Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis

American Journal of Pathology

Volumn 178, Issue 4, 2011, Pages 1500-1508

  Hu, Biao ^a   Gharaee Kermani, Mehrnaz ^a   Wu, Zhe ^a   Phan, Sem H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; DNA; METHYL CPG BINDING PROTEIN 2; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL ISOLATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; IN VIVO STUDY; INFLAMMATORY CELL; LUNG FIBROSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

EID: 79953665837     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.01.002     Document Type: Article

References (37)

1. Phan SH: The myofibroblast in pulmonary fibrosis. Chest 2002, 122:286S-289S
2. Scotton CJ, Chambers RC: Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007, 132:1311-1121
3. Darby IA, Hewitson TD: Fibroblast differentiation in wound healing and fibrosis. Int Rev Cytol 2007, 257:143-179 (Pubitemid 46186476)
4. Thannickal VJ, Toews GB, White ES, Lynch JP 3rd, Martinez FJ: Mechanisms of pulmonary fibrosis. Annu Rev Med 2004, 55:395-417 (Pubitemid 38316734)
5. Gharaee-Kermani M, Hu B, Phan SH, Gyetko MR: Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast. Curr Med Chem 2009, 16:1400-1417
6. Pardo A, Selman M: Idiopathic pulmonary fibrosis: new insights in its pathogenesis. Int J Biochem Cell Biol 2002, 34:1534-1538
7. Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Törnell J, Heath bJK, Betsholtz C: PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996, 85:863-873
8. Hu B, Wu Z, Phan SH: Smad3 mediates transforming growth factor-beta-induced alpha-SMA expression. Am J Respir Cell Mol Biol 2003, 29:397-404 (Pubitemid 37093999)
9. Hu B, Wu Z, Liu T, Ullenbruch MR, Jin H, Phan SH: Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Am J Respir Cell Mol Biol 2007, 36:78-84 (Pubitemid 46067710)
10. Hu B, Wu Z, Jin H, Hashimoto N, Liu T, Phan SH: CCAAT/enhancerbinding protein beta isoforms and the regulation of alpha-SMA gene expression by IL-1 beta. J Immunol 2004, 173:4661-4668 (Pubitemid 39280700)
11. Hu B, Ullenbruch MR, Jin H, Gharaee-Kermani M, Phan SH: An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis. J Pathol 2007, 211:455-462 (Pubitemid 46332557)
12. Cogan JG, Subramanian SV, Polikandriotis JA, Kelm RJ Jr., Strauch AR: Vascular smooth muscle alpha-actin gene transcription during myofibroblast differentiation requires Sp1/3 protein binding proximal to the MCAT enhancer. J Biol Chem 2002, 277:36433-36442
13. Qiu P, Feng XH, Li L: Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation. J Mol Cell Cardiol 2003, 35:1407-1420 (Pubitemid 37491184)
14. Buck M, Kim DJ, Houglum K, Hassanein T, Chojkier M: c-Myb modulates transcription of the alpha-SMA gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2000, 278:G321-G328 (Pubitemid 30131201)
15. Liu T, Hu B, Choi YY, Chung M, Ullenbruch M, Yu H, Lowe JB, Phan SH: Notch1 signaling in FIZZ1 induction of myofibroblast differentiation. Am J Pathol 2009, 174:1745-1755
16. Noseda M, Fu Y, Niessen K, Wong F, Chang L, McLean G, Karsan A: Smooth muscle α-actin is a direct target of Notch/CSL. Circ Res 2006, 98:1468-1470 (Pubitemid 44297068)
17. Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G: The myofibroblast: one function, multiple origins. Am J Pathol 2007, 170:1807-1816 (Pubitemid 47339255)
18. Jaenisch R, Bird A: Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003, 33:245-254 (Pubitemid 36278835)
19. Hu B, Gharaee-Kermani M, Wu Z, Phan SH: Epigenetic regulation of myofibroblast differentiation by DNA methylation. Am J Pathol 2010, 177:21-28
20. Niki T, Rombouts K, De Bleser P, De Smet K, Rogiers V, Schuppan D, Yoshida M, Gabbiani G, Geerts A: A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Hepatology 1999, 29:858-867 (Pubitemid 29109602)
21. Glenisson W, Castronovo V, Waltregny D: Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta 2007, 1773:1572-1582 (Pubitemid 47498609)
22. Guo W, Shan B, Klingsberg RC, Qin X, Lasky JA: Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol 2009, 297:L864-870
23. Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA: MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology 2010, 138:705-714
24. Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA: Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ 2007, 14:275-285 (Pubitemid 46092230)
25. Lewis JD, Meehan RR, Henzel WJ, Maurer-Fogy I, Jeppesen P, Klein F, Bird AI: Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 1992, 69:905-914
26. Yasui DH, Peddada S, Bieda MC, Vallero RO, Hogart A, Nagarajan RP, Thatcher KN, Farnham PJ, Lasalle JM: Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proc Natl Acad Sci USA 2007, 104:19416-19421
27. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY: MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 2008, 320:1224-1229 (Pubitemid 351929512)
28. Nikitina T, Shi X, Ghosh RP, Horowitz-Scherer RA, Hansen JC, Woodcock CL: Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin. Mol Cell Biol 2007, 27:864-877 (Pubitemid 46174552)
29. Georgel PT, Horowitz-Scherer RA, Adkins N, Woodcock CL, Wade PA, Hansen JC: Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 2003, 278:32181-32188 (Pubitemid 37048409)
30. Gregory RI, Randall TE, Johnson CA, Khosla S, Hatada I, O'Neill LP, Turner BM, Feil R: DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol 2001, 21:5426-5436 (Pubitemid 32702447)
31. Nan X, Tate P, Li E, Bird A: DNA methylation specifies chromosomal localization of MeCP. Mol Cell Biol 1996, 16:414-421 (Pubitemid 126506989)
32. Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, Armstrong D, Paylor R, Zoghbi H: Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 2002, 35:243-254 (Pubitemid 34876728)
33. Hite KC, Adams VH, Hansen JC: Recent advances in MeCP2 structure and function. Biochem Cell Biol 2009, 87:219-227
34. Cohen S, Zhou Z, Greenberg ME: Medicine: activating a repressor. Science 2008, 320:1172-1173 (Pubitemid 351929497)
35. Crooke ST, Bradner WT: Bleomycin, a review. J Med 1976, 7:333-428
36. Jones PA, Takai D: The role of DNA methylation in mammalian epigenetics. Science 2001, 293:1068-1070 (Pubitemid 32758075)
37. Miranda TB, Jones PA: DNA methylation: the nuts and bolts of repression. J Cell Physiol 2007, 213:384-390 (Pubitemid 47509717)