Effects of candidate gene polymorphisms on the detailed fatty acids profile determined by gas chromatography in bovine milk

Journal of Dairy Science

Volumn 99, Issue 6, 2016, Pages 4558-4573

  Pegolo, S ^a   Cecchinato, A ^a   Mele, M ^b   Conte, G ^b   Schiavon, S ^a   Bittante, G ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Association analyses; Candidate genes; Milk fatty acids; Single nucleotide polymorphism

Indexed keywords

FATTY ACID; GENETIC MARKER;

ANIMAL; BOVINE; BREEDING; CHEMISTRY; FEMALE; GAS CHROMATOGRAPHY; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; GENOME-WIDE ASSOCIATION STUDY; ITALY; MILK; PHYSIOLOGY; VETERINARY;

ANIMALS; BREEDING; CATTLE; CHROMATOGRAPHY, GAS; FATTY ACIDS; FEMALE; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; ITALY; MILK; POLYMORPHISM, GENETIC;

EID: 84961179486     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2015-10420     Document Type: Article

References (63)

1. Alim M.A., Fan Y.P., Wu X.P., Xie Y., Zhang Y., Zhang S.L., Sun D.X., Zhang Y., Zhang Q., Liu L., Guo G. Genetic effects of stearoyl-coenzyme A desaturase (SCD) polymorphism on milk production traits in the Chinese dairy population. Mol. Biol. Rep. 2012, 39:8733-8740.
2. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
3. Bastin C., Soyeurt H., Gengler N. Genetic parameters of milk production traits and fatty acid contents in milk for Holstein cows in parity 1-3. J. Anim. Breed. Genet. 2013, 130:118-127.
4. Bionaz M., Loor J.J. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. J. Nutr. 2008, 138:1019-1024.
5. Blott S., Kim J.J., Moisio S., Schmidt-Kuntzel A., Cornet A., Berzi P., Cambisano N., Ford C., Grisart B., Johnson D., Karim L., Simon P., Snell R., Spelman R., Wong J., Vilkki J., Georges M., Farnir F., Coppieters W. Molecular dissection of a quantitative trait locus: A phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition. Genetics 2003, 163:253-266.
6. Borreani G., Coppa M., Revello-Chion A., Comino L., Giaccone D., Ferlay A., Tabacco E. Effect of different feeding strategies in intensive dairy farming systems on milk fatty acid profiles, and implications on feeding costs in Italy. J. Dairy Sci. 2013, 96:6840-6855.
7. Bouwman A.C., Bovenhuis H., Visker M.H., van Arendonk J.A. Genome-wide association of milk fatty acids in Dutch dairy cattle. BMC Genet. 2011, 12:43.
8. Bouwman A.C., Valente B.D., Janss L.L., Bovenhuis H., Rosa G.J. Exploring causal networks of bovine milk fatty acids in a multivariate mixed model context. Genet. Sel. Evol. 2014, 46:2.
9. Bouwman A.C., Visker M.H., van Arendonk J.A., Bovenhuis H. Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples. BMC Genet 2012, 13:93.
10. Buchanan F.C., Van Kessel A.G., Waldner C., Christensen D.A., Laarveld B., Schmutz S.M. Hot topic: an association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 2003, 86:3164-3166.
11. Buitenhuis B., Janss L.L., Poulsen N.A., Larsen L.B., Larsen M.K., Sørensen P. Genome-wide association and biological pathway analysis for milk-fat composition in Danish Holstein and Danish Jersey cattle. BMC Genomics 2014, 15:1112.
12. Cecchinato A., Chessa S., Ribeca C., Cipolat-Gotet C., Bobbo T., Casellas J., Bittante G. Genetic variation and effects of candidate-gene polymorphisms on coagulation properties, curd firmness modeling and acidity in milk from Brown Swiss cows. Animal 2015, 9:1104-1112.
13. Cecchinato A., Ribeca C., Chessa S., Cipolat-Gotet C., Maretto F., Casellas J., Bittante G. Candidate gene association analysis for milk yield, composition, urea nitrogen and somatic cell scores in Brown Swiss cows. Animal 2014, 8:1062-1070.
