SCOPUS 정보 검색 플랫폼

Volumn 210, Issue 3, 2013, Pages 563-579

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(16) Anderberg, Charlotte a Cunha, Sara I a Zhai, Zhenhua b Cortez, Eliane a,c Pardali, Evangelia d Johnson, Jill R a Franco, Marcela a Páez Ribes, Marta e Cordiner, Ross b Fuxe, Jonas a Johansson, Bengt R f,g Goumans, Marie José d Casanovas, Oriol e Dijke, Peter ten d Arthur, Helen M b Pietras, Kristian a,c

a KAROLINSKA INSTITUTE (Sweden)

b NEWCASTLE UNIVERSITY (United Kingdom)

c LUND UNIVERSITY (Sweden)

d LEIDEN UNIVERSITY MEDICAL CENTER (Netherlands)

e CATALAN INSTITUTE OF ONCOLOGY (Spain)

f UNIVERSITY OF GOTHENBURG (Sweden)

g UNIVERSITY OF GOTHENBURG (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGLIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN INHIBITOR; ENDOGLIN PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RALBP1 PROTEIN, MOUSE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR TWIST; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; TUMOR VASCULARIZATION; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; FEMALE; LIVER TUMOR; METABOLISM; MOUSE; NEUROENDOCRINE TUMOR; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GTPASE-ACTIVATING PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; TWIST TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MLCS; MLOWN;

EID: 84877629719 PISSN: 00221007 EISSN: 15409538 Source Type: Journal
DOI: 10.1084/jem.20120662 Document Type: Article

Times cited : (106)

References (77)

1
- 0033621804
- Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
- Arthur, H.M., J. Ure, A.J. Smith, G. Renforth, D.I. Wilson, E. Torsney, R. Charlton, D.V. Parums, T. Jowett, D.A. Marchuk, et al. 2000. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev. Biol. 217:42-53. http://dx.doi.org/10.1006/dbio.1999.9534
- (2000) Dev. Biol. , vol.217 , pp. 42-53
- Arthur, H.M.¹ Ure, J.² Smith, A.J.³ Renforth, G.⁴ Wilson, D.I.⁵ Torsney, E.⁶ Charlton, R.⁷ Parums, D.V.⁸ Jowett, T.⁹ Marchuk, D.A.¹⁰

2
- 47949099628
- Modes of resistance to anti-angiogenic therapy
- Bergers, G., and D. Hanahan. 2008. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer. 8:592-603. http://dx.doi.org/10.1038/nrc2442
- (2008) Nat. Rev. Cancer. , vol.8 , pp. 592-603
- Bergers, G.¹ Hanahan, D.²

3
- 70349273685
- The emerging role of TGF-beta superfamily coreceptors in cancer
- Bernabeu, C., J.M. Lopez-Novoa, and M. Quintanilla. 2009. The emerging role of TGF-beta superfamily coreceptors in cancer. Biochim. Biophys. Acta. 1792:954-973. http://dx.doi.org/10.1016/j.bbadis.2009.07.003
- (2009) Biochim. Biophys. Acta. , vol.1792 , pp. 954-973
- Bernabeu, C.¹ Lopez-Novoa, J.M.² Quintanilla, M.³

4
- 21644452716
- Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
- Blanco, F.J., J.F. Santibanez, M. Guerrero-Esteo, C. Langa, C.P. Vary, and C. Bernabeu. 2005. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J. Cell. Physiol. 204:574-584. http://dx.doi.org/10.1002/jcp.20311
- (2005) J. Cell. Physiol. , vol.204 , pp. 574-584
- Blanco, F.J.¹ Santibanez, J.F.² Guerrero-Esteo, M.³ Langa, C.⁴ Vary, C.P.⁵ Bernabeu, C.⁶

5
- 0032720393
- A murine model of hereditary hemorrhagic telangiectasia
- Bourdeau, A., D.J. Dumont, and M. Letarte. 1999. A murine model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 104:1343-1351. http://dx.doi.org/10.1172/JCI8088
- (1999) J. Clin. Invest. , vol.104 , pp. 1343-1351
- Bourdeau, A.¹ Dumont, D.J.² Letarte, M.³

6
- 0029611184
- Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy
- Burrows, F.J., E.J. Derbyshire, P.L. Tazzari, P. Amlot, A.F. Gazdar, S.W. King, M. Letarte, E.S. Vitetta, and P.E. Thorpe. 1995. Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin. Cancer Res. 1:1623-1634.
- (1995) Clin. Cancer Res. , vol.1 , pp. 1623-1634
- Burrows, F.J.¹ Derbyshire, E.J.² Tazzari, P.L.³ Amlot, P.⁴ Gazdar, A.F.⁵ King, S.W.⁶ Letarte, M.⁷ Vitetta, E.S.⁸ Thorpe, P.E.⁹

7
- 26644471951
- Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors
- Casanovas, O., D.J. Hicklin, G. Bergers, and D. Hanahan. 2005. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors. Cancer Cell. 8:299-309. http://dx.doi.org/10.1016/j.ccr.2005.09.005
- (2005) Cancer Cell. , vol.8 , pp. 299-309
- Casanovas, O.¹ Hicklin, D.J.² Bergers, G.³ Hanahan, D.⁴

8
- 58249124333
- Sustained enhanced growth of carcinoma EO771 in C57 black mice
- Casey, A.E., W.R. Laster Jr., and G.L. Ross. 1951. Sustained enhanced growth of carcinoma EO771 in C57 black mice. Proc. Soc. Exp. Biol. Med. 77:358-362.
- (1951) Proc. Soc. Exp. Biol. Med. , vol.77 , pp. 358-362
- Casey, A.E.¹ Laster, Jr.W.R.² Ross, G.L.³

