Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor

Journal of Molecular Biology

Volumn 312, Issue 4, 2001, Pages 743-751

  Nar, Herbert ^a   Werle, Karlheinz ^b   Bauer, Margit M T ^a   Dollinger, Horst ^a   Jung, Birgit ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b SibTeq Stable Isotope Biotechnique GmbH   (Germany)

Author keywords

Chronic obstructive pulmonary disease; Crystal structure; Macrophage metalloelastase; Matrix metalloproteinase; MMP 12

Indexed keywords

CGS 27023A; HYDROXAMIC ACID DERIVATIVE; MACROPHAGE ELASTASE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITOR COMPLEX; HUMAN; HYDROGEN BOND; INHIBITION KINETICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0035965133     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4953     Document Type: Article

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