메뉴 건너뛰기




Volumn 2016, Issue , 2016, Pages

A dietary treatment improves cerebral blood flow and brain connectivity in aging apoE4 mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN E4; ASCORBIC ACID; CHOLINE; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; FATTY ACID; FOLIC ACID; ICOSAPENTAENOIC ACID; PHOSPHOLIPID; POSTSYNAPTIC DENSITY PROTEIN 95; PYRIDOXINE; SELENIUM; STEROL; URIDINE; APOLIPOPROTEIN E; DLGH4 PROTEIN, MOUSE; GUANYLATE KINASE; MEMBRANE PROTEIN;

EID: 84962070978     PISSN: 20905904     EISSN: 16875443     Source Type: Journal    
DOI: 10.1155/2016/6846721     Document Type: Article
Times cited : (47)

References (85)
  • 3
    • 34948883976 scopus 로고    scopus 로고
    • Mediterranean diet and Alzheimer disease mortality
    • N. Scarmeas, J. A. Luchsinger, R. Mayeux, and Y. Stern, "Mediterranean diet and Alzheimer disease mortality, " Neurology, vol. 69, no. 11, pp. 1084-1093, 2007.
    • (2007) Neurology , vol.69 , Issue.11 , pp. 1084-1093
    • Scarmeas, N.1    Luchsinger, J.A.2    Mayeux, R.3    Stern, Y.4
  • 4
    • 84875787136 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with a Mediterranean diet
    • R. Estruch, E. Ros, J. Salas-Salvado, et al., "Primary prevention of cardiovascular disease with a Mediterranean diet, " The New England Journal of Medicine, vol. 368, no. 14, pp. 1279-1290, 2013.
    • (2013) The New England Journal of Medicine , vol.368 , Issue.14 , pp. 1279-1290
    • Estruch, R.1    Ros, E.2    Salas-Salvado, J.3
  • 6
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimers disease
    • C. Iadecola, "Neurovascular regulation in the normal brain and in Alzheimers disease, " Nature Reviews Neuroscience, vol. 5, no. 5, pp. 347-360, 2004.
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.5 , pp. 347-360
    • Iadecola, C.1
  • 7
    • 0037425770 scopus 로고    scopus 로고
    • Association of n polyunsaturated fatty acids with stability of atherosclerotic plaques: A randomised controlled trial
    • F. Thies, J. M. C. Garry, P. Yaqoob, et al., "Association of n polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial, " The Lancet, vol. 361, no. 9356, pp. 477-485, 2003.
    • (2003) The Lancet , vol.361 , Issue.9356 , pp. 477-485
    • Thies, F.1    Garry, J.M.C.2    Yaqoob, P.3
  • 8
    • 0036668195 scopus 로고    scopus 로고
    • Blood pressure response to fish oil supplementation: Metaregression analysis of randomized trials
    • J. M. Geleijnse, E. J. Giltay, D. E. Grobbee, A. R. T. Donders, and F. J. Kok, "Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials, " Journal of Hypertension, vol. 20, no. 8, pp. 1493-1499, 2002.
    • (2002) Journal of Hypertension , vol.20 , Issue.8 , pp. 1493-1499
    • Geleijnse, J.M.1    Giltay, E.J.2    Grobbee, D.E.3    Donders, A.R.T.4    Kok, F.J.5
  • 9
    • 0030899940 scopus 로고    scopus 로고
    • Fish consumption and the 30-year risk of fatal myocardial infarction
    • M. L. Daviglus, J. Stamler, A. J. Orencia, et al., "Fish consumption and the 30-year risk of fatal myocardial infarction, " The New England Journal ofMedicine, vol. 336, no. 15, pp. 1046-1053, 1997.
    • (1997) The New England Journal OfMedicine , vol.336 , Issue.15 , pp. 1046-1053
    • Daviglus, M.L.1    Stamler, J.2    Orencia, A.J.3
  • 10
    • 0037051975 scopus 로고    scopus 로고
    • Fish and omega-3 fatty acid intake and risk of coronary heart disease in women
    • F. B. Hu, L. Bronner, W. C. Willett, et al., "Fish and omega-3 fatty acid intake and risk of coronary heart disease in women, " The Journal of the AmericanMedical Association, vol. 287, no. 14, pp. 1815-1821, 2002.
    • (2002) The Journal of the American Medical Association , vol.287 , Issue.14 , pp. 1815-1821
    • Hu, F.B.1    Bronner, L.2    Willett, W.C.3
  • 11
    • 33845573084 scopus 로고    scopus 로고
    • Cardiovascular benefits of omega-3 fatty acids
    • C. von Schacky and W. S. Harris, "Cardiovascular benefits of omega-3 fatty acids, " Cardiovascular Research, vol. 73, no. 2, pp. 310-315, 2007.
