Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Matrix Biology

Volumn 49, Issue , 2016, Pages 37-60

  Eckhard, Ulrich ^a   Huesgen, Pitter F ^a,b   Schilling, Oliver ^a,c   Bellac, Caroline L ^a,d   Butler, Georgina S ^a   Cox, Jennifer H ^a,e   Dufour, Antoine ^a   Goebeler, Verena ^a   Kappelhoff, Reinhild ^a   auf dem Keller, Ulrich ^a,f   Klein, Theo ^a   Lange, Philipp F ^a   Marino, Giada ^a   Morrison, Charlotte J ^a   Prudova, Anna ^a   Rodriguez, David ^a,g   Starr, Amanda E ^a,h   Wang, Yili ^a   Overall, Christopher M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d Swissmedic   (Switzerland)

^e Inception Sciences ^*  (Canada)

^f ETH ZURICH   (Switzerland)

^g UNIVERSITY OF OVIEDO   (Spain)

^h UNIVERSITY OF OTTAWA   (Canada)

Author keywords

MMPs; Peptide docking; PICS; Proteomics; Quenched fluorescent peptides; Specificity profiling

Indexed keywords

AMINO ACID; ASPARAGINE; FLUORESCENT DYE; LEUCINE; MATRIX METALLOPROTEINASE; PROLINE; SYNTHETIC PEPTIDE; PEPTIDE LIBRARY;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEOMICS; AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR DOCKING; MOLECULAR MODEL; PROCEDURES; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CHROMATOGRAPHY, LIQUID; HUMANS; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PEPTIDE LIBRARY; PROTEOMICS; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84961148172     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2015.09.003     Document Type: Article

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