Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  O'Donoghue, Anthony J ^b   Jin, Ye ^a   Knudsen, Giselle M ^b   Perera, Natascha C ^c   Jenne, Dieter E ^c,d   Murphy, John E ^a   Craik, Charles S ^b   Hermiston, Terry W ^a  

^a Global Biologics Research   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; ELASTASE; MYELOBLASTIN; NEUTROPHIL SERINE PROTEINASE 4; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPONENT; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEOMICS;

AMINO ACID MOTIFS; CATHEPSIN G; COMBINATORIAL CHEMISTRY TECHNIQUES; EXTRACELLULAR MATRIX; HUMANS; IMMUNOPRECIPITATION; LEUKOCYTE ELASTASE; MYELOBLASTIN; NEUTROPHILS; PEPTIDE LIBRARY; PHAGOCYTOSIS; SERINE ENDOPEPTIDASES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 84884477446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075141     Document Type: Article

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