Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 32, Issue 3, 2012, Pages 664-674

  Raithatha, Sheetal ^a   Su, Ting Cheng ^a   Lourenco, Pedro ^a   Goto, Susan ^a   Sadowski, Ivan ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 8; FUNGAL PROTEIN; NITROGEN; PHD1 PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE; UPREGULATION;

CYCLIN-DEPENDENT KINASE 8; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; POLYMORPHISM, GENETIC; PROTEIN STABILITY; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 84856786805     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05420-11     Document Type: Article

References (45)

1. Bao MZ, Schwartz MA, Cantin GT, Yates JR III, Madhani HD. 2004. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119:991-1000.
2. Bardwell L, et al. 1998. Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev. 12:2887-2898.
3. Borneman AR, et al. 2006. Target hub proteins serve as master regulators of development in yeast. Genes Dev. 20:435-448.
4. Chandarlapaty S, Errede B. 1998. Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae. Mol. Cell Biol. 18:2884 -2891.
5. Chen RE, Thorner J. 2010. Systematic epistasis analysis of the contributions of protein kinase A- and mitogen-activated protein kinasedependent signaling to nutrient limitation-evoked responses in the yeast Saccharomyces cerevisiae. Genetics 185:855-870.
6. Chi Y, et al. 2001. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15:1078-1092.
7. Chou S, Huang L, Liu H. 2004. Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast. Cell 119:981-990.
8. Cook JG, Bardwell L, Kron SJ, Thorner J. 1996. Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev. 10:2831-2848.
9. Cook JG, Bardwell L, Thorner J. 1997. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 390:85-88.
10. Cullen PJ, Sprague GF Jr. 2000. Glucose depletion causes haploid invasive growth in yeast. Proc. Natl. Acad. Sci. U. S. A. 97:13619-13624.
11. Donner AJ, Szostek S, Hoover JM, Espinosa JM. 2007. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol. Cell 27: 121-133.
12. Dowell RD, et al. 2010. Genotype to phenotype: a complex problem. Science 328:469.
13. Firestein R, et al. 2008. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455:547-551.
14. Fryer CJ, White JB, Jones KA. 2004. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16:509 -520.
15. Fujita A, et al. 1989. Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor. Gene 85:321-328.
16. Gimeno CJ, Fink GR. 1994. Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol. Cell. Biol. 14:2100-2112.
17. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077-1090.
18. Hallberg M, et al. 2004. Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid. Proc. Natl. Acad. Sci. U. S. A. 101:3370 -3375.
19. Heise B, et al. 2010. The TEA transcription factor Tec1 confers promoterspecific gene regulation by Ste12-dependent and -independent mechanisms. Eukaryot. Cell 9:514-531.
20. Hirst M, Kobor MS, Kuriakose N, Greenblatt J, Sadowski I. 1999. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclindependent protein kinase SRB10/CDK8. Mol. Cell 3:673-678.
21. Holstege FC, et al. 1998. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717-728.
22. Hung W, Olson KA, Breitkreutz A, Sadowski I. 1997. Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p. Eur. J. Biochem. 245:241-251.
23. Keogh MC, et al. 2006. The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev. 20:660-665.
24. Kuchin S, Vyas VK, Carlson M. 2002. Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol. Cell. Biol. 22:3994-4000.
25. Liao SM, et al. 1995. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196.
26. Liu H, Styles CA, Fink GR. 1996. Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144: 967-978.
27. Lorenz MC, Heitman J. 1998. Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics 150:1443-1457.
28. Madhani HD, Fink GR. 1997. Combinatorial control required for the specificity of yeast MAPK signaling. Science 275:1314-1317.
29. Malcher M, Schladebeck S, Mosch HU. 2011. The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae. Genetics 187:717-730.
30. Malcolm T, Kam J, Pour PS, Sadowski I. 2008. Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus. FEBS Lett. 582:3903-3908.
31. Mosch HU, Fink GR. 1997. Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145:671-684.
32. Nelson C, Goto S, Lund K, Hung W, Sadowski I. 2003. Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature 421:187-190.
33. Orlova M, Kanter E, Krakovich D, Kuchin S. 2006. Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot. Cell 5:1831-1837.
34. Pan X, Heitman J. 2002. Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol. Cell. Biol. 22:3981-3993.
35. Rep M, et al. 1999. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Mol. Cell. Biol. 19:5474-5485.
36. Roberts RL, Fink GR. 1994. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8:2974-2985.
37. Robertson LS, Fink GR. 1998. The three yeast A kinases have specific signaling functions in pseudohyphal growth. Proc. Natl. Acad. Sci. U. S. A. 95:13783-13787.
38. Rohde JR, Trinh J, Sadowski I. 2000. Multiple signals regulate GAL transcription in yeast. Mol. Cell. Biol. 20:3880-3886.
39. Rupp S, Summers E, Lo HJ, Madhani H, Fink G. 1999. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 18:1257-1269.
40. Strudwick N, Brown M, Parmar VM, Schroder M. 2010. Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Mol. Cell. Biol. 30:5514-5530.
41. Su TC, Tamarkina E, Sadowski I. 2010. Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae. FEBS J. 277:3235-3248.
42. Thompson CM, Koleske AJ, Chao DM, Young RA. 1993. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73:1361-1375.
43. Vyas VK, Berkey CD, Miyao T, Carlson M. 2005. Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae. Eukaryot. Cell 4:1882-1891.
44. Ward MP, Garrett S. 1994. Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene. Mol. Cell. Biol. 14:5619-5627.
45. Webber AL, Lambrechts MG, Pretorius IS. 1997. MSS11, a novel yeast gene involved in the regulation of starch metabolism. Curr. Genet. 32:260-266.