메뉴 건너뛰기




Volumn 90, Issue 5, 2016, Pages 2240-2253

The 1918 influenza virus PB2 protein enhances virulence through the disruption of inflammatory and Wnt-mediated signaling in mice

Author keywords

[No Author keywords available]

Indexed keywords

1918 INFLUENZA VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE EXACERBATION; EMBRYO; FEMALE; GENE DISRUPTION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; INFLUENZA A VIRUS (H1N1); MOUSE; NONHUMAN; PB2 GENE; PRIORITY JOURNAL; SPANISH INFLUENZA; VIRAL GENETICS; VIRUS GENE; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS VIRULENCE; WNT SIGNALING PATHWAY; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DISEASE MODEL; ENZYMOLOGY; GENETIC REASSORTMENT; GENETICS; IMMUNOLOGY; INFLAMMATION; LUNG; METABOLISM; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; VIROLOGY; VIRULENCE;

EID: 84961146696     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02974-15     Document Type: Article
Times cited : (32)

References (70)
  • 1
    • 79953770830 scopus 로고    scopus 로고
    • The first influenza pandemic of the new millennium
    • Neumann G, Kawaoka Y. 2011. The first influenza pandemic of the new millennium. Influenza Other Respir Viruses 5:157-166. http://dx.doi.org/10.1111/j.1750-2659.2011.00231.x.
    • (2011) Influenza Other Respir Viruses , vol.5 , pp. 157-166
    • Neumann, G.1    Kawaoka, Y.2
  • 2
    • 0036514779 scopus 로고    scopus 로고
    • Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic
    • Johnson NP, Mueller J. 2002. Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med 76:105-115. http://dx.doi.org/10.1353/bhm.2002.0022.
    • (2002) Bull Hist Med , vol.76 , pp. 105-115
    • Johnson, N.P.1    Mueller, J.2
  • 3
    • 31344482504 scopus 로고    scopus 로고
    • 1918 Influenza: the mother of all pandemics
    • Taubenberger JK, Morens DM. 2006. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis 12:15-22. http://dx.doi.org/10.3201/eid1209.05-0979.
    • (2006) Emerg Infect Dis , vol.12 , pp. 15-22
    • Taubenberger, J.K.1    Morens, D.M.2
  • 4
    • 33751214219 scopus 로고    scopus 로고
    • Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes
    • Rabadan R, Levine AJ, Robins H. 2006. Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. J Virol 80:11887-11891. http://dx.doi.org/10.1128/JVI.01414-06.
    • (2006) J Virol , vol.80 , pp. 11887-11891
    • Rabadan, R.1    Levine, A.J.2    Robins, H.3
  • 5
    • 7644243243 scopus 로고    scopus 로고
    • Novel origin of the 1918 pandemic influenza virus nucleoprotein gene
    • Reid AH, Fanning TG, Janczewski TA, Lourens RM, Taubenberger JK. 2004. Novel origin of the 1918 pandemic influenza virus nucleoprotein gene. J Virol 78:12462-12470. http://dx.doi.org/10.1128/JVI.78.22.12462-12470.2004.
    • (2004) J Virol , vol.78 , pp. 12462-12470
    • Reid, A.H.1    Fanning, T.G.2    Janczewski, T.A.3    Lourens, R.M.4    Taubenberger, J.K.5
  • 6
    • 9444252844 scopus 로고    scopus 로고
    • Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
    • Reid AH, Taubenberger JK, Fanning TG. 2004. Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat Rev Microbiol 2:909-914. http://dx.doi.org/10.1038/nrmicro1027.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 909-914
    • Reid, A.H.1    Taubenberger, J.K.2    Fanning, T.G.3
  • 8
    • 84901841068 scopus 로고    scopus 로고
    • Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
    • Worobey M, Han GZ, Rambaut A. 2014. Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus. Proc Natl Acad Sci U S A 111: 8107-8112. http://dx.doi.org/10.1073/pnas.1324197111.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 8107-8112
    • Worobey, M.1    Han, G.Z.2    Rambaut, A.3
  • 11
    • 29444438899 scopus 로고    scopus 로고
    • The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
    • Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J. 2005. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A 102:18590-18595. http://dx.doi.org/10.1073/pnas.0507415102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18590-18595
    • Gabriel, G.1    Dauber, B.2    Wolff, T.3    Planz, O.4    Klenk, H.D.5    Stech, J.6
  • 12
    • 0027468737 scopus 로고
    • A single amino acid in the PB2 gene of influenza A virus is a determinant of host range
    • Subbarao EK, London W, Murphy BR. 1993. A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol 67:1761-1764.