9
- 80051920312
- Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth
- Castonguay, R., E.D. Werner, R.G. Matthews, E. Presman, A.W. Mulivor, N. Solban, D. Sako, R.S. Pearsall, K.W. Underwood, J. Seehra, et al. 2011. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J. Biol. Chem. 286:30034-30046. http://dx.doi.org/10.1074/jbc.M111.260133
- (2011) J. Biol. Chem. , vol.286 , pp. 30034-30046
- Castonguay, R.¹ Werner, E.D.² Matthews, R.G.³ Presman, E.⁴ Mulivor, A.W.⁵ Solban, N.⁶ Sako, D.⁷ Pearsall, R.S.⁸ Underwood, K.W.⁹ Seehra, J.¹⁰

10
- 4444378473
- Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays
- Charpin, C., J.P. Dales, S. Garcia, S. Carpentier, A. Djemli, L. Andrac, M.N. Lavaut, C. Allasia, and P. Bonnier. 2004. Tumor neoangiogenesis by CD31 and CD105 expression evaluation in breast carcinoma tissue microarrays. Clin. Cancer Res. 10:5815-5819. http://dx.doi.org/10.1158/1078-0432.CCR-04-0021
- (2004) Clin. Cancer Res. , vol.10 , pp. 5815-5819
- Charpin, C.¹ Dales, J.P.² Garcia, S.³ Carpentier, S.⁴ Djemli, A.⁵ Andrac, L.⁶ Lavaut, M.N.⁷ Allasia, C.⁸ Bonnier, P.⁹

11
- 79951864002
- Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis
- Chiu, C.W., H. Nozawa, and D. Hanahan. 2010. Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis. J. Clin. Oncol. 28:4425-4433. http://dx.doi.org/10.1200/JCO.2010.28.0198
- (2010) J. Clin. Oncol. , vol.28 , pp. 4425-4433
- Chiu, C.W.¹ Nozawa, H.² Hanahan, D.³

12
- 84863718886
- Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
- Chung, A.S., M. Kowanetz, X. Wu, G. Zhuang, H. Ngu, D. Finkle, L. Komuves, F. Peale, and N. Ferrara. 2012. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J. Pathol. 227:404-416. http://dx.doi.org/10.1002/path.4052
- (2012) J. Pathol. , vol.227 , pp. 404-416
- Chung, A.S.¹ Kowanetz, M.² Wu, X.³ Zhuang, G.⁴ Ngu, H.⁵ Finkle, D.⁶ Komuves, L.⁷ Peale, F.⁸ Ferrara, N.⁹

13
- 34848821993
- PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
- Couty, J.P., C. Rampon, M. Leveque, M.P. Laran-Chich, S. Bourdoulous, J. Greenwood, and P.O. Couraud. 2007. PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells. J. Neurochem. 103:793-801. http://dx.doi.org/10.1111/j.1471-4159.2007.04782.x
- (2007) J. Neurochem. , vol.103 , pp. 793-801
- Couty, J.P.¹ Rampon, C.² Leveque, M.³ Laran-Chich, M.P.⁴ Bourdoulous, S.⁵ Greenwood, J.⁶ Couraud, P.O.⁷

14
- 79959850956
- ALK1 as an emerging target for antiangiogenic therapy of cancer
- Cunha, S.I., and K. Pietras. 2011. ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood. 117:6999-7006. http://dx.doi.org/ 10.1182/blood-2011-01-330142
- (2011) Blood. , vol.117 , pp. 6999-7006
- Cunha, S.I.¹ Pietras, K.²

15
- 76149089505
- Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
- Cunha, S.I., E. Pardali, M. Thorikay, C. Anderberg, L. Hawinkels, M.J. Goumans, J. Seehra, C.H. Heldin, P. ten Dijke, and K. Pietras. 2010. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J. Exp. Med. 207:85-100. http://dx.doi.org/10.1084/jem.20091309
- (2010) J. Exp. Med. , vol.207 , pp. 85-100
- Cunha, S.I.¹ Pardali, E.² Thorikay, M.³ Anderberg, C.⁴ Hawinkels, L.⁵ Goumans, M.J.⁶ Seehra, J.⁷ Heldin, C.H.⁸ ten Dijke, P.⁹ Pietras, K.¹⁰

16
- 6944238394
- Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome
- Dales, J.P., S. Garcia, L. Andrac, S. Carpentier, O. Ramuz, M.N. Lavaut, C. Allasia, P. Bonnier, and C. Charpin. 2004. Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome. Int. J. Oncol. 24:1197-1204.
- (2004) Int. J. Oncol. , vol.24 , pp. 1197-1204
- Dales, J.P.¹ Garcia, S.² Andrac, L.³ Carpentier, S.⁴ Ramuz, O.⁵ Lavaut, M.N.⁶ Allasia, C.⁷ Bonnier, P.⁸ Charpin, C.⁹

17
- 67449146883
- Emerging role of bone morphogenetic proteins in angiogenesis
- David, L., J.J. Feige, and S. Bailly. 2009. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 20:203-212. http://dx.doi.org/10.1016/j.cytogfr.2009.05.001
- (2009) Cytokine Growth Factor Rev. , vol.20 , pp. 203-212
- David, L.¹ Feige, J.J.² Bailly, S.³

18
- 33845752037
- Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice
- Düwel, A., N. Eleno, M. Jerkic, M. Arevalo, J.P. Bolaños, C. Bernabeu, and J.M. López-Novoa. 2007. Reduced tumor growth and angiogenesis in endoglin-haploinsufficient mice. Tumour Biol. 28:1-8.
- (2007) Tumour Biol. , vol.28 , pp. 1-8
- Düwel, A.¹ Eleno, N.² Jerkic, M.³ Arevalo, M.⁴ Bolaños, J.P.⁵ Bernabeu, C.⁶ López-Novoa, J.M.⁷

