Gastric cytoprotection beyond prostaglandins: Cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids

Current Pharmaceutical Design

Volumn 19, Issue 1, 2013, Pages 126-132

  Tarnawski, Andrzej ^a   Ahluwalia, Amrita ^a   Jones, Michael K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antacid; Gastric; Healing; Hydrotalcite; Injury; Mucosal defense; Protection

Indexed keywords

ALCOHOL; ANTACID AGENT; BILE ACID; EPIDERMAL GROWTH FACTOR; FAMOTIDINE; HEAT SHOCK PROTEIN; HYDROCHLORIC ACID; HYDROTALCITE; INDOMETACIN; LYSOPHOSPHATIDYLCHOLINE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PEPSIN A; PROSTAGLANDIN; PROSTAGLANDIN E2; RANITIDINE; SUCRALFATE; THIOL DERIVATIVE; WATER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED CLINICAL TRIAL (TOPIC); DRUG MECHANISM; DRUG STRUCTURE; GENE ACTIVATION; HELICOBACTER PYLORI; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN INDUCTION; RAT; STOMACH MUCOSA; STOMACH ULCER; ULCER HEALING;

EID: 84873957654     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811306010126     Document Type: Article

References (55)

1. Tarnawski A. Cellular and molecular mechanisms of mucosal defense and repair. In: Bioregulation and Its Disorders in Gastrointestinal Tract, Eds. T. Yoshikawa and T. Arakawa Blackwell Science, Japan, Tokyo 1998, pp. 3-17.
2. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology 2008; 135: 41-60.
3. Tarnawski AS, Ahluwalia A, Jones MK. The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Medicinal Chem 2012; 19: 4-15.
4. Tarnawski A. Cellular and molecular mechanism of gastrointestinal ulcer healing. Dig Dis & Sci 2005; 59 (Suppl 1): S24-33.
5. Tarnawski AS, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Update. Curr Medicinal Chem 2012; 19: 16-27.
6. Brzozowski T. Hot Topic: Novel physiological and pharmacological avenues in the mechanism of gastrointestinal integrity, protection and ulcer healing. Curr Medicinal Chem 2012; 19: 2-3.
7. Palileo C, Kaunitz JD. Gastrointestinal defense mechanisms. Curr Opin Gastroenterol 2011; 27(6): 543-8
8. Tache Y. Brainstem Neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents. Curr Medicinal Chem 2012; 19: 35-42.
9. Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981; 214: 200-2.
10. Tarnawski A, Jones MK. The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury and ulcer healing. Involvement of EGF-R signal transduction pathways. J. Clin. Gastroenterology 1998; 27: S12-20.
11. Tarnawski A, Hollander D, Stachura J, Krause WJ, Gergely H. Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone. Gastroenterology 1985; 88(1 Pt 2): 334-52.
12. Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88(1 Pt 2): 228-36.
13. Tarnawski, Jones MK, Baatar D, Pai R. Role of angiogenesis and angiogenic growth factor in mucosal repair and ulcer healing. In: Gastrointestinal Mucosal Repair and Experimental Therapeutic. Eds. CH. Cho and JY. Wang, Karger 2002; vol 25, pp 101-16.
14. Jones MK, Itani RM, Wang H, et al. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am J Physiol 1999; 276(6 Pt 1): G1345-55.
15. Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, Gergely H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 1992; 102: 695-8.
16. Pai R, Ohta M, Itani RM, Sarfeh IJ, Tarnawski AS. Induction of mitogen activated protein kinase signal transduction pathway during gastric ulcer healing in rat model. Gastroenterology 1998; 114: 706-13.
17. 2 transactivates EGF receptor: A novel mechanisms for promoting colon cancer growth and gastrointestinal hypertrophy. Nature Med 2002; 8: 289-93.
