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Volumn 10, Issue 4, 2016, Pages 434-446

The tumor microenvironment: An irreplaceable element of tumor budding and epithelial-mesenchymal transition-mediated cancer metastasis

Author keywords

cancer metastasis; drug resistance; epithelial mesenchymal transition; microenvironment; tumor budding

Indexed keywords

COLONY STIMULATING FACTOR 1; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FATTY ACID SYNTHASE; FIBRONECTIN; GLYCOSPHINGOLIPID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; NERVE CELL ADHESION MOLECULE; PROTEIN BCL 2; STAT3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; VASCULOTROPIN; VIMENTIN;

EID: 84961206867     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.1080/19336918.2015.1129481     Document Type: Review
Times cited : (67)

References (121)
  • 1
    • 33845599552 scopus 로고    scopus 로고
    • Tumour budding in colorectal carcinoma
    • F.Prall. Tumour budding in colorectal carcinoma. Histopathol 2007; 50:151-62; http://dx.doi.org/10.1111/j.1365-2559.2006.02551.x
    • (2007) Histopathol , vol.50 , pp. 151-162
    • Prall, F.1
  • 2
    • 84867019789 scopus 로고    scopus 로고
    • Tumor budding in colorectal carcinoma: time to take notice
    • B.Mitrovic, D.F.Schaeffer, R.H.Riddell, R.Kirsch. Tumor budding in colorectal carcinoma:time to take notice. Modern Pathol Inc 2012; 25:1315-25; http://dx.doi.org/10.1038/modpathol.2012.94
    • (2012) Modern Pathol Inc , vol.25 , pp. 1315-1325
    • Mitrovic, B.1    Schaeffer, D.F.2    Riddell, R.H.3    Kirsch, R.4
  • 3
    • 79958003343 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget
    • 21317460
    • I.Zlobec, A.Lugli. Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer:tumor budding as oncotarget. Oncotarget 2010; 1:651-61; PMID:21317460; http://dx.doi.org/10.18632/oncotarget.199
    • (2010) Oncotarget , vol.1 , pp. 651-661
    • Zlobec, I.1    Lugli, A.2
  • 5
    • 0009039011 scopus 로고
    • The growth of human carcinoma: A morphological analysis
    • T.Imai The growth of human carcinoma:A morphological analysis. Fukuoka Igaku Zasshi 1954; 45:72-102
    • (1954) Fukuoka Igaku Zasshi , vol.45 , pp. 72-102
    • Imai, T.1
  • 6
    • 0024599662 scopus 로고
    • An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer
    • 2912530
    • T.Morodomi, H.Isomoto, K.Shirouzu, K.Kakegawa, K.Irie, M.Morimatsu. An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer 1989; 63:539-43; PMID:2912530; http://dx.doi.org/10.1002/1097-0142(19890201)63:3<539::AID-CNCR2820630323>3.0.CO;2-S
    • (1989) Cancer , vol.63 , pp. 539-543
    • Morodomi, T.1    Isomoto, H.2    Shirouzu, K.3    Kakegawa, K.4    Irie, K.5    Morimatsu, M.6
  • 7
    • 0027272850 scopus 로고
    • Prognostic value of tumor “budding” in patients with colorectal cancer
    • 8348847
    • K.Hase, C.Shatney, D.Johnson, M.Trollope, M.Vierra. Prognostic value of tumor “budding” in patients with colorectal cancer. Dis Colon Rectum 1993; 36:627-35; PMID:8348847; http://dx.doi.org/10.1007/BF02238588
    • (1993) Dis Colon Rectum , vol.36 , pp. 627-635
    • Hase, K.1    Shatney, C.2    Johnson, D.3    Trollope, M.4    Vierra, M.5
  • 8
    • 0029810605 scopus 로고    scopus 로고
    • Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis
    • 8826938
    • M.Ono, M.Sakamoto, Y.Ino, Y.Moriya, K.Sugihara, T.Muto, S.Hirohashi. Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis. Cancer 1996; 78:1179-86; PMID:8826938; http://dx.doi.org/10.1002/(SICI)1097-0142(19960915)78:6<1179::AID-CNCR3>3.0.CO;2-5
    • (1996) Cancer , vol.78 , pp. 1179-1186
    • Ono, M.1    Sakamoto, M.2    Ino, Y.3    Moriya, Y.4    Sugihara, K.5    Muto, T.6    Hirohashi, S.7
  • 9
    • 0032925597 scopus 로고    scopus 로고
    • Histologic features associated with lymph node metastasis in stage T1 and superficial T2 rectal adenocarcinomas in abdominoperineal resection specimens. Identifying a subset of patients for whom treatment with adjuvant therapy or completion abdominoperineal resection should be considered after local excision
    • 9894454
    • N.S.Goldstein, J.Hart. Histologic features associated with lymph node metastasis in stage T1 and superficial T2 rectal adenocarcinomas in abdominoperineal resection specimens. Identifying a subset of patients for whom treatment with adjuvant therapy or completion abdominoperineal resection should be considered after local excision. Am J Clin Pathol 1999; 111:51-8; PMID:9894454
    • (1999) Am J Clin Pathol , vol.111 , pp. 51-58
    • Goldstein, N.S.1    Hart, J.2
  • 10
    • 0036251472 scopus 로고    scopus 로고
    • Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma
    • 12004212
    • T.Okuyama, M.Oya, H.Ishikawa. Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma. Dis Colon Rectum 2002; 45:628-34; PMID:12004212; http://dx.doi.org/10.1007/s10350-004-6259-0
    • (2002) Dis Colon Rectum , vol.45 , pp. 628-634
    • Okuyama, T.1    Oya, M.2    Ishikawa, H.3
  • 11
    • 34548529964 scopus 로고    scopus 로고
    • Study on independent factors on the prognosis of colorectal carcinoma: TNM stage, tumor budding, perineural invasion, peritumoral-lymphocytic infiltration and urine glucose
    • 16053766
    • F.Y.Xu, J.K.Dong, Y.M.Zhu, M.J.Qu, F.J.Wang, Y.S.Jin, G.P.Ren, M.D.Lai. Study on independent factors on the prognosis of colorectal carcinoma:TNM stage, tumor budding, perineural invasion, peritumoral-lymphocytic infiltration and urine glucose. Zhonghua liu xing bing xue za zhi 2005; 26:366-9; PMID:16053766