19
- 60649087564
- Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
- Ebos, J.M., C.R. Lee, W. Cruz-Munoz, G.A. Bjarnason, J.G. Christensen, and R.S. Kerbel. 2009a. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 15:232-239. http://dx.doi.org/10.1016/j.ccr.2009.01.021
- (2009) Cancer Cell. , vol.15 , pp. 232-239
- Ebos, J.M.¹ Lee, C.R.² Cruz-Munoz, W.³ Bjarnason, G.A.⁴ Christensen, J.G.⁵ Kerbel, R.S.⁶

20
- 69349097400
- Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy
- Ebos, J.M., C.R. Lee, and R.S. Kerbel. 2009b. Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin. Cancer Res. 15:5020-5025. http://dx.doi.org/10.1158/1078-0432.CCR-09-0095
- (2009) Clin. Cancer Res. , vol.15 , pp. 5020-5025
- Ebos, J.M.¹ Lee, C.R.² Kerbel, R.S.³

21
- 0000181874
- Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene
- Efrat, S., S. Linde, H. Kofod, D. Spector, M. Delannoy, S. Grant, D. Hanahan, and S. Baekkeskov. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc. Natl. Acad. Sci. USA. 85:9037-9041. http://dx.doi.org/10.1073/pnas.85.23.9037
- (1988) Proc. Natl. Acad. Sci. USA. , vol.85 , pp. 9037-9041
- Efrat, S.¹ Linde, S.² Kofod, H.³ Spector, D.⁴ Delannoy, M.⁵ Grant, S.⁶ Hanahan, D.⁷ Baekkeskov, S.⁸

22
- 79955583104
- Lack of primary cilia primes shearinduced endothelial-to-mesenchymal transition
- Egorova, A.D., P.P. Khedoe, M.J. Goumans, B.K. Yoder, S.M. Nauli, P. ten Dijke, R.E. Poelmann, and B.P. Hierck. 2011. Lack of primary cilia primes shearinduced endothelial-to-mesenchymal transition. Circ. Res. 108:1093- 1101. http://dx.doi.org/10.1161/CIRCRESAHA.110.231860
- (2011) Circ. Res. , vol.108
- Egorova, A.D.¹ Khedoe, P.P.² Goumans, M.J.³ Yoder, B.K.⁴ Nauli, S.M.⁵ ten Dijke, P.⁶ Poelmann, R.E.⁷ Hierck, B.P.⁸

23
- 33846148701
- TARGET Study Group. Sorafenib in advanced clear-cell renal-cell carcinoma
- Escudier, B., T. Eisen, W.M. Stadler, C. Szczylik, S. Oudard, M. Siebels, S. Negrier, C. Chevreau, E. Solska, A.A. Desai, et al; TARGET Study Group. 2007. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356:125-134. http://dx.doi.org/10.1056/NEJMoa060655
- (2007) N. Engl. J. Med. , vol.356 , pp. 125-134
- Escudier, B.¹ Eisen, T.² Stadler, W.M.³ Szczylik, C.⁴ Oudard, S.⁵ Siebels, M.⁶ Negrier, S.⁷ Chevreau, C.⁸ Solska, E.⁹ Desai, A.A.¹⁰

24
- 82155191786
- Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy
- Franco, M., M. Páez-Ribes, E. Cortez, O. Casanovas, and K. Pietras. 2011a. Use of a mouse model of pancreatic neuroendocrine tumors to find pericyte biomarkers of resistance to anti-angiogenic therapy. Horm. Metab. Res. 43:884-889. http://dx.doi.org/10.1055/s-0031-1284381
- (2011) Horm. Metab. Res. , vol.43 , pp. 884-889
- Franco, M.¹ Páez-Ribes, M.² Cortez, E.³ Casanovas, O.⁴ Pietras, K.⁵

25
- 80052667572
- Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
- Franco, M., P. Roswall, E. Cortez, D. Hanahan, and K. Pietras. 2011b. Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression. Blood. 118:2906-2917. http://dx.doi.org/10.1182/blood-2011-01-331694
- (2011) Blood. , vol.118 , pp. 2906-2917
- Franco, M.¹ Roswall, P.² Cortez, E.³ Hanahan, D.⁴ Pietras, K.⁵

26
- 0036167828
- Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice
- Graesser, D., A. Solowiej, M. Bruckner, E. Osterweil, A. Juedes, S. Davis, N.H. Ruddle, B. Engelhardt, and J.A. Madri. 2002. Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. J. Clin. Invest. 109:383-392.
- (2002) J. Clin. Invest. , vol.109 , pp. 383-392
- Graesser, D.¹ Solowiej, A.² Bruckner, M.³ Osterweil, E.⁴ Juedes, A.⁵ Davis, S.⁶ Ruddle, N.H.⁷ Engelhardt, B.⁸ Madri, J.A.⁹

27
- 77950865464
- Vascular endothelial growth factor B controls endothelial fatty acid uptake
- Hagberg, C.E., A. Falkevall, X. Wang, E. Larsson, J. Huusko, I. Nilsson, L.A. van Meeteren, E. Samen, L. Lu, M. Vanwildemeersch, et al. 2010. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature. 464:917-921. http://dx.doi.org/10.1038/nature08945
- (2010) Nature , vol.464 , pp. 917-921
- Hagberg, C.E.¹ Falkevall, A.² Wang, X.³ Larsson, E.⁴ Huusko, J.⁵ Nilsson, I.⁶ van Meeteren, L.A.⁷ Samen, E.⁸ Lu, L.⁹ Vanwildemeersch, M.¹⁰

