메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; BETA CATENIN; CYTOKINE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; GSK3B PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; IL1R1 PROTEIN, MOUSE; MYD88 PROTEIN, MOUSE; TOLL LIKE RECEPTOR;

EID: 84961615427     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11051     Document Type: Article
Times cited : (106)

References (70)
  • 1
    • 84904006242 scopus 로고    scopus 로고
    • Immune modulation of stem cells and regeneration
    • Aurora, A. B. & Olson, E. N. Immune modulation of stem cells and regeneration. Cell Stem Cell 15, 14-25 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 14-25
    • Aurora, A.B.1    Olson, E.N.2
  • 2
    • 84905732910 scopus 로고    scopus 로고
    • Preparing the ground for tissue regeneration: From mechanism to therapy
    • Forbes, S. J. & Rosenthal, N. Preparing the ground for tissue regeneration: from mechanism to therapy. Nat. Med. 20, 857-869 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 857-869
    • Forbes, S.J.1    Rosenthal, N.2
  • 3
    • 84889655325 scopus 로고    scopus 로고
    • Cell therapy of periodontium: From animal to human?
    • Trofin, E. A., Monsarrat, P. & Kemoun, P. Cell therapy of periodontium: from animal to human? Front. Physiol. 4, 325 (2013).
    • (2013) Front. Physiol. , vol.4 , pp. 325
    • Trofin, E.A.1    Monsarrat, P.2    Kemoun, P.3
  • 4
    • 84923642772 scopus 로고    scopus 로고
    • Stromal cells and stem cells in clinical bone regeneration
    • Grayson, W. L. et al. Stromal cells and stem cells in clinical bone regeneration. Nat. Rev. Endocrinol. 11, 140-150 (2015).
    • (2015) Nat. Rev. Endocrinol. , vol.11 , pp. 140-150
    • Grayson, W.L.1
  • 5
    • 77955806398 scopus 로고    scopus 로고
    • Craniofacial reconstruction with bone and biomaterials: Review over the last 11 years
    • Neovius, E. & Engstrand, T. Craniofacial reconstruction with bone and biomaterials: review over the last 11 years. J. Plast. Reconstr. Aesthet. Surg. 63, 1615-1623 (2010).
    • (2010) J. Plast. Reconstr. Aesthet. Surg. , vol.63 , pp. 1615-1623
    • Neovius, E.1    Engstrand, T.2
  • 6
    • 84947617350 scopus 로고    scopus 로고
    • Extracellular matrix-inspired growth factor delivery systems for bone regeneration
    • Martino, M. M., Briquez, P. S., Maruyama, K. & Hubbell, J. A. Extracellular matrix-inspired growth factor delivery systems for bone regeneration. Adv. Drug. Deliv. Rev. 94, 41-52 (2015).
    • (2015) Adv. Drug. Deliv. Rev. , vol.94 , pp. 41-52
    • Martino, M.M.1    Briquez, P.S.2    Maruyama, K.3    Hubbell, J.A.4
  • 7
    • 42149178627 scopus 로고    scopus 로고
    • Biomaterials for bone tissue engineering
    • Stevens, M. M. Biomaterials for bone tissue engineering. Mater. Today 11, 18-25 (2008).
    • (2008) Mater. Today , vol.11 , pp. 18-25
    • Stevens, M.M.1
  • 8
    • 84894256030 scopus 로고    scopus 로고
    • Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing
    • Martino, M. M. et al. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science 343, 885-888 (2014).
    • (2014) Science , vol.343 , pp. 885-888
    • Martino, M.M.1
  • 9
    • 79957837940 scopus 로고    scopus 로고
    • Mesenchymal stem cells and bone regeneration: Current status
    • Jones, E. & Yang, X. Mesenchymal stem cells and bone regeneration: current status. Injury 42, 562-568 (2011).
    • (2011) Injury , vol.42 , pp. 562-568
    • Jones, E.1    Yang, X.2
  • 10
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • Piccinini, A. M. & Midwood, K. S. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm. 2010, 672395 (2010).
