The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity

International Journal of Biochemistry and Cell Biology

Volumn 75, Issue , 2016, Pages 34-44

  Wang, Yi ^a,b   Liu, Jia ^a   Chen, Min ^a   Du, Tingting ^c   Duan, Chunli ^a   Gao, Ge ^a   Yang, Hui ^a  

^a BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c Beijing Normal University   (China)

Author keywords

a Synuclein; Parkinson's disease; Phosphorylation; Protein phosphatase 2A; Rotenone

Indexed keywords

ALPHA SYNUCLEIN; BOSUTINIB; CALMODULIN; CERAMIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN TYROSINE KINASE; ROTENONE; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN AGGREGATE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; BRAIN CORTEX; CHEMISTRY; DRUG EFFECTS; MESENCEPHALON; METABOLISM; NERVE CELL; PARKINSON DISEASE; PHOSPHORYLATION;

ALPHA-SYNUCLEIN; ANIMALS; CALMODULIN; CEREBRAL CORTEX; DOWN-REGULATION; HUMANS; MESENCEPHALON; NEURONS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEIN PHOSPHATASE 2; RATS; ROTENONE; SRC-FAMILY KINASES; TYROSINE;

EID: 84961895910     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2016.03.007     Document Type: Article

References (33)

1. M. Arif, S.F. Kazim, I. Grundke-Iqbal, R.M. Garruto, and K. Iqbal Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam Proc. Natl. Acad. Sci. U. S. A. 111 2014 1144 1149
2. S. Ayton, and P. Lei Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration Biomed. Res. Int. 2014 2014 581256
3. R. Betarbet, T.B. Sherer, G. Mackenzie, M. Garcia-Osuna, A.V. Panov, and J.T. Greenamyre Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nat. Neurosci. 3 2000 1301 1306
4. J.R. Cannon, V. Tapias, H.M. Na, A.S. Honick, R.E. Drolet, and J.T. Greenamyre A highly reproducible rotenone model of Parkinson's disease Neurobiol. Dis. 34 2009 279 290
5. K.Y. Chau, H.L. Ching, A.H. Schapira, and J.M. Cooper Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson's disease pathogenesis J. Neurochem. 110 2009 1005 1013
6. L. Chen, and M.B. Feany Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nat. Neurosci. 8 2005 657 663
7. J. Chen, B.L. Martin, and D.L. Brautigan Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Science 257 1992 1261 1264
8. U.S. Cho, and W. Xu Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme Nature 445 2007 53 57
9. F. Denizot, and R. Lang Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability J. Immunol. Methods 89 1986 271 277
10. 2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth Carcinogenesis 33 2012 740 750
11. C.F. Ferris, M. Marella, B. Smerkers, T.M. Barchet, B. Gershman, A. Matsuno-Yagi, and T. Yagi A phenotypic model recapitulating the neuropathology of Parkinson's disease Brain Behav. 3 2013 351 366
12. S.M. Fleming, Y. Delville, and T. Schallert An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate Behav. Brain Res. 156 2005 201 213
13. L.S. Forno Neuropathology of Parkinson's disease J. Neuropathol. Exp. Neurol. 55 1996 259 272
14. H. Fujiwara, M. Hasegawa, N. Dohmae, A. Kawashima, E. Masliah, M.S. Goldberg, J. Shen, K. Takio, and T. Iwatsubo alpha-Synuclein is phosphorylated in synucleinopathy lesions Nat. Cell Biol. 4 2002 160 164
15. H. Guo, and Z. Damuni Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A Proc. Natl. Acad. Sci. U. S. A. 90 1993 2500 2504
16. B. Law, and S. Rossie The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide J. Biol. Chem. 270 1995 12808 12813
17. N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, J.A. Melendez, and J.P. Robinson Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production J. Biol. Chem. 278 2003 8516 8525
18. S. Lykkebo, and P.H. Jensen Alpha-synuclein and presynaptic function: implications for Parkinson's disease Neuromolecular Med. 2 2002 115 129
19. K.L. Ma, L.K. Song, W.A. Long, Y.H. Yuan, Y. Zhang, X.Y. Song, F. Niu, N. Han, and N.H. Chen Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of alpha-synuclein and toxicity to PC12 cells Brain Res. Bull. 90 2013 127 131
20. L. Martin, X. Latypova, C.M. Wilson, A. Magnaudeix, M.L. Perrin, and F. Terro Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A Ageing Res. Rev. 12 2013 39 49
21. M.G. Maturana, A.S. Pinheiro, T.L. Souza, and C. Follmer Unveiling the role of the pesticides paraquat and rotenone on alpha-synuclein fibrillation in vitro Neurotoxicology 46 2015 35 43
22. S. Ohashi, A. Mori, N. Kurihara, Y. Mitsumoto, and M. Nakai Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice Neurosci. Lett. 401 2006 183 187
23. R. Perfeito, D.F. Lazaro, T.F. Outeiro, and A.C. Rego Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells Mol. Cell. Neurosci. 62 2014 51 59
24. M.H. Polymeropoulos, C. Lavedan, E. Leroy, S.E. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, E.S. Stenroos, S. Chandrasekharappa, A. Athanassiadou, T. Papapetropoulos, W.G. Johnson, A.M. Lazzarini, R.C. Duvoisin, G. Di Iorio, L.I. Golbe, and R.L. Nussbaum Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
25. R.D. Prediger, A.S. Aguiar Jr., A.E. Rojas-Mayorquin, C.P. Figueiredo, F.C. Matheus, L. Ginestet, C. Chevarin, E.D. Bel, R. Mongeau, M. Hamon, L. Lanfumey, and R. Raisman-Vozari Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease Neurotox. Res. 17 2010 114 129
26. T.B. Sherer, J.H. Kim, R. Betarbet, and J.T. Greenamyre Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation Exp. Neurol. 179 2003 9 16
27. W.W. Smith, R.L. Margolis, X. Li, J.C. Troncoso, M.K. Lee, V.L. Dawson, T.M. Dawson, T. Iwatsubo, and C.A. Ross Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells J. Neurosci. 25 2005 5544 5552
28. M.G. Spillantini, M.L. Schmidt, V.M. Lee, J.Q. Trojanowski, R. Jakes, and M. Goedert Alpha-synuclein in lewy bodies Nature 388 1997 839 840
29. S. Strack, R.S. Westphal, R.J. Colbran, F.F. Ebner, and B.E. Wadzinski Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments Brain Res. Mol. Brain Res. 49 1997 15 28
30. N. Sugeno, A. Takeda, T. Hasegawa, M. Kobayashi, A. Kikuchi, F. Mori, K. Wakabayashi, and Y. Itoyama Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death J. Biol. Chem. 283 2008 23179 23188
31. S. Swarnkar, S. Singh, R. Mathur, I.K. Patro, and C. Nath A study to correlate rotenone induced biochemical changes and cerebral damage in brain areas with neuromuscular coordination in rats Toxicology 272 2010 17 22
32. Y. Xiong, X.P. Jing, X.W. Zhou, X.L. Wang, Y. Yang, X.Y. Sun, M. Qiu, F.Y. Cao, Y.M. Lu, R. Liu, and J.Z. Wang Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation Neurobiol. Aging 34 2013 745 756
33. Y.H. Yuan, W.F. Yan, J.D. Sun, J.Y. Huang, Z. Mu, and N.H. Chen The molecular mechanism of rotenone-induced alpha-synuclein aggregation: emphasizing the role of the calcium/GSK3beta pathway Toxicol. Lett. 233 2015 163 171