Photoreceptor loss in age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 7, 1996, Pages 1236-1249

  Curcio, Christine A ^a,b,c   Medeiros, Nancy E ^a   Millican, C Leigh ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

age related macular degeneration; carbonic anhydrase histochemistry; cones; histopathology; morphometry; rods

Indexed keywords

ARTICLE; BRUCH MEMBRANE; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; EYE FUNDUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; NERVE CELL DEGENERATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA CONE; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD;

AGED; AGED, 80 AND OVER; CARBONIC ANHYDRASES; CELL COUNT; CONES (RETINA); FEMALE; FLUORESCEIN ANGIOGRAPHY; FOVEA CENTRALIS; FUNDUS OCULI; HISTOCYTOCHEMISTRY; HUMANS; MACULAR DEGENERATION; MALE; PHOTORECEPTORS; PIGMENT EPITHELIUM OF EYE; RETINAL DRUSEN; RETINITIS PIGMENTOSA; RODS (RETINA);

EID: 0029889833     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Leibowitz HM, Maunder LR, Milton RC, et al. The Framingham Eye Study Monograph. Surv Ophthalmol. 1980;24(suppl):335-610.
2. Green WR, Key SN. Senile macular degeneration: A histopathological study. Trans Am Ophthalmol Soc. 1977;75:180-254.
3. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2:552-577.
4. Group MPS. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration: Results of a randomized clinical trial. Arch Ophthalmol. 1991;109:1220-1231.
5. Østerberg GA. Topography of the layer of rods and cones in the human retina. Acta Ophthalmol. 1935; 13(suppl 6):1-103.
6. Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990;292:497-523.
7. Curcio CA, Millican CL, Allen KA, Kalina RE. Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina. Invest Ophthalmol Vis Sci. 1993;34:3278-3296.
8. Maguire P, Vine AK. Geographic atrophy of the retinal pigment epithelium. Am J Ophthalmol. 1986;102:621-625.
9. Schatz H, McDonald HR. Atrophic macular degeneration: Rate of spread of geographic atrophy and visual loss. Ophthalmology. 1989;96:1541-1551.
10. Young RW. Pathophysiology of age-related macular degeneration. Surv Ophthalmol. 1987;31:291-306.
11. Brown B, Adams AJ, Coletta NJ, Haegerstrom-Portnoy G. Dark adaptation in age-related maculopathy. Ophthalmol Physiol Opt. 1985;6:81-84.
12. Brown B, Tobin C, Roche N, Wolanowski A. Cone adaptation in age-related maculopathy. Am J Opt Physiol Optics. 1986;63:450-454.
13. LaVail MM. Analysis of neurological mutants with inherited retinal degeneration. Invest Ophthalmol Vis Sci. 1981;21:638-657.
14. Jacobson SG, Voigt WJ, Parel J-M, et al. Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology. 1986;93:1604-1611.
15. Klein R, Davis MD, Magli YL, Segal P, Klein BEK, Hubbard L. The Wisconsin Age-Related Maculopathy Grading System. Ophthalmology. 1991;98:1128-1134.
16. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathological correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina. 1994;14:130-142.
17. Nork TM, Mangini NJ, Millecchia LL. Rods and cones contain antigenically distinctive S-antigens. Invest Ophthalmol Vis Sci. 1993;34:2915-2925.
18. Nork TM, McCormick SA, Chao G-M, Odom JV. Distribution of carbonic anhydrase among human photoreceptors. Invest Ophthalmol Vis Sci. 1990;31:1451-1458.
19. Sarks SH. Ageing and degeneration in the macular region: A clinico-pathological study. Br J Ophthalmol. 1976;60:324-341.
20. van der Schaft TL, Mooy CM, de Bruijn WC, Oron FG, Mulder PGH, de Jong PTVM. Histologic features of the early stages of age-related macular degeneration. Ophthalmology. 1992;99:278-286.
21. Green WR, Enger C. Age-related macular degeneration histopathologic studies: The 1992 Lorenz E. Zimmerman Lecture. Ophthalmology. 1993;100:1519-1535.
22. Sarks SH. Drusen and their relationship to senile macular degeneration. Aust J Ophthalmol. 1980;8:117-130.
23. Curcio CA, Allen KA, Sloan KR, et al. Distribution and morphology of human cone photoreceptors stained with anti-blue opsin. J Comp Neurol. 1991;312:611-625.
24. Thirkill CE, Keltner JL, Tyler NK, Roth AM. Antibody reactions with retina and cancer-associated antigens in 10 patients with cancer-associated retinopathy. Arch Ophthalmol. 1993;111:931-937.
25. Gass JDM. Drusen and disciform macular detachment and degeneration. Arch Ophthalmol. 1975;90:206-217.
26. Bressler SB, Maguire MG, Bressler NM, Fine SL, Group MPS. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch Ophthalmol. 1990;108:1442-1447.
27. Group MPS. Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Arch Ophthalmol. 1993;111:1189-1199.
