Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12

Nature

Volumn 421, Issue 6919, 2003, Pages 187-190

  Nelson, Chris ^a   Goto, Susan ^a   Lund, Karen ^a   Hung, Wesley ^a   Sadowski, Ivan ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GENES;

PHOSPHORYLATION;

YEAST;

CYCLIN DEPENDENT KINASE 8; HOLOENZYME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN; PHEROMONE; RECOMBINANT PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR STE12; UNCLASSIFIED DRUG;

NUTRIENT; YEAST;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGUS GROWTH; FUNGUS HYPHAE; GENE EXPRESSION; GENE MUTATION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

CELL DIVISION; CYCLIN-DEPENDENT KINASES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MUTATION; NITROGEN; PHOSPHORYLATION; PHOSPHOSERINE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0037426868     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01243     Document Type: Letter

References (15)

1. Roberts, R. L. & Fink, G. R. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8, 2974-2985 (1994).
2. Cullen, P. J. & Sprague, G. F. Jr Glucose depletion causes haploid invasive growth in yeast. Proc. Natl Acad. Sci. USA 97, 13619-13624 (2000).
3. Madhani, H. D. & Fink, G. R. Combinatorial control required for the specificity of yeast MAPK signaling. Science 275, 1314-1317 (1997).
4. Morillon, A., Springer, M. & Lesage, P. Activation of the Kss1 invasive-filamentous growth pathway induces Ty1 transcription and retrotransposition in Saccharomyces cerevisiae. Mol. Cell. Biol. 20, 5766-5776 (2000).
5. Holstege, F. C. et al. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95, 717-728 (1998).
6. Hung, W., Olson, K. A., Breitkreutz, A. & Sadowski, I. Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p. Eur. J. Biochem. 245, 241-251 (1997).
7. Boyle, W. J., van der Geer, P. & Hunter, T. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201, 110-149 (1991).
8. Pi, H., Chien, C. T. & Fields, S. Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Mol. Cell. Biol. 17, 6410-6418 1997).
9. Olson, K. A. et al. Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Mol. Cell. Biol. 20, 4199-4209 (2000).
10. Fields, S. & Herskowitz, I. Regulation by the yeast mating-type locus of STE12, a gene required for cell-type-specific expression. Mol. Cell. Biol. 7, 3818-3821 (1987).
11. Chang, Y. W., Howard, S. C., Budovskaya, Y. V., Rine, J. & Herman, P. K. The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae. Genetics 157, 17-26 (2001).
12. Chi, Y. et al. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes Dev. 15, 1076-1092 (2001).
13. Rohde, J. R., Trinh, J. & Sadowski, I. Multiple signals regulate GAL transcription in yeast. Mol. Cell. Biol. 20, 3880-3886 (2000).
14. Gimeno, C. J., Ljungdahl, P. O., Styles, C. A. & Fink, G. R. Unipolar cell divisions in the yeast S. Cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68, 1077-1090 (1992).
15. Hirst, M., Kobor, M. S., Kuriakose, N., Greenblatt, J. & Sadowski, I. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8. Mol. Cell 3, 673-678 (1999).