    • (2005) Zhonghua liu xing bing xue za zhi , vol.26 , pp. 366-369
    • Xu, F.Y.1    Dong, J.K.2    Zhu, Y.M.3    Qu, M.J.4    Wang, F.J.5    Jin, Y.S.6    Ren, G.P.7    Lai, M.D.8
  • 12
    • 79551631724 scopus 로고    scopus 로고
    • Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells
    • M.Katoh. Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells. Curr Pharmaceutical Biotechnol 2011; 12:160-70; http://dx.doi.org/10.2174/138920111794295710
    • (2011) Curr Pharmaceutical Biotechnol , vol.12 , pp. 160-170
    • Katoh, M.1
  • 13
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    • 19487820
    • H.Acloque, M.S.Adams, K.Fishwick, M.Bronner-Fraser, M.A.Nieto. Epithelial-mesenchymal transitions:the importance of changing cell state in development and disease. J Clin Invest 2009; 119:1438-49; PMID:19487820; http://dx.doi.org/10.1172/JCI38019
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 14
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • 19945376
    • J.P.Thiery, H.Acloque, R.Y.Huang, M.A.Nieto. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 15
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • 23201165
    • J.H.Tsai, J.L.Donaher, D.A.Murphy, S.Chau, J.Yang. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22:725-36; PMID:23201165; http://dx.doi.org/10.1016/j.ccr.2012.09.022
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 16
    • 84857052013 scopus 로고    scopus 로고
    • Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression
    • 22099597
    • S.B.Krantz, M.A.Shields, S.Dangi-Garimella, H.G.Munshi, D.J.Bentrem. Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression. J Surg Res 2012; 173:105-12; PMID:22099597; http://dx.doi.org/10.1016/j.jss.2011.09.020
    • (2012) J Surg Res , vol.173 , pp. 105-112
    • Krantz, S.B.1    Shields, M.A.2    Dangi-Garimella, S.3    Munshi, H.G.4    Bentrem, D.J.5
  • 17
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: twist in development and metastasis
    • 15294153
    • Y.Kang, J.Massague. Epithelial-mesenchymal transitions:twist in development and metastasis. Cell 2004; 118:277-9; PMID:15294153; http://dx.doi.org/10.1016/j.cell.2004.07.011
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 19
    • 84858288644 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transition in tumor microenvironment
    • 21880137
    • Y.Jing, Z.Han, S.Zhang, Y.Liu, L.Wei. Epithelial-Mesenchymal Transition in tumor microenvironment. Cell Biosci 2011; 1:29; PMID:21880137; http://dx.doi.org/10.1186/2045-3701-1-29
    • (2011) Cell Biosci , vol.1 , pp. 29
    • Jing, Y.1    Han, Z.2    Zhang, S.3    Liu, Y.4    Wei, L.5
  • 20
    • 84872040888 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment for cancer therapy
    • 23193058
    • N.E.Sounni, A.Noel. Targeting the tumor microenvironment for cancer therapy. Clin Chem 2013; 59:85-93; PMID:23193058; http://dx.doi.org/10.1373/clinchem.2012.185363
    • (2013) Clin Chem , vol.59 , pp. 85-93
    • Sounni, N.E.1    Noel, A.2
  • 21
    • 84907501988 scopus 로고    scopus 로고
    • Signaling mechanisms of the epithelial-mesenchymal transition
    • 25249658
    • D.M.Gonzalez, D.Medici. Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal 2014; 7:re8; PMID:25249658; http://dx.doi.org/10.1126/scisignal.2005189
    • (2014) Sci Signal , vol.7 , pp. re8
    • Gonzalez, D.M.1    Medici, D.2
  • 22
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • H.Peinado, D.Olmeda, A.Cano. Snail, Zeb and bHLH factors in tumour progression:an alliance against the epithelial phenotype?. Nature Rev Cancer 2007; 7:415-28; http://dx.doi.org/10.1038/nrc2131
    • (2007) Nature Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 23
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    • 21199805
    • E.Casas, J.Kim, A.Bendesky, L.Ohno-Machado, C.J.Wolfe, J.Yang. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 2011; 71:245-54; PMID:21199805; http://dx.doi.org/10.1158/0008-5472.CAN-10-2330
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 24
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • M.A.Nieto The ins and outs of the epithelial to mesenchymal transition in health and disease. Ann Rev Cell Dev Biol 2011; 27:347-76; http://dx.doi.org/10.1146/annurev-cellbio-092910-154036
    • (2011) Ann Rev Cell Dev Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 25
    • 34447272058 scopus 로고    scopus 로고
    • Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment
    • 17243120
    • J.C.Tse, R.Kalluri. Mechanisms of metastasis:epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 2007; 101:816-29; PMID:17243120; http://dx.doi.org/10.1002/jcb.21215
    • (2007) J Cell Biochem , vol.101 , pp. 816-829
    • Tse, J.C.1    Kalluri, R.2
  • 26
    • 31444456086 scopus 로고    scopus 로고
    • Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2
    • 16404429
    • S.Kazama, T.Watanabe, Y.Ajioka, T.Kanazawa, H.Nagawa. Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 2006; 94:293-8; PMID:16404429; http://dx.doi.org/10.1038/sj.bjc.6602927
    • (2006) Br J Cancer , vol.94 , pp. 293-298
    • Kazama, S.1    Watanabe, T.2    Ajioka, Y.3    Kanazawa, T.4    Nagawa, H.5
  • 27
    • 84862869785 scopus 로고    scopus 로고
    • Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells
    • 22569829
    • S.S.Yusra, Semba S, H.Yokozaki. Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells. Int J Oncol 2012; 41:201-10; PMID:22569829
    • (2012) Int J Oncol , vol.41 , pp. 201-210
    • Yusra, S.S.1    Yokozaki, H.2
  • 28
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • 2673568
    • S.Paget. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 1989; 8:98-101; PMID:2673568
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 29
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • 11357145
    • L.A.Liotta, E.C.Kohn. The microenvironment of the tumour-host interface. Nature 2001; 411:375-9; PMID:11357145; http://dx.doi.org/10.1038/35077241
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 30
    • 84901767734 scopus 로고    scopus 로고
    • Chronic inflammation and cytokines in the tumor microenvironment
    • 24901008
    • G.Landskron, M.De la Fuente, P.Thuwajit, C.Thuwajit, M.A.Hermoso. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014; 2014:149185; PMID:24901008; http://dx.doi.org/10.1155/2014/149185
    • (2014) J Immunol Res , vol.2014 , pp. 149185
    • Landskron, G.1    De la Fuente, M.2    Thuwajit, P.3    Thuwajit, C.4    Hermoso, M.A.5
  • 31
    • 84892497106 scopus 로고    scopus 로고
    • Role of inflammation-associated microenvironment in tumorigenesis and metastasis
    • 24200082
    • F.Gao, B.Liang, S.T.Reddy, R.Farias-Eisner, X.Su. Role of inflammation-associated microenvironment in tumorigenesis and metastasis. Curr Cancer Drug Targets 2014; 14:30-45; PMID:24200082; http://dx.doi.org/10.2174/15680096113136660107
    • (2014) Curr Cancer Drug Targets , vol.14 , pp. 30-45
    • Gao, F.1    Liang, B.2    Reddy, S.T.3    Farias-Eisner, R.4    Su, X.5
  • 32
    • 84891585956 scopus 로고    scopus 로고
    • Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures
    • 24403855
    • T.Leibovich-Rivkin, Y.Liubomirski, B.Bernstein, T.Meshel, A.Ben-Baruch. Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells:EMT, invasion, and collapse of normally organized breast textures. Neoplasia 2013; 15:1330-46; PMID:24403855; http://dx.doi.org/10.1593/neo.131688
    • (2013) Neoplasia , vol.15 , pp. 1330-1346
    • Leibovich-Rivkin, T.1    Liubomirski, Y.2    Bernstein, B.3    Meshel, T.4    Ben-Baruch, A.5
  • 33
    • 79953904617 scopus 로고    scopus 로고
    • Inflammatory mediators in breast cancer: coordinated expression of TNFalpha & IL-1beta with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    • 21486440
    • G.Soria, M.Ofri-Shahak, I.Haas, N.Yaal-Hahoshen, L.Leider-Trejo, T.Leibovich-Rivkin, P.Weitzenfeld, T.Meshel, E.Shabtai, M.Gutman, et al. Inflammatory mediators in breast cancer:coordinated expression of TNFalpha & IL-1beta with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer 2011; 11:130; PMID:21486440; http://dx.doi.org/10.1186/1471-2407-11-130
    • (2011) BMC Cancer , vol.11 , pp. 130
    • Soria, G.1    Ofri-Shahak, M.2    Haas, I.3    Yaal-Hahoshen, N.4    Leider-Trejo, L.5    Leibovich-Rivkin, T.6    Weitzenfeld, P.7    Meshel, T.8    Shabtai, E.9    Gutman, M.10
  • 34
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    • 16862183
    • H.L.Chua, P.Bhat-Nakshatri, S.E.Clare, A.Morimiya, S.Badve, H.Nakshatri. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells:potential involvement of ZEB-1 and ZEB-2. Oncogene 2007; 26:711-24; PMID:16862183; http://dx.doi.org/10.1038/sj.onc.1209808
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 35
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: a double-edged sword
    • 12949498
    • B.B.Aggarwal Signalling pathways of the TNF superfamily:a double-edged sword. Nat Rev Immunol 2003; 3:745-56; PMID:12949498; http://dx.doi.org/10.1038/nri1184
    • (2003) Nat Rev Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 36
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • 16175180
    • M.Karin, F.R.Greten. NF-kappaB:linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5:749-59; PMID:16175180; http://dx.doi.org/10.1038/nri1703
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 37
    • 84923082160 scopus 로고    scopus 로고
    • S100 proteins in cancer
    • 25614008
    • A.R.Bresnick, D.J.Weber, D.B.Zimmer. S100 proteins in cancer. Nat Rev Cancer 2015; 15:96-109; PMID:25614008; http://dx.doi.org/10.1038/nrc3893
    • (2015) Nat Rev Cancer , vol.15 , pp. 96-109
    • Bresnick, A.R.1    Weber, D.J.2    Zimmer, D.B.3
  • 38
    • 84898769460 scopus 로고    scopus 로고
    • TGF-beta1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells
    • 24705025
    • R.Singh, B.S.Shankar, K.B.Sainis. TGF-beta1-ROS-ATM-CREB signaling axis in macrophage mediated migration of human breast cancer MCF7 cells. Cell Signal 2014; 26:1604-15; PMID:24705025; http://dx.doi.org/10.1016/j.cellsig.2014.03.028
    • (2014) Cell Signal , vol.26 , pp. 1604-1615
    • Singh, R.1    Shankar, B.S.2    Sainis, K.B.3
  • 39
    • 80053609350 scopus 로고    scopus 로고
    • Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment
    • 21839702
    • B.R.Achyut, L.Yang. Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment. Gastroenterology 2011; 141:1167-78; PMID:21839702; http://dx.doi.org/10.1053/j.gastro.2011.07.048
    • (2011) Gastroenterology , vol.141 , pp. 1167-1178
    • Achyut, B.R.1    Yang, L.2
  • 40
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes
    • 20519943