    • (2010) Mediators Inflamm. , vol.2010 , pp. 672395
    • Piccinini, A.M.1    Midwood, K.S.2
  • 11
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen, G. Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 12
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 13
    • 1242336786 scopus 로고    scopus 로고
    • Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice
    • Oyama, J. et al. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109, 784-789 (2004).
    • (2004) Circulation , vol.109 , pp. 784-789
    • Oyama, J.1
  • 14
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung, A. et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201, 1135-1143 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1135-1143
    • Tsung, A.1
  • 15
    • 34948835806 scopus 로고    scopus 로고
    • TLR4 activation mediates kidney ischemia/reperfusion injury
    • Wu, H. et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J. Clin. Invest. 117, 2847-2859 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2847-2859
    • Wu, H.1
  • 16
    • 35348860696 scopus 로고    scopus 로고
    • Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    • Tang, S. C. et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc. Natl. Acad. Sci. USA 104, 13798-13803 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 13798-13803
    • Tang, S.C.1
  • 17
    • 46749144616 scopus 로고    scopus 로고
    • Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling
    • Bujak, M. et al. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am. J. Pathol. 173, 57-67 (2008).
    • (2008) Am. J. Pathol. , vol.173 , pp. 57-67
    • Bujak, M.1
  • 18
    • 67049160679 scopus 로고    scopus 로고
    • Disruption of interleukin-1 signaling improves the quality of wound healing
    • Thomay, A. A. et al. Disruption of interleukin-1 signaling improves the quality of wound healing. Am. J. Pathol. 174, 2129-2136 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 2129-2136
    • Thomay, A.A.1
  • 19
    • 77957858212 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    • Hyakkoku, K. et al. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience 171, 258-267 (2010).
    • (2010) Neuroscience , vol.171 , pp. 258-267
    • Hyakkoku, K.1
  • 20
    • 84861999263 scopus 로고    scopus 로고
    • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
    • Shichita, T. et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat. Med. 18, 911-917 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 911-917
    • Shichita, T.1
  • 21
    • 84883678932 scopus 로고    scopus 로고
    • Blocking interleukin-1beta induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes
    • Mirza, R. E., Fang, M. M., Ennis, W. J. & Koh, T. J. Blocking interleukin-1beta induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes 62, 2579-2587 (2013).
    • (2013) Diabetes , vol.62 , pp. 2579-2587
    • Mirza, R.E.1    Fang, M.M.2    Ennis, W.J.3    Koh, T.J.4
  • 22
    • 84899051032 scopus 로고    scopus 로고
    • FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling
    • Bhattacharyya, S. et al. FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling. Sci. Transl. Med. 6, 232ra50 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 232ra50
    • Bhattacharyya, S.1
  • 23
    • 84897895944 scopus 로고    scopus 로고
    • Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome
    • Takemura, N. et al. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat. Commun. 5, 3492 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3492
    • Takemura, N.1
  • 24
    • 78751686333 scopus 로고    scopus 로고
    • Rodent models in bone-related research: The relevance of calvarial defects in the assessment of bone regeneration strategies
    • Gomes, P. S. & Fernandes, M. H. Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies. Lab. Anim. 45, 14-24 (2011).
    • (2011) Lab. Anim. , vol.45 , pp. 14-24
    • Gomes, P.S.1    Fernandes, M.H.2
  • 25
    • 84870023704 scopus 로고    scopus 로고
    • Evaluation of bone regeneration using the rat critical size calvarial defect
    • Spicer, P. P. et al. Evaluation of bone regeneration using the rat critical size calvarial defect. Nat. Protoc. 7, 1918-1929 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 1918-1929
    • Spicer, P.P.1
  • 26
    • 75549091673 scopus 로고    scopus 로고
    • The IL-1 family: Regulators of immunity
    • Sims, J. E. & Smith, D. E. The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10, 89-102 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 89-102
    • Sims, J.E.1    Smith, D.E.2
  • 27
    • 84872914245 scopus 로고    scopus 로고
    • Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion
    • Eggenhofer, E. et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front. Immunol. 3, 297 (2012).
