Accelerated ulcer healing and resistance to ulcer recurrence with gastroprotectants in rat model of acetic acid-induced gastric ulcer

Journal of Clinical Biochemistry and Nutrition

Volumn 42, Issue 3, 2008, Pages 204-214

  Oh, Tae Young ^a   Ann, Byung Ok ^a   Jang, Eun Jung ^b   Park, Joo Sang ^b   Park, Sang Jong ^b   Baik, Hyun Wook ^b   Hahm, Ki Baik ^b  

^a Dong A Pharmaceutical Company   (South Korea)

^b Bundang Jesaeng Hospital   (South Korea)

Author keywords

Gastroprotectant; Ideal ulcer healing; QOUH; Remodeling; Ulcer recurrence

Indexed keywords

3 NITROTYROSINE; ACETIC ACID; ARTEMISIA ASIATICA EXTRACT; CYCLOOXYGENASE 2; DA 9601; EPIDERMAL GROWTH FACTOR; GASTROINTESTINAL AGENT; INTERLEUKIN 2; MUCIN; OMEPRAZOLE; PLANT EXTRACT; PROTECTIVE AGENT; PROTEIN PS2; RECOMBINANT INTERLEUKIN 1BETA; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTEMISIA; ARTEMISIA ASIATICA; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; NONHUMAN; RAT; RECURRENT DISEASE; SPRAGUE DAWLEY RAT; STOMACH PROTECTION; STOMACH ULCER; TREATMENT OUTCOME; ULCER HEALING;

RATTUS;

EID: 46249121069     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.2008030     Document Type: Article

References (39)

