Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 389, Issue 4, 2016, Pages 403-417

  De Barros, Mariel ^a   Mota Da Silva, Luisa ^a   Boeing, Thaise ^a   Somensi, Lincon Bordignon ^a   Cury, Benhur Judah ^a   De Moura Burci, Ligia ^b   Santin, José Roberto ^a   De Andrade, Sérgio Faloni ^a   Monache, Franco Delle ^a   Cechinel Filho, Valdir ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Afzelin; Fibroblasts; H+,K+ ATPase; Healing gastric ulcer; Quercitrin; Solidago chilensis

Indexed keywords

ACETIC ACID; AFZELIN; CARBENOXOLONE; GASTROINTESTINAL AGENT; GLUTATHIONE; METHANOL; MYELOPEROXIDASE; PLANT EXTRACT; QUERCITRIN; SOLIDAGO CHILENSIS EXTRACT; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MANNOSIDE; PROANTHOCYANIDIN; PROTON PUMP INHIBITOR; QUERCETIN; SOLVENT;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; MOUSE; NONHUMAN; PLANT LEAF; SOLIDAGO; SOLIDAGO CHILENSIS; STOMACH PROTECTION; STOMACH ULCER; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; FIBROBLAST; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PATHOLOGY; PH; PHYTOTHERAPY; RABBITS AND HARES; STOMACH MUCOSA; WISTAR RAT; WOUND HEALING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-ULCER AGENTS; CELL LINE; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLASTS; GASTRIC MUCOSA; GLUTATHIONE; H(+)-K(+)-EXCHANGING ATPASE; HYDROGEN-ION CONCENTRATION; MANNOSIDES; METHANOL; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; PROANTHOCYANIDINS; PROTON PUMP INHIBITORS; QUERCETIN; RABBITS; RATS, WISTAR; SOLIDAGO; SOLVENTS; STOMACH ULCER; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 84960803481     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1208-0     Document Type: Article

References (73)

