Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation

Experimental Lung Research

Volumn 40, Issue 5, 2014, Pages 251-258

  Wu, Yuanyuan ^a   Liu, Lu ^a   Zhang, Yonghong ^a   Wang, Guizuo ^a   Han, Dong ^a   Ke, Rui ^a   Li, Shaojun ^a   Feng, Wei ^a   Li, Manxiang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

AMPK; P27; Proliferation; Pulmonary arterial smooth muscle cells; Skp2

Indexed keywords

ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2; CDKN1B PROTEIN, RAT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; S PHASE KINASE ASSOCIATED PROTEIN;

AIRWAY REMODELING; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENDOTHELIN-1; ENZYME ACTIVATION; METFORMIN; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; S-PHASE KINASE-ASSOCIATED PROTEINS;

EID: 84900425857     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2014.913092     Document Type: Article

References (35)

1. Miura Y, Fukumoto Y, Sugimura K, Oikawa M, Nakano M, Tatebe S, Miyamichi S, Sat oh K, Shimokawa H: Identification of new prognostic factors of pulmonary hypertension. Circ J. 2010;74:1965-1971.
2. Souza R, Jardim C: Trends in pulmonary arterial hypertension. Eur Respir Rev. 2009;18:7-12.
3. Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX-J: Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypert ension. Am J Physiol Lung Cell Mol Physiol. 2010;298:L548-L557.
4. Fukumoto Y, Shimokawa H: Recent progress in the management of pulmonary hypertension. Circ J. 2011;75:1801-1810.
5. Hardie DG Carling D Carlson M: The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell Annu Rev Biochem. 1998 67 821-855
6. Zou MH, Hou XY, Shi CM, Kirkpatick S, Liu F, Goldman MH, Cohen RA: Activation of 5-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells Role of peroxynitrite. J Biol Chem. 2003;278:34003-34010.
7. Jeong HW, Hsu KC, Lee JW, Ham M, Huh JY, Shin HJ, Kim WS, Kim JB: Berberine suppresses proinflammatory responses thro ugh AMPK activation in macrophages. Am J Physiol Endocrinol Metab. 2009;296:E955-E964.
8. Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, Auberger P: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res. 2010;70:1042-1052.
9. Ye SW, Chen L, Giacomini KM: The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012;44:359-360.
10. Peairs A, Radjavi A, Davis S, Li L, Ahmed A, Giri S, Reilly C: Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells. Clin Exp Immunol. 2009;156:542-551.
11. Motoshima H, Goldstein BJ, Igata M, Araki E: AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol. 2006;574:63-71.
12. Cantrell LA, Zhou C,Mendivil A,Malloy KM, Gehrig PA, Bae-Jump VL: Metformin is a potent inhibitor of endometrial cancer ce ll proliferation- implications for a novel treatment strategy. Gynecol Oncol. 2010;116:92-98.
13. Sahra IB, Le Marchand-Brustel Y, Tanti JF, Bost F: Metformin in cancer therapy: A new perspective for an old antidiabetic drug Mol Cancer Ther. 2010;9:1092-1099.
14. Hardie DG: AMP-activated protein kinase: A cellular energy sensor with a key role in metabolic disorders and in cancer. Biochem Soc Trans. 2011;39:1-13.
15. EwartMA, Kennedy S: AMPK and vasculoprotection. Pharmacol Ther. 2011;131:242-253.
16. Beauloye C, Bertrand L, Horman S, Hue L: AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Pharmacol Ther. 2011;90:224-233.
17. Teng, RJ, Du J, Afolayan, AJ, Eis, A, Shi, Y, Konduri, GG:AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonar y hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;304:L29-L42.
18. Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, Delisser H, Krymskaya VP, Tuder RM, Kawut SM, G oncharova EA: MTORC2 Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation and Survival in Pulmonary Arterial Hypertension. Circulation. 2014;129: 864-874.
19. AgardC, Rolli-DerkinderenM,Dumas-de-La-Roque E, RioM, Sagan C, Savineau J, Loirand G, Pacaud P: Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. Br J Pharmacol. 2009;158:1285-1294.
20. Hsu, JD, Kao, SH, Ou, TT, Chen, YJ, Li, YJ, Wang, CJ: Gallic acid induces G2/M phase arrest of breast cancer cell MCF-7 through stabilization of p27Kip1 attributed to disruption of p27Kip1/Skp2 complex. J Agr Fo od Chem. 2011;59:1996-2003.
21. Ferri N: AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease. Vascul Pharmacol. 2012;56:9-13.
22. Wang C, Wang J, Zhao L, Wang Y, Liu J, Shi L, Xu M, Wang C: Sildenafil inhibits human pulmonary artery smooth muscle cell proliferation by decreasing capacitative Ca 2+ entry. J Pharmacol Sci. 2008;108:71-78.
23. Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX-J: Bosentan inhibits transient receptor potential channel expression in pulmonary vas cular myocytes. Am J Respir Crit Care Med. 2004;170:1101-1107.
24. Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester J, Semenza GL, Shimoda LA: Activation of hypoxiainducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2013;304:L549-L561.
25. Lu J, Wang X, Xie X, Han D, Li S, Li M: Calcineurin/NFAT signaling pathway mediates endothelin-1-induced pulmonary artery smooth muscle cell proliferation by regulating phosphodiesterase-5. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:26-29.
26. Chu IM Hengst L Slingerland JM The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy. Nat Rev Cancer. 2008 8 253-267.
27. Larrea MD, Wander SA, Slingerland J: P27 as Jekyll and Hyde: Regulation of cell cycle and cell motility. Cell Cycle. 2009;8:3455-3461.
28. Ammit AJ, Panettieri RA: Invi ted review: The circle of life: Cell cycle regulation in airway smooth muscle. J Appl Physiol. (1985).2001;91:1431-1437.
29. Chahdi A, Sorokin A: Endothelin-1 couples Pix to p66Shc: Role of Pix i n cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell. 2008;19:2609-2619.
30. Memmott RM, Dennis PA: Akt-dependent and-independent mechanisms of mTOR regulation in cancer. Cell Signal. 2009;21:656-664.
31. Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL: TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 2006;126:955-968.
32. Shapira MA, Kakiashvili E, Rosenberg T, Hershko D: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells. Breast Cancer Res. 2006;8:R46-R49.
33. Bond M,Wu YJ: Proliferation unleashed: The role of Skp2 in vascular smooth muscle cell proliferation. Front Biosci (Landmark Ed). 2011;16:1517-1535.
34. Short JD, Dere R, Ho uston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL: AMPKmediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carci nog. 2010;49:429-439.
35. Liu SC, Tu YK, Chien MN, Chien KL: Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: A network meta-analysis. Diabetes Obes Metab. 2012;14:810-820.