    • (2007) Cardiovascular Research , vol.73 , Issue.2 , pp. 310-315
    • Von Schacky, C.1    Harris, W.S.2
  • 12
    • 78649436932 scopus 로고    scopus 로고
    • Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses
    • R. J. Wurtman, M. Cansev, T. Sakamoto, and I. Ulus, "Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses, " Nutrition Reviews, vol. 68, no. 2, pp. S88-S101, 2010.
    • (2010) Nutrition Reviews , vol.68 , Issue.2 , pp. S88-S101
    • Wurtman, R.J.1    Cansev, M.2    Sakamoto, T.3    Ulus, I.4
  • 13
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • S. B. Weiss and E. P. Kennedy, "The function of cytidine coenzymes in the biosynthesis of phospholipides, " The Journal of Biological Chemistry, vol. 222, no. 1, pp. 193-214, 1956.
    • (1956) The Journal of Biological Chemistry , vol.222 , Issue.1 , pp. 193-214
    • Weiss, S.B.1    Kennedy, E.P.2
  • 14
    • 33646592555 scopus 로고    scopus 로고
    • Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally
    • R. J. Wurtman, I. H. Ulus, M. Cansev, C. J. Watkins, L. Wang, and G. Marzloff, "Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally, " Brain Research, vol. 1088, no. 1, pp. 83-92, 2006.
    • (2006) Brain Research , vol.1088 , Issue.1 , pp. 83-92
    • Wurtman, R.J.1    Ulus, I.H.2    Cansev, M.3    Watkins, C.J.4    Wang, L.5    Marzloff, G.6
  • 15
    • 34548430850 scopus 로고    scopus 로고
    • Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils
    • M. Cansev and R. J. Wurtman, "Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils, " Neuroscience, vol. 148, no. 2, pp. 421-431, 2007.
    • (2007) Neuroscience , vol.148 , Issue.2 , pp. 421-431
    • Cansev, M.1    Wurtman, R.J.2
  • 16
    • 36049020643 scopus 로고    scopus 로고
    • Oral supplementation with docosahexaenoic acid and uridine-5-monophosphate increases dendritic spine density in adult gerbil hippocampus
    • T. Sakamoto, M. Cansev, and R. J. Wurtman, "Oral supplementation with docosahexaenoic acid and uridine-5-monophosphate increases dendritic spine density in adult gerbil hippocampus, " Brain Research, vol. 1182, no. 1, pp. 50-59, 2007.
    • (2007) Brain Research , vol.1182 , Issue.1 , pp. 50-59
    • Sakamoto, T.1    Cansev, M.2    Wurtman, R.J.3
  • 17
    • 84889581933 scopus 로고    scopus 로고
    • Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimers disease
    • V. Zerbi, D. Jansen, M. Wiesmann, et al., "Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimers disease, " Neurobiology of Aging, vol. 35, no. 3, pp. 600-613, 2014.
    • (2014) Neurobiology of Aging , vol.35 , Issue.3 , pp. 600-613
    • Zerbi, V.1    Jansen, D.2    Wiesmann, M.3
  • 18
    • 84883199083 scopus 로고    scopus 로고
    • Improved spatial learning strategy and memory in aged Alzheimer AbetaPPswe/PS1dE9 mice on a multi-nutrient diet
    • M. Wiesmann, D. Jansen, V. Zerbi, L. M. Broersen, A. Garthe, and A. J. Kiliaan, "Improved spatial learning strategy and memory in aged Alzheimer AbetaPPswe/PS1dE9 mice on a multi-nutrient diet, " Journal of Alzheimers Disease, vol. 37, no. 1, pp. 233-245, 2013.
    • (2013) Journal of Alzheimers Disease , vol.37 , Issue.1 , pp. 233-245
    • Wiesmann, M.1    Jansen, D.2    Zerbi, V.3    Broersen, L.M.4    Garthe, A.5    Kiliaan, A.J.6
  • 19
    • 77954558669 scopus 로고    scopus 로고
    • Can nutrients prevent or delay onset of Alzheimers disease?
    • P. J. G. H. Kamphuis and P. Scheltens, "Can nutrients prevent or delay onset of Alzheimers disease?" Journal of Alzheimers Disease, vol. 20, no. 3, pp. 765-775, 2010.
    • (2010) Journal of Alzheimers Disease , vol.20 , Issue.3 , pp. 765-775
    • Kamphuis, P.J.G.H.1    Scheltens, P.2
  • 20
    • 84863965060 scopus 로고    scopus 로고
    • Food for thought: Souvenaid in mild Alzheimers disease
    • J. L. Cummings, "Food for thought: Souvenaid in mild Alzheimers disease, " Journal of Alzheimers Disease, vol. 31, no. 1, pp. 237-238, 2012.
    • (2012) Journal of Alzheimers Disease , vol.31 , Issue.1 , pp. 237-238
    • Cummings, J.L.1
  • 21
    • 73249116434 scopus 로고    scopus 로고
    • Efficacy of a medical food in mild Alzheimers disease: A randomized, controlled trial
    • P. Scheltens, P. J. G. H. Kamphuis, F. R. J. Verhey, et al., "Efficacy of a medical food in mild Alzheimers disease: a randomized, controlled trial, " Alzheimers & Dementia, vol. 6, no. 1, pp. 1. e1-10. e1, 2010.