    • (1993) J Virol , vol.67 , pp. 1761-1764
    • Subbarao, E.K.1    London, W.2    Murphy, B.R.3
  • 13
    • 26444506691 scopus 로고    scopus 로고
    • Characterization of the 1918 influenza virus polymerase genes
    • Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG. 2005. Characterization of the 1918 influenza virus polymerase genes. Nature 437:889-893. http://dx.doi.org/10.1038/nature04230.
    • (2005) Nature , vol.437 , pp. 889-893
    • Taubenberger, J.K.1    Reid, A.H.2    Lourens, R.M.3    Wang, R.4    Jin, G.5    Fanning, T.G.6
  • 14
    • 84908377315 scopus 로고    scopus 로고
    • Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells
    • Danzy S, Studdard LR, Manicassamy B, Solorzano A, Marshall N, Garcia-Sastre A, Steel J, Lowen AC. 2014. Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells. J Virol 88:13436-13446. http://dx.doi.org/10.1128/JVI.01093-14.
    • (2014) J Virol , vol.88 , pp. 13436-13446
    • Danzy, S.1    Studdard, L.R.2    Manicassamy, B.3    Solorzano, A.4    Marshall, N.5    Garcia-Sastre, A.6    Steel, J.7    Lowen, A.C.8
  • 17
    • 84876317447 scopus 로고    scopus 로고
    • 1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice
    • Watanabe T, Tisoncik-Go J, Tchitchek N, Watanabe S, Benecke AG, Katze MG, Kawaoka Y. 2013. 1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice. J Virol 87:5239-5254. http://dx.doi.org/10.1128/JVI.02753-12.
    • (2013) J Virol , vol.87 , pp. 5239-5254
    • Watanabe, T.1    Tisoncik-Go, J.2    Tchitchek, N.3    Watanabe, S.4    Benecke, A.G.5    Katze, M.G.6    Kawaoka, Y.7
  • 19
    • 27744598497 scopus 로고    scopus 로고
    • Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    • Tumpey TM, Garcia-Sastre A, Taubenberger JK, Palese P, Swayne DE, Pantin-Jackwood MJ, Schultz-Cherry S, Solorzano A, Van Rooijen N, Katz JM, Basler CF. 2005. Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol 79:14933-14944. http://dx.doi.org/10.1128/JVI.79.23.14933-14944.2005.
    • (2005) J Virol , vol.79 , pp. 14933-14944
    • Tumpey, T.M.1    Garcia-Sastre, A.2    Taubenberger, J.K.3    Palese, P.4    Swayne, D.E.5    Pantin-Jackwood, M.J.6    Schultz-Cherry, S.7    Solorzano, A.8    Van Rooijen, N.9    Katz, J.M.10    Basler, C.F.11
  • 20
    • 0030748536 scopus 로고    scopus 로고
    • Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of theHAreceptor-binding site
    • Matrosovich MN, Gambaryan AS, Teneberg S, Piskarev VE, Yamnikova SS, Lvov DK, Robertson JS, Karlsson KA. 1997. Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of theHAreceptor-binding site. Virology 233:224-234. http://dx.doi.org/10.1006/viro.1997.8580.
    • (1997) Virology , vol.233 , pp. 224-234
    • Matrosovich, M.N.1    Gambaryan, A.S.2    Teneberg, S.3    Piskarev, V.E.4    Yamnikova, S.S.5    Lvov, D.K.6    Robertson, J.S.7    Karlsson, K.A.8
  • 21
    • 0030737610 scopus 로고    scopus 로고
    • Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6'-sialyl(N-acetyllactosamine)
    • Gambaryan AS, Tuzikov AB, Piskarev VE, Yamnikova SS, Lvov DK, Robertson JS, Bovin NV, Matrosovich MN. 1997. Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6'-sialyl(N-acetyllactosamine). Virology 232:345-350. http://dx.doi.org/10.1006/viro.1997.8572.
    • (1997) Virology , vol.232 , pp. 345-350
    • Gambaryan, A.S.1    Tuzikov, A.B.2    Piskarev, V.E.3    Yamnikova, S.S.4    Lvov, D.K.5    Robertson, J.S.6    Bovin, N.V.7    Matrosovich, M.N.8
  • 22
    • 0023915219 scopus 로고
    • Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
    • Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC. 1988. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature 333:426-431. http://dx.doi.org/10.1038/333426a0.
