Activation of AMPK inhibits PDGF-induced pulmonary arterial smooth muscle cells proliferation and its potential mechanisms

Pharmacological Research

Volumn 107, Issue , 2016, Pages 117-124

  Song, Yang ^a   Wu, Yuanyuan ^a   Su, Xiaofan ^a   Zhu, Yanting ^a   Liu, Lu ^a   Pan, Yilin ^a   Zhu, Bo ^a   Yang, Lan ^a   Gao, Li ^b   Li, Manxiang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPK; mTOR; p27; Pulmonary arterial smooth muscle cells; Skp2

Indexed keywords

ADENYLATE KINASE; AMPK ALPHA2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; S PHASE KINASE ASSOCIATED PROTEIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERIAL SMOOTH MUSCLE CELL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; METABOLISM; PULMONARY ARTERY; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RATS, SPRAGUE-DAWLEY; S-PHASE KINASE-ASSOCIATED PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84961589933     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.03.010     Document Type: Article

References (45)

1. Y. Fukumotoand, and H. Shimokawa Recent progress in the management of pulmonary hypertension Circ. J. 75 2011 1801 1810
2. S. Rosenkranz Pulmonary hypertension 2015: current definitions, terminology, and novel treatment options Clin. Res. Cardiol. 104 2015 197 207
3. G. Strange, D. Playford, S. Stewart, J.A. Deague, H. Nelson, A. Kent, and E. Gabbay Pulmonary hypertension: prevalence and mortality in the Armadale echocardiography cohort Heart 98 2012 1805 1811
4. Y. Miura, Y. Fukumoto, K. Sugimura, M. Oikawa, M. Nakano, S. Tatebe, S. Miyamichi, K. Satoh, and H. Shimokawa Identification of new prognostic factors of pulmonary hypertension Circ. J. 74 2010 1965 1971
5. M.H. Zou, X.Y. Hou, C.M. Shi, S. Kirkpatick, F. Liu, M.H. Goldman, and R.A. Cohen Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite J Biol. Chem. 278 2003 34003 34010
6. Y. Jiang, W. Huang, J. Wang, Z. Xu, J. He, X. Lin, Z. Zhou, and J. Zhang Metformin plays a dual role in MIN6 pancreatic beta cell function through AMPK-dependent autophagy Int. J. Biol. Sci. 10 2014 268 277
7. W. Zhang, R. Wu, F. Zhang, Y. Xu, B. Liu, Y. Yang, H. Zhou, L. Wang, K. Wan, X. Xiao, and X. Zhang Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway Clin. Exp. Pharmacol. Physiol. 39 2012 1026 1033
8. J.K. Zhan, Y.J. Wang, Y. Wang, Z.Y. Tang, P. Tan, W. Huang, and Y.S. Liu Adiponectin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the AMPK/mTOR pathway Exp. Cell Res. 323 2014 352 358
9. A. Peairs, A. Radjavi, S. Davis, L. Li, A. Ahmed, S. Giri, and C. Reilly Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells Clin. Exp. Immunol. 156 2009 542 551
10. H. Motoshima, B.J. Goldstein, M. Igata, and E. Araki AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer J. Physiol. 574 2006 63 71
11. L.A. Cantrell, C. Zhou, A. Mendivil, K.M. Malloy, P.A. Gehrig, and V.L. Bae-Jump Metformin is a potent inhibitor of endometrial cancer cell proliferation - implications for a novel treatment strategy Gynecol. Oncol. 116 2010 92 98
12. I.B. Sahra, Y. Le Marchand-Brustel, J.-F. Tanti, and F. Bost Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol. Cancer Ther. 9 2010 1092 1099
13. A. Ratnovsky, M. Mellema, S.S. An, J.J. Fredberg, and S.A. Shore Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists Mol. Cell Biomech. 4 2007 143 157
14. P. Zhang, M. Cao, Y. Liu, Z. Lv, Q. Yang, X. Lin, H. Li, and Q. Wan PDGF-induced airway smooth muscle proliferation is associated with human antigen R activation and could be weakened by AMPK activation Mol. Biol. Rep. 39 2012 5819 5829
15. C. Agard, M. Rolli-Derkinderen, E. Dumas-de-La-Roque, M. Rio, C. Sagan, J. Savineau, G. Loirand, and P. Pacaud Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension Br. J. Pharmacol. 158 2009 1285 1294
16. R.-J. Teng, J. Du, A.J. Afolayan, A. Eis, Y. Shi, and G.G. Konduri AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension Am. J. Physiol. 304 2013 L29 L42
17. Y. Zhao, W. Lv, H. Piao, X. Chu, and H. Wang Role of platelet-derived growth factor-BB (PDGF-BB) in human pulmonary artery smooth muscle cell proliferation J. Recept. Signal Transduct Res. 34 2014 254 260
18. X. Zhang, F. Zhang, D. Kong, X. Wu, N. Lian, L. Chen, Y. Lu, and S. Zheng Tetramethylpyrazine inhibits angiotensin II-induced activation of hepatic stellate cells associated with interference of platelet-derived growth factor beta receptor pathways FEBS J. 281 2014 2754 2768