28
- 0021888904
- Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
- Hanahan, D. 1985. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature. 315:115-122. http://dx.doi.org/10.1038/315115a0
- (1985) Nature , vol.315 , pp. 115-122
- Hanahan, D.¹

29
- 77952828002
- Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis
- Hawinkels, L.J., P. Kuiper, E. Wiercinska, H.W. Verspaget, Z. Liu, E. Pardali, C.F. Sier, and P. ten Dijke. 2010. Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res. 70:4141-4150. http://dx.doi.org/10.1158/0008-5472. CAN-09-4466
- (2010) Cancer Res. , vol.70 , pp. 4141-4150
- Hawinkels, L.J.¹ Kuiper, P.² Wiercinska, E.³ Verspaget, H.W.⁴ Liu, Z.⁵ Pardali, E.⁶ Sier, C.F.⁷ ten Dijke, P.⁸

30
- 77949494504
- Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
- Helfrich, I., I. Scheffrahn, S. Bartling, J. Weis, V. von Felbert, M. Middleton, M. Kato, S. Ergün, and D. Schadendorf. 2010. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J. Exp. Med. 207:491-503. http://dx.doi.org/10.1084/jem.20091846
- (2010) J. Exp. Med. , vol.207 , pp. 491-503
- Helfrich, I.¹ Scheffrahn, I.² Bartling, S.³ Weis, J.⁴ von Felbert, V.⁵ Middleton, M.⁶ Kato, M.⁷ Ergün, S.⁸ Schadendorf, D.⁹

31
- 0022612268
- Endothelial cell membranes contain podocalyxin-the major sialoprotein of visceral glomerular epithelial cells
- Horvat, R., A. Hovorka, G. Dekan, H. Poczewski, and D. Kerjaschki. 1986. Endothelial cell membranes contain podocalyxin-the major sialoprotein of visceral glomerular epithelial cells. J. Cell Biol. 102:484-491. http://dx.doi.org/10.1083/jcb.102.2.484
- (1986) J. Cell Biol. , vol.102 , pp. 484-491
- Horvat, R.¹ Hovorka, A.² Dekan, G.³ Poczewski, H.⁴ Kerjaschki, D.⁵

32
- 79951828866
- Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies
- Hu-Lowe, D.D., E. Chen, L. Zhang, K.D. Watson, P. Mancuso, P. Lappin, G. Wickman, J.H. Chen, J. Wang, X. Jiang, et al. 2011. Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res. 71:1362-1373. http://dx.doi.org/10.1158/0008-5472.CAN-10-1451
- (2011) Cancer Res , vol.71 , pp. 1362-1373
- Hu-Lowe, D.D.¹ Chen, E.² Zhang, L.³ Watson, K.D.⁴ Mancuso, P.⁵ Lappin, P.⁶ Wickman, G.⁷ Chen, J.H.⁸ Wang, J.⁹ Jiang, X.¹⁰

33
- 2542561964
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
- Hurwitz, H., L. Fehrenbacher, W. Novotny, T. Cartwright, J. Hainsworth, W. Heim, J. Berlin, A. Baron, S. Griffing, E. Holmgren, et al. 2004. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350:2335-2342. http://dx.doi.org/10.1056/NEJMoa032691
- (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
- Hurwitz, H.¹ Fehrenbacher, L.² Novotny, W.³ Cartwright, T.⁴ Hainsworth, J.⁵ Heim, W.⁶ Berlin, J.⁷ Baron, A.⁸ Griffing, S.⁹ Holmgren, E.¹⁰

34
- 32444435138
- Reduced angiogenic responses in adult Endoglin heterozygous mice
- Jerkic, M., A. Rodríguez-Barbero, M. Prieto, M. Toporsian, M. Pericacho, J.V. Rivas-Elena, J. Obreo, A. Wang, F. Pérez-Barriocanal, M. Arévalo, et al. 2006. Reduced angiogenic responses in adult Endoglin heterozygous mice. Cardiovasc. Res. 69:845-854. http://dx.doi.org/10.1016/j.cardiores.2005.11.020
- (2006) Cardiovasc. Res. , vol.69 , pp. 845-854
- Jerkic, M.¹ Rodríguez-Barbero, A.² Prieto, M.³ Toporsian, M.⁴ Pericacho, M.⁵ Rivas-Elena, J.V.⁶ Obreo, J.⁷ Wang, A.⁸ Pérez-Barriocanal, F.⁹ Arévalo, M.¹⁰

35
- 78249232956
- Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice
- Jerkic, M., M. Peter, D. Ardelean, M. Fine, M.A. Konerding, and M. Letarte. 2010. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice. Inflamm. Bowel Dis. 16:1859- 1870. http://dx.doi.org/10.1002/ibd.21288
- (2010) Inflamm. Bowel Dis. , vol.16
- Jerkic, M.¹ Peter, M.² Ardelean, D.³ Fine, M.⁴ Konerding, M.A.⁵ Letarte, M.⁶

36
- 0035666199
- Endoglin expression in early development is associated with vasculogenesis and angiogenesis
- Jonker, L., and H.M. Arthur. 2002. Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Mech. Dev. 110:193-196. http://dx.doi.org/10.1016/S0925-4773(01)00562-7
- (2002) Mech. Dev. , vol.110 , pp. 193-196
- Jonker, L.¹ Arthur, H.M.²

37
- 0025717523
- Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
- Kerbel, R.S. 1991. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays. 13:31-36. http://dx.doi.org/10.1002/bies.950130106
- (1991) Bioessays , vol.13 , pp. 31-36
- Kerbel, R.S.¹