    • (1988) Nature , vol.333 , pp. 426-431
    • Weis, W.1    Brown, J.H.2    Cusack, S.3    Paulson, J.C.4    Skehel, J.J.5    Wiley, D.C.6
  • 23
    • 0035823083 scopus 로고    scopus 로고
    • Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
    • Hatta M, Gao P, Halfmann P, Kawaoka Y. 2001. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293:1840-1842. http://dx.doi.org/10.1126/science.1062882.
    • (2001) Science , vol.293 , pp. 1840-1842
    • Hatta, M.1    Gao, P.2    Halfmann, P.3    Kawaoka, Y.4
  • 25
    • 70350330586 scopus 로고    scopus 로고
    • A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice
    • Fornek JL, Gillim-Ross L, Santos C, Carter V, Ward JM, Cheng LI, Proll S, Katze MG, Subbarao K. 2009. A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice. J Virol 83:11102-11115. http://dx.doi.org/10.1128/JVI.00994-09.
    • (2009) J Virol , vol.83 , pp. 11102-11115
    • Fornek, J.L.1    Gillim-Ross, L.2    Santos, C.3    Carter, V.4    Ward, J.M.5    Cheng, L.I.6    Proll, S.7    Katze, M.G.8    Subbarao, K.9
  • 26
    • 0022006471 scopus 로고
    • Purification and enzymatic properties of an RNA polymerase-RNA complex from influenza virus
    • Kato A, Mizumoto K, Ishihama A. 1985. Purification and enzymatic properties of an RNA polymerase-RNA complex from influenza virus. Virus Res 3:115-127. http://dx.doi.org/10.1016/0168-1702(85)90002-4.
    • (1985) Virus Res , vol.3 , pp. 115-127
    • Kato, A.1    Mizumoto, K.2    Ishihama, A.3
  • 27
    • 33744942931 scopus 로고    scopus 로고
    • Host range restriction and pathogenicity in the context of influenza pandemic
    • Neumann G, Kawaoka Y. 2006. Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis 12:881-886. http://dx.doi.org/10.3201/eid1206.051336.
    • (2006) Emerg Infect Dis , vol.12 , pp. 881-886
    • Neumann, G.1    Kawaoka, Y.2
  • 29
    • 84887623342 scopus 로고    scopus 로고
    • Adaptive mutations in the H5N1 polymerase complex
    • Gabriel G, Czudai-Matwich V, Klenk HD. 2013. Adaptive mutations in the H5N1 polymerase complex. Virus Res 178:53-62. http://dx.doi.org/10.1016/j.virusres.2013.05.010.
    • (2013) Virus Res , vol.178 , pp. 53-62
    • Gabriel, G.1    Czudai-Matwich, V.2    Klenk, H.D.3
  • 30
    • 84880366045 scopus 로고    scopus 로고
    • Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier
    • Manz B, Schwemmle M, Brunotte L. 2013. Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J Virol 87:7200-7209. http://dx.doi.org/10.1128/JVI.00980-13.
    • (2013) J Virol , vol.87 , pp. 7200-7209
    • Manz, B.1    Schwemmle, M.2    Brunotte, L.3
  • 31
    • 84866175431 scopus 로고    scopus 로고
    • Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    • Qi L, Davis AS, Jagger BW, Schwartzman LM, Dunham EJ, Kash JC, Taubenberger JK. 2012. Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice. J Virol 86:9211-9220. http://dx.doi.org/10.1128/JVI.00887-12.
    • (2012) J Virol , vol.86 , pp. 9211-9220
    • Qi, L.1    Davis, A.S.2    Jagger, B.W.3    Schwartzman, L.M.4    Dunham, E.J.5    Kash, J.C.6    Taubenberger, J.K.7
  • 34
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed LJM, H. 1938. A simple method of estimating fifty percent endpoints. Am J Hyg 27:493-497.
    • (1938) Am J Hyg , vol.27 , pp. 493-497
    • Reed, L.J.M.H.1
  • 35
    • 84864120373 scopus 로고    scopus 로고
    • Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation
    • Josset L, Belser JA, Pantin-Jackwood MJ, Chang JH, Chang ST, Belisle SE, Tumpey TM, Katze MG. 2012. Implication of inflammatory macrophages, nuclear receptors, and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J Virol 86:7192-7206. http://dx.doi.org/10.1128/JVI.00563-12.
    • (2012) J Virol , vol.86 , pp. 7192-7206
    • Josset, L.1    Belser, J.A.2    Pantin-Jackwood, M.J.3    Chang, J.H.4    Chang, S.T.5    Belisle, S.E.6    Tumpey, T.M.7    Katze, M.G.8
  • 36
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson WE, Li C, Rabinovic A. 2007. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8:118-127. http://dx.doi.org/10.1093/biostatistics/kxj037.