14. Chessa S., Bulgari O., Rossoni A., Ceriotti G., Caroli A.M. Bovine β-casein: Detection of two single nucleotide polymorphisms by bidirectional allele specific polymerase chain reaction (BAS-PCR) and monitoring of their variation. OJAS 2013, 3:36-41.
15. Chilliard Y., Ferlay A., Faulconnier Y., Bonnet M., Rouel J., Bocquier F. Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants. Proc. Nutr. Soc. 2000, 59:127-134.
16. Cipolat-Gotet C., Cecchinato A., De Marchi M., Bittante G. Factors affecting variation of different measures of cheese yield and milk nutrients recovery from an individual model cheese-manufacturing process. J. Dairy Sci. 2013, 96:7952-7965.
17. Clempson A.M., Pollott G.E., Brickell J.S., Bourne N.E., Munce N., Wathes D.C. Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows. J. Dairy Sci. 2011, 94:3618-3628.
18. Cobanoglu O., Zaitoun I., Chang Y.M., Shook G.E., Khatib H. Effects of the signal transducer and activator of transcription 1 (STAT1) gene on milk production traits in Holstein dairy cattle. J. Dairy Sci. 2006, 89:4433-4437.
19. Conte G., Mele M., Chessa S., Castiglioni B., Serra A., Pagnacco G., Secchiari P. Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J. Dairy Sci. 2010, 93:753-763.
20. Dagnachew B.S., Ådnøy T. Additive and dominance effects of casein haplotypes on milk composition and quality in Norwegian dairy goat. Small Rumin. Res. 2014, 122:59-69.
21. Dilzer A., Park Y. Implication of conjugated linoleic acid (CLA) in human health. Crit. Rev. Food Sci. Nutr. 2012, 52:488-513.
22. Falconer D.S., Mackay T.F.C. Introduction to Quantitative Genetics 1996, Longman, Essex, UK. 4th ed.
23. Feng S., Lock A.L., Gasnsworthy P.C. A rapid lipid separation method for determining fatty acid composition of milk. J. Dairy Sci. 2004, 87:3785-3788.
24. Feuermann Y., Mabjeesh S.J., Shamay A. Leptin affects prolactin action on milk protein and fat synthesis in the bovine mammary gland. J. Dairy Sci. 2004, 87:2941-2946.
25. Fievez V., Colman E., Castro-Montoya J.M., Stefanov I., Vlaeminck B. Milk odd- and branched-chain fatty acids as biomarkers of rumen function-An update. Anim. Feed Sci. Technol. 2012, 172:51-65.
26. Gebauer S.K., Chardigny J.M., Jakobsen M.U., Lamarche B., Lock A.L., Proctor S.D., Baer D.J. Effects of ruminant trans fatty acids on cardiovascular disease and cancer: A comprehensive review of epidemiological, clinical, and mechanistic studies. Adv. Nutr. 2011, 2:332-354.
27. German J.B. Dietary lipids from an evolutionary perspective: sources, structures and functions. Matern. Child Nutr. 2011, 7(Suppl. 2):2-16.
28. Geweke J. Evaluating the accuracy of sampling-based approaches to the calculation of posterior moments (with discussion). Bayesian Statistics 1992, 164-193. Oxford University Press, Oxford, UK. J.O. Berger, J.M. Bernardo, A.P. Dawid, A.F.M. Smith (Eds.).
29. Geyer C.J. Practical Markov chain Monte Carlo. Stat. Sci. 1992, 7:473-483.
30. Krag K., Poulsen N.A., Larsen M.K., Larsen L.B., Janss L.L., Buitenhuis B. Genetic parameters for milk fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach. BMC Genet. 2013, 14:79.
31. Kramer J.K.G., Hernandez M., Cruz-Hernandez C., Kraft J., Dugan M.E.R. Combining results of two GC separations partly achieves determination of all cis and trans 16:1, 18:1, 18:2 and 18:3 except CLA isomers of milk fat as demonstrated using Ag-ion SPE fractionation. Lipids 2008, 43:259-273.
