.1    Manabe, I.2    Nagai, R.3
  • 84
    • 0142059804 scopus 로고    scopus 로고
    • Systemic and cell type-specific gene expression patterns in scleroderma skin
    • Whitfield ML, Finlay DR, Murray JI, et al,. Systemic and cell type-specific gene expression patterns in scleroderma skin. Proc Natl Acad Sci USA 2003; 100: 12319-12324.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12319-12324
    • Whitfield, M.L.1    Finlay, D.R.2    Murray, J.I.3
  • 85
    • 84922765338 scopus 로고    scopus 로고
    • Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated fli-1-haploinsufficient mice
    • Taniguchi T, Asano Y, Akamata K, et al,. Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated fli-1-haploinsufficient mice. Arthritis Rheumatol 2015; 67: 517-526.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 517-526
    • Taniguchi, T.1    Asano, Y.2    Akamata, K.3
  • 86
    • 84863126451 scopus 로고    scopus 로고
    • A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis
    • Noda S, Asano Y, Akamata K, et al,. A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. PLoS ONE 2012; 7: e32272.
    • (2012) PLoS ONE , vol.7 , pp. e32272
    • Noda, S.1    Asano, Y.2    Akamata, K.3
  • 87
    • 84876699983 scopus 로고    scopus 로고
    • Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis
    • Noda S, Asano Y, Takahashi T, et al,. Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis. Rheumatology (Oxford) 2013; 52: 790-799.
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 790-799
    • Noda, S.1    Asano, Y.2    Takahashi, T.3
  • 88
    • 84900816826 scopus 로고    scopus 로고
    • Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis
    • Ichimura Y, Asano Y, Akamata K, et al,. Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis. Arch Dermatol Res 2014; 306: 331-338.
    • (2014) Arch Dermatol Res , vol.306 , pp. 331-338
    • Ichimura, Y.1    Asano, Y.2    Akamata, K.3
  • 89
    • 84926084844 scopus 로고    scopus 로고
    • A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis
    • Saigusa R, Asano Y, Taniguchi T, et al,. A possible contribution of endothelial CCN1 downregulation due to Fli1 deficiency to the development of digital ulcers in systemic sclerosis. Exp Dermatol 2015; 24: 127-132.
    • (2015) Exp Dermatol , vol.24 , pp. 127-132
    • Saigusa, R.1    Asano, Y.2    Taniguchi, T.3
  • 90
    • 84936871641 scopus 로고    scopus 로고
    • Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis
    • Akamata K, Asano Y, Taniguchi T, et al,. Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis. Rheumatology (Oxford) 2015; 54: 1308-1316.
    • (2015) Rheumatology (Oxford) , vol.54 , pp. 1308-1316
    • Akamata, K.1    Asano, Y.2    Taniguchi, T.3
  • 91
    • 84942364449 scopus 로고    scopus 로고
    • A possible contribution of lipocalin-2 to the development of dermal fibrosis, pulmonary vascular involvement, and renal dysfunction in systemic sclerosis
    • Takahashi T, Asano Y, Noda S, et al,. A possible contribution of lipocalin-2 to the development of dermal fibrosis, pulmonary vascular involvement, and renal dysfunction in systemic sclerosis. Br J Dermatol 2015; 173: 681-689.
    • (2015) Br J Dermatol , vol.173 , pp. 681-689
    • Takahashi, T.1    Asano, Y.2    Noda, S.3
  • 92
    • 0037133596 scopus 로고    scopus 로고
    • Deficient Smad7 expression: A putative molecular defect in scleroderma
    • Dong C, Zhu S, Wang T, et al,. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci USA 2002; 99: 3908-3913.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3908-3913
    • Dong, C.1    Zhu, S.2    Wang, T.3
  • 93
    • 1642329882 scopus 로고    scopus 로고
    • Increased expression levels of integrin αvβ5 on scleroderma fibroblasts
    • Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K,. Increased expression levels of integrin αVβ5 on scleroderma fibroblasts. Am J Pathol 2004; 164: 1275-1292.
    • (2004) Am J Pathol , vol.164 , pp. 1275-1292
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Kubo, M.4    Tamaki, K.5
  • 94
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K,. Increased expression of integrin αVβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts. J Immunol 2005; 175: 7708-7718.
    • (2005) J Immunol , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 95
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K,. Involvement of αVβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts. Arthritis Rheum 2005; 52: 2897-2905.
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 96
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts
    • Asano Y, Ihn H, Yamane K, Jinnin M, Tamaki K,. Increased expression of integrin αVβ5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol 2006; 168: 499-510.
    • (2006) Am J Pathol , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 97
    • 32144454167 scopus 로고    scopus 로고
    • Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: Association of interleukin 12 elevation with spontaneous regression of skin sclerosis
    • Matsushita T, Hasegawa M, Hamaguchi Y, Takehara K, Sato S,. Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis. J Rheumatol 2006; 33: 275-284.
