The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells

Journal of Biological Chemistry

Volumn 290, Issue 3, 2015, Pages 1623-1638

  Davis, Angela L ^a   Qiao, Shuxi ^a   Lesson, Jessica L ^a   De La Vega, Montserrat Rojo ^a   Park, Sophia L ^a   Seanez, Carol M ^a   Gokhale, Vijay ^a   Cabello, Christopher M ^a   Wondrak, Georg T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL DEATH; CELLS; CYTOLOGY; DERMATOLOGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; ONCOLOGY; PROTEINS;

CCAAT/ENHANCER-BINDING PROTEINS; FLUORESCENCE POLARIZATION; HEAT SHOCK FACTORS; HEAT SHOCK RESPONSE; HOMOLOGOUS PROTEINS; MALIGNANT MELANOMA; TRANSCRIPTIONAL ACTIVATIONS; UNFOLDED PROTEIN RESPONSE;

CELL SIGNALING;

CELASTROL; GELDANAMYCIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90ALPHA; HEME OXYGENASE 1; INITIATION FACTOR 2ALPHA; PROTEIN NOXA; ROSEOLIC ACID; UNCLASSIFIED DRUG; AURINTRICARBOXYLIC ACID; GLUTATHIONE; HEAT SHOCK PROTEIN; INDOLE DERIVATIVE; NOXA1 PROTEIN, HUMAN; QUINONE METHIDE; SMALL INTERFERING RNA; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNAJB4 GENE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; FLUORESCENCE POLARIZATION; GENE; GENE EXPRESSION; HEAT SHOCK RESPONSE; HMOX1 GENE; HSPA1A GENE; HSPA6 GENE; HUMAN; HUMAN CELL; MELANOMA CELL; MOLECULAR DOCKING; OXIDATIVE STRESS; PROTEIN HOMEOSTASIS; PROTEOTOXIC STRESS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FLOW CYTOMETRY; GENETICS; IC50; KERATINOCYTE; MELANOCYTE; MELANOMA; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TUMOR CELL LINE; UPREGULATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; APOPTOSIS; AURINTRICARBOXYLIC ACID; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; GLUTATHIONE; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HUMANS; INDOLEQUINONES; INHIBITORY CONCENTRATION 50; KERATINOCYTES; MELANOCYTES; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, MOLECULAR; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SKIN NEOPLASMS; UP-REGULATION;

EID: 84961288388     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.592626     Document Type: Article

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