Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Zhong, Jixin ^a,b   Yang, Ping ^b,c   Muta, Kenjiro ^b   Dong, Robert ^b   Marrero, Mario ^b   Gong, Feili ^a   Wang, Cong Yi ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; JANUS KINASE 2; LIPOPOLYSACCHARIDE; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA; STAT5 PROTEIN; STAT6 PROTEIN; STAT6 PROTEIN, MOUSE;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; INNATE IMMUNITY; LISTERIA; MACROPHAGE; MALE; MOUSE; NONHUMAN; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SPLEEN CELL; SPLEEN SIZE; ANIMAL; CYTOLOGY; INFLAMMATION; METABOLISM; SPLEEN; TRANSGENIC MOUSE;

LISTERIA; MUS;

ANIMALS; DENDRITIC CELLS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-12; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, TRANSGENIC; SPLEEN; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77949759544     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009593     Document Type: Article

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