    • (2010) Alzheimers & Dementia , vol.6 , Issue.1 , pp. 1e1-10e1
    • Scheltens, P.1    Kamphuis, P.J.G.H.2    Verhey, F.R.J.3
  • 22
    • 84863946102 scopus 로고    scopus 로고
    • Efficacy of souvenaid in mild alzheimers disease: Results from a randomized, controlled trial
    • P. Scheltens, J. W. R. Twisk, R. Blesa, et al., "Efficacy of souvenaid in mild alzheimers disease: results from a randomized, controlled trial, " Journal of Alzheimers Disease, vol. 31, no. 1, pp. 225-236, 2012.
    • (2012) Journal of Alzheimers Disease , vol.31 , Issue.1 , pp. 225-236
    • Scheltens, P.1    Twisk, J.W.R.2    Blesa, R.3
  • 23
    • 84900312887 scopus 로고    scopus 로고
    • The effect of souvenaid on functional brain network organisation in patients with mild Alzheimers disease: A randomised controlled study
    • Article ID e86558
    • H. de Waal, C. J. Stam, M. M. Lansbergen, et al., "The effect of souvenaid on functional brain network organisation in patients with mild Alzheimers disease: a randomised controlled study, " PLoS ONE, vol. 9, no. 1, Article ID e86558, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.1
    • De Waal, H.1    Stam, C.J.2    Lansbergen, M.M.3
  • 24
    • 0033840462 scopus 로고    scopus 로고
    • ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype
    • A. M. Minihane, S. Khan, E. C. Leigh-Firbank, et al., "ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 8, pp. 1990-1997, 2000.
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , Issue.8 , pp. 1990-1997
    • Minihane, A.M.1    Khan, S.2    Leigh-Firbank, E.C.3
  • 25
    • 38949110024 scopus 로고    scopus 로고
    • N-3 Fatty acid erythrocyte membrane content, APOE 4, and cognitive variation: An observational follow-up study in late adulthood
    • L. J. Whalley, I. J. Deary, J. M. Starr, et al., "n-3 Fatty acid erythrocyte membrane content, APOE 4, and cognitive variation: an observational follow-up study in late adulthood, " American Journal of Clinical Nutrition, vol. 87, no. 2, pp. 449-454, 2008.
    • (2008) American Journal of Clinical Nutrition , vol.87 , Issue.2 , pp. 449-454
    • Whalley, L.J.1    Deary, I.J.2    Starr, J.M.3
  • 26
    • 84883193540 scopus 로고    scopus 로고
    • Relationship between diet and plasma long-chain n-3 PUFAs in older people: Impact of apolipoprotein e genotype
    • C. Samieri, S. Lorrain, B. Buaud, et al., "Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype, " Journal of Lipid Research, vol. 54, no. 9, pp. 2559-2567, 2013.
    • (2013) Journal of Lipid Research , vol.54 , Issue.9 , pp. 2559-2567
    • Samieri, C.1    Lorrain, S.2    Buaud, B.3
  • 27
    • 0020419894 scopus 로고
    • Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes
    • V. I. Zannis, J. L. Breslow, G. Utermann, et al., "Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes, " Journal of Lipid Research, vol. 23, no. 6, pp. 911914, 1982.
    • (1982) Journal of Lipid Research , vol.23 , Issue.6 , pp. 911-914
    • Zannis, V.I.1    Breslow, J.L.2    Utermann, G.3
  • 28
    • 84861903643 scopus 로고    scopus 로고
    • Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimers disease
    • C. Frieden and K. Garai, "Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimers disease, " Proceedings of the National Academy of Sciences of theUnited States ofAmerica, vol. 109, no. 23, pp. 8913-8918, 2012.
    • (2012) Proceedings of the National Academy of Sciences of TheUnited States of America , vol.109 , Issue.23 , pp. 8913-8918
    • Frieden, C.1    Garai, K.2
  • 29
    • 84873722367 scopus 로고    scopus 로고
    • Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy
    • C. C. Liu, T. Kanekiyo, H. Xu, and G. Bu, "Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy, " Nature Reviews Neurology, vol. 9, no. 2, pp. 106-118, 2013.
    • (2013) Nature Reviews Neurology , vol.9 , Issue.2 , pp. 106-118
    • Liu, C.C.1    Kanekiyo, T.2    Xu, H.3    Bu, G.4
  • 30
    • 84876136764 scopus 로고    scopus 로고
    • Cerebrovascular effects of apolipoprotein E: Implications for Alzheimer disease
    • B. V. Zlokovic, "Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease, " JAMA Neurology, vol. 70, no. 4, pp. 440-444, 2013.