    • J.Fuxe, T.Vincent, A.Garcia de Herreros. Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion:role of EMT promoting Smad complexes. Cell cycle 2010; 9:2363-74; PMID:20519943; http://dx.doi.org/10.4161/cc.9.12.12050
    • (2010) Cell cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    Garcia de Herreros, A.3
  • 41
    • 78651322595 scopus 로고    scopus 로고
    • Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells
    • 21069735
    • J.A.Shin, O.K.Hong, H.J.Lee, S.Y.Jeon, J.W.Kim, S.H.Lee, J.H.Cho, J.M.Lee, Y.H.Choi, S.A.Chang, et al. Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells. J Cell Biochem 2011; 112:179-88; PMID:21069735; http://dx.doi.org/10.1002/jcb.22929
    • (2011) J Cell Biochem , vol.112 , pp. 179-188
    • Shin, J.A.1    Hong, O.K.2    Lee, H.J.3    Jeon, S.Y.4    Kim, J.W.5    Lee, S.H.6    Cho, J.H.7    Lee, J.M.8    Choi, Y.H.9    Chang, S.A.10
  • 42
    • 84858967143 scopus 로고    scopus 로고
    • Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor β-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3
    • 22458379
    • L.Zhu, H.Qin, P.Y.Li, S.N.Xu, H.F.Pang, H.Z.Zhao, D.M.Li, Q.Zhao. Response gene to complement-32 enhances metastatic phenotype by mediating transforming growth factor β-induced epithelial-mesenchymal transition in human pancreatic cancer cell line BxPC-3. J Exp Clin Cancer Res 2012; 31:29; PMID:22458379; http://dx.doi.org/10.1186/1756-9966-31-29
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 29
    • Zhu, L.1    Qin, H.2    Li, P.Y.3    Xu, S.N.4    Pang, H.F.5    Zhao, H.Z.6    Li, D.M.7    Zhao, Q.8
  • 44
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • 21102609
    • L.Trusolino, A.Bertotti, P.M.Comoglio. MET signalling:principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010; 11:834-48; PMID:21102609; http://dx.doi.org/10.1038/nrm3012
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 45
    • 84887024873 scopus 로고    scopus 로고
    • Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6
    • 24011634
    • A.Abulaiti, Y.Shintani, S.Funaki, T.Nakagiri, M.Inoue, N.Sawabata, M.Minami, M.Okumura. Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6. Lung Cancer 2013; 82:204-13; PMID:24011634; http://dx.doi.org/10.1016/j.lungcan.2013.08.008
    • (2013) Lung Cancer , vol.82 , pp. 204-213
    • Abulaiti, A.1    Shintani, Y.2    Funaki, S.3    Nakagiri, T.4    Inoue, M.5    Sawabata, N.6    Minami, M.7    Okumura, M.8
  • 46
    • 84055207487 scopus 로고    scopus 로고
    • IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
    • 21976712
    • A.Yadav, B.Kumar, J.Datta, T.N.Teknos, P.Kumar. IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway. Mol Cancer Res 2011; 9:1658-67; PMID:21976712; http://dx.doi.org/10.1158/1541-7786.MCR-11-0271
    • (2011) Mol Cancer Res , vol.9 , pp. 1658-1667
    • Yadav, A.1    Kumar, B.2    Datta, J.3    Teknos, T.N.4    Kumar, P.5
  • 48
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: adapting the foreign soil
    • B.Psaila, D.Lyden. The metastatic niche:adapting the foreign soil. Nature Rev Cancer 2009; 9:285-93; http://dx.doi.org/10.1038/nrc2621
    • (2009) Nature Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 49
    • 84890314061 scopus 로고    scopus 로고
    • The pre-metastatic niche: finding common ground
    • 23636348
    • J.Sceneay, M.J.Smyth, A.Moller. The pre-metastatic niche:finding common ground. Cancer Metastasis Rev 2013; 32:449-64; PMID:23636348; http://dx.doi.org/10.1007/s10555-013-9420-1
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 449-464
    • Sceneay, J.1    Smyth, M.J.2    Moller, A.3
  • 50
    • 0034984740 scopus 로고    scopus 로고
    • VEGF as a mediator of tumor-associated immunodeficiency
    • J.E.Ohm, D.P.Carbone. VEGF as a mediator of tumor-associated immunodeficiency. Immunologic Res 2001; 23:263-72; http://dx.doi.org/10.1385/IR:23:2-3:263
    • (2001) Immunologic Res , vol.23 , pp. 263-272
    • Ohm, J.E.1    Carbone, D.P.2
  • 51
    • 78650319036 scopus 로고    scopus 로고
    • Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions
    • 21150330
    • H.W.Wang, J.A.Joyce. Alternative activation of tumor-associated macrophages by IL-4:priming for protumoral functions. Cell Cycle 2010; 9:4824-35; PMID:21150330; http://dx.doi.org/10.4161/cc.9.24.14322
    • (2010) Cell Cycle , vol.9 , pp. 4824-4835
    • Wang, H.W.1    Joyce, J.A.2
  • 52
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    • 23284651
    • Q.W.Zhang, L.Liu, C.Y.Gong, H.S.Shi, Y.H.Zeng, X.Z.Wang, Y.W.Zhao, Y.Q.Wei. Prognostic significance of tumor-associated macrophages in solid tumor:a meta-analysis of the literature. PloS One 2012; 7:e50946; PMID:23284651; http://dx.doi.org/10.1371/journal.pone.0050946
    • (2012) PloS One , vol.7 , pp. 50946
    • Zhang, Q.W.1    Liu, L.2    Gong, C.Y.3    Shi, H.S.4    Zeng, Y.H.5    Wang, X.Z.6    Zhao, Y.W.7    Wei, Y.Q.8
  • 53
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • 20371344
    • B.Z.Qian, J.W.Pollard. Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141:39-51; PMID:20371344; http://dx.doi.org/10.1016/j.cell.2010.03.014
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 54
    • 84900335537 scopus 로고    scopus 로고
    • A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
    • 24823638
    • S.Su, Q.Liu, J.Chen, J.Chen, F.Chen, C.He, D.Huang, W.Wu, L.Lin, W.Huang, et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 2014; 25:605-20; PMID:24823638; http://dx.doi.org/10.1016/j.ccr.2014.03.021