1. Tsukim, Y. and Okabe, S.: Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing. Biol. Pharm. Bull., 24, 1-9, 2001.
2. Robert, A., Nezumis, J.E., and Phillips, J.P.: Inhibition of gastric secretion by prostaglandin. Am. J. Dig. Dis., 12, 1073-1076, 1967.
3. Robert, A.: Cytoprotection by prostaglandins. Gastroentero-logy, 77, 761-767, 1979.
4. Davenport, H.W.: Salicylate damage to the gastric mucosal barrier. N. Engl. J. Med., 8, 1307-1312, 1967.
5. Allen, A.: Garner A. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Gut, 21, 249-262, 1980.
6. Wallace, J.L.: Mechanisms of protection and healing: current knowledge and future research. Am. J. Med., 110, 19S-23S, 2001.
7. Jones, M.K., Tomikawa, M., Mohajer, B., and Tarnawski, A.S.: Gastrointestinal mucosal regeneration; role of prowth factors. Frontiers in Bioscience, 4, 303-309, 1999.
8. Arakawa, T., Kobayashi, K., Yoshikawa, T., and Tarnawski, A.: Rebamipide, Overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig. Dis. Sci., 43, 5S-13S, 1998.
9. Murata, H., Kawano, S., Tsuji, S., Kamada, T., Matsuzawa, Y., Katsu, K., Inoue, K., Kobayashi, K., Mitsufuji, S., Bamba, T., Kawasaki, H., Kajiyama, G., Umegaki, E., Inoue, M., and Saito, I.: Combination therapy of ecobet sodium and cimetidine compared with cimetidine alone for gastric ulcer: prospective randomized multicenter study. J. Gastroenterol. Hepatol, 18, 1029-1033, 2003.
10. Kabir, A.M., Shimizu, K., Aiba, Y., Igarashi, M., Takagi, A., and Koga, Y: The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-induced gnobiotic murine model. Aliment. Pharmacol. Ther., 14, 223-229, 2000.
11. Oh, T.Y., Lee, J.S., Ann, B.O., Cho, H., Kim, Y.B., Surh, Y.J., Cho, S.W., Lee, K.M., and Hahm, K.B.: Oxidative stress is more important than acid in the pathogenesis of reflux esophagitis in rats. Gut, 49, 364-371, 2001.
12. Pai, R., Ohta, M., Itoni, R.M., Sarfeh, I.J., and Tarnawski, A.S.: Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Gastroenterology, 114, 706-713, 1998.
13. Tetreault, M.P., Chailler, P., Rivard, N., and Menard, D.: Differential growth factor induction and modulation of human gastric epithelial regeneration. Exp. Cell Res., 306, 285-297, 2005.
14. Tanigawa, T., Pai, R., Arakawa, T., Higuchi, K., and Tarnawski, A.S.: TGF-p signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing. J. Physiol. Pharmacol., 56, 3-13, 2005.
15. Harsch, I.A., Brzozowski, T., Bazela, K., Konturek, S.J., Kukharsky, V., Pawlik, T., Pawlowski, E., Hahn, E.G., and Konturek, PC: Impaired gastric ulcer healing in diabetic rats; role of heat shock protein; growth factor, prostaglandins and proinflammatory cytokines. Eur. J. Pharmacol., 481, 249-260, 2003.
16. Pai, R. and Tarnawski, A.S.: Signal transduction cascades triggered by EGF receptor activation: Relevance to gastric injury repair and ulcer healing. Dig. Dis. Sci., 43, 14S-22S, 1998.
17. Arakawa, T., Watanabe, T., Fukuda, T., Higuchi, K., Fujiwara, Y., Kobayashi, K., and Tarnawski, A.S.: Ulcer recurrence: cytokine and inflammatory response-dependent process. Dig. Dis. Sci., 43, 61S-66S, 1998.
18. Arakawa, T., Higuchi, K., Takashi, F., Fujiwara, Y., Kobayashi, K., and Kuroki, T.: Prostaglandins in the stomach; an update. J. Clin. Gastroenterol., 27, S1-S11, 1998.
19. Arakawa, T., Nebiki, H., Uchida, T., Kimura, S., Higuchi, K., and Kobayashi, K.: Clinical assessment of quality of ulcer healing a new approach of endoscopic evaluation. Eur. J. Gastroenterol. Hepatol., 5, S87-S92, 1993.
20. Arakawa, T. and Kobayashi, K.: Quality of ulcer healing a new concept to rank healed peptic ulcers. Gastroenterol. Jpn., 28, 158S-162S, 1993.
21. Oh, T.Y., Shin, C.Y., Sohn, Y.S., Kim, D.H., Ann, B.O., Lee, E.B., and Park, C.H.: Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats. World J. Gastroenterol., 11, 7430-7435, 2005.
22. Oh, T.Y., Ahn, G.J., Choi, S.M., Ahn, B.O., and Kim, W.B.: Increased susceptibility of ethanol-treated gastric mucosa to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract. World J. Gastroenterol., 11, 7450-7556, 2005.
23. Lee, S., Park, H.H., Son, H.Y., Ha, J.H., Lee, M.G., Oh, T.Y., Sohn, D.H., Jeong, T.C., Lee, S.H., Son, J.K., Lee, S.G., Jun, CD., and Kim, S.H.: DA-9601 inhibits activation of the human mast cell line HMC-1 through inhibition of NF-κB. Cell Biol. Toxicol., 23, 105-112, 2007.
24. Ahn, B.O., Ko, K.H., Oh, T.Y., Cho, H., Kim, W.B., Lee, K.J., Cho, S.W., and Hahm, K.B.: Efficacy of use of colonoscopy in dextran sulfate sodium induced ulcerative colitis in rats; the evaluation of the effects of antioxidant by colonoscopy. Int. J. Colorectal Dis., 16, 174-181, 2001.
25. Miyake, T., Suzaki, T., and Oishi, M.: Correlation of gastric ulcer healing features by endoscopy, stereoscopic microscopy and histology and a reclassification of the epithelial regenerative process. Dig. Dis. Sci., 25, 8-14, 1980.
26. Watanabe, T., Arakawa, T., Fukuda, T., Higuchi, K., and Kobayashi, K.: Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin 1β. Am. J. Pathol., 150, 971-979, 1997.
27. Nagaike, R., Sawaguchi, A., Kawano, J., Aoyama, F., Oinuma, T., and Suganuma, T.: Regeneration of gastric mucosa during ulcer healing follows pathways that correspond to the ontogenetic course of rat fundic glands. Virchows Arch., 445, 580-588, 2004.
28. Shahin, M., Konturek, J.W., Pohle, T., Schuppan, D., Herbst, H., and Domschke, W.: Remodeling of extracellular matrix in gastric ulceration. Microsc. Res. Tech., 53, 396-408, 2001.
29. Longman, R.J., Douth Waite, J., Sylvester, P.A., Poulsom, R., Corfield, A.P., Thomas, M.G., and Wright, N.A.: Coordinated localization of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut, 47, 792-800, 2000.
30. Ribieras, S., Tomasetto, C., and Rio, M.C.: The pS2/TFF 1 trefoid factor, from basic research to clinical application. Biochim. Biophys. Acta., 1378, 61-77, 1998.
31. Newton, J.L., Allen, A., Westley, B.R., and May, F.E.: The human trefoil peptide, TFF 1 is present in different molecular forms that are intimately associated with mucus in normal stomach. Gut, 46, 312-320, 2000.
32. Watanabe, T., Higuchi, K., Tominaga, K., Fujiwara, Y., and Arakawa, T.: Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1β. Gut, 48, 774-781, 2001.
33. Ebert, M.P.A., Schafer, C., Chen, J., Hoffmann, J., Gu, P., Kubisch, C., Carl-McGrath, S., Treiber, G., Malfertheiner, P., and Rocken, C: Protective role of heat shock protein 27 in gastric mucosal injury. J. Pathol., 207, 177-184, 2005.
34. Tsukimi, Y. and Okabe, S.: Recent advances in gastrointestinal pathophysiology role of heat shock protein in mucosal defense and ulcer healing. Biol. Pharm. Bull., 24, 1-9, 2001.
35. Halter, F., Tarnawski, A.S., Schmassmann, A., and Peskar, B.M.: Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing controversial issues and perspectives. Gut, 49, 443-453, 2001.
36. Kimura, A., Tsuji, S., Tsuji, M., Sawaoka, H., lijima, H., Kawai, N., Yasumaru, M., Kakiuchi, Y., Okuda, Y., Ali, Z., Nishimura, Y., Sasaki, Y., Kawano, S., and Hori, S.: Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucosa before and after Helicobacter pylolri eradication. Prostaglandins Leukotrienes Essential Fatty Acids, 63, 315-322, 2002.
37. Halliwell, B.: What nitrates tyrosine? Is nitrotyrosine specific as biomarker of peroxynitrite formation in vivo. FEBS Lett., 411, 157-160, 1997.
38. Ernst, H., Grunert, S., Schneider, H.T., Beck, W.S., Brune, K., and Hahn, E.G.: Distribution of extra cellular matrix proteins in indomethacin-induced lesions in the rat stomach. Scand. J. Gastroenterol., 30, 847-853, 1995.
39. Wahl, S.M. and Wang, H.: Mccartney-Francis N. Role of growth factors in inflammation and repair. J. Cell. Biochem., 40, 193-199, 1989.