    • (2007) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 38
    • 77957243164 scopus 로고    scopus 로고
    • ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments
    • Lachmann A, Xu H, Krishnan J, Berger SI, Mazloom AR, Ma'ayan A. 2010. ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26:2438-2444. http://dx.doi.org/10.1093/bioinformatics/btq466.
    • (2010) Bioinformatics , vol.26 , pp. 2438-2444
    • Lachmann, A.1    Xu, H.2    Krishnan, J.3    Berger, S.I.4    Mazloom, A.R.5    Ma'ayan, A.6
  • 40
    • 58749086442 scopus 로고    scopus 로고
    • Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs
    • Biechele TL, Moon RT. 2008. Assaying beta-catenin/TCF transcription with beta-catenin/TCF transcription-based reporter constructs. Methods Mol Biol 468:99-110. http://dx.doi.org/10.1007/978-1-59745-249-6_8.
    • (2008) Methods Mol Biol , vol.468 , pp. 99-110
    • Biechele, T.L.1    Moon, R.T.2
  • 42
    • 24644484686 scopus 로고    scopus 로고
    • Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model
    • Li Z, Chen H, Jiao P, Deng G, Tian G, Li Y, Hoffmann E, Webster RG, Matsuoka Y, Yu K. 2005. Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol 79:12058-12064. http://dx.doi.org/10.1128/JVI.79.18.12058-12064.2005.
    • (2005) J Virol , vol.79 , pp. 12058-12064
    • Li, Z.1    Chen, H.2    Jiao, P.3    Deng, G.4    Tian, G.5    Li, Y.6    Hoffmann, E.7    Webster, R.G.8    Matsuoka, Y.9    Yu, K.10
  • 43
    • 44849139210 scopus 로고    scopus 로고
    • GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium
    • Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172:1542-1554. http://dx.doi.org/10.2353/ajpath.2008.071052.
    • (2008) Am J Pathol , vol.172 , pp. 1542-1554
    • Kida, H.1    Mucenski, M.L.2    Thitoff, A.R.3    Le Cras, T.D.4    Park, K.S.5    Ikegami, M.6    Muller, W.7    Whitsett, J.A.8
  • 45
    • 84906346490 scopus 로고    scopus 로고
    • H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice
    • Morrison J, Josset L, Tchitchek N, Chang J, Belser JA, Swayne DE, Pantin-Jackwood MJ, Tumpey TM, Katze MG. 2014. H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice. J Virol 88:10556-10568. http://dx.doi.org/10.1128/JVI.00570-14.
    • (2014) J Virol , vol.88 , pp. 10556-10568
    • Morrison, J.1    Josset, L.2    Tchitchek, N.3    Chang, J.4    Belser, J.A.5    Swayne, D.E.6    Pantin-Jackwood, M.J.7    Tumpey, T.M.8    Katze, M.G.9
  • 46
    • 84888434853 scopus 로고    scopus 로고
    • Immunological Genome Project and systems immunology
    • Shay T, Kang J. 2013. Immunological Genome Project and systems immunology. Trends Immunol 34:602-609. http://dx.doi.org/10.1016/j.it.2013.03.004.
    • (2013) Trends Immunol , vol.34 , pp. 602-609
    • Shay, T.1    Kang, J.2
  • 47
    • 50849097044 scopus 로고    scopus 로고
    • H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice
    • Perrone LA, Plowden JK, Garcia-Sastre A, Katz JM, Tumpey TM. 2008. H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog 4:e1000115. http://dx.doi.org/10.1371/journal.ppat.1000115.
    • (2008) PLoS Pathog , vol.4
    • Perrone, L.A.1    Plowden, J.K.2    Garcia-Sastre, A.3    Katz, J.M.4    Tumpey, T.M.5
  • 49
    • 40449128619 scopus 로고    scopus 로고
    • + effector T cells limits immunopathology in influenza pneumonia
    • + effector T cells limits immunopathology in influenza pneumonia. J Immunol 180:25-29. http://dx.doi.org/10.4049/jimmunol.180.1.25.
    • (2008) J Immunol , vol.180 , pp. 25-29
    • Zhou, J.1    Matsuoka, M.2    Cantor, H.3    Homer, R.4    Enelow, R.I.5
  • 52
    • 84928491983 scopus 로고    scopus 로고
    • Role of PRC2-associated factors in stem cells and disease
    • Vizán P, Beringer M, Ballaré C, Di Croce L. 2015. Role of PRC2-associated factors in stem cells and disease. FEBS J 282:1723-1735. http://dx.doi.org/10.1111/febs.13083.