    • (2014) Cancer Cell , vol.25 , pp. 605-620
    • Su, S.1    Liu, Q.2    Chen, J.3    Chen, J.4    Chen, F.5    He, C.6    Huang, D.7    Wu, W.8    Lin, L.9    Huang, W.10
  • 55
    • 84879663836 scopus 로고    scopus 로고
    • M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway
    • C.Y.Liu, J.Y.Xu, X.Y.Shi, W.Huang, T.Y.Ruan, P.Xie, J.L.Ding. M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Investi J Tech Methods Pathol 2013; 93:844-54; http://dx.doi.org/10.1038/labinvest.2013.69
    • (2013) Lab Investi J Tech Methods Pathol , vol.93 , pp. 844-854
    • Liu, C.Y.1    Xu, J.Y.2    Shi, X.Y.3    Huang, W.4    Ruan, T.Y.5    Xie, P.6    Ding, J.L.7
  • 56
    • 84903952426 scopus 로고    scopus 로고
    • Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition
    • 24743511
    • J.Ou, Y.Peng, J.Deng, H.Miao, J.Zhou, L.Zha, R.Zhou, L.Yu, H.Shi, H.Liang. Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition. Carcinogenesis 2014; 35:1661-70; PMID:24743511; http://dx.doi.org/10.1093/carcin/bgu090
    • (2014) Carcinogenesis , vol.35 , pp. 1661-1670
    • Ou, J.1    Peng, Y.2    Deng, J.3    Miao, H.4    Zhou, J.5    Zha, L.6    Zhou, R.7    Yu, L.8    Shi, H.9    Liang, H.10
  • 57
    • 84920853031 scopus 로고    scopus 로고
    • Tumor matrix protein collagen XIalpha1 in cancer
    • 25511741
    • Z.Raglow, S.M.Thomas. Tumor matrix protein collagen XIalpha1 in cancer. Cancer Letters 2015; 357:448-53; PMID:25511741; http://dx.doi.org/10.1016/j.canlet.2014.12.011
    • (2015) Cancer Letters , vol.357 , pp. 448-453
    • Raglow, Z.1    Thomas, S.M.2
  • 58
  • 59
    • 0029312252 scopus 로고
    • Involvement of extracellular matrix constituents in breast cancer
    • A.Lochter, M.J.Bissell. Involvement of extracellular matrix constituents in breast cancer. Seminars Cancer Biol 1995; 6:165-73; http://dx.doi.org/10.1006/scbi.1995.0017
    • (1995) Seminars Cancer Biol , vol.6 , pp. 165-173
    • Lochter, A.1    Bissell, M.J.2
  • 60
    • 0036178475 scopus 로고    scopus 로고
    • Order and disorder: the role of extracellular matrix in epithelial cancer
    • 11852996
    • D.Radisky, J.Muschler, M.J.Bissell. Order and disorder:the role of extracellular matrix in epithelial cancer. Cancer Invest 2002; 20:139-53; PMID:11852996; http://dx.doi.org/10.1081/CNV-120000374
    • (2002) Cancer Invest , vol.20 , pp. 139-153
    • Radisky, D.1    Muschler, J.2    Bissell, M.J.3
  • 61
    • 69449095475 scopus 로고    scopus 로고
    • Stroma-epithelium crosstalk in prostate cancer
    • 19098934
    • Y.N.Niu, S.J.Xia. Stroma-epithelium crosstalk in prostate cancer. Asian J Androl 2009; 11:28-35; PMID:19098934; http://dx.doi.org/10.1038/aja.2008.39
    • (2009) Asian J Androl , vol.11 , pp. 28-35
    • Niu, Y.N.1    Xia, S.J.2
  • 62
    • 33846782878 scopus 로고    scopus 로고
    • Collagen reorganization at the tumor-stromal interface facilitates local invasion
    • 17190588
    • P.P.Provenzano, K.W.Eliceiri, J.M.Campbell, D.R.Inman, J.G.White, P.J.Keely. Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med 2006; 4:38; PMID:17190588; http://dx.doi.org/10.1186/1741-7015-4-38
    • (2006) BMC Med , vol.4 , pp. 38
    • Provenzano, P.P.1    Eliceiri, K.W.2    Campbell, J.M.3    Inman, D.R.4    White, J.G.5    Keely, P.J.6
  • 63
    • 33745603471 scopus 로고    scopus 로고
    • Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and upregulation of N-cadherin expression in mouse mammary epithelial cells
    • 16624865
    • Y.Shintani, M.J.Wheelock, K.R.Johnson. Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and upregulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell 2006; 17:2963-75; PMID:16624865; http://dx.doi.org/10.1091/mbc.E05-12-1123
    • (2006) Mol Biol Cell , vol.17 , pp. 2963-2975
    • Shintani, Y.1    Wheelock, M.J.2    Johnson, K.R.3
  • 64
    • 84872200290 scopus 로고    scopus 로고
    • The laminin family
    • 23263632
    • M.Aumailley The laminin family. Cell Adhesion Migration 2013; 7:48-55; PMID:23263632; http://dx.doi.org/10.4161/cam.22826
    • (2013) Cell Adhesion Migration , vol.7 , pp. 48-55
    • Aumailley, M.1
  • 66
    • 84884990423 scopus 로고    scopus 로고
    • Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells
    • 23660532
    • Q.K.Chen, K.Lee, D.C.Radisky, C.M.Nelson. Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differ Res Biol Diversity 2013; 86:126-32; PMID:23660532; http://dx.doi.org/10.1016/j.diff.2013.03.003
    • (2013) Differ Res Biol Diversity , vol.86 , pp. 126-132
    • Chen, Q.K.1    Lee, K.2    Radisky, D.C.3    Nelson, C.M.4
  • 67
    • 0026559653 scopus 로고
    • Hyaluronan and cell locomotion
    • 1380898
    • E.A.Turley. Hyaluronan and cell locomotion. Cancer Metastasis Rev 1992; 11:21-30; PMID:1380898; http://dx.doi.org/10.1007/BF00047600
    • (1992) Cancer Metastasis Rev , vol.11 , pp. 21-30
    • Turley, E.A.1
  • 70
    • 77957746194 scopus 로고    scopus 로고
    • Metabolic microenvironment of tumor cells: a key factor in malignant progression
    • 21403604
    • P.Vaupel. Metabolic microenvironment of tumor cells:a key factor in malignant progression. Exp Oncol 2010; 32:125-7; PMID:21403604
    • (2010) Exp Oncol , vol.32 , pp. 125-127
    • Vaupel, P.1
  • 71
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • 21508971