    • (2012) Front. Immunol. , vol.3 , pp. 297
    • Eggenhofer, E.1
  • 28
    • 66249096305 scopus 로고    scopus 로고
    • Pulmonary passage is a major obstacle for intravenous stem cell delivery: The pulmonary first-pass effect
    • Fischer, U. M. et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev. 18, 683-692 (2009).
    • (2009) Stem Cells Dev. , vol.18 , pp. 683-692
    • Fischer, U.M.1
  • 30
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine
    • Bianco, P. et al. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat. Med. 19, 35-42 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 35-42
    • Bianco, P.1
  • 31
    • 84905861462 scopus 로고    scopus 로고
    • Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow
    • Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G. & Morrison, S. J. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 154-168
    • Zhou, B.O.1    Yue, R.2    Murphy, M.M.3    Peyer, J.G.4    Morrison, S.J.5
  • 32
    • 84921000919 scopus 로고    scopus 로고
    • Identification and specification of the mouse skeletal stem cell
    • Chan, C. K. et al. Identification and specification of the mouse skeletal stem cell. Cell 160, 285-298 (2015).
    • (2015) Cell , vol.160 , pp. 285-298
    • Chan, C.K.1
  • 33
    • 84920972443 scopus 로고    scopus 로고
    • Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
    • Worthley, D. L. et al. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 160, 269-284 (2015).
    • (2015) Cell , vol.160 , pp. 269-284
    • Worthley, D.L.1
  • 34
    • 77950479716 scopus 로고    scopus 로고
    • Liposomes for specific depletion of macrophages from organs and tissues
    • van Rooijen, N. & Hendrikx, E. Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol. Biol. 605, 189-203 (2010).
    • (2010) Methods Mol. Biol. , vol.605 , pp. 189-203
    • Van Rooijen, N.1    Hendrikx, E.2
  • 35
    • 80955178835 scopus 로고    scopus 로고
    • PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs
    • Caplan, A. I. & Correa, D. PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs. J. Orthop. Res. 29, 1795-1803 (2011).
    • (2011) J. Orthop. Res. , vol.29 , pp. 1795-1803
    • Caplan, A.I.1    Correa, D.2
  • 36
    • 84255200563 scopus 로고    scopus 로고
    • Building strong bones: Molecular regulation of the osteoblast lineage
    • Long, F. Building strong bones: molecular regulation of the osteoblast lineage. Nat. Rev. Mol. Cell. Biol. 13, 27-38 (2012).
    • (2012) Nat. Rev. Mol. Cell. Biol. , vol.13 , pp. 27-38
    • Long, F.1
  • 37
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: From human mutations to treatments
    • Baron, R. & Kneissel, M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat. Med. 19, 179-192 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 38
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (2007).
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 39
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    • Huang, S. M. et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614-620 (2009).
    • (2009) Nature , vol.461 , pp. 614-620
    • Huang, S.M.1
  • 40
    • 45549107664 scopus 로고    scopus 로고
    • Development of a novel noncompetitive antagonist of IL-1 receptor
    • Quiniou, C. et al. Development of a novel noncompetitive antagonist of IL-1 receptor. J. Immunol. 180, 6977-6987 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 6977-6987
    • Quiniou, C.1
  • 41
    • 0032940534 scopus 로고    scopus 로고
    • Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa
    • Schense, J. C. & Hubbell, J. A. Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug. Chem. 10, 75-81 (1999).
