메뉴 건너뛰기




Volumn 90, Issue 1, 2013, Pages 127-131

Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells

Author keywords

Synuclein; Oligomerization; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; COMPLEMENTARY DNA; ROTENONE; SNCA PROTEIN; UNCLASSIFIED DRUG;

EID: 84870552532     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.10.007     Document Type: Article
Times cited : (13)

References (45)
  • 2
    • 9444272812 scopus 로고    scopus 로고
    • Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70
    • Albani D., Peverelli E., Rametta R., Batelli S., Veschini L., Negro A., Forloni G. Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70. FASEB Journal 2004, 18:1713-1715.
    • (2004) FASEB Journal , vol.18 , pp. 1713-1715
    • Albani, D.1    Peverelli, E.2    Rametta, R.3    Batelli, S.4    Veschini, L.5    Negro, A.6    Forloni, G.7
  • 4
    • 33747769942 scopus 로고    scopus 로고
    • Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
    • Beyer K. Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers. Acta Neuropathologica 2006, 112:237-251.
    • (2006) Acta Neuropathologica , vol.112 , pp. 237-251
    • Beyer, K.1
  • 5
    • 46149119425 scopus 로고    scopus 로고
    • Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
    • Beyer K., Domingo-Sabat M., Humbert J., Carrato C., Ferrer I., Ariza A. Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease. Neurogenetics 2008, 9:163-172.
    • (2008) Neurogenetics , vol.9 , pp. 163-172
    • Beyer, K.1    Domingo-Sabat, M.2    Humbert, J.3    Carrato, C.4    Ferrer, I.5    Ariza, A.6
  • 6
    • 38649119157 scopus 로고    scopus 로고
    • Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
    • Beyer K., Domingo-Sabat M., Lao J.I., Carrato C., Ferrer I., Ariza A. Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases. Neurogenetics 2008, 9:15-23.
    • (2008) Neurogenetics , vol.9 , pp. 15-23
    • Beyer, K.1    Domingo-Sabat, M.2    Lao, J.I.3    Carrato, C.4    Ferrer, I.5    Ariza, A.6
  • 12
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
    • Caughey B., Lansbury P.T. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annual Review of Neuroscience 2003, 26:267-298.
    • (2003) Annual Review of Neuroscience , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury, P.T.2
  • 13
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway K.A., Harper J.D., Lansbury P.T. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nature Medicine 1998, 4:1318-1320.
    • (1998) Nature Medicine , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 14
    • 0034646391 scopus 로고    scopus 로고
    • Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
    • Conway K.A., Harper J.D., Lansbury P.T. Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 2000, 39:2552-2563.
    • (2000) Biochemistry , vol.39 , pp. 2552-2563
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 16
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
    • Conway K.A., Lee S.J., Rochet J.C., Ding T.T., Williamson R.E., Lansbury P.T. Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:571-576.
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury, P.T.6
  • 17
    • 0031728689 scopus 로고    scopus 로고
    • Synthetic filaments assembled from C-terminally truncated alpha-synuclein
    • Crowther R.A., Jakes R., Spillantini M.G., Goedert M. Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Letters 1998, 436:309-312.
    • (1998) FEBS Letters , vol.436 , pp. 309-312
    • Crowther, R.A.1    Jakes, R.2    Spillantini, M.G.3    Goedert, M.4
  • 19
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson T.M., Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 2003, 302:819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 21
    • 0037237927 scopus 로고    scopus 로고
    • Oxidative stress and nitration in neurodegeneration: cause, effect, or association
    • Ischiropoulos H., Beckman J.S. Oxidative stress and nitration in neurodegeneration: cause, effect, or association. The Journal of Clinical Investigation 2003, 111:163-169.
    • (2003) The Journal of Clinical Investigation , vol.111 , pp. 163-169
    • Ischiropoulos, H.1    Beckman, J.S.2
  • 23
    • 0037016741 scopus 로고    scopus 로고
    • Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
    • Lee H.J., Choi C., Lee S.J. Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. The Journal of Biological Chemistry 2002, 277:671-678.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 671-678
    • Lee, H.J.1    Choi, C.2    Lee, S.J.3
  • 25
    • 79951580097 scopus 로고    scopus 로고
    • Over-expression of alpha-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone
    • Ma K.L., Yuan Y.H., Song L.K., Han N., Chen N.H. Over-expression of alpha-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. Neuroscience Letters 2011, 491:148-152.
    • (2011) Neuroscience Letters , vol.491 , pp. 148-152
    • Ma, K.L.1    Yuan, Y.H.2    Song, L.K.3    Han, N.4    Chen, N.H.5
  • 26
    • 35748975424 scopus 로고    scopus 로고
    • Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence
    • Mazzulli J.R., Armakola M., Dumoulin M., Parastatidis I., Ischiropoulos H. Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence. The Journal of Biological Chemistry 2007, 282:31621-31630.
    • (2007) The Journal of Biological Chemistry , vol.282 , pp. 31621-31630
    • Mazzulli, J.R.1    Armakola, M.2    Dumoulin, M.3    Parastatidis, I.4    Ischiropoulos, H.5
  • 28
    • 20144369335 scopus 로고    scopus 로고
    • Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10
    • Moon Y., Lee K.H., Park J.H., Geum D., Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. Journal of Neurochemistry 2005, 93:1199-1208.
    • (2005) Journal of Neurochemistry , vol.93 , pp. 1199-1208
    • Moon, Y.1    Lee, K.H.2    Park, J.H.3    Geum, D.4    Kim, K.5
  • 32
    • 26944470839 scopus 로고    scopus 로고
    • Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth
    • Pan D.N., Li J.J., Wei L., Yao M., Wan D.F., Gu J.R. Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth. Acta Biochimica et Biophysica Sinica 2005, 37:588-592.
    • (2005) Acta Biochimica et Biophysica Sinica , vol.37 , pp. 588-592
    • Pan, D.N.1    Li, J.J.2    Wei, L.3    Yao, M.4    Wan, D.F.5    Gu, J.R.6
  • 33
    • 33746326513 scopus 로고    scopus 로고
    • Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration
    • Radad K., Rausch W.D., Gille G. Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration. Neurochemistry International 2006, 49:379-386.
    • (2006) Neurochemistry International , vol.49 , pp. 379-386
    • Radad, K.1    Rausch, W.D.2    Gille, G.3
  • 43
    • 0028618190 scopus 로고
    • Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid
    • Ueda K., Saitoh T., Mori H. Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid. Biochemical and Biophysical Research Communications 1994, 205:1366-1372.
    • (1994) Biochemical and Biophysical Research Communications , vol.205 , pp. 1366-1372
    • Ueda, K.1    Saitoh, T.2    Mori, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.