A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice

Journal of Virology

Volumn 83, Issue 21, 2009, Pages 11102-11115

  Fornek, Jamie L ^a   Gillim Ross, Laura ^b,c   Santos, Celia ^b   Carter, Victoria ^a   Ward, Jerrold M ^b   Cheng, Lily I ^b   Proll, Sean ^a   Katze, Michael G ^a   Subbarao, Kanta ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c Colorado Department of Public Health and Environment ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; POLYMERASE PB2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; INFLUENZA; INFLUENZA VIRUS A H5N1; LUNG INFECTION; LUNG PARENCHYMA; MOUSE; NATURAL KILLER CELL; NONHUMAN; OXYGEN SATURATION; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; RECEPTOR UPREGULATION; SPLEEN DISEASE; T LYMPHOCYTE ACTIVATION; VIRULENCE; VIRUS CELL INTERACTION; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; FEMALE; GENE EXPRESSION PROFILING; GENOME, VIRAL; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; LUNG; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICROARRAY ANALYSIS; MOLECULAR SEQUENCE DATA; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; VIRAL PROTEINS; VIRUS REPLICATION;

AVES; MUS; ORTHOMYXOVIRIDAE;

EID: 70350330586     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00994-09     Document Type: Article

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