The effect of the aqueous extract of Kohautia grandiflora on paracetamol induced liver damage in albino rats

Nigerian Journal of Physiological Sciences

Volumn 24, Issue 1, 2009, Pages 17-23

  Garba, S H ^a   Sambo, N ^a   Bala, U ^a  

^a UNIVERSITY OF MAIDUGURI   (Nigeria)

Author keywords

Hepatotoxicity; Kohautia grandiflora; Liver enzymes; Paracetamol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; PARACETAMOL; PLANT EXTRACT; SERUM ALBUMIN;

ANIMAL; BLOOD; BODY WEIGHT; CELL PROTECTION; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; ENZYMOLOGY; LIVER; METABOLISM; PATHOLOGY; RAT; RUBIACEAE;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BIOMARKERS; BODY WEIGHT; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; LIVER; PLANT EXTRACTS; RATS; RUBIACEAE; SERUM ALBUMIN;

EID: 77953761200     PISSN: 0794859X     EISSN: None     Source Type: Journal    
DOI: 10.4314/njps.v24i1.46376     Document Type: Article

References (24)

1. Achuthan, C. R., B. H. Babu and Padikkala, J. (2003). Antioxidant and Hepatoprotective effects of Rosa damascena. Pharmaceut. Biol. 41: 357- 361.
2. Akintonwa, A. and Essein, A. R. (1990). Protective effect of Garcinia kola Seed extract against paracetamol induced hepatotoxicity in rats. J. Ethnopharmacol. 29 (2): 207-211.
3. Aniya, Y., Miyagi, A., Nakandakari, N., Kamiya, N., Imaizumi N. and Ichiba, T. (2002). Free radical scavenging action of the medicinal herb Limonium wrightii from the Okinawa islands. Phytomedicine. 9:239-244.
4. Benjamin M. N, (1978). Outline of veterinary Clinical Pathology. University press. Iowa, pp. 229-232.
5. Boyd, E. M. and Bereckzky, G.. M. (1996). Liver damage from Paracetamol. Br. J. Pharmacol. 26: 606.
6. Chaterjee, T. K. (2000). Medicinal Plants with Hepatoprotective Properties. Herbal Options. Books & Allied (P) Ltd., Calcutta, pp: 155.
7. Chattopadhyay, R. R. (2003). Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: Part II. J. Ethanopharmacol. 89: 217- 219.
8. Clark, R., Thompson, R. P. H., Borirackanyavat, V., Widoop, B., Davidson, A. R., Goulding, R. and Williams, R., (1974). Hepatic damage and death from Overdose of paracetamol. Lancet, 1: 66-69.
9. 4 induced hepatotoxicity in rats. J. Biol. Sci. 7(2): 276-281.
10. 4- induced liver injury in rats. J. Pharmacol. Toxicol. 1: 101- 107.
11. Iwu, M. M, Igboko, O. A, Onwuchekwa, U, Okunji, C. O. (1987). Evaluation of the antihepatotoxicity of the biflavanoids of Garcinia kola seeds. J. Ethnopharmacol. 21: 127-142.
12. Jollow, D. J., Thorgeirsson, S. S., Potter, W. Z., Hashimoto, M. and Mitchell, J. R. (1974). Acetaminophen induced hepatic necrosis VI. Metabolic disposition of toxic and non-toxic doses of acetaminophen. Pharmacology. 12: 251- 271.
13. Moore, M., Thor, H., Moore, G., Nelson, S., Moldeus, P. and Orrenius, S. (1985). The toxicity of acetaminophen and N-acetyl P-benzoquinoneimine in isolated hepatocytes is associated with thio depletion and increased cystosolic Ca2+. J. Biol. Chem. 260: 13035-13040.
14. OECD (2001). OECD Guideline 425: Acute Oral Toxicity-Up-and-Down Procedure. In: OECD Guidelines for the Testing of Chemicals Vol.2 Organization for Economic Cooperation and Development. Paris, France.
15. Rabo, J. S. (1998). Toxicity studies and Trypanosuppressive effect of stem- back extract of Buturospermum and paradoxin, in Laboratory animals. Ph.D. Thesis, Department of Veterinary Pathology University of Maiduguri, pp: 15-50.
16. Ringler, D.H. and L. Dabich, 1979. Hematology and Clinical Biochemistry. In: The Laboratory Rat. Vol.1, Baker, H.J., J.R. Lindsey and S. H. Weisbroth (Eds.) Academic Press. London. pp:105-118.
17. Singh, I. (1980). In: Textbook of Biochemistry and Human Biology. Talwar, G. P. (ed.), Prentice Hall of India, New Delhi. pp. 201-203.
18. Savides, M. C. and Oehme, F. W. (1983). Acetaminophen and its toxicity. J. Appl. Toxicol. 3: 95-111.
19. U.S.EPA, 2006: International classification schemes for environmental effects. Available at; http:/www.nicnas.gov.au/About_NICNAS/ Reforms/ LRCC/ Discussion_paper1 _A_3_PDF.pdf / Accessed: December 2008.
20. Vermeulen, N. P. E., Bessems, J. G. M. and Van de Streat, R (1992). Molecular aspects of paracetamol-induced hepatotoxicity and it mechanism based prevention. Drug Metab. Rev. 24: 367-407.
21. Wong, L. T., Whitehouse, L. W., Solemonraj, G. and Paul, C. J. (1981). Pathways of acetaminophen conjugate in the mouse. Toxicity Lett; 9: 145-151.
22. WHO (1992). World Health Organizations Quality control methods for medicinal plant materials. Geneva, Pp. 58 - 63.
23. Wittwer, F. M. and Bohmwald, L. H. (1986). Manuel de Patologia Clinica Veterinaria. Valdivia Chile, pp; 53-93.
24. Yoshinkuyi, M., Toshikaru, H. and Shogi, A. (1992). High Molecular protein aggregates formed in liver of rats. J. Pharm. Pharmacol. 44: 932 - 934.