    • (1999) Bioconjug. Chem. , vol.10 , pp. 75-81
    • Schense, J.C.1    Hubbell, J.A.2
  • 42
    • 84875248854 scopus 로고    scopus 로고
    • Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix
    • Martino, M. M., Briquez, P. S., Ranga, A., Lutolf, M. P. & Hubbell, J. A. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc. Natl Acad. Sci. USA 110, 4563-4568 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4563-4568
    • Martino, M.M.1    Briquez, P.S.2    Ranga, A.3    Lutolf, M.P.4    Hubbell, J.A.5
  • 43
    • 0028239908 scopus 로고
    • The third helix of the Antennapedia homeodomain translocates through biological membranes
    • Derossi, D., Joliot, A. H., Chassaing, G. & Prochiantz, A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem. 269, 10444-10450 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 10444-10450
    • Derossi, D.1    Joliot, A.H.2    Chassaing, G.3    Prochiantz, A.4
  • 44
    • 84911307627 scopus 로고
    • The critical size defect as an experimental model to test bone repair materials
    • Hollinger, J. O. & Kleinschmidt, J. C. The critical size defect as an experimental model to test bone repair materials. J. Craniofac. Surg. 1, 60-68 (1990).
    • (1990) J. Craniofac. Surg. , vol.1 , pp. 60-68
    • Hollinger, J.O.1    Kleinschmidt, J.C.2
  • 45
    • 84855517156 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha
    • Liu, Y. et al. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-gamma and TNF-alpha. Nat. Med. 17, 1594-1601 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1594-1601
    • Liu, Y.1
  • 46
    • 84890050252 scopus 로고    scopus 로고
    • A special population of regulatory T cells potentiates muscle repair
    • Burzyn, D. et al. A special population of regulatory T cells potentiates muscle repair. Cell 155, 1282-1295 (2013).
    • (2013) Cell , vol.155 , pp. 1282-1295
    • Burzyn, D.1
  • 47
    • 79952745548 scopus 로고    scopus 로고
    • Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction
    • Arslan, F. et al. Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction. Circ. Res. 108, 582-592 (2011).
    • (2011) Circ. Res. , vol.108 , pp. 582-592
    • Arslan, F.1
  • 48
    • 84880652108 scopus 로고    scopus 로고
    • PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion
    • Pinho, S. et al. PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J. Exp. Med. 210, 1351-1367 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1351-1367
    • Pinho, S.1
  • 49
    • 85009909730 scopus 로고    scopus 로고
    • Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: A comparative analysis
    • Fernandez-Moure, J. S. et al. Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis. Stem Cell Res. Ther. 6, 203 (2015).
    • (2015) Stem Cell Res. Ther. , vol.6 , pp. 203
    • Fernandez-Moure, J.S.1
  • 50
    • 84901477349 scopus 로고    scopus 로고
    • Concise review: The surface markers and identity of human mesenchymal stem cells
    • Lv, F. J., Tuan, R. S., Cheung, K. M. & Leung, V. Y. Concise review: the surface markers and identity of human mesenchymal stem cells. Stem Cells 32, 1408-1419 (2014).
    • (2014) Stem Cells , vol.32 , pp. 1408-1419
    • Lv, F.J.1    Tuan, R.S.2    Cheung, K.M.3    Leung, V.Y.4
  • 51
    • 84878736561 scopus 로고    scopus 로고
    • NF-kappaB inhibits osteogenic differentiation of mesenchymal stem cells by promoting beta-catenin degradation
    • Chang, J. et al. NF-kappaB inhibits osteogenic differentiation of mesenchymal stem cells by promoting beta-catenin degradation. Proc. Natl Acad. Sci. USA 110, 9469-9474 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9469-9474
    • Chang, J.1
  • 52
    • 84887877306 scopus 로고    scopus 로고
    • The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration
    • Chen, J., Crawford, R., Chen, C. & Xiao, Y. The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue. Eng. Part B Rev. 19, 516-528 (2013).
