Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2 AR

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 46, 2015, Pages 14254-14259

  Lamichhane, Rajan ^a   Liu, Jeffrey J ^a,d   Pljevaljcic, Goran ^a,e   White, Kate L ^b   Van Schans, Edwin Der ^a   Katritch, Vsevolod ^a,b   Stevens, Raymond C ^a,b   Wüthrich, Kurt ^a,c   Millar, David P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c ETH ZURICH   (Switzerland)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e USA   (United States)

Author keywords

Agonists and inverse agonists; Conformational polymorphism; Phospholipid nanodiscs; Signal transduction mechanisms; Single molecule fluorescence spectroscopy

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA ADRENERGIC RECEPTOR; FORMOTEROL; G PROTEIN COUPLED RECEPTOR; NANODISC; PHOSPHOLIPID; BETA 2 ADRENERGIC RECEPTOR; CARBOCYANINE; CYANINE DYE 3; PROPANOLAMINE DERIVATIVE;

ARTICLE; CONFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; HUMAN; MOLECULAR MECHANICS; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; MOLECULAR DYNAMICS;

BINDING SITES; CARBOCYANINES; HUMANS; MOLECULAR DYNAMICS SIMULATION; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-2;

EID: 84961177760     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519626112     Document Type: Article

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