32. Kurokawa N., Young E.H., Oka Y., Satoh H., Wareham N.J., Sandhu M.S., Loos R.J. The ADRB3 Trp64Arg variant and BMI: A meta-analysis of 44 833 individuals. Int. J. Obes. (Lond.) 2008, 32:1240-1249.
33. Li C., Sun D., Zhang S., Wang S., Wu X., Zhang Q., Liu L., Li Y., Qiao L. Genome wide association study identifies 20 novel promising genes associated with milk fatty acid traits in Chinese Holstein. PLoS ONE 2014, 9:e96186.
34. Marchitelli C., Contarini G., De Matteis G., Crisà A., Pariset L., Scatà M.C., Catillo G., Napolitano F., Moioli B. Milk fatty acid variability: Effect of some candidate genes involved in lipid synthesis. J. Dairy Res. 2013, 80:165-173.
35. Matsumoto H., Sasaki K., Bessho T., Kobayashi E., Abe T., Sasazaki S., Oyama K., Mannen H. The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk. Mol. Biol. Rep. 2012, 39:8637-8644.
36. Mele M. Designing milk fat to improve healthfulness and functional properties of dairy products: From feeding strategies to a genetic approach. Ital. J. Anim. Sci. 2009, 8:365-373.
37. Mele M., Conte G., Castiglioni B., Chessa S., Macciotta N.P., Serra A., Buccioni A., Pagnacco G., Secchiari P. Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. J. Dairy Sci. 2007, 90:4458-4465.
38. Mele M., Serra A., Buccioni A., Conte G., Pollicardo A., Secchiari P. Effect of soybean oil supplementation on milk fatty acid composition from Saanen goats fed diets with different forage:concentrate ratios. Ital. J. Anim. Sci. 2008, 7:297-311.
39. Mente A., de Koning L., Shannon H.S., Anand S.S. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 2009, 169:659e69.
40. Michal J.J., Zhang Z.W., Gaskins C.T. The bovine fatty acid binding protein 4 gene is significantly associated with marbling and subcutaneous fat depth in Wagyu × Limousin F2 crosses. Anim. Genet. 2006, 37:400-402.
41. Michas G., Micha R., Zampelas A. Dietary fats and cardiovascular disease: Putting together the pieces of a complicated puzzle. Atherosclerosis 2014, 234:320-328.
42. Muñoz A., Costa M. Nutritionally mediated oxidative stress and inflammation. Oxid. Med. Cell. Longev. 2013, 2013:610950.
43. Nafikov R.A., Schoonmaker J.P., Korn K.T., Noack K., Garrick D.J., Koehler K.J., Minick-Bormann J., Reecy J.M., Spurlock D.E., Beitz D.C. Sterol regulatory element binding transcription factor 1 (SREBF1) polymorphism and milk fatty acid composition. J. Dairy Sci. 2013, 96:2605-2616. a.
44. Nafikov R.A., Schoonmaker J.P., Korn K.T., Noack K., Garrick D.J., Koehler K.J., Minick-Bormann J., Reecy J.M., Spurlock D.E., Beitz D.C. Association of polymorphisms in solute carrier family 27, isoform A6 (SLC27A6) and fatty acid-binding protein-3 and fatty acid-binding protein-4 (FABP3 and FABP4) with fatty acid composition of bovine milk. J. Dairy Sci. 2013, 96:6007-6021. b.
45. Nafikov R.A., Schoonmaker J.P., Korn K.T., Noack K., Garrick D.J., Koehler K.J., Minick-Bormann J., Reecy J.M., Spurlock D.E., Beitz D.C. Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle. Genomics 2014, 104:572-581.
46. Pannier L., Mullen A.M., Hamill R.M., Stapleton P.C., Sweeney T., Jiang Z. Association analysis of single nucleotide polymorphisms in DGAT1, TG and FABP4 genes and intramuscular fat in crossbred Bos taurus cattle. Meat Sci. 2010, 85:515-518.
47. Pegolo S., Cecchinato A., Casellas J., Conte G., Mele M., Schiavon S., Bittante G. Genetic and environmental relationships of detailed milk fatty acids profile determined by gas chromatography in Brown Swiss cows. J. Dairy Sci. 2016, 99:1315-1330.