    • W.H.Koppenol, P.L.Bounds, C.V.Dang. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11:325-37; PMID:21508971; http://dx.doi.org/10.1038/nrc3038
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 72
    • 80054776840 scopus 로고    scopus 로고
    • Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer
    • 22039417
    • M.Chen, J.Zhang, N.Li, Z.Qian, M.Zhu, Q.Li, J.Zheng, X.Wang, G.Shi. Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer. PloS One 2011; 6:e25564; PMID:22039417; http://dx.doi.org/10.1371/journal.pone.0025564
    • (2011) PloS One , vol.6 , pp. 25564
    • Chen, M.1    Zhang, J.2    Li, N.3    Qian, Z.4    Zhu, M.5    Li, Q.6    Zheng, J.7    Wang, X.8    Shi, G.9
  • 73
    • 75149159101 scopus 로고    scopus 로고
    • Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
    • 19881551
    • X.Liu, X.Wang, J.Zhang, E.K.Lam, V.Y.Shin, A.S.Cheng, J.Yu, F.K.Chan, J.J.Sung, H.C.Jin. Warburg effect revisited:an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene 2010; 29:442-50; PMID:19881551; http://dx.doi.org/10.1038/onc.2009.332
    • (2010) Oncogene , vol.29 , pp. 442-450
    • Liu, X.1    Wang, X.2    Zhang, J.3    Lam, E.K.4    Shin, V.Y.5    Cheng, A.S.6    Yu, J.7    Chan, F.K.8    Sung, J.J.9    Jin, H.C.10
  • 74
    • 84876434755 scopus 로고    scopus 로고
    • Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer
    • 23453623
    • C.Dong, T.Yuan, Y.Wu, Y.Wang, T.W.Fan, S.Miriyala, Y.Lin, J.Yao, J.Shi, T.Kang, et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 2013; 23:316-31; PMID:23453623; http://dx.doi.org/10.1016/j.ccr.2013.01.022
    • (2013) Cancer Cell , vol.23 , pp. 316-331
    • Dong, C.1    Yuan, T.2    Wu, Y.3    Wang, Y.4    Fan, T.W.5    Miriyala, S.6    Lin, Y.7    Yao, J.8    Shi, J.9    Kang, T.10
  • 75
    • 84876450646 scopus 로고    scopus 로고
    • ROS links glucose metabolism to breast cancer stem cell and EMT phenotype
    • 23518342
    • M.S.Schieber, N.S.Chandel. ROS links glucose metabolism to breast cancer stem cell and EMT phenotype. Cancer Cell 2013; 23:265-7; PMID:23518342; http://dx.doi.org/10.1016/j.ccr.2013.02.021
    • (2013) Cancer Cell , vol.23 , pp. 265-267
    • Schieber, M.S.1    Chandel, N.S.2
  • 78
    • 34247184670 scopus 로고    scopus 로고
    • Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
    • 17215249
    • A.R.Todeschini, J.N.Dos Santos, K.Handa, S.I.Hakomori. Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. J Biol Chem 2007; 282:8123-33; PMID:17215249; http://dx.doi.org/10.1074/jbc.M611407200
    • (2007) J Biol Chem , vol.282 , pp. 8123-8133
    • Todeschini, A.R.1    Dos Santos, J.N.2    Handa, K.3    Hakomori, S.I.4
  • 79
    • 84934439435 scopus 로고    scopus 로고
    • Hypoxia-mediated metastasis
    • 24272354
    • J.Chang, J.Erler. Hypoxia-mediated metastasis. Adv Exp Med Biol 2014; 772:55-81; PMID:24272354; http://dx.doi.org/10.1007/978-1-4614-5915-6_3
    • (2014) Adv Exp Med Biol , vol.772 , pp. 55-81
    • Chang, J.1    Erler, J.2
  • 80
    • 84874693196 scopus 로고    scopus 로고
    • The tumor microenvironment at a glance
    • 23420197
    • F.R.Balkwill, M.Capasso, T.Hagemann. The tumor microenvironment at a glance. J Cell Sci 2012; 125:5591-6; PMID:23420197; http://dx.doi.org/10.1242/jcs.116392
    • (2012) J Cell Sci , vol.125 , pp. 5591-5596
    • Balkwill, F.R.1    Capasso, M.2    Hagemann, T.3
  • 81
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • 8756718
    • D.Hanahan, J.Folkman. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-64; PMID:8756718; http://dx.doi.org/10.1016/S0092-8674(00)80108-7
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 82
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • 19479945
    • K.Ruan, G.Song, G.Ouyang. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 2009; 107:1053-62; PMID:19479945; http://dx.doi.org/10.1002/jcb.22214
    • (2009) J Cell Biochem , vol.107 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 83
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
    • 11181773
    • M.Hockel, P.Vaupel. Tumor hypoxia:definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001; 93:266-76; PMID:11181773; http://dx.doi.org/10.1093/jnci/93.4.266
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 84
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • 16724055
    • J.Pouyssegur, F.Dayan, N.M.Mazure. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441:437-43; PMID:16724055; http://dx.doi.org/10.1038/nature04871
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 85
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • 8813149
    • M.Hockel, K.Schlenger, B.Aral, M.Mitze, U.Schaffer, P.Vaupel. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996; 56:4509-15; PMID:8813149
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 86
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • 17440684
    • P.Vaupel, A.Mayer. Hypoxia in cancer:significance and impact on clinical outcome. Cancer Metastasis Rev 2007; 26:225-39; PMID:17440684; http://dx.doi.org/10.1007/s10555-007-9055-1
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 87
    • 1542408478 scopus 로고    scopus 로고
    • Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours
    • 15007254
    • M.Weinmann, C.Belka, L.Plasswilm. Tumour hypoxia:impact on biology, prognosis and treatment of solid malignant tumours. Onkologie 2004; 27:83-90; PMID:15007254; http://dx.doi.org/10.1159/000075611
    • (2004) Onkologie , vol.27 , pp. 83-90
