Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock

Journal of Trauma and Acute Care Surgery

Volumn 78, Issue 4, 2015, Pages 793-800

  Kuncewitch, Michael ^a   Yang, Weng Lang ^a   Jacob, Asha ^a   Khader, Adam ^a   Giangola, Matthew ^a   Nicastro, Jeffrey ^a   Coppa, Gene F ^a   Wang, Ping ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Hemorrhagic shock; inflammation, lung injury; rats; Wnt signaling

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BETA CATENIN; CASPASE 3; CREATININE; CYCLIN D1; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LACTIC ACID; MESSENGER RNA; MYELOPEROXIDASE; PROTEIN BCL 2; PROTEIN INHIBITOR; 1,3 BENZODIOXOLE DERIVATIVE; 2-AMINO-4-(3,4-(METHYLENEDIOXY)BENZYLAMINO)-6-(3-METHOXYPHENYL)PYRIMIDINE; BIOLOGICAL MARKER; CRYSTALLOID; ISOTONIC SOLUTION; PEROXIDASE; PYRIMIDINE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD VOLUME; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOWN REGULATION; ENZYME ACTIVITY; HEMORRHAGIC SHOCK; HOUSEKEEPING GENE; HUMAN; KIDNEY FUNCTION; LACTATE BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG INJURY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE INJURY; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PROCEDURES; RESUSCITATION; SHOCK, HEMORRHAGIC; SPRAGUE DAWLEY RAT;

ANIMALS; BENZODIOXOLES; BIOMARKERS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; INTERLEUKIN-6; ISOTONIC SOLUTIONS; MALE; PEROXIDASE; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RESUSCITATION; SHOCK, HEMORRHAGIC; WNT SIGNALING PATHWAY;

EID: 84926304454     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000566     Document Type: Conference Paper

References (44)

