Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney

World Journal of Urology

Volumn 26, Issue 4, 2008, Pages 401-407

  Senturk, Hakan ^a   Kabay, Sahin ^b   Bayramoglu, Gokhan ^a   Ozden, Hilmi ^a   Yaylak, Faik ^b   Yucel, Mehmet ^b   Olgun, Esra Gurlek ^b   Kutlu, Ali ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b DUMLUPINAR UNIVERSITY   (Turkey)

Author keywords

Ischemia reperfusion injury; Morphology; Renal; Silymarin

Indexed keywords

PROTECTIVE AGENT; SILYMARIN;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; GLOMERULUS; MALE; OXIDATIVE STRESS; PATHOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; SURGICAL INSTRUMENT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY GLOMERULUS; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SILYMARIN; SURGICAL INSTRUMENTS;

EID: 50249145691     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-008-0256-1     Document Type: Article

References (29)

1. Avlan D, Tamer L, Ayaz L, Polat A, Ozturk C, Ozturhan H, Camdeviren H, Aksoyek S (2006) Effects of trapidil on renal ischemia-reperfusion injury. J Pediatric Surg 41:1686-1693
2. Thadhani R, Pascual M, Bonvetre JV (1996) Acute renal failure. N Engl J Med 334: 1448-1460
3. Levy EM, Viscoli CM, Horwitz RI (1996) The effect of acute renal failure on mortality. A cohort analysis. JAMA 275:1489-1494
4. Rodrigo R, Bosco C (2006) Oxidative stress and protective effects of polyphenols: Comparative studies in human and rodent kidney. A review. Comp Biochem Physiol 142:317-327
5. Thurman JM (2007) Triggers of inflammation after renal ischemia/ reperfusion. Clin Immunol 123:7-13
6. Sener G, Tugtepe H, Yuksel M, Cetinel S, Gedik N, Yegen BC (2006) Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats. Arch Med Res 37:822-829
7. Gobe G, Johnson DW (2007) Distal tubular epithelial cells of the kidney: Potential support for proximal tubular cell survival after renal injury. Int J Biochem Cell Biol 39: 1551-1561
8. Havsteen B (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32:1141-1148
9. Mora A, Paya M, Rios J, Alcaraz M (1990) Structure activity relationships of polymetoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation. Biochem Pharmacol 40:793-794
10. Zhao B (2005) Natural antioxidants for neurodegenerative diseases. Mol Neurobiol 31:283-294
11. Karimi G, Ramezani M, Tahoonian Z (2005) Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evid Based Complement Alternat Med 2:383-386
12. Marubayashi S, Dohi K (1996) Therapeutic modulation of free radical-mediated reperfusion injury of the liver and its surgical implications. Surg Today 26:573-580
13. Granger DN, Korthuis RJ (1995) Physiological mechanisms of postischemic tissue injury. Annu Rev Physiol 57:311-332
14. Zimmerman BJ, Grisham MB, Granger DN (1990) Role of oxidants in ischemia/ reperfusion-induced granulocyte infiltration. Am J Physiol 258:G185-G190
15. Donnahoo KK, Meng X, Ayala A, Cain MP, Harken AH, Meldrum DR (1999) Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol 277:R922-R929
16. Weight SC, Bell PR, Nicholson ML (1996) Renal ischemia-reperfusion injury. Br J Surg 83:162-170
17. Willams P, Lopez H, Britt D, Chan C, Ezrin A, Hottendorf R (1997) Characterization of renal ischemia-reperfusion injury in rats. J Pharmacol Toxicol Methods 37:1-7
18. Molitoris BA, Mars J (1999) The role of cell adhesion molecules in ischemic acute renal failure. Am J Med 106:583-592
19. Huang W, Lee SL, Sjöquist M (1995) Natriuretic role of endogenous oxytocin in male rats infused with hypertonic NaCl. Am J Physiol 268:R634-R640
20. Sehirli AO, Sener G, Satiroglu H, Ayanoglu-Dulger G (2003) Protective effect of N -acetylcysteine on the renal ischemia/reperfusion injury in the rat. J Nephrol 16:75-80
21. Sener G, Sehirli O, Erkanli G, Cetinel S, Gedik N, Yegen BC (2004) 2-mercaptoethane sulfonate (MESNA) protects against burn-induced renal injury in rats. Burns 30:557-564
22. Ferenci P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H, Meryn S, Base W, Schneider B (1989) Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol 9:105-113
23. Luper S (1998) A review of plants used in the treatment of liver disease: Part 1. Alternat Med Rev 3:410-421
24. Chang JW, Kim CS, Kim SB, Park SK, Park JS, Lee SK (2006) Proinflammatory cytokine-induced NF-kappaB activation in human mesangial cells is mediated through intracellular calcium but not ROS: Effects of silymarin. Nephron Exp Nephrol 103:e156-e165
25. Kren V, Walterova D (2005) Silybin and silymarin - new effects and applications. Biomed Papers 149:29-41
26. Sonnenbichler J, Zetl I (1986) Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. Prog Clin Biol Res 213:319-331
27. Moscarell S, Giusti A, Marra F, Marena C, Lampertico M, Relli P, Gentilini P, Buzzelli G (1993) Therapeutic and antilipoperoxidant effects of silybin phophatidylcholine complex in chronic liver disease: preliminary results. Curr Therapeut Res 53:1
28. Farghali H, Kameniková L, Hynie S, Kmonicková E (2000) Silymarin effects on intracellular calcuim and cytotoxicity: A study in perfused rat hepatocytes after oxidative stress injury. Pharmacol Res 41:231-237
29. Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA (2002) Milk thistle for the treatment of liver disease: A systemic review and meta-analysis. Am J Med 113:506-515