38
- 0031443206
- A cancer therapy resistant to resistance
- Kerbel, R.S. 1997. A cancer therapy resistant to resistance. Nature. 390:335- 336. http://dx.doi.org/10.1038/36978
- (1997) Nature , vol.390 , pp. 335-336
- Kerbel, R.S.¹

39
- 0033557520
- Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis
- Kumar, S., A. Ghellal, C. Li, G. Byrne, N. Haboubi, J.M. Wang, and N. Bundred. 1999. Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. Cancer Res. 59:856-861.
- (1999) Cancer Res. , vol.59 , pp. 856-861
- Kumar, S.¹ Ghellal, A.² Li, C.³ Byrne, G.⁴ Haboubi, N.⁵ Wang, J.M.⁶ Bundred, N.⁷

40
- 8144230707
- Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
- Lebrin, F., M.J. Goumans, L. Jonker, R.L. Carvalho, G. Valdimarsdottir, M. Thorikay, C. Mummery, H.M. Arthur, and P. ten Dijke. 2004. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. EMBO J. 23:4018-4028. http://dx.doi.org/10.1038/sj. emboj.7600386
- (2004) EMBO J. , vol.23 , pp. 4018-4028
- Lebrin, F.¹ Goumans, M.J.² Jonker, L.³ Carvalho, R.L.⁴ Valdimarsdottir, G.⁵ Thorikay, M.⁶ Mummery, C.⁷ Arthur, H.M.⁸ ten Dijke, P.⁹

41
- 0033612141
- Defective angiogenesis in mice lacking endoglin
- Li, D.Y., L.K. Sorensen, B.S. Brooke, L.D. Urness, E.C. Davis, D.G. Taylor, B.B. Boak, and D.P. Wendel. 1999. Defective angiogenesis in mice lacking endoglin. Science. 284:1534-1537. http://dx.doi.org/ 10.1126/science.284.5419.1534
- (1999) Science. , vol.284 , pp. 1534-1537
- Li, D.Y.¹ Sorensen, L.K.² Brooke, B.S.³ Urness, L.D.⁴ Davis, E.C.⁵ Taylor, D.G.⁶ Boak, B.B.⁷ Wendel, D.P.⁸

42
- 77952478858
- Pathogenesis of arteriovenous malformations in the absence of endoglin
- Mahmoud, M., K.R. Allinson, Z. Zhai, R. Oakenfull, P. Ghandi, R.H. Adams, M. Fruttiger, and H.M. Arthur. 2010. Pathogenesis of arteriovenous malformations in the absence of endoglin. Circ. Res. 106:1425- 1433. http://dx.doi.org/10.1161/CIRCRESAHA.109.211037
- (2010) Circ. Res. , vol.106 , pp. 1425-1433
- Mahmoud, M.¹ Allinson, K.R.² Zhai, Z.³ Oakenfull, R.⁴ Ghandi, P.⁵ Adams, R.H.⁶ Fruttiger, M.⁷ Arthur, H.M.⁸

43
- 13444270807
- Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome
- Martone, T., P. Rosso, R. Albera, G. Migliaretti, F. Fraire, L. Pignataro, G. Pruneri, G. Bellone, and G. Cortesina. 2005. Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncol. 41:147-155. http://dx.doi.org/10.1016/j.oraloncology. 2004.08.001
- (2005) Oral Oncol. , vol.41 , pp. 147-155
- Martone, T.¹ Rosso, P.² Albera, R.³ Migliaretti, G.⁴ Fraire, F.⁵ Pignataro, L.⁶ Pruneri, G.⁷ Bellone, G.⁸ Cortesina, G.⁹

44
- 47549090432
- TGFbeta in Cancer
- Massagué, J. 2008. TGFbeta in Cancer. Cell. 134:215-230. http://dx.doi. org/10.1016/j.cell.2008.07.001
- (2008) Cell. , vol.134 , pp. 215-230
- Massagué, J.¹

45
- 78650018824
- Conversion of vascular endothelial cells into multipotent stem-like cells
- Medici, D., E.M. Shore, V.Y. Lounev, F.S. Kaplan, R. Kalluri, and B.R. Olsen. 2010. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat. Med. 16:1400-1406. http://dx.doi.org/10.1038/ nm.2252
- (2010) Nat. Med. , vol.16 , pp. 1400-1406
- Medici, D.¹ Shore, E.M.² Lounev, V.Y.³ Kaplan, F.S.⁴ Kalluri, R.⁵ Olsen, B.R.⁶

46
- 0032908133
- Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells
- (SICI)1097-0215(19990517)81:4568::AID-IJC11>3.0.CO;2-X
- Miller, D.W., W. Graulich, B. Karges, S. Stahl, M. Ernst, A. Ramaswamy, H.H. Sedlacek, R. Müller, and J. Adamkiewicz. 1999. Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cells. Int. J. Cancer. 81:568-572. http://dx.doi.org/10.1002/(SICI)1097-0215(19990517) 81:4<568::AID-IJC11>3.0.CO;2-X
- (1999) Int. J. Cancer. , vol.81 , pp. 568-572
- Miller, D.W.¹ Graulich, W.² Karges, B.³ Stahl, S.⁴ Ernst, M.⁵ Ramaswamy, A.⁶ Sedlacek, H.H.⁷ Müller, R.⁸ Adamkiewicz, J.⁹

47
- 76649106431
- ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
- Mitchell, D., E.G. Pobre, A.W. Mulivor, A.V. Grinberg, R. Castonguay, T.E. Monnell, N. Solban, J.A. Ucran, R.S. Pearsall, K.W. Underwood, et al. 2010. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol. Cancer Ther. 9:379-388. http://dx.doi. org/10.1158/1535-7163.MCT-09-0650
- (2010) Mol. Cancer Ther. , vol.9 , pp. 379-388
- Mitchell, D.¹ Pobre, E.G.² Mulivor, A.W.³ Grinberg, A.V.⁴ Castonguay, R.⁵ Monnell, T.E.⁶ Solban, N.⁷ Ucran, J.A.⁸ Pearsall, R.S.⁹ Underwood, K.W.¹⁰

