T-bet as a key regulator of mucosal immunity

Immunology

Volumn 147, Issue 4, 2016, Pages 367-376

  Mohamed, Rami ^a,b,c   Lord, Graham M ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

Author keywords

Mucosal homeostasis; Mucosal immunity; T bet; TBX21

Indexed keywords

TRANSCRIPTION FACTOR T BET; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ADAPTIVE IMMUNITY; BINDING AFFINITY; DENDRITIC CELL; DRUG TARGETING; GENE CONTROL; HELPER CELL; HOMEOSTASIS; HUMAN; INNATE IMMUNITY; LYMPHOCYTE; LYMPHOID CELL; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSCRIPTION REGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG DEVELOPMENT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; METABOLISM; MUCOSA;

ADAPTIVE IMMUNITY; ANIMALS; DRUG DISCOVERY; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; IMMUNITY, MUCOSAL; IMMUNOMODULATION; MUCOUS MEMBRANE; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION, GENETIC;

EID: 84961230888     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12575     Document Type: Review

References (59)

1. Sebe-Pedros A, Ariza-Cosano A, Weirauch MT, Leininger S, Yang A, Torruella G et al. Early evolution of the T-box transcription factor family. Proc Natl Acad Sci USA 2013; 110:16050-5.
2. Wilson V, Conlon FL. The T-box family. Genome Biol 2002; 3:REVIEWS3008.
3. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.
4. Lazarevic V, Glimcher LH, Lord GM. T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol 2013; 13:777-89.
5. Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007; 131:33-45.
6. Glimcher LH, Murphy KM. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev 2000; 14:1693-711.
7. Evans CM, Jenner RG. Transcription factor interplay in T helper cell differentiation. Brief Funct Genomics 2013; 12:499-511.
8. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57.
9. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89:587-96.
10. Kanhere A, Hertweck A, Bhatia U, Gokmen MR, Perucha E, Jackson I et al. T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun 2012; 3:1268.
11. Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005; 307:430-3.
12. Nakayamada S, Kanno Y, Takahashi H, Jankovic D, Lu K, Johnson T et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 2015; 35:919-31.
13. Jenner RG, Townsend MJ, Jackson I, Sun K, Bouwman RD, Young RA et al. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci USA 2009; 106:17876-81.
14. Zhu J, Jankovic D, Oler A, Wei G, Sharma S, Hu G et al. The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity 2012; 37:660-73.
15. + T-cell trafficking. Blood 2005; 106:3432-9.
16. + T cell. Eur J Immunol 2011; 41:60-6.
17. Powell N, Canavan JB, MacDonald TT, Lord GM. Transcriptional regulation of the mucosal immune system mediated by T-bet. Mucosal Immunol 2010; 3:567-77.
18. Takeda K. Introduction: Mucosal Immunology Special issue. Int Immunol 2014; 26:479-80.
19. Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010; 8:292-300.
20. -/- (TRUC) mice. Proc Natl Acad Sci USA 2014; 111:E2559-66.
21. + innate lymphoid cells. Immunity 2012; 37:674-84.
22. Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL et al. Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med 2012; 209:2331-8.
23. + innate lymphocytes via the Notch pathway. Nat Immunol 2013; 14:389-95.
24. + innate lymphoid cells. Nature 2013; 494:261-5.
25. Abt MC, Lewis BB, Caballero S, Xiong H, Carter RA, Susac B et al. Innate immune defenses mediated by two ILC subsets are critical for protection against acute Clostridium difficile infection. Cell Host Microbe 2015; 18:27-37.
26. Klose CS, Flach M, Mohle L, Rogell L, Hoyler T, Ebert K et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 2014; 157:340-56.
27. Diefenbach A, Colonna M, Koyasu S. Development, differentiation, and diversity of innate lymphoid cells. Immunity 2014; 41:354-65.
28. Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero MA et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med 2014; 211:89-104.
29. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E et al. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J Exp Med 2014; 211:563-77.
30. Peng H, Tian Z. Re-examining the origin and function of liver-resident NK cells. Trends Immunol 2015; 36:293-9.
31. Peng H, Jiang X, Chen Y, Sojka DK, Wei H, Gao X et al. Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest 2013; 123:1444-56.
32. Sojka DK, Plougastel-Douglas B, Yang L, Pak-Wittel MA, Artyomov MN, Ivanova Y et al. Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells. eLife 2014; 3:e01659.
33. Takeda K, Cretney E, Hayakawa Y, Ota T, Akiba H, Ogasawara K et al. TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 2004; 105:2082-9.
34. + group 1 and group 3 innate lymphoid cells in the intestinal lamina propria. Immunity 2015; 43:146-60.
35. Robinette ML, Fuchs A, Cortez VS, Lee JS, Wang Y, Durum SK et al. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol 2015; 16:306-17.
36. Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 2013; 31:563-604.
37. Lugo-Villarino G, Ito S, Klinman DM, Glimcher LH. The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci USA 2005; 102:13248-53.
38. Cheroutre H, Lambolez F, Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol 2011; 11:445-56.
39. Chang F, Mahadeva U, Deere H. Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa. APMIS 2005; 113:385-99.
40. Egan CE, Craven MD, Leng J, Mack M, Simpson KW, Denkers EY. CCR2-dependent intraepithelial lymphocytes mediate inflammatory gut pathology during Toxoplasma gondii infection. Mucosal Immunol 2009; 2:527-35.
41. Lepage AC, Buzoni-Gatel D, Bout DT, Kasper LH. Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 1998; 161:4902-8.
42. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity 2014; 41:244-56.
43. + intraepithelial lymphocyte development. Immunity 2014; 41:230-43.
44. Kee BL. E and ID proteins branch out. Nat Rev Immunol 2009; 9:175-84.
45. Yu F, Sharma S, Edwards J, Feigenbaum L, Zhu J. Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. Nat Immunol 2015; 16:197-206.
46. Wei G, Abraham BJ, Yagi R, Jothi R, Cui K, Sharma S et al. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011; 35:299-311.
47. Lazarevic V, Glimcher LH. T-bet in disease. Nat Immunol 2011; 12:597-606.
48. Hartl D, Casaca VI, Illi S, Suttner K, Schleich I, Ballenberger N et al. TBX21 and HLX1 polymorphisms influence cytokine secretion at birth. PLoS ONE 2012; 7:e31069.
49. Krug N, Hohlfeld JM, Kirsten A, Kornmann O, Beeh KM, Kappeler D et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015; 372:1987-95.
50. Lopert A, Rijavec M, Zavbi M, Korosec P, Flezar M. Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene. Sci Rep 2013; 3:2915.
51. Yan C, Higgins PJ. Drugging the undruggable: transcription therapy for cancer. Biochim Biophys Acta 2013; 1835:76-85.
52. Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Ratts RB et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 2004; 21:719-31.
53. Serdar Sel HR. (2015) Patent CA2776997A1 - Method for the production of a cell and/or tissue and/or disease phase... - Google Patents. URL http://www.google.com/patents/CA2776997A1?cl=en [accessed on 23 October 2015].
54. Huh JR, Littman DR. Small molecule inhibitors of RORγt: targeting Th17 cells and other applications. Eur J Immunol 2012; 42:2232-7.
55. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 2014; 40:477-89.
56. Harbour SN, Maynard CL, Zindl CL, Schoeb TR, Weaver CT. Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis. Proc Natl Acad Sci USA 2015; 112:7061-6.
57. Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, Cua DJ et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 2011; 12:255-63.
58. Rotem A, Ram O, Shoresh N, Sperling RA, Goren A, Weitz DA et al. Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state. Nat Biotechnol 2015; 33:1165-1172.
59. Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J et al. STRING 8-a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 2009; 37(Suppl. 1):D412-6.