18. Tarnawski A, Stachura J, KrauseWJ, Douglass TG, Gergely H. Quality of gastric ulcer healing-a new, emerging concept. J Clin Gastroenterol 1991; 13(1): S42-7.
19. Tarnawski A, Douglass TG, Stachura J, Krause WJ. Quality of gastric ulcer healing: histological and ultrastructural assessment. Aliment Pharmacol & Therap 1991; 5(Suppl 1): 80-90.
20. Halter F, Schmassmann A, Peskar BM, Tarnawski AS. Cyclooxygenase-2 implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives. Gut 2001; 49: 443-53.
21. Kobayashi K, Arakawa T. Arachidonic acid cascade and gastric mucosal injury, protection, and healing: topics of this decade. J Clin Gastroenterol 1995; 21 (Suppl 1): S12-7.
22. Atay S, Tarnawski AS, Dubois A. Eicosanoids and the stomach. Prostaglandins & other Lipid Mediators 2000; 1:105-24.
23. Tarnawski A, Hollander D. Cytoprotection of gastric and duodenal mucosa. The Royal Society of Medicine Curr. Med. Literature (Gastroenterol) 1987; 6: 3-11.
24. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1978; 77: 433-43.
25. Tarnawski A, Hollander D, Gergely H, Stachura J. Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury. Am J Med 1985; 79(2C): 19-23.
26. Erickson RA, Bezabah S, Jonas G, Lifrak E, Tarnawski AS. Chronic omeprazole treatment increases duodenal susceptibility to ethanol injury in rats. Dig Dis Sci 1991; 36: 897-904.
27. Tarnawski A, Stachura J, Ivey KJ, Mach T, Bogdal J, Klimczyk B. Ethanol-induced duodenal lesions in man. Protective effect of prostaglandin. Prostaglandins 1981; 21(Suppl): 147-53.
28. Tarnawski A, Stachura J, Hollander D, Sarfeh IJ, Bogdal J. Cellular aspects of alcohol-induced injury and prostaglandin protection of the human gastric mucosa. J. Clin. Gastroenterol 1988; 19 (Suppl 1): S35.
29. Sikiric P, Seiwerth S, Rucman R, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des 2011; 17(16): 1612-32.
30. cdc2 cyclin dependent kinase. J Cell Physiol 2008; 215: 750-64.
31. Jones MK, Padilla OR, Zhu E. Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury. J Physiol Pharm 2010; 61: 253-64.
32. Tarnawski A, Hollander D, Gergely H. Antacids-new perspectives in cytoprotection. Scand. J. Gastroenterol 1990; 25 (Suppl 174): 9-14.
33. Tarnawski A. Cytoprotective drugs. Focus on antacids. Drug Investigation 1990; 2(1): 1-6.
34. Tarnawski A, Tomikawa M, Ohta M, Sarfeh IJ. Antacid talcid activates in gastric mucosa genes encoding EGF and its receptor. The molecular basis for its ulcer healing action. J. Physiol (Paris) 2000; 94: 93-8.
35. Tarnawski A, Wahlstrom KJ, Ohta M, Sarfeh IJ. Treatment with antacid hydrotalcite activates gastric mucosal genes encoding for EGF, bFGF and FGF receptor-1. The molecular mechanism for its ulcer healing action. Gastroenterology 1996; 110: A276.
36. Brackmann HP, Dollinger H, Guldutuna S, Herzog P, Kurtz W, Miederer SE, Preclik G, Stass H. Hydrotalcite-a multi-functional polyadsorbent. Current aspects of the status of lattice-emulsion antacids. Fortsch Med Suppl 1990; 94: 3-15.
37. Vatier J, Ramdani A, Vitre MT, Mignon M. Antacid activity of calcium carbonate and hydrotalcite tablets. Comparison between in vitro evaluation using the "artificial stomach-duodenum" model and in vivo pH-metry in healthy volunteers. Arzneimittelforschung 1994; 44: 514-8.
38. Vatier J, Vitre MT, Lionnet F, Poitevin C, Mignon M. Assessment of antacid characteristics of drugs containing a combination of aluminum and magnesium salts using the "artificial stomach" model. Arzneimittelforschung 1990; 40: 42-8.
