The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A (p21) upregulation in human cancer cell lines

Biochemical Pharmacology

Volumn 77, Issue 7, 2009, Pages 1125-1138

  Cabello, Christopher M ^a   Bair III, Warner B ^a   Ley, Stephanie ^a   Lamore, Sarah D ^a   Azimian, Sara ^a   Wondrak, Georg T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

ATP depletion; Cancer; CDKN1A; Genotoxic stress; Kinetin; N6 furfuryladenosine

Indexed keywords

ADENOSINE KINASE; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; KINETIN; N6 FURFURYLADENOSINE; PROTEIN P21; RIBOSE; UNCLASSIFIED DRUG; ADENOSINE; KINETIN RIBOSIDE;

ARTICLE; BIOTRANSFORMATION; CANCER CELL CULTURE; CONTROLLED STUDY; DDIT3 GENE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; FIBROBLAST; GADD45A GENE; GENE; GENOTOXICITY; HMOX1 GENE; HUMAN; HUMAN CELL; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION; BIOSYNTHESIS; CELL PROLIFERATION; COMPARATIVE STUDY; DNA DAMAGE; GENETICS; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ADENOSINE; ADENOSINE TRIPHOSPHATE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FIBROBLASTS; HUMANS; KINETIN; MALE; UP-REGULATION;

EID: 61449230561     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.12.002     Document Type: Article

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