1. Abe Y, Inagaki K, Fujiwara A, Kuriyama K (2000) Wound healing acceleration of a novel transforming growth factor-β inducer, SEK-1005. Eur J Pharmacol 408:213-218
2. Abreu Miranda M, Lemos M, Alves Cowart K, Rodenburg D, D McChesney J, Radwan MM, Furtado NA, Kenupp Bastos J (2015) Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell. J Ethnopharmacol 172:421-429
3. Allen A, Flemström G (2005) Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288:C1-C19
4. Alonso J, Desmarchelier C (2006) Plantas medicinales autóctonas de la Argentina. Bases científicas para su aplicación en atención primaria de la salud. Lola, Buenos Aires, p 663
5. Anson ML (1938) The estimation of pepsin, trypsin, papain, and cathepsin with hemoglobin. J Gen Physiol 22:79-89
6. Apáti P, Houghton PJ, Kéry A (2004) HPLC investigation of antioxidant components in Solidago herba. Acta Pharm Hung 74:223-231
7. Balekar N, Katkam NG, Nakpheng T, Jehtae K, Srichana T (2012) Evaluation of the wound healing potential of Wedelia trilobata (L.) leaves. J J Ethnopharmacol 141:817-824
8. Ballvé Alice C, de Siqueira NCS, Mentz LA, de Assis Brasil e Silva GA, José KFD (1995) Plantas medicinais de uso popular: atlas farmacognóstico. Ulbra, Canoas, p 205
9. Berté PE, da Silva LJ, Comandulli NG, Rangel DW, Monache FD, Filho VC, Niero R, de Andrade SF (2014) Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models. Naunyn Schmiedebergs Arch Pharmacol 387:313-319
10. Blois MS (1958) Antioxidant determinations by use of a stable free radical. Nature 181:1199-1200
11. Boltin D, Niv Y (2014) Pharmacological and alimentary alteration of the gastric barrier. Best Pract Res Clin Gastroenterol 28:981-994
12. Boyce M, Dowen S, Turnbull G, van den Berg F, Zhao CM, Chen D, Black J (2014) Effect of netazepide, a gastrin/CCK(2) receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects. Br J Clin Pharmacol 79:744-755
13. Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-209
14. Brzozowski T, Konturek PC, Sliwowski Z, Kwiecie S, Drozdowicz D, Pawlik M, Mach K, Konturek SJ, Pawlik WW (2006) Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. J Physiol Pharmacol 57:67-79
15. Bucciarelli A, Minetti A, Milczakowskyg C, Skliar M (2010) Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae). Pharm Biol 48:1025-1030
16. Chai J, Norng M, Tarnawski AS, Chow J (2007) A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats. Gut 56:621-630
17. Chen FA, Wu AB, Chen CY (2004) The influence of treatments on the free radical scavenging activity of burdock and variations of its activity. Food Chem 86:479-484
18. Coqueiro A, Regasini LO, Skrzek SC, Queiroz MM, Silva DH, da Silva BV (2013) Free radical scavenging activity of Kielmeyera variabilis (Clusiaceae). Molecules 18:2376-2385
19. Corne SJ, Morrissey SM, Woods RJ (1974) A method for the quantitative estimation of gastric barrier mucous. J Physiol 242:116-117
20. Da Silva AG, Sousa CP, Koehler J, Fontana J, Christo AG, Guedes-Bruni RR (2010) Evaluation of an extract of Brazilian arnica (Solidago chilensis Meyen, Asteraceae) in treating lumbago. Phytother Res 24:283-287
21. Da Silva AG, Machado ER, de Almeida LM, Nunes RM, Giesbrecht PC, Costa RM, Costa HB, Romão W, Kuster RM (2015) A clinical trial with Brazilian arnica (Solidago chilensis Meyen) glycolic extract in the treatment of tendonitis of flexor and extensor tendons of wrist and hand. Phytother Res 29:864-869
22. De Young LM, Kheifets JB, Ballaron SJ, Young JM (1989) Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions 26:335-341
23. Demircan B, Çelik G, Süleyman H, Akçay F (2005) Effects of indomethacin, celecoxib and meloxicam on glutathione, malondialdehyde and myeloperoxidase in rat gastric tissue. Pain Clinic 17:383-388
24. DeVault KR, Talley NJ (2009) Insights into the future of gastric acid suppression. Nat Rev Gastroenterol Hepatol 6:524-532
25. Fiske CH, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66:375-400
26. Fornai M, Natale G, Colucci R, Tuccori M, Carazzina G, Antonioli L, Baldi S, Lubrano V, Abramo A, Blandizzi C, Del Tacca M (2005) Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage. Naunyn Schmiedebergs Arch Pharmacol 372:79-87
27. Franke A, Teyssen S, Singer MV (2005) Alcohol-related diseases of the esophagus and stomach. Dig Dis 23:204-213
28. Goulart S, Moritz MI, Lang KL, Liz R, Schenkel EP, Fröde TS (2007) Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. J Ethnopharmacol 113:346-353
29. Halliwell B, Gutteridge JMC (2006) Free radicals in biology and medicine, 4th edn. Clarendon, Oxford
30. Ham M, Kaunitz JD (2007) Gastroduodenal defense. Curr Opin Gastroenterol 23:607-616
31. Hara N, Okabe S (1985) Effects of gefarnate on acute gastric lesions in rats. Nihon Yakurigaku Zasshi 85:443-446
32. Hong CO, Lee HA, Rhee CH, Choung SY, Lee KW (2013) Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells. Biosci Biotechnol Biochem 77:58-64
33. Johansson ME, Sjövall H, Hansson GC (2013) The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol 10:352-361
34. Jones MP (2006) The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs. J Psychosom Res 60:407-412
35. Kangwan N, Park JM, Kim EH, Hahm KB (2014) Quality of healing of gastric ulcers: natural products beyond acid suppression. World J Gastrointest Pathophysiol 5:40-47
36. Kaplan KA, Odabasoglu F, Halici Z, Halici M, Cadirci E, Atalay F, Aydin O, Cakir A (2012) Alpha-lipoic acid protects against indomethacin-induced gastric oxidative toxicity by modulating antioxidant system. J Food Sci 77:H224-H230
37. Konturek SJ, Brzozowski T, Majka J, Szlachcic A, Bielanski W, Stachura J, Otto W (1993) Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate. Gut 34:881-887
38. Kubecova M, Kolostova K, Pinterova D, Kacprzak G, Bobek V (2011) Cimetidine: an anticancer drug? Eur J Pharm Sci 18:439-444