    • (2013) JAMA Neurology , vol.70 , Issue.4 , pp. 440-444
    • Zlokovic, B.V.1
  • 31
    • 84896736695 scopus 로고    scopus 로고
    • APOE associations with severe CAA-associated vasculopathic changes: Collaborative meta-analysis
    • K. Rannikmae, R. N. Kalaria, S. M. Greenberg, et al., "APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis, " Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 3, pp. 300-305, 2014.
    • (2014) Journal of Neurology, Neurosurgery and Psychiatry , vol.85 , Issue.3 , pp. 300-305
    • Rannikmae, K.1    Kalaria, R.N.2    Greenberg, S.M.3
  • 32
    • 84881181605 scopus 로고    scopus 로고
    • The APOE 4/4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimers disease patients
    • K. Hultman, S. Strickland, and E. H. Norris, "The APOE 4/4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimers disease patients, " Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 8, pp. 1251-1258, 2013.
    • (2013) Journal of Cerebral Blood Flow and Metabolism , vol.33 , Issue.8 , pp. 1251-1258
    • Hultman, K.1    Strickland, S.2    Norris, E.H.3
  • 33
    • 0032721537 scopus 로고    scopus 로고
    • Apo e structure determines VLDL clearance and atherosclerosis risk in mice
    • C. Knouff, M. E. Hinsdale, H. Mezdour, et al., "Apo E structure determines VLDL clearance and atherosclerosis risk in mice, " Journal of Clinical Investigation, vol. 103, no. 11, pp. 1579-1586, 1999.
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.11 , pp. 1579-1586
    • Knouff, C.1    Hinsdale, M.E.2    Mezdour, H.3
  • 34
    • 84897471299 scopus 로고    scopus 로고
    • Association of amyloid burden, brain atrophy and memory deficits in aged apolipoprotein epsilon4 mice
    • J. Yin, G. H. Turner, S. W. Coons, M. Maalouf, E. M. Reiman, and J. Shi, "Association of amyloid burden, brain atrophy and memory deficits in aged apolipoprotein epsilon4 mice, " Current Alzheimer Research, vol. 11, no. 3, pp. 283-290, 2014.
    • (2014) Current Alzheimer Research , vol.11 , Issue.3 , pp. 283-290
    • Yin, J.1    Turner, G.H.2    Coons, S.W.3    Maalouf, M.4    Reiman, E.M.5    Shi, J.6
  • 35
    • 85027951281 scopus 로고    scopus 로고
    • Impact of a multinutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice
    • D. Jansen, V. Zerbi, C. I. Janssen, et al., "Impact of a multinutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice, " Brain Structure and Function, vol. 219, no. 5, pp. 1841-1868, 2014.
    • (2014) Brain Structure and Function , vol.219 , Issue.5 , pp. 1841-1868
    • Jansen, D.1    Zerbi, V.2    Janssen, C.I.3
  • 36
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein e gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • P. M. Sullivan, H. Mezdour, Y. Aratani, et al., "Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis, " The Journal of Biological Chemistry, vol. 272, no. 29, pp. 17972-17980, 1997.
    • (1997) The Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3
  • 37
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute ofNutrition ad hocwriting committee on the reformulation of the AIN-76A rodent diet
    • P. G. Reeves, F. H. Nielsen, and G. C. Fahey Jr., "AIN-93 purified diets for laboratory rodents: final report of the American Institute ofNutrition ad hocwriting committee on the reformulation of the AIN-76A rodent diet, " The Journal of Nutrition, vol. 123, no. 11, pp. 1939-1951, 1993.
    • (1993) The Journal of Nutrition , vol.123 , Issue.11 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey, G.C.3
  • 38
    • 0029151256 scopus 로고
    • Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: Application to functional mapping
    • S.-G. Kim, "Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping, " Magnetic Resonance in Medicine, vol. 34, no. 3, pp. 293-301, 1995.
    • (1995) Magnetic Resonance in Medicine , vol.34 , Issue.3 , pp. 293-301
    • Kim, S.-G.1
  • 39
    • 78650424520 scopus 로고    scopus 로고
    • In vivo diffusion tensor magnetic resonance imaging and fiber tracking of the mouse brain
    • L.-A. Harsan, D. Paul, S. Schnell, et al., "In vivo diffusion tensor magnetic resonance imaging and fiber tracking of the mouse brain, " NMR in Biomedicine, vol. 23, no. 7, pp. 884-896, 2010.
    • (2010) NMR in Biomedicine , vol.23 , Issue.7 , pp. 884-896
    • Harsan, L.-A.1    Paul, D.2    Schnell, S.3
  • 40
    • 77956060332 scopus 로고    scopus 로고
    • Patching cardiac and head motion artefacts in diffusion-weighted images
    • M. P. Zwiers, "Patching cardiac and head motion artefacts in diffusion-weighted images, " NeuroImage, vol. 53, no. 2, pp. 565-575, 2010.