39. Grubel P, Bhaska KR, Cave DR, Garik P, Stanley HE, Lamont JT. Interaction of an aluminum-magnesium containing antacid and gastric mucous: possible contribution to the cytoprotective function of antacids. Aliment Pharmacol Ther 1997; 11: 139-45.
40. Ishihara Y, Okabe S. Effects of cholestyramine and synthetic hydrotalcite on acute gastric or intestinal lesion formation rats and dogs. Dig Dis Sci 1981; 26: 553-60.
41. Tarnawski A, Wahlstrom K, Gergely H, Sarfeh IJ. Expression of cyclooxygenase-1 and-2 (COX-1 and COX-2) in normal gastric mucosa. Effect of antacid (Hydrotalcite). Gastroenterology 1996; 110: A275.
42. Tarnawski A, Wang H, Tomikawa M, Pai R, Sarfeh IJ. Talcid triggers induction of heat shock proteins HSP-70 in gastric mucosa: a key to its mucosal protective action? Gastroenterology 1999; 116(A331): G1447.
43. Yu BP, Sun J, Li MQ, Luo HS, Yu JP. Preventive effect of hydrotalcite on gastric mucosal injury in rats induced by taurocholate. World J Gastroenterol 2003; 9: 1427-30.
44. Tarnawski A, Pai R, Itani R, Wyle FA. Antacid talcid adsorbs and neutralizes all proteins secreted by H. pylori including Vac A cytotoxin. A new mechanism for its ulcer healing action? Digestion 1999; 60: 449-55.
45. Tarnawski A, Itani R, Pai R, Sarfeh IJ. Antacid Talcid activates genes encoding for basic fibroblast growth factor and its receptors in rat gastric mucosal and human endothelial cells. The molecular basis for its ulcer healing action. Digestion 1998; 59(3): 78.
46. Lambrecht N, Trautmann M, Korolkiewicz R, Liszkay M, Peskar BM. Role of eicosanoids, nitric oxide, and afferent neurons in antacid induced protection in the rat stomach. Gut 1993; 34: 329-34.
47. Schmidt C, Baumeister B, Kipnowski J, Miederer SE, Vetter H. Magaldrate stimulates endogenous prostaglandin E2 synthesis in human gastric mucosa in vitro and in vivo. Hepatogastroenterology 1998; 45(24): 2443-6.
48. Tarnawski A, Santos AM, Ichikawa Y, Lu SY, Sarfeh IJ. Antacid talcid stimulates angiogenesis in injured gastric mucosa. A new mechanism for its mucosal healing action. Eur J Gastroenterol and Hepatology, 1993; 5(3): S125-32.
49. Holtermuller KH, Liszkay M, Bernard I, Hasse W. Therapy of stomach ulcer-a comparison between the low dosage antacid hydrotalcite and ranitidine-results of a randomized multicenter double-blind study. Talcivent Study Group. Z Gastroenterol 1992; 39: 717-21.
50. Konturek JW, Beneke M, Koppermann R, Petersen-Braun M, Weingärtner U. The efficacy of hydrotalcite compared with OTC famotidine in the on-demand treatment of gastroesphageal reflux disease: A non-inferiority trial. Med Sci Monit 2006; 13: CR44-9.
51. Schmassmann A, Tarnawski A, Flogerzi B, Sanner M, Varga L, Halter F. Antacids in experimental gastric ulcer healing: pharmacokinetics of aluminum and quality of healing. Eur J Gastroent and Hepatol 1993; 5(3): S14-6.
52. Schmassmann A, Tarnawski A, Gerber HA, Flogerzi B, Sanner M, Varga L, Halter F. Antacid provides better restoration of glandular structures within the gastric ulcer scar than omeprazole. Gut 1994; 35: 896-904.
53. Gabel G, Hoa NT, Tarnawski A, Chen J, Domek M, Ma TY. Helicobacter pylori infection inhibits healing of the wounded duodenal epithelium in vitro. J Lab Clin Med 2003; 143: 421-30.
54. Pai R, Sasaki E, Tarnawski AS. H. pylori vacuolating cytotoxin (VacA) alters cytoskeleton associated proteins and interferes with re-epithelialization of wounded gastric epithelial monolayers. Cell Biol Int 2000; 24: 291-301.
55. Wyle FA, Chang KJ, Stachura J, Tarnawski A. Helicobacter pylori cytotoxin and the healing of experimental gastric ulcers. Eur J Gastroent and Hepatol 1993; 5(3): S75-79.