Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy

Oncotarget

Volumn 7, Issue 9, 2016, Pages 9620-9633

  Zieger, Marina ^a   Punzo, Claudio ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AMD; Cone degeneration; Geographic atrophy; Gerotarget; MTORC1; Rod degeneration

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; SODIUM IODATE; IODATE; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; GEOGRAPHIC ATROPHY; MOUSE; NONHUMAN; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; RETINA CONE; RETINA ROD; ANIMAL; CYTOLOGY; DISEASE MODEL; ELECTRORETINOGRAPHY; ENZYME ACTIVATION; GENETICS; METABOLISM; PATHOLOGY; RETINAL PIGMENT EPITHELIUM;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; ENZYME ACTIVATION; GEOGRAPHIC ATROPHY; INSULIN; IODATES; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; MULTIPROTEIN COMPLEXES; PTEN PHOSPHOHYDROLASE; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL PIGMENT EPITHELIUM; RETINAL ROD PHOTORECEPTOR CELLS; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEINS;

EID: 84961653096     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7330     Document Type: Article

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