P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

Genes and Development

Volumn 30, Issue 1, 2016, Pages 117-131

  Sansó, Miriam ^a   Levin, Rebecca S ^b,c   Lipp, Jesse J ^b,c   Wang, Vivien Ya Fan ^d   Greifenberg, Ann Katrin ^e   Quezada, Elizabeth M ^a   Ali, Akbar ^f   Ghosh, Animesh ^f   Larochelle, Stéphane ^a   Rana, Tariq M ^f,g   Geyer, Matthias ^g   Tong, Liang ^d   Shokat, Kevan M ^b,c   Fisher, Robert P ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Howard Hughes Medical Institute   (United States)

^e UNIVERSITY OF BONN   (Germany)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chemical genetics; P TEFb; Protein phosphorylation; RNA polymerase II; Transcription termination; Xrn2

Indexed keywords

CYCLIN DEPENDENT KINASE 9; EXORIBONUCLEASE; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION TERMINATION FACTOR XRN2; UNCLASSIFIED DRUG; CHROMATIN; PROTEIN BINDING; XRN2 PROTEIN, HUMAN;

ARTICLE; CELL ELONGATION; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE IDENTIFICATION; GENE MUTATION; GENETIC SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; RNA METABOLISM; RNA PROCESSING; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; HCT 116 CELL LINE; METABOLISM; PHOSPHORYLATION;

CHROMATIN; CYCLIN-DEPENDENT KINASE 9; ENZYME ACTIVATION; EXORIBONUCLEASES; GENE EXPRESSION REGULATION; GENETIC TESTING; HCT116 CELLS; HUMANS; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEIN BINDING;

EID: 84953381916     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.269589.115     Document Type: Article

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