    • Weinmann, M.1    Belka, C.2    Plasswilm, L.3
  • 88
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 13130303
    • G.L.Semenza Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32; PMID:13130303; http://dx.doi.org/10.1038/nrc1187
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 89
    • 84891629719 scopus 로고    scopus 로고
    • Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition
    • 24070739
    • A.Kannan, A.Krishnan, M.Ali, S.Subramaniam, D.Halagowder, N.D.Sivasithamparam. Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition. Eur J Cancer 2014; 50:204-15; PMID:24070739; http://dx.doi.org/10.1016/j.ejca.2013.08.016
    • (2014) Eur J Cancer , vol.50 , pp. 204-215
    • Kannan, A.1    Krishnan, A.2    Ali, M.3    Subramaniam, S.4    Halagowder, D.5    Sivasithamparam, N.D.6
  • 90
    • 84911991734 scopus 로고    scopus 로고
    • Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia
    • 25130389
    • T.Ren, W.Zhang, X.Liu, H.Zhao, J.Zhang, J.Zhang, X.Li, Y.Zhang, X.Bu, M.Shi, et al. Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia. J Pathol 2014; 234:526-37; PMID:25130389; http://dx.doi.org/10.1002/path.4415
    • (2014) J Pathol , vol.234 , pp. 526-537
    • Ren, T.1    Zhang, W.2    Liu, X.3    Zhao, H.4    Zhang, J.5    Zhang, J.6    Li, X.7    Zhang, Y.8    Bu, X.9    Shi, M.10
  • 91
    • 84894231936 scopus 로고    scopus 로고
    • A ROS/STAT3/HIF-1alpha signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion
    • 24435707
    • K.H.Cho, M.J.Choi, K.J.Jeong, J.J.Kim, M.H.Hwang, S.C.Shin, C.G.Park, H.Y.Lee. A ROS/STAT3/HIF-1alpha signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion. Prostate 2014; 74:528-36; PMID:24435707; http://dx.doi.org/10.1002/pros.22776
    • (2014) Prostate , vol.74 , pp. 528-536
    • Cho, K.H.1    Choi, M.J.2    Jeong, K.J.3    Kim, J.J.4    Hwang, M.H.5    Shin, S.C.6    Park, C.G.7    Lee, H.Y.8
  • 92
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • T.Ide, Y.Kitajima, A.Miyoshi, T.Ohtsuka, M.Mitsuno, K.Ohtaka, Y.Koga, K.Miyazaki. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J Cancer J Int Du Cancer 2006; 119:2750-9; http://dx.doi.org/10.1002/ijc.22178
    • (2006) Int J Cancer J Int Du Cancer , vol.119 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6    Koga, Y.7    Miyazaki, K.8
  • 94
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • 18682804
    • A.P.Morel, M.Lievre, C.Thomas, G.Hinkal, S.Ansieau, A.Puisieux. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS one 2008; 3:e2888; PMID:18682804; http://dx.doi.org/10.1371/journal.pone.0002888
    • (2008) PloS one , vol.3 , pp. 2888
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 95
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: models and concepts
    • 17002552
    • P.Dalerba, R.W.Cho, M.F.Clarke. Cancer stem cells:models and concepts. Ann Rev Med 2007; 58:267-84; PMID:17002552; http://dx.doi.org/10.1146/annurev.med.58.062105.204854
    • (2007) Ann Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 96
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • K.Polyak, R.A.Weinberg. Transitions between epithelial and mesenchymal states:acquisition of malignant and stem cell traits. Nature Rev Cancer 2009; 9:265-73; http://dx.doi.org/10.1038/nrc2620
    • (2009) Nature Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 97
    • 54949141186 scopus 로고    scopus 로고
    • The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells
    • 18984157
    • Y.F.Chou, H.H.Chen, M.Eijpe, A.Yabuuchi, J.G.Chenoweth, P.Tesar, J.Lu, R.D.McKay, N.Geijsen. The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell 2008; 135:449-61; PMID:18984157; http://dx.doi.org/10.1016/j.cell.2008.08.035
    • (2008) Cell , vol.135 , pp. 449-461
    • Chou, Y.F.1    Chen, H.H.2    Eijpe, M.3    Yabuuchi, A.4    Chenoweth, J.G.5    Tesar, P.6    Lu, J.7    McKay, R.D.8    Geijsen, N.9
  • 99
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: a major contributor to minimal residual disease
    • 19693095
    • M.B.Meads, R.A.Gatenby, W.S.Dalton. Environment-mediated drug resistance:a major contributor to minimal residual disease. Nat Rev Cancer 2009; 9:665-74; PMID:19693095; http://dx.doi.org/10.1038/nrc2714
    • (2009) Nat Rev Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 101
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines
    • 10029595
    • J.S.Damiano, A.E.Cress, L.A.Hazlehurst, A.A.Shtil, W.S.Dalton. Cell adhesion mediated drug resistance (CAM-DR):role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999; 93:1658-67; PMID:10029595
    • (1999) Blood , vol.93 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 102
    • 33845877722 scopus 로고    scopus 로고
    • Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells
    • 17233818
    • L.A.Hazlehurst, R.F.Argilagos, W.S.Dalton. Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells. Br J Haematol 2007; 136:269-75; PMID:17233818; http://dx.doi.org/10.1111/j.1365-2141.2006.06435.x
    • (2007) Br J Haematol , vol.136 , pp. 269-275
    • Hazlehurst, L.A.1    Argilagos, R.F.2    Dalton, W.S.3
  • 103
    • 0028921477 scopus 로고
    • Interleukin-6 in human multiple myeloma
    • 7849308
    • B.Klein, X.G.Zhang, Z.Y.Lu, R.Bataille. Interleukin-6 in human multiple myeloma. Blood 1995; 85:863-72; PMID:7849308
    • (1995) Blood , vol.85 , pp. 863-872
    • Klein, B.1    Zhang, X.G.2    Lu, Z.Y.3    Bataille, R.4
