Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Leppkes, Moritz ^a   Maueröder, Christian ^a   Hirth, Sebastian ^b   Nowecki, Stefanie ^a   Günther, Claudia ^a   Billmeier, Ulrike ^a   Paulus, Susanne ^a   Biermann, Mona ^a   Munoz, Luis E ^a   Hoffmann, Markus ^a   Wildner, Dane ^a   Croxford, Andrew L ^b   Waisman, Ari ^b,g   Mowen, Kerri ^c   Jenne, Dieter E ^d   Krenn, Veit ^e   Mayerle, Julia ^f   Lerch, Markus M ^f   Schett, Georg ^a   Wirtz, Stefan ^a   Neurath, Markus F ^a   Herrmann, Martin ^a   Becker, Christoph ^a   more..

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d Asklepios Clinic Munich Gauting   (Germany)

^e MVZ of Pathology ^*  (Germany)

^f UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BICARBONATE; CALCIUM; CALCIUM CARBONATE; CARBON DIOXIDE; ENZYME PRECURSOR; GLUCOSE; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 6; LEUKOCYTE ELASTASE; MATRIX METALLOPROTEINASE; PEPTIDYL ARGININE DEIMINASE 4; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN ARGININE DEIMINASE; SERINE PROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; CERULETIDE; CHROMATIN; CYTOKINE; HYDROLASE; IL17A PROTEIN, MOUSE; PEPTIDYLARGININE DEIMINASE TYPE IV;

BICARBONATE; CALCIUM CARBONATE; CELLS AND CELL COMPONENTS; PIGMENT; PROTEIN; RODENT;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CARBON DIOXIDE BLOOD LEVEL; CELL DEATH; CELL DENSITY; CELL EXPANSION; CELL FRACTIONATION; CELL INFILTRATION; CELL LOSS; CELL MOTILITY; CELL PH; CELLULAR DISTRIBUTION; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; EXTRACELLULAR TRAP; FECES LEVEL; GLUCOSE BLOOD LEVEL; GRANULOCYTE; GRANULOPOIESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; LEUKOCYTE; LYMPHOCYTIC INFILTRATION; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANCREAS DUCT STENOSIS; PANCREAS EXOCRINE INSUFFICIENCY; PANCREAS JUICE; PANCREATIC TISSUE; PANCREATITIS; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TISSUE STRUCTURE; WEIGHT REDUCTION; ANIMAL; CHEMICALLY INDUCED; CHROMATIN; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; PANCREAS; PANCREATIC DUCT; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; CERULETIDE; CHROMATIN; CYTOKINES; DISEASE MODELS, ANIMAL; EXTRACELLULAR TRAPS; FLOW CYTOMETRY; HUMANS; HYDROLASES; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; MICE; NEUTROPHILS; PANCREAS; PANCREATIC DUCTS; PANCREATIC JUICE; PANCREATITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84961751149     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10973     Document Type: Article

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