    • (2006) J Rheumatol , vol.33 , pp. 275-284
    • Matsushita, T.1    Hasegawa, M.2    Hamaguchi, Y.3    Takehara, K.4    Sato, S.5
  • 98
    • 42649134787 scopus 로고    scopus 로고
    • Clinical association of serum interleukin-17 levels in systemic sclerosis: Is systemic sclerosis a Th17 disease?
    • Murata M, Fujimoto M, Matsushita T, et al,. Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease? J Dermatol Sci 2008; 50: 240-242.
    • (2008) J Dermatol Sci , vol.50 , pp. 240-242
    • Murata, M.1    Fujimoto, M.2    Matsushita, T.3
  • 99
    • 0033366780 scopus 로고    scopus 로고
    • T lymphocyte and fibroblast interactions: The case of skin involvement in systemic sclerosis and other examples
    • Chizzolini C,. T lymphocyte and fibroblast interactions: the case of skin involvement in systemic sclerosis and other examples. Springer Semin Immunopathol 1999; 21: 431-450.
    • (1999) Springer Semin Immunopathol , vol.21 , pp. 431-450
    • Chizzolini, C.1
  • 100
    • 84860330745 scopus 로고    scopus 로고
    • Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts
    • Nakashima T, Jinnin M, Yamane K, et al,. Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. J Immunol 2012; 188: 3573-3583.
    • (2012) J Immunol , vol.188 , pp. 3573-3583
    • Nakashima, T.1    Jinnin, M.2    Yamane, K.3
  • 101
    • 77956899738 scopus 로고    scopus 로고
    • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    • Yoshizaki A, Yanaba K, Iwata Y, et al,. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol 2010; 185: 2502-2515.
    • (2010) J Immunol , vol.185 , pp. 2502-2515
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3
  • 102
    • 78651412553 scopus 로고    scopus 로고
    • Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
    • Higashi-Kuwata N, Jinnin M, Makino T, et al,. Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arthritis Res Ther 2010; 12: R128.
    • (2010) Arthritis Res Ther , vol.12 , pp. R128
    • Higashi-Kuwata, N.1    Jinnin, M.2    Makino, T.3
  • 103
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor β as a therapeutic target in systemic sclerosis
    • Varga J, Pasche B,. Transforming growth factor β as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol 2009; 5: 200-206.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 104
    • 27544452988 scopus 로고    scopus 로고
    • B lymphocytes and systemic sclerosis
    • Fujimoto M, Sato S,. B lymphocytes and systemic sclerosis. Curr Opin Rheumatol 2005; 17: 746-751.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 746-751
    • Fujimoto, M.1    Sato, S.2
  • 105
    • 34848833579 scopus 로고    scopus 로고
    • B cell infiltration in systemic sclerosis-associated interstitial lung disease
    • Lafyatis R, O'Hara C, Feghali-Bostwick CA, Matteson E,. B cell infiltration in systemic sclerosis-associated interstitial lung disease. Arthritis Rheum 2007; 56: 3167-3168.
    • (2007) Arthritis Rheum , vol.56 , pp. 3167-3168
    • Lafyatis, R.1    O'Hara, C.2    Feghali-Bostwick, C.A.3    Matteson, E.4
  • 106
    • 84862520877 scopus 로고    scopus 로고
    • Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis
    • Khan K, Xu S, Nihtyanova S, et al,. Clinical and pathological significance of interleukin 6 overexpression in systemic sclerosis. Ann Rheum Dis 2012; 71: 1235-1242.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1235-1242
    • Khan, K.1    Xu, S.2    Nihtyanova, S.3
  • 107
    • 0029913252 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cells of patients with systemic sclerosis produce increased amounts of interleukin 6, but not transforming growth factor β1
    • Giacomelli R, Cipriani P, Danese C, et al,. Peripheral blood mononuclear cells of patients with systemic sclerosis produce increased amounts of interleukin 6, but not transforming growth factor β1. J Rheumatol 1996; 23: 291-296.
    • (1996) J Rheumatol , vol.23 , pp. 291-296
    • Giacomelli, R.1    Cipriani, P.2    Danese, C.3
  • 108
    • 84934991714 scopus 로고    scopus 로고
    • Effects and safety of rituximab in systemic sclerosis: An analysis from the European Scleroderma Trial and Research (EUSTAR) group
    • Group obotERs
    • Jordan S, Distler JH, Maurer B, et al,., Group obotERs. Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group. Ann Rheum Dis 2015; 74: 1188-1194.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1188-1194
    • Jordan, S.1    Distler, J.H.2    Maurer, B.3
  • 109
    • 84900009349 scopus 로고    scopus 로고
    • Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus
    • Sumida H, Asano Y, Tamaki Z, et al,. Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus. J Dermatol 2014; 41: 418-420.
    • (2014) J Dermatol , vol.41 , pp. 418-420
    • Sumida, H.1    Asano, Y.2    Tamaki, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.