-
2
-
-
0036758662
-
Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
-
Dai Y, Iwata K, Fukuoka T, Kondo E, Tokunaga A, Yamanaka H, Tachibana T, Liu Y, Noguchi K. Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 2002;22:7737-45
-
(2002)
J Neurosci
, vol.22
, pp. 7737-7745
-
-
Dai, Y.1
Iwata, K.2
Fukuoka, T.3
Kondo, E.4
Tokunaga, A.5
Yamanaka, H.6
Tachibana, T.7
Liu, Y.8
Noguchi, K.9
-
3
-
-
0037179755
-
P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
-
Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002;36:57-68
-
(2002)
Neuron
, vol.36
, pp. 57-68
-
-
Ji, R.R.1
Samad, T.A.2
Jin, S.X.3
Schmoll, R.4
Woolf, C.J.5
-
4
-
-
0037705314
-
P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
-
Jin SX, Zhuang ZY, Woolf CJ, Ji RR. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 2003;23:4017-22
-
(2003)
J Neurosci
, vol.23
, pp. 4017-4022
-
-
Jin, S.X.1
Zhuang, Z.Y.2
Woolf, C.J.3
Ji, R.R.4
-
5
-
-
0037704450
-
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury
-
Obata K, Yamanaka H, Dai Y, Tachibana T, Fukuoka T, Tokunaga A, Yoshikawa H, Noguchi K. Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 2003;23:4117-26
-
(2003)
J Neurosci
, vol.23
, pp. 4117-4126
-
-
Obata, K.1
Yamanaka, H.2
Dai, Y.3
Tachibana, T.4
Fukuoka, T.5
Tokunaga, A.6
Yoshikawa, H.7
Noguchi, K.8
-
6
-
-
8544239374
-
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
-
Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci 2004;24:10211-22
-
(2004)
J Neurosci
, vol.24
, pp. 10211-10222
-
-
Obata, K.1
Yamanaka, H.2
Kobayashi, K.3
Dai, Y.4
Mizushima, T.5
Katsura, H.6
Fukuoka, T.7
Tokunaga, A.8
Noguchi, K.9
-
7
-
-
33645460235
-
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
-
Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 2006;26:3551-60
-
(2006)
J Neurosci
, vol.26
, pp. 3551-3560
-
-
Zhuang, Z.Y.1
Wen, Y.R.2
Zhang, D.R.3
Borsello, T.4
Bonny, C.5
Strichartz, G.R.6
Decosterd, I.7
Ji, R.R.8
-
8
-
-
58849119888
-
Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in couscious rats
-
Chen HS, He X, Qu F, Kang SM, Yu Y, Liao D, Lu SJ. Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in couscious rats. J Pain 2009;10:201-7
-
(2009)
J Pain
, vol.10
, pp. 201-207
-
-
Chen, H.S.1
He, X.2
Qu, F.3
Kang, S.M.4
Yu, Y.5
Liao, D.6
Lu, S.J.7
-
9
-
-
41549147221
-
Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia
-
Hao J, Liu MG, Yu YQ, Cao FL, Li Z, Lu ZM, Chen J. Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia. Neuroscience 2008;152:1067-75
-
(2008)
Neuroscience
, vol.152
, pp. 1067-1075
-
-
Hao, J.1
Liu, M.G.2
Yu, Y.Q.3
Cao, F.L.4
Li, Z.5
Lu, Z.M.6
Chen, J.7
-
10
-
-
0024387848
-
Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint
-
O'Brien C, Woolf CJ, Fitzgerald M, Lindsay RM, Molander C. Differences in the chemical expression of rat primary afferent neurons which innervate skin, muscle or joint. Neuroscience 1989;32:493-502
-
(1989)
Neuroscience
, vol.32
, pp. 493-502
-
-
O'Brien, C.1
Woolf, C.J.2
Fitzgerald, M.3
Lindsay, R.M.4
Molander, C.5
-
11
-
-
0027433726
-
Afferent and spinal mechanisms of joint pain
-
Schaible HG, Grubb BD. Afferent and spinal mechanisms of joint pain. Pain 1993;55:5-54
-
(1993)
Pain
, vol.55
, pp. 5-54
-
-
Schaible, H.G.1
Grubb, B.D.2
-
12
-
-
0021286757
-
Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat
-
Wall PD, Woolf CJ. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol 1984;356:443-58
-
(1984)
J Physiol
, vol.356
, pp. 443-458
-
-
Wall, P.D.1
Woolf, C.J.2
-
13
-
-
21844449963
-
Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
-