  • 104
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • 8140422
    • Z.Zhong, Z.Wen, J.E.Darnell, Jr. Stat3:a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994; 264:95-8; PMID:8140422; http://dx.doi.org/10.1126/science.8140422
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 107
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • 10655586
    • A.Cano, M.A.Perez-Moreno, I.Rodrigo, A.Locascio, M.J.Blanco, M.G.del Barrio, F.Portillo, M.A.Nieto. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2:76-83; PMID:10655586; http://dx.doi.org/10.1038/35000025
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    del Barrio, M.G.6    Portillo, F.7    Nieto, M.A.8
  • 109
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • 12189386
    • J.P.Thiery. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2:442-54; PMID:12189386; http://dx.doi.org/10.1038/nrc822
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 110
    • 84860264531 scopus 로고    scopus 로고
    • Snail overexpression induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells
    • L.F.Zhu, Y.Hu, C.C.Yang, X.H.Xu, T.Y.Ning, Z.L.Wang, J.H.Ye, L.K.Liu. Snail overexpression induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells. Lab Invest J Tech Methods Pathol 2012; 92:744-52; http://dx.doi.org/10.1038/labinvest.2012.8
    • (2012) Lab Invest J Tech Methods Pathol , vol.92 , pp. 744-752
    • Zhu, L.F.1    Hu, Y.2    Yang, C.C.3    Xu, X.H.4    Ning, T.Y.5    Wang, Z.L.6    Ye, J.H.7    Liu, L.K.8
  • 111
    • 65349116534 scopus 로고    scopus 로고
    • Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition
    • 19411069
    • V.Evdokimova, C.Tognon, T.Ng, P.Ruzanov, N.Melnyk, D.Fink, A.Sorokin, L.P.Ovchinnikov, E.Davicioni, T.J.Triche, et al. Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell 2009; 15:402-15; PMID:19411069; http://dx.doi.org/10.1016/j.ccr.2009.03.017
    • (2009) Cancer Cell , vol.15 , pp. 402-415
    • Evdokimova, V.1    Tognon, C.2    Ng, T.3    Ruzanov, P.4    Melnyk, N.5    Fink, D.6    Sorokin, A.7    Ovchinnikov, L.P.8    Davicioni, E.9    Triche, T.J.10
  • 112
    • 2442705493 scopus 로고    scopus 로고
    • Snail blocks the cell cycle and confers resistance to cell death
    • 15155580
    • S.Vega, A.V.Morales, O.H.Ocana, F.Valdes, I.Fabregat, M.A.Nieto. Snail blocks the cell cycle and confers resistance to cell death. Genes Dev 2004; 18:1131-43; PMID:15155580; http://dx.doi.org/10.1101/gad.294104
    • (2004) Genes Dev , vol.18 , pp. 1131-1143
    • Vega, S.1    Morales, A.V.2    Ocana, O.H.3    Valdes, F.4    Fabregat, I.5    Nieto, M.A.6
  • 113
    • 84858199187 scopus 로고    scopus 로고
    • Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
    • 22282653
    • D.Gao, N.Joshi, H.Choi, S.Ryu, M.Hahn, R.Catena, H.Sadik, P.Argani, P.Wagner, L.T.Vahdat, et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res 2012; 72:1384-94; PMID:22282653; http://dx.doi.org/10.1158/0008-5472.CAN-11-2905
    • (2012) Cancer Res , vol.72 , pp. 1384-1394
    • Gao, D.1    Joshi, N.2    Choi, H.3    Ryu, S.4    Hahn, M.5    Catena, R.6    Sadik, H.7    Argani, P.8    Wagner, P.9    Vahdat, L.T.10
  • 114
    • 75149143363 scopus 로고    scopus 로고
    • ABC transporters in cancer: more than just drug efflux pumps
    • 20075923
    • J.I.Fletcher, M.Haber, M.J.Henderson, M.D.Norris. ABC transporters in cancer:more than just drug efflux pumps. Nat Rev Cancer 2010; 10:147-56; PMID:20075923; http://dx.doi.org/10.1038/nrc2789
    • (2010) Nat Rev Cancer , vol.10 , pp. 147-156
    • Fletcher, J.I.1    Haber, M.2    Henderson, M.J.3    Norris, M.D.4
  • 117
    • 80051495448 scopus 로고    scopus 로고
    • Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
    • 21734725
    • M.Saxena, M.A.Stephens, H.Pathak, A.Rangarajan. Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis 2011; 2:e179; PMID:21734725; http://dx.doi.org/10.1038/cddis.2011.61
    • (2011) Cell Death Dis , vol.2 , pp. 179
    • Saxena, M.1    Stephens, M.A.2    Pathak, H.3    Rangarajan, A.4
  • 118
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • 10952316
    • E.A.Clark, T.R.Golub, E.S.Lander, R.O.Hynes. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406:532-5; PMID:10952316; http://dx.doi.org/10.1038/35020106
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 119
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • 17440531
    • D.X.Nguyen, J.Massague. Genetic determinants of cancer metastasis. Nat Rev Genet 2007; 8:341-52; PMID:17440531; http://dx.doi.org/10.1038/nrg2101
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 120
    • 33751517492 scopus 로고    scopus 로고
    • S100 chemokines mediate bookmarking of premetastatic niches
    • 17139281
    • S.Rafii, D.Lyden. S100 chemokines mediate bookmarking of premetastatic niches. Nat Cell Biol 2006; 8:1321-3; PMID:17139281; http://dx.doi.org/10.1038/ncb1206-1321
    • (2006) Nat Cell Biol , vol.8 , pp. 1321-1323
    • Rafii, S.1    Lyden, D.2
  • 121
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: tumor-associated niche cells
    • 18316475
    • J.Wels, R.N.Kaplan, S.Rafii, D.Lyden. Migratory neighbors and distant invaders:tumor-associated niche cells. Genes Dev 2008; 22:559-74; PMID:18316475; http://dx.doi.org/10.1101/gad.1636908
    • (2008) Genes Dev , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4


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