39. Kubo K, Uehara A, Kubota T, Nozu T, Moriya M, Watanabe Y, Shoji E, Santos SB, Harada K, Kohgo Y (1995) Effects of ranitidine on gastric vesicles containing H+,K(+)-adenosine triphosphatase in rats. Scand J Gastroenterol 30:944-951
40. Laine L, Takeuchi K, Tarnawski A (2008) Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 135:41-60
41. Lee BH, Kim N, Nam RH, Lee JY, Lee HS, Lee CH, Park JH, Lee DH (2014) Difficult establishment of a chronic nonsteroidal anti-inflammatory drugs induced gastric inflammation rat model due to gastric adaptation and small bowel damage. Korean J Gastroenterol 63:341-347
42. Liz R, Vigil SV, Goulart S, Moritz MI, Schenkel EP, Fröde TS (2008) The anti-inflammatory modulatory role of Solidago chilensis Meyen in the murine model of the air pouch. J Pharm Pharmacol 60:515-521
43. Lorenzi H, Matos FJA (2002) Plantas Medicinais no Brasil-nativas e exoticas: Solidago chilensis Meyen. Instituto Plantarum de Estudos da Flora, São Paulo, pp 170-171
44. Malfertheiner P, Chan FKL, Mccoll KEL (2009) Peptic ulcer disease. Lancet 374:1449-1461
45. Mei XT, Xu DH, Xu SK, Zheng YP, Xu SB (2013) Zinc(II)-curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9. Food Chem Toxicol 60:448-454
46. Mok SY, Lee S (2013) Identification of flavonoids and flavonoid rhamnosides from Rhododendron mucronulatum for. albiflorum and their inhibitory activities against aldose reductase. Food Chem 136:969-974
47. Mors WB, Rizzini CT, Pereira NA (2000) Medicinal plants of Brazil. Reference, Algonac, p 65
48. Mota da Silva L, Boeing T, Somensi LB, Cury BJ, Bispo Steimbach VM, Oliveira Silveria AC, Niero R, Cechinel Filho V, Santin JR, de Andrade SF (2015) Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: in vitro and in vivo studies. J Ethnopharmacol 175:75-85
49. Naito Y, Yoshikawa T, Yoshida N, Kondo M (1998) Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig Dis Sci 43:30S-34S
50. Nishida T, Tsuji S, Kimura A, Tsujii M, Ishii S, Yoshio T, Shinzaki S, Egawa S, Irie T, Yasumaru M, Iijima H, Murata H, Kawano S, Hayashi N (2006) Endothelin-1, an ulcer inducer, promotes gastric ulcer healing via mobilizing gastric myofibroblasts and stimulates production of stroma-derived factors. Am J Physiol Gastrointest Liver Physiol 290:1041-1050
51. Okabe S, Pfeiffer CJ (1972) Chronicity of acetic acid ulcer in the rat stomach. Am J Dig Dis 17:619-629
52. Périco LL, Heredia-Vieira SC, Beserra FP, de Cássia Dos Santos R, Weiss MB, Resende FA, Dos Santos Ramos MA, Bonifácio BV, Bauab TM, Varanda EA, de Gobbi JI, da Rocha LR, Vilegas W, Hiruma-Lima CA (2015) Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats. J Ethnopharmacol 172:312-324
53. Ramakrishnan K, Salinas RC (2007) Peptic ulcer disease. Am Fam Physician 76:1005-1012
54. Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25:192-205
55. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 5:43-61
56. Shimoyama AT, Santin JR, Machado ID, de Oliveira e Silva AM, de Melo IL, Mancini-Filho J, Farsky SH (2013) Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. Naunyn Schmiedebergs Arch Pharmacol 386:5-14
57. Szabo S (1987) Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol Suppl 127:21-28
58. Szabo S (2014) "Gastric cytoprotection" is still relevant. J Gastroenterol Hepatol 29:124-132
59. Takeuchi K (2012) Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility. World J Gastroenterol 18:2147-2160
60. Tamura EK, Jimenez RS, Waismam K, Gobbo-Neto L, Lopes NP, Malpezzi-Marinho EA, Marinho EA, Farsky SH (2009) Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation. J Ethnopharmacol 122:478-485
61. Tarnawski AS (2005) Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 50:24-33
62. Tarnawski A, Ahluwalia A, Jones MK (2013) Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids. Curr Pharm Des 19:126-132
63. Teves MR, Rotelli AE, Wendel GH, Paredes JD, Giraudo E, Petenatti ME, Pelzer LE (2015) Records of medicinal plants utilized as gastroprotective and for treatment of gastrointestinal ulcers, gastritis, and heartburn in Argentina: a survey of the literature. J Herbs Spices Med Plants 21:333-371
64. Thomson AB, Sauve MD, Kassam N, Kamitakahara H (2010) Safety of the long-term use of proton pump inhibitors. World J Gastroenterol 16:2323-2330
65. Vellosa JCR, Regasini LO, Khalil NM, da Silva BV, Khalil OAK, Manente FA, Netto HP, de Faria Oliveira OMM (2011) Antioxidant and cytotoxic studies for kaempferol, quercetin and isoquercitrin. Eclet Quím 36:2
66. Vellosa JC, Regasini LO, Belló C, Schemberger JA, Khalil NM, de Araújo M-GA, da Silva BV, Brunetti IL, de Faria Oliveira OM (2015) Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species. Arch Pharm Res 38:1168-1177
67. Wallace JL (2008) Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 88:1547-1565
68. Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K (1997) Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1 beta. Am J Pathol 150:971-979
69. Xu GH, Ryoo IJ, Kim YH, Choo SJ, Yoo ID (2009) Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis. Arch Pharm Res 32:275-282
70. Yamamoto A (1975) Proteolytic enzymes. In: REED G (ed) Enzymes in food processing, 2nd edn. Academic, London, pp 123-179
71. Yang YX (2012) Chronic proton pump inihibitor therapy and calcium metabolism. Curr Gastroenterol Rep 14:473-479
72. Yang JC, Lu CW, Lin CJ (2014) Treatment of Helicobacter pylori infection: current status and future concepts. World J Gastroenterol 20:5283-5293
73. Young OT, Ok AB, Jung JE, Sang PJ, Jong PS, Wook BH, Hahm KB (2008) Accelerated ulcer healing and resistance to ulcer recurrence with gastroprotectants in rat model of acetic acid-induced gastric ulcer. J Clin Biochem Nutr 42:204-214