ADAM10 cell surface expression but not activity is critical for staphylococcus aureus a-hemolysin-mediated activation of the nlrp3 inflammasome in human monocytes

Toxins

Volumn 8, Issue 4, 2016, Pages 1-14

  Ezekwe, Ejiofor A D ^a   Weng, Chengyu ^a   Duncan, Joseph A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

A hemolysin; ADAM10; NLRP3

Indexed keywords

ALPHA HEMOLYSIN; CRYOPYRIN; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; METALLOPROTEINASE; PROTEINASE; SMALL INTERFERING RNA; 3-(FORMYLHYDROXYAMINO)-2-(3-PHENYL-1-PROPYL)BUTANOIC ACID (2,2-DIMETHYL-1-METHYLCARBAMOYL-1-PROPYL)AMIDE; ADAM10 ENDOPEPTIDASE; ADAM10 PROTEIN, HUMAN; BACTERIAL TOXIN; DIPEPTIDE; HEMOLYSIN; HYDROXAMIC ACID; MEMBRANE PROTEIN; NLRP3 PROTEIN, HUMAN; SECRETASE; STAPHYLOCOCCAL ALPHA-TOXIN;

ARTICLE; CELL DAMAGE; CELL DEATH; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MONOCYTE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL MEMBRANE; DRUG EFFECTS; GENETICS; METABOLISM; U-937 CELL LINE;

ADAM10 PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; BACTERIAL TOXINS; CASPASE 1; CELL LINE; CELL MEMBRANE; DIPEPTIDES; HEMOLYSIN PROTEINS; HUMANS; HYDROXAMIC ACIDS; INFLAMMASOMES; MEMBRANE PROTEINS; MONOCYTES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RNA, SMALL INTERFERING; U937 CELLS;

EID: 84962079699     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins8040095     Document Type: Article

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