    • (2010) NeuroImage , vol.53 , Issue.2 , pp. 565-575
    • Zwiers, M.P.1
  • 42
    • 57449107357 scopus 로고    scopus 로고
    • Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry
    • S. J. Sawiak, N. I. Wood, G. B. Williams, A. J. Morton, and T. A. Carpenter, "Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry, " Neurobiology of Disease, vol. 33, no. 1, pp. 20-27, 2009.
    • (2009) Neurobiology of Disease , vol.33 , Issue.1 , pp. 20-27
    • Sawiak, S.J.1    Wood, N.I.2    Williams, G.B.3    Morton, A.J.4    Carpenter, T.A.5
  • 43
    • 79955159545 scopus 로고    scopus 로고
    • Functional connectivity FMRI of the rodent brain: Comparison of functional connectivity networks in rat and mouse
    • Article ID e18876
    • E. Jonckers, J. vanAudekerke, G. deVisscher, A. van der Linden, and M. Verhoye, "Functional connectivity fMRI of the rodent brain: comparison of functional connectivity networks in rat and mouse, " PLoS ONE, vol. 6, no. 4, Article ID e18876, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.4
    • Jonckers, E.1    VanAudekerke, J.2    DeVisscher, G.3    Van Der Linden, A.4    Verhoye, M.5
  • 44
    • 0036314309 scopus 로고    scopus 로고
    • Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
    • D. Lutjohann, A. Brzezinka, E. Barth, et al., "Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain, " Journal of Lipid Research, vol. 43, no. 7, pp. 1078-1085, 2002.
    • (2002) Journal of Lipid Research , vol.43 , Issue.7 , pp. 1078-1085
    • Lutjohann, D.1    Brzezinka, A.2    Barth, E.3
  • 45
  • 47
    • 79951713725 scopus 로고    scopus 로고
    • Apolipoprotein e in Alzheimers disease and other neurological disorders
    • P. B. Verghese, J. M. Castellano, and D. M. Holtzman, "Apolipoprotein E in Alzheimers disease and other neurological disorders, "TheLancetNeurology, vol. 10, no. 3, pp. 241-252, 2011.
    • (2011) TheLancet Neurology , vol.10 , Issue.3 , pp. 241-252
    • Verghese, P.B.1    Castellano, J.M.2    Holtzman, D.M.3
  • 48
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimers disease and other disorders
    • B. V. Zlokovic, "Neurovascular pathways to neurodegeneration in Alzheimers disease and other disorders, " Nature Reviews Neuroscience, vol. 12, no. 12, pp. 723-738, 2011.
    • (2011) Nature Reviews Neuroscience , vol.12 , Issue.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 49
    • 78650371044 scopus 로고    scopus 로고
    • APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A42
    • Y. I. Sheline, J. C. Morris, A. Z. Snyder, et al., "APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF A42, " Journal of Neuroscience, vol. 30, no. 50, pp. 17035-17040, 2010.
    • (2010) Journal of Neuroscience , vol.30 , Issue.50 , pp. 17035-17040
    • Sheline, Y.I.1    Morris, J.C.2    Snyder, A.Z.3
  • 50
    • 84907992885 scopus 로고    scopus 로고
    • Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice
    • V. Zerbi, M. Wiesmann, T. L. Emmerzaal, et al., "Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice, " The Journal of Neuroscience, vol. 34, no. 42, pp. 13963-13975, 2014.
    • (2014) The Journal of Neuroscience , vol.34 , Issue.42 , pp. 13963-13975
    • Zerbi, V.1    Wiesmann, M.2    Emmerzaal, T.L.3
  • 51
    • 84878335422 scopus 로고    scopus 로고
    • Arterial spin labeled MRI in prodromal Alzheimers disease: A multi-site study
    • Z. Wang, S. R. Das, S. X. Xie, S. E. Arnold, J. A. Detre, and D. A. Wolk, "Arterial spin labeled MRI in prodromal Alzheimers disease: a multi-site study, " NeuroImage: Clinical, vol. 2, no. 1, pp. 630-636, 2013.
    • (2013) NeuroImage: Clinical , vol.2 , Issue.1 , pp. 630-636
    • Wang, Z.1    Das, S.R.2    Xie, S.X.3    Arnold, S.E.4    Detre, J.A.5    Wolk, D.A.6
  • 52
    • 77954706306 scopus 로고    scopus 로고
    • SerialMRI andCSF biomarkers in normal aging, MCI, and AD
    • P. Vemuri, H. J. Wiste, S. D. Weigand, et al., "SerialMRI andCSF biomarkers in normal aging, MCI, and AD, " Neurology, vol. 75, no. 2, pp. 143-151, 2010.
    • (2010) Neurology , vol.75 , Issue.2 , pp. 143-151
    • Vemuri, P.1    Wiste, H.J.2    Weigand, S.D.3
  • 53
    • 84872379077 scopus 로고    scopus 로고
    • Tracking pathophysiological processes in Alzheimers disease: An updated hypothetical model of dynamic biomarkers
    • C. R. Jack Jr., D. S. Knopman, W. J. Jagust, et al., "Tracking pathophysiological processes in Alzheimers disease: an updated hypothetical model of dynamic biomarkers, " The Lancet Neurology, vol. 12, no. 2, pp. 207-216, 2013.