    • (2015) FEBS J , vol.282 , pp. 1723-1735
    • Vizán, P.1    Beringer, M.2    Ballaré, C.3    Di Croce, L.4
  • 54
    • 75349104610 scopus 로고    scopus 로고
    • Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation
    • Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL. 2010. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell 6:153-166. http://dx.doi.org/10.1016/j.stem.2009.12.014.
    • (2010) Cell Stem Cell , vol.6 , pp. 153-166
    • Walker, E.1    Chang, W.Y.2    Hunkapiller, J.3    Cagney, G.4    Garcha, K.5    Torchia, J.6    Krogan, N.J.7    Reiter, J.F.8    Stanford, W.L.9
  • 58
    • 84871784297 scopus 로고    scopus 로고
    • Endogenous lung regeneration: potential and limitations
    • Rock J, Konigshoff M. 2012. Endogenous lung regeneration: potential and limitations. Am J Respir Crit Care Med 186:1213-1219. http://dx.doi.org/10.1164/rccm.201207-1151PP.
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 1213-1219
    • Rock, J.1    Konigshoff, M.2
  • 61
    • 84866169036 scopus 로고    scopus 로고
    • Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus
    • Zhang Y, Zhang Q, Gao Y, He X, Kong H, Jiang Y, Guan Y, Xia X, Shu Y, Kawaoka Y, Bu Z, Chen H. 2012. Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol 86:9666-9674. http://dx.doi.org/10.1128/JVI.00958-12.
    • (2012) J Virol , vol.86 , pp. 9666-9674
    • Zhang, Y.1    Zhang, Q.2    Gao, Y.3    He, X.4    Kong, H.5    Jiang, Y.6    Guan, Y.7    Xia, X.8    Shu, Y.9    Kawaoka, Y.10    Bu, Z.11    Chen, H.12
  • 65
    • 84926304454 scopus 로고    scopus 로고
    • Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock
    • Kuncewitch M, Yang WL, Jacob A, Khader A, Giangola M, Nicastro J, Coppa GF, Wang P. 2015. Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock. J Trauma Acute Care Surg 78:793-800. http://dx.doi.org/10.1097/TA.0000000000000566.
    • (2015) J Trauma Acute Care Surg , vol.78 , pp. 793-800
    • Kuncewitch, M.1    Yang, W.L.2    Jacob, A.3    Khader, A.4    Giangola, M.5    Nicastro, J.6    Coppa, G.F.7    Wang, P.8
  • 67
    • 84899969249 scopus 로고    scopus 로고
    • β-Catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-+B signaling
    • Hillesheim A, Nordhoff C, Boergeling Y, Ludwig S, Wixler V. 2014. β-Catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-+B signaling. Cell Commun Signal 12:29. http://dx.doi.org/10.1186/1478-811X-12-29.
    • (2014) Cell Commun Signal , vol.12 , pp. 29
    • Hillesheim, A.1    Nordhoff, C.2    Boergeling, Y.3    Ludwig, S.4    Wixler, V.5
  • 68
    • 77956634918 scopus 로고    scopus 로고
    • The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon
    • Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E. 2010. The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon. J Virol 84:8433-8445. http://dx.doi.org/10.1128/JVI.00879-10.
    • (2010) J Virol , vol.84 , pp. 8433-8445
    • Graef, K.M.1    Vreede, F.T.2    Lau, Y.F.3    McCall, A.W.4    Carr, S.M.5    Subbarao, K.6    Fodor, E.7
  • 69
    • 84873745999 scopus 로고    scopus 로고
    • Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins
    • Patel D, Schultz LW, Umland TC. 2013. Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins. Virus Res 172:75-80. http://dx.doi.org/10.1016/j.virusres.2012.12.003.
    • (2013) Virus Res , vol.172 , pp. 75-80
    • Patel, D.1    Schultz, L.W.2    Umland, T.C.3
  • 70
    • 84865095316 scopus 로고    scopus 로고
    • Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potential
    • Varga ZT, Grant A, Manicassamy B, Palese P. 2012. Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potential. J Virol 86: 8359-8366. http://dx.doi.org/10.1128/JVI.01122-12.
    • (2012) J Virol , vol.86 , pp. 8359-8366
    • Varga, Z.T.1    Grant, A.2    Manicassamy, B.3    Palese, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.