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Volumn 10, Issue 3, 2016, Pages 297-316

Precision medicine for the treatment of severe pneumonia in intensive care

Author keywords

adjunctive therapy; antibiotic therapy; bacterial load; personalized medicine; pneumonia; Precision medicine; sepsis

Indexed keywords

AERUCIN; ANTIBIOTIC AGENT; ASN 100; BACTERIAL DNA; BACTERIAL TOXIN; IC 43; KB 001; LIPOSOME; MEDI 3902; MEDI 4893; MONOCLONAL ANTIBODY; PANOBACUMAB; POLYSACCHARIDE VACCINE; SALVECIN; SAR 279356; SM 17220; STEROID; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL VACCINE;

EID: 84960448055     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2016.1144477     Document Type: Review
Times cited : (31)

References (176)
  • 2
    • 0030031642 scopus 로고    scopus 로고
    • Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis
    • Fine MJ, Smith MA, Carson CA, et al Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA. 1996;275:134-141.
    • (1996) JAMA , vol.275 , pp. 134-141
    • Fine, M.J.1    Smith, M.A.2    Carson, C.A.3
  • 3
    • 27144503793 scopus 로고    scopus 로고
    • Cost analyses of community-acquired pneumonia from the hospital perspective
    • Bauer TT, Welte T, Ernen C, et al Cost analyses of community-acquired pneumonia from the hospital perspective. Chest. 2005;128:2238-2246.
    • (2005) Chest , vol.128 , pp. 2238-2246
    • Bauer, T.T.1    Welte, T.2    Ernen, C.3
  • 4
    • 2942722305 scopus 로고    scopus 로고
    • Treatment costs of community-acquired pneumonia in an employed population
    • Colice GL, Morley MA, Asche C, et al Treatment costs of community-acquired pneumonia in an employed population. Chest. 2004;125:2140-2145.
    • (2004) Chest , vol.125 , pp. 2140-2145
    • Colice, G.L.1    Morley, M.A.2    Asche, C.3
  • 5
    • 0036724321 scopus 로고    scopus 로고
    • Severe community-acquired pneumonia. Use of intensive care services and evaluation of American and british thoracic society diagnostic criteria
    • Angus DC, Marrie TJ, Obrosky DS, et al. Severe community-acquired pneumonia. Use of intensive care services and evaluation of American and British Thoracic Society diagnostic criteria. Am J Respir Crit Care Med. 2002;166:717-723.
    • (2002) Am J Respir Crit Care Med. , vol.166 , pp. 717-723
    • Angus, D.C.1    Marrie, T.J.2    Obrosky, D.S.3
  • 6
    • 0031794530 scopus 로고    scopus 로고
    • Severe communityacquired pneumonia. Assessment of severity criteria
    • Ewig S, Ruiz M, Mensa J, et al Severe communityacquired pneumonia. Assessment of severity criteria. Am J Respir Crit Care Med. 1998;158:1102-1108.
    • (1998) Am J Respir Crit Care Med. , vol.158 , pp. 1102-1108
    • Ewig, S.1    Ruiz, M.2    Mensa, J.3
  • 7
    • 0031012761 scopus 로고    scopus 로고
    • A prediction rule to identify low-risk patients with community-acquired pneumonia
    • Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336:243-250.
    • (1997) N Engl J Med. , vol.336 , pp. 243-250
    • Fine, M.J.1    Auble, T.E.2    Yealy, D.M.3
  • 8
    • 34249304464 scopus 로고    scopus 로고
    • Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock
    • Rodríguez A, Mendia A, Sirvent J-M, et al. Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Crit Care Med. 2007;35:1493-1498.
    • (2007) Crit Care Med. , vol.35 , pp. 1493-1498
    • Rodríguez, A.1    Mendia, A.2    Sirvent, J.-M.3
  • 9
    • 0025330089 scopus 로고
    • Severe communityacquired pneumonia. Etiology, prognosis, and treatment
    • Pachon J, Prados MD, Capote F, et al. Severe communityacquired pneumonia. Etiology, prognosis, and treatment. Am Rev Respir Dis. 1990;142:369-373.
    • (1990) Am Rev Respir Dis. , vol.142 , pp. 369-373
    • Pachon, J.1    Prados, M.D.2    Capote, F.3
  • 10
    • 0026378758 scopus 로고
    • Severe community-acquired pneumonia. Epidemiology and prognostic factors
    • Torres A, Serra-Batlles J, Ferrer A, et al. Severe community-acquired pneumonia. Epidemiology and prognostic factors. Am Rev Respir Dis. 1991;144:312-318.