48
- 77952330265
- Endothelial progenitor cells give rise to proangiogenic smooth muscle-like progeny
- Moonen, J.R., G. Krenning, M.G. Brinker, J.A. Koerts, M.J. van Luyn, and M.C. Harmsen. 2010. Endothelial progenitor cells give rise to proangiogenic smooth muscle-like progeny. Cardiovasc. Res. 86:506-515. http://dx.doi.org/10.1093/cvr/cvq012
- (2010) Cardiovasc. Res. , vol.86 , pp. 506-515
- Moonen, J.R.¹ Krenning, G.² Brinker, M.G.³ Koerts, J.A.⁴ van Luyn, M.J.⁵ Harmsen, M.C.⁶

49
- 33846181370
- Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
- Motzer, R.J., T.E. Hutson, P. Tomczak, M.D. Michaelson, R.M. Bukowski, O. Rixe, S. Oudard, S. Negrier, C. Szczylik, S.T. Kim, et al. 2007. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356:115-124. http://dx.doi.org/10.1056/ NEJMoa065044
- (2007) N. Engl. J. Med. , vol.356 , pp. 115-124
- Motzer, R.J.¹ Hutson, T.E.² Tomczak, P.³ Michaelson, M.D.⁴ Bukowski, R.M.⁵ Rixe, O.⁶ Oudard, S.⁷ Negrier, S.⁸ Szczylik, C.⁹ Kim, S.T.¹⁰

50
- 79960462574
- Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy
- Nassiri, F., M.D. Cusimano, B.W. Scheithauer, F. Rotondo, A. Fazio, G.M. Yousef, L.V. Syro, K. Kovacs, and R.V. Lloyd. 2011. Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy. Anticancer Res. 31:2283-2290.
- (2011) Anticancer Res. , vol.31 , pp. 2283-2290
- Nassiri, F.¹ Cusimano, M.D.² Scheithauer, B.W.³ Rotondo, F.⁴ Fazio, A.⁵ Yousef, G.M.⁶ Syro, L.V.⁷ Kovacs, K.⁸ Lloyd, R.V.⁹

51
- 63049090100
- Metastasis: from dissemination to organ-specific colonization
- Nguyen, D.X., P.D. Bos, and J. Massagué. 2009. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer. 9:274-284. http://dx.doi.org/10.1038/nrc2622
- (2009) Nat. Rev. Cancer. , vol.9 , pp. 274-284
- Nguyen, D.X.¹ Bos, P.D.² Massagué, J.³

52
- 58149236744
- Roles of TGFbeta in metastasis
- Padua, D., and J. Massagué. 2009. Roles of TGFbeta in metastasis. Cell Res. 19:89-102. http://dx.doi.org/10.1038/cr.2008.316
- (2009) Cell Res. , vol.19 , pp. 89-102
- Padua, D.¹ Massagué, J.²

53
- 60649106195
- Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
- Páez-Ribes, M., E. Allen, J. Hudock, T. Takeda, H. Okuyama, F. Viñals, M. Inoue, G. Bergers, D. Hanahan, and O. Casanovas. 2009. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 15:220-231. http://dx.doi.org/ 10.1016/j.ccr.2009.01.027
- (2009) Cancer Cell. , vol.15 , pp. 220-231
- Páez-Ribes, M.¹ Allen, E.² Hudock, J.³ Takeda, T.⁴ Okuyama, H.⁵ Viñals, F.⁶ Inoue, M.⁷ Bergers, G.⁸ Hanahan, D.⁹ Casanovas, O.¹⁰

54
- 77956187467
- Signaling by members of the TGF-beta family in vascular morphogenesis and disease
- Pardali, E., M.J. Goumans, and P. ten Dijke. 2010. Signaling by members of the TGF-beta family in vascular morphogenesis and disease. Trends Cell Biol. 20:556-567. http://dx.doi.org/10.1016/j.tcb.2010.06.006
- (2010) Trends Cell Biol. , vol.20 , pp. 556-567
- Pardali, E.¹ Goumans, M.J.² ten Dijke, P.³

55
- 84857838286
- Barcelona Consensus Conference participants. ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary.
- Pavel, M., E. Baudin, A. Couvelard, E. Krenning, K. Öberg, T. Steinmüller, M. Anlauf, B. Wiedenmann, and R. Salazar; Barcelona Consensus Conference participants. 2012. ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary. Neuroendocrinology. 95:157-176. http://dx.doi.org/10.1159/ 000335597
- (2012) Neuroendocrinology , vol.95 , pp. 157-176
- Pavel, M.¹ Baudin, E.² Couvelard, A.³ Krenning, E.⁴ Öberg, K.⁵ Steinmüller, T.⁶ Anlauf, M.⁷ Wiedenmann, B.⁸ Salazar, R.⁹

56
- 78650255998
- The role of the TGF-? coreceptor endoglin in cancer
- Pérez-Gómez, E., G. Del Castillo, S. Juan Francisco, J.M. López-Novoa, C. Bernabéu, and M. Quintanilla. 2010. The role of the TGF-? coreceptor endoglin in cancer. ScientificWorldJournal. 10:2367-2384. http://dx.doi. org/10.1100/tsw.2010.230
- (2010) ScientificWorldJournal , vol.10 , pp. 2367-2384
- Pérez-Gómez, E.¹ Del Castillo, G.² Juan Francisco, S.³ López-Novoa, J.M.⁴ Bernabéu, C.⁵ Quintanilla, M.⁶