    • (2013) Tissue. Eng. Part B Rev. , vol.19 , pp. 516-528
    • Chen, J.1    Crawford, R.2    Chen, C.3    Xiao, Y.4
  • 54
    • 76849109024 scopus 로고    scopus 로고
    • The design and use of animal models for translational research in bone tissue engineering and regenerative medicine
    • Muschler, G. F., Raut, V. P., Patterson, T. E., Wenke, J. C. & Hollinger, J. O. The design and use of animal models for translational research in bone tissue engineering and regenerative medicine. Tissue Eng. Part B Rev. 16, 123-145 (2010).
    • (2010) Tissue Eng. Part B Rev. , vol.16 , pp. 123-145
    • Muschler, G.F.1    Raut, V.P.2    Patterson, T.E.3    Wenke, J.C.4    Hollinger, J.O.5
  • 55
    • 84863568189 scopus 로고    scopus 로고
    • A tissue engineering solution for segmental defect regeneration in load-bearing long bones
    • Reichert, J. C. et al. A tissue engineering solution for segmental defect regeneration in load-bearing long bones. Sci. Transl. Med. 4, 141ra93 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , pp. 141ra93
    • Reichert, J.C.1
  • 56
    • 84902078639 scopus 로고    scopus 로고
    • A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP
    • Gao, X. et al. A comparison of bone regeneration with human mesenchymal stem cells and muscle-derived stem cells and the critical role of BMP. Biomaterials 35, 6859-6870 (2014).
    • (2014) Biomaterials , vol.35 , pp. 6859-6870
    • Gao, X.1
  • 57
    • 84890088110 scopus 로고    scopus 로고
    • Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: Case studies
    • Ratcliffe, E., Glen, K. E., Naing, M. W. & Williams, D. J. Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: case studies. Br. Med. Bull. 108, 73-94 (2013).
    • (2013) Br. Med. Bull. , vol.108 , pp. 73-94
    • Ratcliffe, E.1    Glen, K.E.2    Naing, M.W.3    Williams, D.J.4
  • 58
    • 84871698177 scopus 로고    scopus 로고
    • Concise review: The clinical application of mesenchymal stem cells for musculoskeletal regeneration: Current status and perspectives
    • Steinert, A. F., Rackwitz, L., Gilbert, F., Noth, U. & Tuan, R. S. Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives. Stem Cells Transl. Med. 1, 237-247 (2012).
    • (2012) Stem Cells Transl. Med. , vol.1 , pp. 237-247
    • Steinert, A.F.1    Rackwitz, L.2    Gilbert, F.3    Noth, U.4    Tuan, R.S.5
  • 59
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 60
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643 (2003).
    • (2003) Science , vol.301 , pp. 640-643
    • Yamamoto, M.1
  • 61
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi, O. et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1
  • 62
    • 33746161021 scopus 로고    scopus 로고
    • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
    • Uematsu, S. et al. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat. Immunol. 7, 868-874 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 868-874
    • Uematsu, S.1
  • 63
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3, 196-200 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1
  • 64
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1
  • 65
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi, O. et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451 (1999).
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1
  • 66
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 67
    • 0033047422 scopus 로고    scopus 로고
    • Direct three-dimensional morphometric analysis of human cancellous bone: Microstructural data from spine, femur, iliac crest, and calcaneus
    • Hildebrand, T., Laib, A., Muller, R., Dequeker, J. & Ruegsegger, P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 14, 1167-1174 (1999).
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1167-1174
    • Hildebrand, T.1    Laib, A.2    Muller, R.3    Dequeker, J.4    Ruegsegger, P.5
  • 68
    • 0037547104 scopus 로고    scopus 로고
    • Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
    • Lutolf, M. P. et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat. Biotechnol. 21, 513-518 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , pp. 513-518
    • Lutolf, M.P.1
  • 69
    • 84885466797 scopus 로고    scopus 로고
    • Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
    • Maruyama, K. et al. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210, 1947-1960 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1947-1960
    • Maruyama, K.1
  • 70
    • 80052951552 scopus 로고    scopus 로고
    • Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing
    • Martino, M. M. et al. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci. Transl. Med. 3, 100ra89 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 100ra89
    • Martino, M.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.