Myeloid-specific disruption of tyrosine phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 2801-2811

  Tao, Bo ^a,b   Jin, Wei ^a   Xu, Jiaqi ^a,b   Liang, Zuyu ^a   Yao, Junlin ^a   Zhang, Yun ^a,b   Wang, Kai ^a   Cheng, Hongqiang ^a,b   Zhang, Xue ^a,b   Ke, Yuehai ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Center for Brain Imaging Science and Technology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; ARGINASE 1; CELL PROTEIN; CRE RECOMBINASE; FIZZ1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 5; INTERLEUKIN 6; JANUS KINASE 1; MRC1 PROTEIN; PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; YM1 PROTEIN; BLEOMYCIN; CELL SURFACE RECEPTOR; CHITIN; IL4RA PROTEIN, MOUSE; JAK1 PROTEIN, MOUSE; PTPN11 PROTEIN, MOUSE; SMALL INTERFERING RNA; STAT6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; ENZYME INACTIVATION; EOSINOPHIL; INFECTION PREVENTION; LEUKOCYTE MIGRATION; LUNG FIBROSIS; M2 MACROPHAGE; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; POLARIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; PARASITOLOGY; PATHOLOGY; RNA INTERFERENCE; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA;

ANIMALS; ARGINASE; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CHITIN; INFLAMMATION; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; JANUS KINASE 1; LUNG; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PULMONARY FIBROSIS; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SCHISTOSOMA JAPONICUM; SCHISTOSOMIASIS JAPONICA; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR;

EID: 84907087669     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303463     Document Type: Article

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