57
- 14644446018
- A multitargeted, metronomic, and maximum- tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
- Pietras, K., and D. Hanahan. 2005. A multitargeted, metronomic, and maximum- tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 23:939-952. http://dx.doi.org/10.1200/JCO.2005.07.093
- (2005) J. Clin. Oncol. , vol.23 , pp. 939-952
- Pietras, K.¹ Hanahan, D.²

58
- 79851482955
- Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
- Raymond, E., L. Dahan, J.L. Raoul, Y.J. Bang, I. Borbath, C. Lombard-Bohas, J. Valle, P. Metrakos, D. Smith, A. Vinik, et al. 2011. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N. Engl. J. Med. 364:501-513. http://dx.doi.org/10.1056/NEJMoa1003825
- (2011) N. Engl. J. Med. , vol.364 , pp. 501-513
- Raymond, E.¹ Dahan, L.² Raoul, J.L.³ Bang, Y.J.⁴ Borbath, I.⁵ Lombard-Bohas, C.⁶ Valle, J.⁷ Metrakos, P.⁸ Smith, D.⁹ Vinik, A.¹⁰

59
- 21244483045
- Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression
- Sadick, H., F. Riedel, R. Naim, U. Goessler, K. Hörmann, M. Hafner, and A. Lux. 2005. Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression. Haematologica. 90:818-828.
- (2005) Haematologica , vol.90 , pp. 818-828
- Sadick, H.¹ Riedel, F.² Naim, R.³ Goessler, U.⁴ Hörmann, K.⁵ Hafner, M.⁶ Lux, A.⁷

60
- 59149089645
- Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? Int
- Sadick, H., J. Hage, U. Goessler, G. Bran, F. Riedel, P. Bugert, and K. Hoermann. 2008. Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? Int. J. Mol. Med. 22:575-580.
- (2008) J. Mol. Med. , vol.22 , pp. 575-580
- Sadick, H.¹ Hage, J.² Goessler, U.³ Bran, G.⁴ Riedel, F.⁵ Bugert, P.⁶ Hoermann, K.⁷

61
- 0030858765
- Longlasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin
- Seon, B.K., F. Matsuno, Y. Haruta, M. Kondo, and M. Barcos. 1997. Longlasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin. Cancer Res. 3:1031-1044.
- (1997) Clin. Cancer Res. , vol.3 , pp. 1031-1044
- Seon, B.K.¹ Matsuno, F.² Haruta, Y.³ Kondo, M.⁴ Barcos, M.⁵

62
- 78650901951
- Endoglin-targeted cancer therapy
- Seon, B.K., A. Haba, F. Matsuno, N. Takahashi, M. Tsujie, X. She, N. Harada, S. Uneda, T. Tsujie, H. Toi, et al. 2011. Endoglin-targeted cancer therapy. Curr. Drug Deliv. 8:135-143. http://dx.doi.org/10.2174/ 156720111793663570
- (2011) Curr. Drug Deliv. , vol.8 , pp. 135-143
- Seon, B.K.¹ Haba, A.² Matsuno, F.³ Takahashi, N.⁴ Tsujie, M.⁵ She, X.⁶ Harada, N.⁷ Uneda, S.⁸ Tsujie, T.⁹ Toi, H.¹⁰

63
- 77955880114
- Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment
- Shovlin, C.L. 2010. Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment. Blood Rev. 24:203-219. http://dx.doi.org/ 10.1016/j.blre.2010.07.001
- (2010) Blood Rev. , vol.24 , pp. 203-219
- Shovlin, C.L.¹

64
- 84863715967
- Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
- Singh, M., S.S. Couto, W.F. Forrest, A. Lima, J.H. Cheng, R. Molina, J.E. Long, P. Hamilton, A. McNutt, I. Kasman, et al. 2012. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J. Pathol. 227:417-430. http://dx.doi.org/10.1002/path. 4053
- (2012) J. Pathol. , vol.227 , pp. 417-430
- Singh, M.¹ Couto, S.S.² Forrest, W.F.³ Lima, A.⁴ Cheng, J.H.⁵ Molina, R.⁶ Long, J.E.⁷ Hamilton, P.⁸ McNutt, A.⁹ Kasman, I.¹⁰

65
- 0035503538
- Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
- Takahashi, N., A. Haba, F. Matsuno, and B.K. Seon. 2001a. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res. 61:7846-7854.
- (2001) Cancer Res. , vol.61 , pp. 7846-7854
- Takahashi, N.¹ Haba, A.² Matsuno, F.³ Seon, B.K.⁴

66
- 0034907326
- Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin
- Takahashi, N., R. Kawanishi-Tabata, A. Haba, M. Tabata, Y. Haruta, H. Tsai, and B.K. Seon. 2001b. Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin. Cancer Res. 7:524-532.
- (2001) Clin. Cancer Res. , vol.7 , pp. 524-532
- Takahashi, N.¹ Kawanishi-Tabata, R.² Haba, A.³ Tabata, M.⁴ Haruta, Y.⁵ Tsai, H.⁶ Seon, B.K.⁷

67
- 35448991324
- Extracellular control of TGFbeta signalling in vascular development and disease
- ten Dijke, P., and H.M. Arthur. 2007. Extracellular control of TGFbeta signalling in vascular development and disease. Nat. Rev. Mol. Cell Biol. 8:857-869. http://dx.doi.org/10.1038/nrm2262
- (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 857-869
- ten Dijke, P.¹ Arthur, H.M.²