19. V.P. Krymskaya, J. Snow, G. Cesarone, I. Khavin, D.A. Goncharov, P.N. Lim, S.C. Veasey, K. Ihida-Stansbury, P.L. Jones, and E.A. Goncharova mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia FASEB J. 25 2011 1922 1933
20. Y. Wu, L. Liu, Y. Zhang, G. Wang, D. Han, R. Ke, S. Li, W. Feng, and M. Li Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation Exp. Lung Res. 40 2014 251 258
21. M. Bondand, and Y.J. Wu Proliferation unleashed: the role of Skp2 in vascular smooth muscle cell proliferation Front. Biosci. (Landmark Ed). 16 2011 1517 1535
22. M.a. Shapira, E. Kakiashvili, T. Rosenberg, and D.D. Hershko The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells Breast Cancer Res. 8 2006 R46
23. M. Pagano Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis Mol. Cell 14 2004 414 416
24. F. Perros, D. Montani, P. Dorfmuller, I. Durand-Gasselin, C. Tcherakian, J. Le Pavec, M. Mazmanian, E. Fadel, S. Mussot, and O. Mercier Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 178 2008 81 88
25. V.P. Krymskaya, J. Snow, G. Cesarone, I. Khavin, D.A. Goncharov, P.N. Lim, S.C. Veasey, K. Ihida-Stansbury, P.L. Jones, and E.A. Goncharova mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia FASEB J. 25 2011 1922 1933
26. J. Liu, J. Xiu, J. Cao, Q. Gao, D. Ma, and L. Fu Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway Mol. Cell. Biochem. 355 2011 127 134
27. T. Yanagi, J.C. Reed, and S. Matsuzawa PCTAIRE1 regulates p27 stability: apoptosis and tumor growth in malignant melanoma Oncoscience 1 2014 624 633
28. A. Royand, and S. Banerjee p27 leukemia: cell cycle and beyond J. Cell Physiol. 230 2015 504 509
29. U.V. Wesley, J.F. Hatcher, and R.J. Dempsey Sphingomyelin synthase 1 regulates neuro-2a cell proliferation and cell cycle progression through modulation of p27 expression and akt signaling Mol. Neurobiol. 2 2014 2
30. M. Lonjedo, E. Poch, E. Mocholi, M. Hernandez-Sanchez, C. Ivorra, T.F. Franke, R.M. Guasch, and I. Perez-Roger The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression J. Biol. Chem. 288 2013 30872 33088
31. L. Wu, A.V. Grigoryan, Y. Li, B. Hao, M. Pagano, and T.J. Cardozo Specific small molecule inhibitors of Skp2-mediated p27 degradation Chem. Biol. 19 2012 1515 1524
32. H. Zhang, C. Li, H. Chen, C. Wei, F. Dai, H. Wu, W. Dui, W.M. Deng, and R. Jiao SCF(Slmb) E3 ligase-mediated degradation of expanded is inhibited by the Hippo pathway in Drosophila Cell Res. 25 2015 93 109
33. Z. Lu, F. Bauzon, H. Fu, J. Cui, H. Zhao, K. Nakayama, K.I. Nakayama, and L. Zhu Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity Nat. Commun. 5 2014 3463
34. T. Fujita, W. Liu, H. Doihara, and Y. Wan Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis Am. J. Pathol. 173 2008 217 228
35. E. Dazertand, and M.N. Hall mTOR signaling in disease Curr. Opin. Cell Biol. 23 2011 744 755
36. Y. Zhaoand, and Y. Sun Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application Neoplasia 14 2012 360
37. 2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension Am. J. Physiol. 297 2009 L666
38. D.A. Goncharov, T.V. Kudryashova, H. Ziai, K. Ihida-Stansbury, H. DeLisser, V.P. Krymskaya, R.M. Tuder, S.M. Kawut, and E.A. Goncharova mTORC2Coordinates pulmonary artery smooth muscle cell metabolism proliferation and survival in pulmonary arterial hypertension Circulation 2013 10.1161/CIRCULATIONAHA.113.004581
39. D. Han, S.J. Li, Y.T. Zhu, L. Liu, and M.X. Li LKB1/AMPK/mTOR signaling pathway in non-small-cell lung cancer Asian Pac. J. Cancer Prev. 14 2013 4033 4039
40. D.M. Gwinn, D.B. Shackelford, D.F. Egan, M.M. Mihaylova, A. Mery, D.S. Vasquez, B.E. Turk, and R.J. Shaw AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol. Cell 30 2008 214 226
41. J.D. Short, R. Dere, K.D. Houston, S.L. Cai, J. Kim, J.M. Bergeron, J. Shen, J. Liang, M.T. Bedford, G.B. Mills, and C.L. Walker AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability Mol. Carcinog. 49 2010 429 439
42. M.-H. Zou, X.-Y. Hou, C.-M. Shi, S. Kirkpatick, F. Liu, M.H. Goldman, and R.A. Cohen Activation of 5′-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells Role of peroxynitrite J. Biol. Chem. 278 2003 34003 34010
43. S.C. Liu, Y.K. Tu, M.N. Chien, and K.L. Chien Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis Diabetes Obes. Metab. 14 2012 810 820
44. R.J. Dowling, M. Zakikhani, I.G. Fantus, M. Pollak, and N. Sonenberg Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells Cancer Res. 67 2007 10804 10812
45. W. Shi, D. Xiao, L. Wang, L. Dong, Z. Yan, Z. Shen, S. Chen, Y. Chen, and W. Zhao Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy Cell Death Dis. 3 2012 e275