28. Hartnett ME, Weiter JJ, Garsd A, Jalkh AE. Classification of retinal pigment epithelial detachments associated with drusen. Graefe's Arch Clin Exp Ophthalmol. 1992;230:11-19.
29. Anderson DH, Guérin CJ, Erickson PA, Stern WH, Fisher SK. Morphological recovery in the reattached retina. Invest Ophthalmol Vis Sci. 1986;27:168-183.
30. Milam AH, Jacobson SG. Photoreceptor rosettes with blue cone opsin immunoreactivity in retinitis pigmentosa. Ophthalmology. 1990;97:1620-1631.
31. Eisner A, Fleming SA, Klein ml, Mauldin WM. Sensitivity in older eyes with good acuity: Eyes whose fellow eye has exudative AMD. Invest Ophthalmol Vis Sci. 1987;28:1832-1837.
32. Sunness JS, Massof RW, Johnson MA, Finkelstein D, Fine SL. Peripheral retinal function in age-related macular degeneration. Arch Ophthalmol. 1985;103: 811-816.
33. Sunness JA, Bressler NM, Maguire MG. Scanning laser ophthalmoscopic analysis of the pattern of visual loss in age-related geographic atrophy of the macula. Am J Ophthalmol. 1995;119:143-151.
34. Cheng AS, Vingrys AJ. Visual losses in early age-related maculopathy. Optom Vis Sci. 1993;70:89-96.
35. Aschero M, LaCapria A, Staurenghi G, Lonati C, Orzalesi N. Map distribution of initial atrophy and drusen in patients with age-related macular degeneration. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1993; 34:1163.
36. Crabtree DV, Adler AJ, Snodderly DM. A local minimum of vitamin E in macaque retina is anatomically coincident with a common locus of atrophy in human retina. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1994;35:1392.
37. Snodderly DM. Evidence for protection against age-related macular degeneration (AMD) by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995;62: 1448S-1461S.
38. Haley TL, Pochet R, Baizer L, et al. Calbindin D-28K immunoreactivity of human cone cells varies with retinal position. Vis Neurosci. 1995;12:301-307.
39. Sunness JS, Massof RW, Johnson MA, Bressler NM, Bressler SB, Fine SL. Diminished foveal sensitivity may predict the development of advanced age-related macular degeneration. Ophthalmology. 1989;375-381.
40. Eisner A, Klein ml, Zilis JD, Watkins MD. Visual function and the subsequent development of exudative age-related macular degeneration. Invest Ophthalmol Vis Sci. 1992;33:3091-3102.
41. Mayer MJ, Ward B, Klein R, Talcott JB, Dougherty RF, Glucs A. Flicker sensitivity and fundus appearance in pre-exudative age-related maculopathy. Invest Ophthalmol Vis Sci. 1994;35:1138-1149.
42. Sandberg MA, Miller S, Gaudio AR. Foveal cone ERGs in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 1993;34:3477-3480.
43. Steinmetz RL, Haimovici R, Jubb C, Fitzke FW, Bird AC. Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane change. Br J Ophthalmol. 1993;77:549-554.
44. Hogan MJ. Role of the retinal pigment epithelium in macular disease. Trans Am Acad Ophthalmol Otolaryngol. 1972;76:64-80.
45. Gorin MB, Jackson KE, Ferrell RE, et al. A peripherin/ retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. Ophthalmology. 1995;102:246-255.
46. Stone EM, Nichols BE, Kimura AE, Weingeist TA, Drack A, Sheffield VC. Clinical features of Stargardt-like dominant progressive macular genetic dystrophy with genetic linkage to chromosome 6q. Arch Ophthalmol. 1994;112:765-772.
47. Bird AC. Retinal photoreceptor dystrophies: LI: Edward Jackson Memorial Lecture. Am J Ophthalmol. 1995;119:543-562.
48. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol. 1976;17:489-498.
49. Li Z-Y, Jacobson SG, Milam AH. Autosomal dominant retinitis pigmentosa caused by the threonine-17-methionine rhodopsin mutation: Retinal histopathology and immunocytochemistry. Exp Eye Res. 1994;58:397-408.
50. Weleber RG, Carr RE, Murphery WH, Sheffield VC, Stone EM. Phenotypic variation including retinitis pigmentosa, pattern dystrophy, and fundus flavimaculatus in a single family with a deletion of codon 153 or 154 of the peripherin/RDS gene. Arch Ophthalmol. 1993;111:1531-1542.
51. Kemp CM, Jacobson SG, Cideciyan AV, Kimura AE, Sheffield VC, Stone EM. RDS gene mutations causing retinitis pigmentosa or macular degeneration lead to the same abnormality in photoreceptor function. Invest Ophthalmol Vis Sci. 1994;35:3154-3162.
52. Richards SC, Creel DJ. Pattern dystrophy and retinitis pigmentosa caused by a peripherin/RDS mutation. Retina. 1995;15:68-72.
53. Aguirre GD, Stramm LE. The RPE: A model system for disease expression and disease correction. In: Osborne N, Chader GJ, eds. Progress in Retinal Research. Oxford: Pergamon; 1991:153-191.