    • (2013) The Lancet Neurology , vol.12 , Issue.2 , pp. 207-216
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3
  • 54
    • 66549106850 scopus 로고    scopus 로고
    • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: Implications for sequence of pathological events in Alzheimers disease
    • C. R. Jack Jr., V. J. Lowe, S. D. Weigand, et al., "Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease, " Brain, vol. 132, no. 5, pp. 1355-1365, 2009.
    • (2009) Brain , vol.132 , Issue.5 , pp. 1355-1365
    • Jack, C.R.1    Lowe, V.J.2    Weigand, S.D.3
  • 55
    • 84904701075 scopus 로고    scopus 로고
    • Apolipoprotein e genotype, gender and age modulate connectivity of the hippocampus in healthy adults
    • V. Heise, N. Filippini, A. J. Trachtenberg, S. Suri, K. P. Ebmeier, and C. E. Mackay, "Apolipoprotein E genotype, gender and age modulate connectivity of the hippocampus in healthy adults, " NeuroImage, vol. 98, pp. 23-30, 2014.
    • (2014) NeuroImage , vol.98 , pp. 23-30
    • Heise, V.1    Filippini, N.2    Trachtenberg, A.J.3    Suri, S.4    Ebmeier, K.P.5    MacKay, C.E.6
  • 56
    • 80052044269 scopus 로고    scopus 로고
    • The APOE 4 allele modulates brain white matter integrity in healthy adults
    • V. Heise, N. Filippini, K. P. Ebmeier, and C. E. MacKay, "The APOE 4 allele modulates brain white matter integrity in healthy adults, "Molecular Psychiatry, vol. 16, no. 9, pp. 908-916, 2011.
    • (2011) Molecular Psychiatry , vol.16 , Issue.9 , pp. 908-916
    • Heise, V.1    Filippini, N.2    Ebmeier, K.P.3    MacKay, C.E.4
  • 57
    • 24044514028 scopus 로고    scopus 로고
    • Abnormal white matter integrity in healthy apolipoprotein e epsilon4 carriers
    • J. Nierenberg, N. Pomara, M. J. Hoptman, J. J. Sidtis, B. A. Ardekani, and K. O. Lim, "Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers, " NeuroReport, vol. 16, no. 12, pp. 1369-1372, 2005.
    • (2005) NeuroReport , vol.16 , Issue.12 , pp. 1369-1372
    • Nierenberg, J.1    Pomara, N.2    Hoptman, M.J.3    Sidtis, J.J.4    Ardekani, B.A.5    Lim, K.O.6
  • 58
    • 75149197270 scopus 로고    scopus 로고
    • Impact of APOE on the healthy aging brain: A voxel-based MRI and DTI study
    • R. A. Honea, E. Vidoni, A. Harsha, and J. M. Burns, "Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study, " Journal of AlzheimersDisease, vol. 18, no. 3, pp. 553-564, 2009.
    • (2009) Journal of AlzheimersDisease , vol.18 , Issue.3 , pp. 553-564
    • Honea, R.A.1    Vidoni, E.2    Harsha, A.3    Burns, J.M.4
  • 59
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein e in Alzheimers disease
    • J. Kim, J. M. Basak, and D. M. Holtzman, "The role of apolipoprotein E in Alzheimers disease, " Neuron, vol. 63, no. 3, pp. 287-303, 2009.
    • (2009) Neuron , vol.63 , Issue.3 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 60
    • 84871211847 scopus 로고    scopus 로고
    • Effects of APOE on brain white matter microstructure in healthy adults
    • L. T. Westlye, I. Reinvang, H. Rootwelt, and T. Espeseth, "Effects of APOE on brain white matter microstructure in healthy adults, " Neurology, vol. 79, no. 19, pp. 1961-1969, 2012.
    • (2012) Neurology , vol.79 , Issue.19 , pp. 1961-1969
    • Westlye, L.T.1    Reinvang, I.2    Rootwelt, H.3    Espeseth, T.4
  • 61
    • 33645091234 scopus 로고    scopus 로고
    • Imaging studies andAPOE genotype in persons at risk for Alzheimers disease
    • N. Scarmeas and Y. Stern, "Imaging studies andAPOE genotype in persons at risk for Alzheimers disease, " Current Psychiatry Reports, vol. 8, no. 1, pp. 11-17, 2006.
    • (2006) Current Psychiatry Reports , vol.8 , Issue.1 , pp. 11-17
    • Scarmeas, N.1    Stern, Y.2
  • 62
    • 84876380474 scopus 로고    scopus 로고
    • Interaction of age and APOE genotype on cerebral blood flow at rest
    • C. E. Wierenga, L. R. Clark, S. I. Dev, et al., "Interaction of age and APOE genotype on cerebral blood flow at rest, " Journal of Alzheimers Disease, vol. 34, no. 4, pp. 921-935, 2013.