Cruz CD, Neto FL, Castro-Lopes J, McMahon SB, Cruz F. Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats. Pain 2005;116:411-9
-
(2005)
Pain
, vol.116
, pp. 411-419
-
-
Cruz, C.D.1
Neto, F.L.2
Castro-Lopes, J.3
McMahon, S.B.4
Cruz, F.5
-
14
-
-
33744511186
-
The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint
-
Seino D, Tokunaga A, Tachibana T, Yoshiya S, Dai Y, Obata K, Yamanaka H, Kobayashi K, Noguchi K. The role of ERK signaling and the P2X receptor on mechanical pain evoked by movement of inflamed knee joint. Pain 2006;123:193-203
-
(2006)
Pain
, vol.123
, pp. 193-203
-
-
Seino, D.1
Tokunaga, A.2
Tachibana, T.3
Yoshiya, S.4
Dai, Y.5
Obata, K.6
Yamanaka, H.7
Kobayashi, K.8
Noguchi, K.9
-
15
-
-
17044392271
-
ERK1/2 regulates epidermal chemokine expression and skin inflammation
-
Pastore S, Mascia F, Mariotti F, Dattilo C, Mariani V, Girolomoni G. ERK1/2 regulates epidermal chemokine expression and skin inflammation. J Immunol 2005;174:5047-56
-
(2005)
J Immunol
, vol.174
, pp. 5047-5056
-
-
Pastore, S.1
Mascia, F.2
Mariotti, F.3
Dattilo, C.4
Mariani, V.5
Girolomoni, G.6
-
16
-
-
3042651612
-
Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: Relevance to the decrease of spinal c-fos expression in rats
-
Zhang GH, Min SS, Lee KS, Back SK, Yoon SJ, Yoon YW, Kim YI, Na HS, Hong SK, Han HC. Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats. Anesth Analg 2004;99:152-8
-
(2004)
Anesth Analg
, vol.99
, pp. 152-158
-
-
Zhang, G.H.1
Min, S.S.2
Lee, K.S.3
Back, S.K.4
Yoon, S.J.5
Yoon, Y.W.6
Kim, Y.I.7
Na, H.S.8
Hong, S.K.9
Han, H.C.10
-
17
-
-
67349085749
-
Inhibition of the N-methyl-D-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery
-
Zhang GH, Min SS, Seol GH, Lee KS, Han H, Kim YI, Han HC. Inhibition of the N-methyl-D-aspartate receptor unmasks the antinociception of endogenous opioids in the periphery. Pain 2009;143:233-7
-
(2009)
Pain
, vol.143
, pp. 233-237
-
-
Zhang, G.H.1
Min, S.S.2
Seol, G.H.3
Lee, K.S.4
Han, H.5
Kim, Y.I.6
Han, H.C.7
-
18
-
-
77957904816
-
Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice
-
Manjavachi MN, Motta EM, Marotta DM, Leite DF, Calixto JB. Mechanisms involved in IL-6-induced muscular mechanical hyperalgesia in mice. Pain 2010;151:345-55
-
(2010)
Pain
, vol.151
, pp. 345-355
-
-
Manjavachi, M.N.1
Motta, E.M.2
Marotta, D.M.3
Leite, D.F.4
Calixto, J.B.5
-
19
-
-
25144513521
-
C-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity
-
Doya H, Ohtori S, Fujitani M, Saito T, Hata K, Ino H, Takahashi K, Moriya H, Yamashita T. c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochem Biophys Res Commun 2005;335:132-8
-
(2005)
Biochem Biophys Res Commun
, vol.335
, pp. 132-138
-
-
Doya, H.1
Ohtori, S.2
Fujitani, M.3
Saito, T.4
Hata, K.5
Ino, H.6
Takahashi, K.7
Moriya, H.8
Yamashita, T.9
-
20
-
-
0033001088
-
Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy
-
Fernyhough P, Gallagher A, Averill SA, Priestley JV, Hounsom L, Patel J, Tomlinson DR. Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes 1999;48:881-9
-
(1999)
Diabetes
, vol.48
, pp. 881-889
-
-
Fernyhough, P.1
Gallagher, A.2
Averill, S.A.3
Priestley, J.V.4
Hounsom, L.5
Patel, J.6
Tomlinson, D.R.7
-
21
-
-
0034846991
-
Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones
-
Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV. Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 2001;18:183-96
-
(2001)
Mol Cell Neurosci
, vol.18
, pp. 183-196
-
-
Averill, S.1
Delcroix, J.D.2
Michael, G.J.3
Tomlinson, D.R.4
Fernyhough, P.5
Priestley, J.V.6
-
22
-
-
0037899137
-
NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals
-
Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, Mobley WC. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 2003;39:69-84
-
(2003)
Neuron
, vol.39
, pp. 69-84
-
-
Delcroix, J.D.1
Valletta, J.S.2
Wu, C.3
Hunt, S.J.4
Kowal, A.S.5
Mobley, W.C.6
-
23
-
-
0034623098
-
Carrageenan-induced thermal hyperalgesia in the mouse: Role of nerve growth factor and the mitogen-activated protein kinase pathway
-
Sammons MJ, Raval P, Davey PT, Rogers D, Parsons AA, Bringham S. Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. Brain Res 2000;876:48-54
-
(2000)
Brain Res
, vol.876
, pp. 48-54
-
-
Sammons, M.J.1
Raval, P.2
Davey, P.T.3
Rogers, D.4
Parsons, A.A.5
Bringham, S.6
-
24
-
-
0032928798
-
Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide- mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages
-
Paul A, Cuenda A, Bryant CE, Murray J, Chilvers ER, Cohen P, Gould GW, Plevin R. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide- mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. Cell Signal 1999;11:491-7
-
(1999)
Cell Signal
, vol.11
, pp. 491-497
-
-
Paul, A.1
Cuenda, A.2
Bryant, C.E.3
Murray, J.4
Chilvers, E.R.5
Cohen, P.6
Gould, G.W.7
Plevin, R.8
-
25
-
-
0032928614
-
Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
-
Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 1999;79:143-80
-
(1999)
Physiol Rev
, vol.79
, pp. 143-180
-
-
Widmann, C.1
Gibson, S.2
Jarpe, M.B.3
Johnson, G.L.4
-
26
-
-
34548800403
-
P38 pathway kinases as anti-inflammatory drug targets
-
Schindler JF, Monahan JB, Smith WG. P38 pathway kinases as anti-inflammatory drug targets. J Dent Res 2007;86:800-11
-
(2007)
J Dent Res
, vol.86
, pp. 800-811
-
-
Schindler, J.F.1
Monahan, J.B.2
Smith, W.G.3
-
27
-
-
84859874162
-
The clinical effect of the dual-targeting strategy involving P13K/ AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer
-
Shimizu T, Tolcher AW, Papadopoulos KP, Beeram M, Rasco DW, Smith LS, Gunn S, Smetzer L, Mavs TA, Kaiser B, Wick MJ, Alvarez C, Cavazos A, Mangold GL, Patnaik A. The clinical effect of the dual-targeting strategy involving P13K/ AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. Clin Cancer Res 2012;18:2316-25
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2316-2325
-
-
Shimizu, T.1
Tolcher, A.W.2
Papadopoulos, K.P.3
Beeram, M.4
Rasco, D.W.5
Smith, L.S.6
Gunn, S.7
Smetzer, L.8
Mavs, T.A.9
Kaiser, B.10
Wick, M.J.11
Alvarez, C.12
Cavazos, A.13
Mangold, G.L.14
Patnaik, A.15
-
28
-
-
66049086274
-
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
-
Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 2009;60:1232-41
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1232-1241
-
-
Damjanov, N.1
Kauffman, R.S.2
Spencer-Green, G.T.3
-
29
-
-
80455174056
-
Clinical trial of the p38 MAK kinase inhibitor dilmapimod in neuropathic pain following nerve injury
-
Anand P, Shenoy R, Plmer JE, Baines AJ, Lai RY, Robertson J, Bird N, Ostenfeld T, Chizh BA. Clinical trial of the p38 MAK kinase inhibitor dilmapimod in neuropathic pain following nerve injury. Eur J Pain 2011;15:1040-8
-
(2011)
Eur J Pain
, vol.15
, pp. 1040-1048
-
-
Anand, P.1
Shenoy, R.2
Plmer, J.E.3
Baines, A.J.4
Lai, R.Y.5
Robertson, J.6
Bird, N.7
Ostenfeld, T.8
Chizh, B.A.9
-
30
-
-
34548361839
-
Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: A prospective randomized phase I/ II study
-
Suckfuell M, Canis M, Strieth S, Scherer H, Haisch A. Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/ II study. Acta Otolaryngol 2007;127:938-42
-
(2007)
Acta Otolaryngol
, vol.127
, pp. 938-942
-
-
Suckfuell, M.1
Canis, M.2
Strieth, S.3
Scherer, H.4
Haisch, A.5
|