68
- 41049094560
- Endoglin in angiogenesis and vascular diseases
- ten Dijke, P., M.J. Goumans, and E. Pardali. 2008. Endoglin in angiogenesis and vascular diseases. Angiogenesis. 11:79-89. http://dx.doi.org/ 10.1007/s10456-008-9101-9
- (2008) Angiogenesis , vol.11 , pp. 79-89
- ten Dijke, P.¹ Goumans, M.J.² Pardali, E.³

69
- 0037380583
- Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality
- Torsney, E., R. Charlton, A.G. Diamond, J. Burn, J.V. Soames, and H.M. Arthur. 2003. Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality. Circulation. 107:1653-1657. http://dx.doi.org/10.1161/01.CIR.0000058170.92267.00
- (2003) Circulation. , vol.107 , pp. 1653-1657
- Torsney, E.¹ Charlton, R.² Diamond, A.G.³ Burn, J.⁴ Soames, J.V.⁵ Arthur, H.M.⁶

70
- 80054761476
- TGF-? receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy
- van Meeteren, L.A., M.J. Goumans, and P. ten Dijke. 2011. TGF-? receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr. Pharm. Biotechnol. 12:2108-2120. http://dx.doi.org/ 10.2174/138920111798808338
- (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 2108-2120
- van Meeteren, L.A.¹ Goumans, M.J.² ten Dijke, P.³

71
- 84875051632
- Contrasting effects of sunitinib within in vivo models of metastasis
- Welti, J.C., T. Powles, S. Foo, M. Gourlaouen, N. Preece, J. Foster, S. Frentzas, D. Bird, K. Sharpe, A. van Weverwijk, et al. 2012. Contrasting effects of sunitinib within in vivo models of metastasis. Angiogenesis. 15:623-641. http://dx.doi.org/10.1007/s10456-012-9291-z
- (2012) Angiogenesis , vol.15 , pp. 623-641
- Welti, J.C.¹ Powles, T.² Foo, S.³ Gourlaouen, M.⁴ Preece, N.⁵ Foster, J.⁶ Frentzas, S.⁷ Bird, D.⁸ Sharpe, K.⁹ van Weverwijk, A.¹⁰

72
- 0027639632
- Characteristics and possible function of endoglin, a TGFbeta binding protein
- Westphal, J.R., H.W. Willems, C.J. Schalkwijk, D.J. Ruiter, and R.M. De Waal. 1993. Characteristics and possible function of endoglin, a TGFbeta binding protein. Behring Inst. Mitt. 92:15-22.
- (1993) Behring Inst. Mitt. , vol.92 , pp. 15-22
- Westphal, J.R.¹ Willems, H.W.² Schalkwijk, C.J.³ Ruiter, D.J.⁴ Waal, R.M.D.⁵

73
- 0036591699
- Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer
- Wikström, P., I.F. Lissbrant, P. Stattin, L. Egevad, and A. Bergh. 2002. Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate. 51:268-275. http://dx.doi.org/10.1002/pros.10083
- (2002) Prostate , vol.51 , pp. 268-275
- Wikström, P.¹ Lissbrant, I.F.² Stattin, P.³ Egevad, L.⁴ Bergh, A.⁵

74
- 33644643376
- Pericytes limit tumor cell metastasis
- Xian, X., J. Håkansson, A. Ståhlberg, P. Lindblom, C. Betsholtz, H. Gerhardt, and H. Semb. 2006. Pericytes limit tumor cell metastasis. J. Clin. Invest. 116:642-651. http://dx.doi.org/10.1172/JCI25705
- (2006) J. Clin. Invest. , vol.116 , pp. 642-651
- Xian, X.¹ Håkansson, J.² Ståhlberg, A.³ Lindblom, P.⁴ Betsholtz, C.⁵ Gerhardt, H.⁶ Semb, H.⁷

75
- 2942707848
- Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
- Yang, J., S.A. Mani, J.L. Donaher, S. Ramaswamy, R.A. Itzykson, C. Come, P. Savagner, I. Gitelman, A. Richardson, and R.A. Weinberg. 2004. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927-939. http://dx.doi.org/10.1016/ j.cell.2004.06.006
- (2004) Cell. , vol.117 , pp. 927-939
- Yang, J.¹ Mani, S.A.² Donaher, J.L.³ Ramaswamy, S.⁴ Itzykson, R.A.⁵ Come, C.⁶ Savagner, P.⁷ Gitelman, I.⁸ Richardson, A.⁹ Weinberg, R.A.¹⁰

76
- 79851500081
- Everolimus for advanced pancreatic neuroendocrine tumors
- RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group
- Yao, J.C., M.H. Shah, T. Ito, C.L. Bohas, E.M. Wolin, E. Van Cutsem, T.J. Hobday, T. Okusaka, J. Capdevila, E.G. de Vries, et al; RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group. 2011. Everolimus for advanced pancreatic neuroendocrine tumors. N. Engl. J. Med. 364:514-523. http://dx.doi.org/10.1056/NEJMoa1009290
- (2011) N. Engl. J. Med. , vol.364 , pp. 514-523
- Yao, J.C.¹ Shah, M.H.² Ito, T.³ Bohas, C.L.⁴ Wolin, E.M.⁵ Van Cutsem, E.⁶ Hobday, T.J.⁷ Okusaka, T.⁸ Capdevila, J.⁹ de Vries, E.G.¹⁰

77
- 35948945337
- Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
- Zeisberg, E.M., S. Potenta, L. Xie, M. Zeisberg, and R. Kalluri. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67:10123-10128. http://dx.doi.org/10.1158/0008-5472.CAN-07-3127
- (2007) Cancer Res. , vol.67 , pp. 10123-10128
- Zeisberg, E.M.¹ Potenta, S.² Xie, L.³ Zeisberg, M.⁴ Kalluri, R.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.