    • (2013) Journal of Alzheimers Disease , vol.34 , Issue.4 , pp. 921-935
    • Wierenga, C.E.1    Clark, L.R.2    Dev, S.I.3
  • 63
    • 77953776221 scopus 로고    scopus 로고
    • Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
    • J. L. O'Brien, K. M. O'Keefe, P. S. Laviolette, et al., "Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline, " Neurology, vol. 74, no. 24, pp. 1969-1976, 2010.
    • (2010) Neurology , vol.74 , Issue.24 , pp. 1969-1976
    • O'Brien, J.L.1    O'Keefe, K.M.2    Laviolette, P.S.3
  • 64
    • 80052725755 scopus 로고    scopus 로고
    • Effect of APOE epsilon4 status on intrinsic network connectivity in cognitively normal elderly subjects
    • M. M. Machulda, D. T. Jones, P. Vemuri, et al., "Effect of APOE epsilon4 status on intrinsic network connectivity in cognitively normal elderly subjects, " Archives of Neurology, vol. 68, no. 9, pp. 1131-1136, 2011.
    • (2011) Archives of Neurology , vol.68 , Issue.9 , pp. 1131-1136
    • Machulda, M.M.1    Jones, D.T.2    Vemuri, P.3
  • 66
    • 84879719066 scopus 로고    scopus 로고
    • APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimers disease
    • I. Reinvang, T. Espeseth, and L. T. Westlye, "APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimers disease, " Neuroscience and Biobehavioral Reviews, vol. 37, no. 8, pp. 1322-1335, 2013.
    • (2013) Neuroscience and Biobehavioral Reviews , vol.37 , Issue.8 , pp. 1322-1335
    • Reinvang, I.1    Espeseth, T.2    Westlye, L.T.3
  • 67
    • 84889770932 scopus 로고    scopus 로고
    • Targeting synaptic dysfunction in Alzheimers disease by administering a specific nutrient combination
    • N. van Wijk, L. M. Broersen, M. C. De Wilde, et al., "Targeting synaptic dysfunction in Alzheimers disease by administering a specific nutrient combination, " Journal of Alzheimers Disease, vol. 38, no. 3, pp. 459-479, 2014.
    • (2014) Journal of Alzheimers Disease , vol.38 , Issue.3 , pp. 459-479
    • Van Wijk, N.1    Broersen, L.M.2    De Wilde, M.C.3
  • 68
    • 77957334617 scopus 로고    scopus 로고
    • N-3 LCPUFA-enriched dairy products are able to reduce cardiovascular risk factors: A double-blind, cross-over study
    • C. Dawczynski, L. Martin, A. Wagner, and G. Jahreis, "n-3 LCPUFA-enriched dairy products are able to reduce cardiovascular risk factors: a double-blind, cross-over study, " Clinical Nutrition, vol. 29, no. 5, pp. 592-599, 2010.
    • (2010) Clinical Nutrition , vol.29 , Issue.5 , pp. 592-599
    • Dawczynski, C.1    Martin, L.2    Wagner, A.3    Jahreis, G.4
  • 69
    • 73049109353 scopus 로고    scopus 로고
    • Treatment of aspirinresistant patients with omega-3 fatty acids versus aspirin dose escalation
    • E. I. Lev, A. Solodky, N. Harel, et al., "Treatment of aspirinresistant patients with omega-3 fatty acids versus aspirin dose escalation, " Journal of the American College of Cardiology, vol. 55, no. 2, pp. 114-121, 2010.
    • (2010) Journal of the American College of Cardiology , vol.55 , Issue.2 , pp. 114-121
    • Lev, E.I.1    Solodky, A.2    Harel, N.3
  • 70
    • 41349089494 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acid in peripheral arterial disease: Effect on lipid pattern, disease severity, inflammation profile, and endothelial function
    • V. Schiano, E. Laurenzano, G. Brevetti, et al., "Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function, " Clinical Nutrition, vol. 27, no. 2, pp. 241-247, 2008.
    • (2008) Clinical Nutrition , vol.27 , Issue.2 , pp. 241-247
    • Schiano, V.1    Laurenzano, E.2    Brevetti, G.3
  • 71
    • 77956228178 scopus 로고    scopus 로고
    • Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
    • A. Zampelas, "Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability, " Atherosclerosis, vol. 212, no. 1, pp. 34-35, 2010.
    • (2010) Atherosclerosis , vol.212 , Issue.1 , pp. 34-35
    • Zampelas, A.1
  • 72
    • 78650634569 scopus 로고    scopus 로고
    • Bvitamins and fatty acids in the prevention and treatment of Alzheimers disease and dementia: A systematic review
    • A. D. Dangour, P. J. Whitehouse, K. Rafferty, et al., "Bvitamins and fatty acids in the prevention and treatment of Alzheimers disease and dementia: a systematic review, " Journal of Alzheimers Disease, vol. 22, no. 1, pp. 205-224, 2010.
