Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling

Acta Neuropathologica

Volumn 126, Issue 4, 2013, Pages 575-594

  Cama, Alessandro ^a   Verginelli, Fabio ^a   Lotti, Lavinia Vittoria ^b   Napolitano, Francesco ^c   Morgano, Annalisa ^a,d   D'Orazio, Andria ^d   Vacca, Michele ^d,e   Perconti, Silvia ^a   Pepe, Felice ^a,c   Romani, Federico ^b   Vitullo, Francesca ^f   Di Lella, Filippo ^f   Visone, Rosa ^a   Mannelli, Massimo ^g   Neumann, Hartmut P H ^h   Raiconi, Giancarlo ^c   Paties, Carlo ⁱ   Moschetta, Antonio ^d,e   Tagliaferri, Roberto ^c   Veronese, Angelo ^a   Sanna, Mario ^a,f   Mariani Costantini, Renato ^a   more..

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d University of Salerno ^*  (Italy)

^e NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^f GRUPPO OTOLOGICO   (Italy)

^g UNIVERSITY OF FLORENCE   (Italy)

^h UNIVERSITY OF FREIBURG   (Germany)

ⁱ GUGLIELMO DA SALICETO HOSPITAL   (Italy)

Author keywords

CNV; Head and neck; MicroRNA; NOTCH signaling; Paraganglioma; Paraganglioma cell culture

Indexed keywords

JAG2 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 200A; MICRORNA 200B; MICRORNA 200C; MICRORNA 34B; MICRORNA 34C; NOTCH RECEPTOR; NOTCH1 RECEPTOR; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC PREDISPOSITION; HEAD AND NECK CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR PATHOLOGY; NOTCH1 GENE; NUCLEOTIDE SEQUENCE; PARAGANGLIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SDH GENE; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CASPASES; CELL DEATH; CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; EPIGENESIS, GENETIC; FLUORESCENT ANTIBODY TECHNIQUE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; MICROARRAY ANALYSIS; MICROSCOPY, IMMUNOELECTRON; PARAGANGLIOMA; PERIPHERAL NERVES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUCCINATE DEHYDROGENASE; TRANSFECTION;

EID: 84885468590     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1165-y     Document Type: Article

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