A critical role of serum response factor in myofibroblast differentiation during experimental oesophageal ulcer healing in rats

Gut

Volumn 56, Issue 5, 2007, Pages 621-630

  Chai, Jianyuan ^a   Norng, Manith ^a   Tarnawski, Andrzej S ^a   Chow, Justine ^a  

^a VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALPHA ACTIN; ANTISENSE OLIGONUCLEOTIDE; INTEGRIN LINKED KINASE; PLASMID VECTOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SERUM RESPONSE FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; ESOPHAGUS MUCOSA; ESOPHAGUS ULCER; GENE THERAPY; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; RAT; ULCER HEALING; UPREGULATION;

ACETIC ACID; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ESOPHAGEAL DISEASES; FIBROBLASTS; GENE THERAPY; MALE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SERUM RESPONSE FACTOR; TRANSFORMING GROWTH FACTOR BETA; ULCER; WOUND HEALING;

EID: 33947312608     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.106674     Document Type: Article

References (43)

1. Treisman R. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 1986;46:567-74.
2. Chai J, Tarnawski AS. Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing. J Physiol Pharmacol 2002;53:147-57.
3. Rivera VM, Miranti CK, Misra RP, et al. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol 1993;13:6260-73.
4. Orr L. Scientists align billion-year-old protein with embryonic heart defects. Medical News Today 2004.
5. Wang JY, Johnson LR. Expression of protooncogenes c-fos and c-myc in healing of gastric mucosal stress ulcers. Am J Physiol 1994;266:G878-86.
6. Schober JM, Lau LF, Ugarova TP, et al. Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. J Biol Chem 2003;278:25808-15.
7. Mack CP, Thompson MM, Lawrenz-Smith S, et al. Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex. Circ Res 2000;86:221-32.
8. Rensen SS, Niessen PM, Long X, et al. Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins. Cardiovasc Res 2006;70:136-45.
9. Poser S, Impey S, Trinh K, et al. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO J 2000;19:4955-66.
10. Schratt G, Philippar U, Berger J, et al. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol 2002;156:737-50.
11. Yang Y, Zhe X, Phan SH, et al. Involvement of srf isoforms in myofibroblast differentiation during bleomycin-induced lung injury. Am J Respir Cell Mol Biol 2003;29:583-90.
12. Brittan M, Chance V, Elia G, et al. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology 2005;128:1984-95.
13. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001;159:1465-75.
14. Evans RA, Tian YC, Steadman R, et al. TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res 2003;282:90-100.
15. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002;3:349-63.
16. Powell DW, Mifflin RC, Valentich JD, et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999;277:C1-9.
17. Feugate JE, Li Q, Wong L, et al. The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J Cell Biol 2002;156:161-72.
18. Desmouliere A, Geinoz A, Gabbiani F, et al. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993;122:103-11.
19. Tonigawa T, Pai R, Arakawa T, et al. TGF-beta signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing. J Physiol Pharmacol 2005;56:3-13.
20. Tominaga K, Arakawa T, Kim S, et al. Increased expression of transforming growth factor-beta1 during gastric ulcer healing in rats. Dig Dis Sci 1997;42:616-25.
21. Ernst H, Konturek PC, Brzozowski T, et al. Subserosal application of transforming growth factor-beta 1 in rats with chronic gastric ulcers: effect on gastric ulcer healing and blood flow. J Physiol Pharmacol 1996;47:443-54.
22. Ernst H, Konturek P, Hahn EG, et al. Acceleration of wound healing in gastric ulcers by local injection of neutralising antibody to transforming growth factor beta 1. Gut 1996;39:172-5.
23. Ueyama T, Kawashima S, Sakoda T, et al. Transforming growth factor-beta1 and protein kinase C synergistically activate the c-fos serum response element in myocardial cells. J Mol Cell Cardiol 1998;30:551-62.
24. Qiu P, Feng XH, Li L. Interaction of Smad3 and SRF-associated complex mediates TGF-beta1 signals to regulate SM22 transcription during myofibroblast differentiation. J Mol Cell Cardiol 2003;35:1407-20.
25. Marais RM, Hsuan JJ, McGuigan C, et al. Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO J 1992;11:97-105.
26. Heidenreich O, Neininger A, Schratt G, et al. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem 1999;274:14434-43.
27. Lee YI, Kwon YJ, Joo CK. Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition. Biochem Biophys Res Commun 2004;316:997-1001.
28. Legale KR, Montanez E, Kudlacek O, et al. ILK, PINCH and parvin: the HPP of integrin signalling. Nat Rev Mol Cell Biol 2006;7:20-31.
29. Shafiei M, Rockey DC. The role of integrin linked kinase in liver wound healing. J Biol Chem 2006;281:24863-72.
30. Baatar D, Kawanaka H, Szabo IL, et al. Esophageal ulceration activates keratinocyte growth factor and its receptor in rats: implications for ulcer healing. Gastroenterology 2002;122:458-68.
31. Baatar D, Jones MK, Tsugawa K, et al. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing. Am J Pathol 2002;161:1449-57.
32. Basson MD. Gut mucosal healing: is the science relevant? Am J Pathol 2002;161:1101-5.
33. Baatar D, Jones MK, Pai R, et al. Selective cyclcoxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Am J Pathol 2002;160:963-72.
34. Choi J, Jones MK, Tarnawski AS. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. FASEB J 2004;18:1264-6.
35. Chai J, Baatar D, Tarnawski A. Serum response factor promotes reepithelialization and muscular structure restoration during gastric ulcer healing. Gastroenterology 2004;126:1809-18.
36. Livstone EM, Sheahan DG, Behar J. Studies of esophageal epithelial cell proliferation in patients with reflux esophagitis. Gastroenterology 1977;73:1315-19.
37. Stoner GD, Kaighn ME, Reddel RR, et al. Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res 1991;51:365-71.
38. Topp WC. Normal rat cell lines deficient in nuclear thymidine kinase. Virology, 1981;113, 408-11.
39. Zhang X, Chai J, Azhar G, et al. Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor. J Biol Chem 2001;276:40033-40.
40. Tomasek JJ, McRae J, Owens GK, et al. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am J Pathol 2005;166:1343-51.
41. Landerholm TE, Dong XR, Lu J, et al. A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells. Development 1999;126:2053-62.
42. Camoretti-Mercado B, Fernandes DJ, Dewundara S, et al. Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7. J Biol Chem 2006;281: 20383-92.
43. Iyer VR, Eisen MB, Ross DT, et al. The transcriptional program in the response of human fibroblasts to serum. Science 1999;283:83-7.