1. Cothren CC, Moore EE, Hedegaard HB, Meng K. Epidemiology of urban trauma deaths: a comprehensive reassessment 10 years later. World J Surg. 2007;31(7):1507-1511.
2. Heron M, Hoyert DL, Murphy SL, Xu J, Kochanek KD, Tejada-Vera B. Deaths: final data for 2006. Natl Vital Stat Rep. 2009;57(14):1-134.
3. Nunez TC, Cotton BA. Transfusion therapy in hemorrhagic shock. Curr Opin Crit Care. 2009;15(6):536-541.
4. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190(3):255-266.
5. Rushing GD, Britt LD. Reperfusion injury after hemorrhage: a collective review. Ann Surg. 2008;247(6):929-937.
6. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127(3):469-480.
7. Clevers H, Nusse R. Wnt/A-catenin signaling and disease. Cell. 2012; 149(6):1192-1205.
8. MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell. 2009;17(1):9-26.
9. KohnAD, Moon RT. Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium. 2005;38(3-4):439-446.
10. Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of beta-cateninYindependent Wnt signaling. Dev Cell. 2003; 5(3):367-377.
11. Gao C, Xiao G, Hu J. Regulation of Wnt/A-catenin signaling by posttranslational modifications. Cell Biosci. 2014;4(1):13.
12. Wright M, Aikawa M, SzetoW, Papkoff J. Identification of aWnt-responsive signal transduction pathway in primary endothelial cells. Biochem Biophys Res Commun. 1999;263(2):384-388.
13. Masckauchan TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J. Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis. 2005;8(1):43-451.
14. Kuncewitch M, Yang WL, Molmenti E, Nicastro J, Coppa GF, Wang P. Wnt agonist attenuates liver injury and improves survival after hepatic ischemia/reperfusion. Shock. 2013;39(1):3-10.
15. Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005; 44(13):1987-1990.
16. Cui X, Wu R, Zhou M, Dong W, Ulloa L, Yang H, Wang H, Tracey KJ, Simms HH, Wang P. Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage. Crit Care Med. 2005; 33(2):391-398.
17. Wu R, Cui X, Dong W, Zhou M, Simms HH, Wang P. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Ann Surg. 2005;242(1):115-123.
18. Wu R, DongW, Zhou M, Cui X, Simms HH, Wang P. A novel approach to maintaining cardiovascular stability after hemorrhagic shock: beneficial effects of adrenomedullin and its binding protein. Surgery. 2005;137 (2):200-208.
19. Chaung WW, Wu R, Ji Y, Dong W, Wang P. Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock. Int J Mol Med. 2012;30(1):199-203.
20. Bachofen M, Weibel ER. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med. 1982;3(1):35-56.
21. Matsuda A, Jacob A, Wu R, Zhou M, Nicastro JM, Coppa GF, Wang P. Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury. Mol Med. 2011;17(1-2):126-133.
22. Koike K, Moore EE, Moore FA, Read RA, Carl VS, Banerjee A. Gut ischemia/reperfusion produces lung injury independent of endotoxin. Crit Care Med. 1994;22(9):1438-1444.
23. Cui T, Miksa M, Wu R, Komura H, Zhou M, DongW, Wang Z, Higuchi S, Chaung W, Blau SA, et al. Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. Am J Respir Crit Care Med. 2010;181(3):238-246.
24. Fulop A, Turoczi Z, Garbaisz D, Harsanyi L, Szijarto A. Experimental models of hemorrhagic shock: a review. Eur Surg Res. 2013;50(2):57-70.
25. Gutierrez G, Reines HD, Wulf-Gutierrez ME. Clinical review: hemorrhagic shock. Crit Care. 2004;8(5):373-381.
26. Sherr CJ. Cancer cell cycles. Science. 1996;274(5293):1672-1677.
27. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A. 1999;96(10):5522-5527.
28. Liu X, Lu R, Wu S, Zhang YG, Xia Y, Sartor RB, Sun J. Wnt2 inhibits enteric bacterial-induced inflammation in intestinal epithelial cells. Inflamm Bowel Dis. 2012;18(3):418-429.
29. Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A. 2010;107(9):4194-4199.
30. Cairns CB, Moore FA, Haenel JB, Gallea BL, Ortner JP, Rose SJ, Moore EE. Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma. J Trauma. 1997; 42(3):532-6.
31. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102(1):33-42.
32. Li S, Zhao Y, He X, Kim TH, Kuharsky DK, Rabinowich H, Chen J, Du C, Yin XM. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J Biol Chem. 2002;277(30):26912-20.
33. Shigematsu S, Ishida S, Hara M, Takahashi N, Yoshimatsu H, Sakata T, Korthuis RJ. Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-Activating factor, or oxidants. Free Radic Biol Med. 2003;34(7):810-7.
34. Nelson SK, Gao B, Bose S, Rizeq M, McCord JM. A novel heparinbinding, human chimeric, superoxide dismutase improves myocardial preservation and protects from ischemia-reperfusion injury. J Heart Lung Transplant. 2002;21(12):1296-303.
35. Flynn WJ Jr, Pilati D, Hoover EL. Effect of allopurinol on venous endothelial dysfunction after resuscitated hemorrhagic shock. Int J Surg Investig. 1999;1(1):11-8.
36. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med. 1998;187(6):917-28.
37. Ding WX, Yin XM. Dissection of the multiple mechanisms of TNFalphaYinduced apoptosis in liver injury. J CellMolMed. 2004;8(4):445-54.
38. Yamada T, Takaoka AS, Naishiro Y, Hayashi R, Maruyama K, Maesawa C, Ochiai A, Hirohashi S. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis. Cancer Res. 2000;60(17):4761-6.
39. Lim JC, Kania KD, Wijesuriya H, Chawla S, Sethi JK, Pulaski L, Romero IA, Couraud PO, Weksler BB, Hladky SB, et al. Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008;106(4):1855-65.
40. Chien AJ, Conrad WH, Moon RT. A Wnt survival guide: from flies to human disease. J Invest Dermatol. 2009;129(7):1614-27.
41. Wu R, DongW, Qiang X, Ji Y, Cui T, Yang J, Zhou M, Blau S, Marini CP, Ravikumar TS, et al. Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock. Peptides. 2008; 29(7):1223-30.
42. Alderson P, Schierhout G, Roberts I, Bunn F. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2000;2. CD000567.
43. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350(22):2247-56.
44. Roberts I, Alderson P, Bunn F, Chinnock P, Ker K, Schierhout G. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2004;4. CD000567.