    • (2010) Journal of Alzheimers Disease , vol.22 , Issue.1 , pp. 205-224
    • Dangour, A.D.1    Whitehouse, P.J.2    Rafferty, K.3
  • 74
    • 0024788867 scopus 로고
    • The effects of dietary β-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats
    • J.-M. Bourre, M. Francois, A. Youyou, et al., "The effects of dietary β-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats, " Journal of Nutrition, vol. 119, no. 12, pp. 1880-1892, 1989.
    • (1989) Journal of Nutrition , vol.119 , Issue.12 , pp. 1880-1892
    • Bourre, J.-M.1    Francois, M.2    Youyou, A.3
  • 75
    • 0026085109 scopus 로고
    • Essentiality of omega 3 fatty acids for brain structure and function
    • J. M. Bourre, O. Dumont, M. Piciotti, et al., "Essentiality of omega 3 fatty acids for brain structure and function, " World Review of Nutrition and Dietetics, vol. 66, pp. 103-117, 1991.
    • (1991) World Review of Nutrition and Dietetics , vol.66 , pp. 103-117
    • Bourre, J.M.1    Dumont, O.2    Piciotti, M.3
  • 76
    • 0036827771 scopus 로고    scopus 로고
    • Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusion
    • E. Farkas, M. C. De Wilde, A. J. Kiliaan, J. Meijer, J. N. Keijser, and P. G. M. Luiten, "Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusion, " Brain Research, vol. 954, no. 1, pp. 32-41, 2002.
    • (2002) Brain Research , vol.954 , Issue.1 , pp. 32-41
    • Farkas, E.1    De Wilde, M.C.2    Kiliaan, A.J.3    Meijer, J.4    Keijser, J.N.5    Luiten, P.G.M.6
  • 77
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • D. Lutjohann, O. Breuer, G. Ahlborg, et al., "Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9799-9804, 1996.
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , Issue.18 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3
  • 79
    • 65349164191 scopus 로고    scopus 로고
    • Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals
    • J. Koschack, D. Lutjohann, C. Schmidt-Samoa, and E. Irle, "Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals, " Neurobiology ofAging, vol. 30, no. 6, pp. 898-902, 2009.
    • (2009) Neurobiology of Aging , vol.30 , Issue.6 , pp. 898-902
    • Koschack, J.1    Lutjohann, D.2    Schmidt-Samoa, C.3    Irle, E.4
  • 80
    • 0030729021 scopus 로고    scopus 로고
    • Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro
    • I. Bjorkhem, D. Lutjohann, O. Breuer, A. Sakinis, and A. Wennmalm, "Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro, " Journal of Biological Chemistry, vol. 272, no. 48, pp. 30178-30184, 1997.
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.48 , pp. 30178-30184
    • Bjorkhem, I.1    Lutjohann, D.2    Breuer, O.3    Sakinis, A.4    Wennmalm, A.5
  • 81
    • 84884569843 scopus 로고    scopus 로고
    • Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in APPswe-PS1dE9 mice
    • Article ID e75393
    • D. Jansen, V. Zerbi, I. A. C. Arnoldussen, et al., "Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in APPswe-PS1dE9 mice, " PLoS ONE, vol. 8, no. 9, Article ID e75393, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.9
    • Jansen, D.1    Zerbi, V.2    Arnoldussen, I.A.C.3
  • 83
    • 77956410028 scopus 로고    scopus 로고
    • The vascular contribution to Alzheimers disease
    • R. Altman and J. C. Rutledge, "The vascular contribution to Alzheimers disease, " Clinical Science, vol. 119, no. 10, pp. 407-421, 2010.
    • (2010) Clinical Science , vol.119 , Issue.10 , pp. 407-421
    • Altman, R.1    Rutledge, J.C.2
  • 84
    • 84885348644 scopus 로고    scopus 로고
    • Higher rates of decline for women and apolipoprotein E4 carriers
    • D. Holland, R. S. Desikan, A. M. Dale, and L. K. McEvoy, "Higher rates of decline for women and apolipoprotein E4 carriers, " American Journal of Neuroradiology, vol. 34, no. 12, pp. 2287-2293, 2013.
    • (2013) American Journal of Neuroradiology , vol.34 , Issue.12 , pp. 2287-2293
    • Holland, D.1    Desikan, R.S.2    Dale, A.M.3    McEvoy, L.K.4
  • 85
    • 84883541769 scopus 로고    scopus 로고
    • Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
    • article 102
    • H. Dhungana, T. Rolova, E. Savchenko, et al., "Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele, " Journal of Neuroinflammation, vol. 10, article 102, 2013.
    • (2013) Journal of Neuroinflammation , vol.10
    • Dhungana, H.1    Rolova, T.2    Savchenko, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.