48. Raftery A.E., Lewis S.M. Implementing MCMC. Markov Chain Monte Carlo in Practice 1996, 115-130. Chapman and Hall, London, UK. W.R. Gilks, D.J. Spiegelhalter, S. Richardson (Eds.).
49. Ramírez O., Quintanilla R., Varona L., Gallardo D., Diaz I., Pena R.N., Amills M. DECR1 and ME1 genotypes are associated with lipid composition traits in Duroc pigs. J. Anim. Breed. Genet. 2014, 131:46-52.
50. Rincon G., Islas-Trejo A., Castillo A.R., Bauman D.E., German B.J., Medrano J.F. Polymorphisms in genes in the SREBP1 signalling pathway and SCD are associated with milk fatty acid composition in Holstein cattle. J. Dairy Res. 2012, 79:66-75.
51. Rudolph M.C., Russell T.D., Webb P., Neville M.C., Anderson S.M. Prolactin-mediated regulation of lipid biosynthesis genes in vivo in the lactating mammary epithelial cell. Am. J. Physiol. Endocrinol. Metab. 2011, 300:E1059-E1068.
52. Schennink A., Heck J.M.L., Bovenhuis H., Visker M.H.P.W., van Valenberg H.J.F., van Arendonk J.A.M. Milk fatty acid unsaturation: Genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1). J. Dairy Sci. 2008, 91:2135-2143.
53. Schennink A., Stoop W.M., Visker M.H., Heck J.M., Bovenhuis H., van der Poel J.J., van Valenberg H.J., van Arendonk J.A. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Anim. Genet. 2007, 38:467-473.
54. Schennink A., Stoop W.M., Visker M.H.P.W., van der Poel J.J., Bovenhuis H., van Arendonk J.A.M. Short communication: Genome-wide scan for bovine milk-fat composition. II. Quantitative trait loci for long-chain fatty acids. J. Dairy Sci. 2009, 92:4676-4682.
55. Shingfield K.J., Bonnet M., Scollan N.D. Recent developments in altering the fatty acid composition of ruminant-derived foods. Animal 2013, 7:132-162.
56. Siri-Tarino P.W., Sun Q., Hu F.B., Krauss R.M. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am. J. Clin. Nutr. 2010, 91:535e46.
57. Sorensen D., Gianola D. Likelihood, Bayesian, and MCMC Methods in Quantitative Genetics 2002, Springer-Verlag, New York, NY.
58. Stoop W.M., Schennink A., Visker M.H., Mullaart E., van Arendonk J.A., Bovenhuis H. Genome-wide scan for bovine milk-fat composition. I. Quantitative trait loci for short- and medium-chain fatty acids. J. Dairy Sci. 2009, 92:4664-4675.
59. Strillacci M.G., Frigo E., Canavesi F., Ungar Y., Schiavini F., Zaniboni L., Reghenzani L., Cozzi M.C., Samoré A.B., Kashi Y., Shimoni E., Tal-Stein R., Soller M., Lipkin E., Bagnato A. Quantitative trait loci mapping for conjugated linoleic acid, vaccenic acid and δ(9)-desaturase in Italian Brown Swiss dairy cattle using selective DNA pooling. Anim. Genet. 2014, 45:485-499.
60. Sumner-Thomson J.M., Vierck J.L., McNamara J.P. Differential expression of genes in adipose tissue of first-lactation dairy cattle. J. Dairy Sci. 2011, 94:361-369.
61. Wang X., Maltecca C., Tal-Stein R., Lipkin E., Khatib H. Association of bovine fibroblast growth factor 2 (FGF2) gene with milk fat and productive life: An example of the ability of the candidate pathway strategy to identify quantitative trait genes. J. Dairy Sci. 2008, 91:2475-2480.
62. Welte T., Garimorth K., Philipp S., Doppler W. Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells. Mol. Endocrinol. 1994, 8:1091-1102.
63. Zetouni L., de Camargo G.M., da Silva Fonseca P.D., Gil F.M., Lugo N.A., Aspilcueta-Borquis R.R., Cervini M., Tonhati H. Effects of a single nucleotide polymorphism in the leptin gene on the productive traits of dairy buffaloes (Bubalus bubalis). Mol. Biol. Rep. 2013, 40:5159-5163.