Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 372, Issue 1, 2005, Pages 79-87

  Fornai, M ^a   Natale, G ^a   Colucci, R ^a   Tuccori, M ^a   Carazzina, G ^b   Antonioli, L ^a   Baldi, S ^a   Lubrano, V ^a   Abramo, A ^a   Blandizzi, C ^a   Del Tacca, M ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Recordati SpA   (Italy)

Author keywords

Antioxidant; Cyclooxygenase; Gastric lesions; Gastroprotection; Myeloperoxidase; Nonsteroidal anti inflammatory drugs; Prostaglandins; Proton pump inhibitors

Indexed keywords

COPPER SULFATE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; GLUTATHIONE; INDOMETACIN; KETOPROFEN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MESSENGER RNA; MYELOPEROXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PANTOPRAZOLE; PIROXICAM; PROSTAGLANDIN E2; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME BLOOD LEVEL; IN VITRO STUDY; LIGATION; MALE; MORPHOMETRICS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATION; PARAMETER; PROTEIN EXPRESSION; PYLORUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA LESION; STOMACH SECRETION;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; BENZIMIDAZOLES; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; GASTRIC MUCOSA; GLUTATHIONE; H(+)-K(+)-EXCHANGING ATPASE; INDOMETHACIN; LIGATION; LIPOPROTEINS, LDL; MALE; MALONDIALDEHYDE; OMEPRAZOLE; OXIDATION-REDUCTION; PEROXIDASE; PIROXICAM; PYLORUS; RATS; RATS, WISTAR; SULFOXIDES;

EID: 26244452992     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-005-1075-1     Document Type: Article

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