    • (1991) Am Rev Respir Dis. , vol.144 , pp. 312-318
    • Torres, A.1    Serra-Batlles, J.2    Ferrer, A.3
  • 11
    • 84920376264 scopus 로고    scopus 로고
    • Genome-wide association study of survival from sepsis due to pneumonia: An observational cohort study
    • Epub 2015 Dec 18
    • Rautanen A, Mills TC, Gordon AC, et al. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med. 2015;3:53-60. Epub 2015 Dec 18. doi:10.1016/S2213-2600(14)70290-5.
    • (2015) Lancet Respir Med. , vol.3 , pp. 53-60
    • Rautanen, A.1    Mills, T.C.2    Gordon, A.C.3
  • 12
    • 67749106168 scopus 로고    scopus 로고
    • Severity assessment in community-acquired pneumonia: A review
    • Singanayagam A, Chalmers JD, Hill AT. Severity assessment in community-acquired pneumonia: a review. QJM. 2009;102:379-388.
    • (2009) QJM , vol.102 , pp. 379-388
    • Singanayagam, A.1    Chalmers, J.D.2    Hill, A.T.3
  • 13
    • 0027308912 scopus 로고
    • Early management of younger adults dying of community acquired pneumonia
    • Tang CM, Macfarlane JT. Early management of younger adults dying of community acquired pneumonia. Respir Med. 1993;87:289-294.
    • (1993) Respir Med. , vol.87 , pp. 289-294
    • Tang, C.M.1    Macfarlane, J.T.2
  • 14
    • 10244265940 scopus 로고    scopus 로고
    • Community acquired pneumonia: Aetiology and usefulness of severity criteria on admission
    • Neill AM, Martin IR, Weir R, et al. Community acquired pneumonia: aetiology and usefulness of severity criteria on admission. Thorax. 1996;51:1010-1016.
    • (1996) Thorax , vol.51 , pp. 1010-1016
    • Neill, A.M.1    Martin, I.R.2    Weir, R.3
  • 15
    • 0032551140 scopus 로고    scopus 로고
    • Confidential inquiry into quality of care before admission to intensive care
    • McQuillan P, Pilkington S, Allan A, et al. Confidential inquiry into quality of care before admission to intensive care. BMJ. 1998;316:1853-1858.
    • (1998) BMJ , vol.316 , pp. 1853-1858
    • McQuillan, P.1    Pilkington, S.2    Allan, A.3
  • 16
    • 34147199347 scopus 로고    scopus 로고
    • Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong
    • Man SY, Lee N, Ip M, et al. Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong. Thorax. 2007;62:348-353.
    • (2007) Thorax , vol.62 , pp. 348-353
    • Man, S.Y.1    Lee, N.2    Ip, M.3
  • 17
    • 16244385921 scopus 로고    scopus 로고
    • Prospective comparison of three validated prediction rules for prognosis in community acquired pneumonia
    • Aujesky D, Auble TE, Yealy DM, et al. Prospective comparison of three validated prediction rules for prognosis in community acquired pneumonia. Am J Med. 2005;118:384-392.
    • (2005) Am J Med. , vol.118 , pp. 384-392
    • Aujesky, D.1    Auble, T.E.2    Yealy, D.M.3
  • 18
    • 80054754800 scopus 로고    scopus 로고
    • Severity assessment tools to guide ICU admission in communityacquired pneumonia: Systematic review and meta-analysis
    • Chalmers JD, Mandal P, Singanayagam A, et al. Severity assessment tools to guide ICU admission in communityacquired pneumonia: systematic review and meta-analysis. Intensive Care Med. 2011;37:1409-1420.
    • (2011) Intensive Care Med. , vol.37 , pp. 1409-1420
    • Chalmers, J.D.1    Mandal, P.2    Singanayagam, A.3
  • 19
    • 84939240679 scopus 로고    scopus 로고
    • British thoracic society community acquired pneumonia guideline and the NICE pneumonia guideline: How they fit together
    • Lim WS, Smith DL, Wise MP, et al. British Thoracic Society community acquired pneumonia guideline and the NICE pneumonia guideline: how they fit together. Thorax. 2015;70:698-700.
    • (2015) Thorax , vol.70 , pp. 698-700
    • Lim, W.S.1    Smith, D.L.2    Wise, M.P.3
  • 20
    • 49149086800 scopus 로고    scopus 로고
    • Systolic blood pressure is superior to other haemodynamic predictors of outcome in community acquired pneumonia
    • Chalmers JD, Singanayagam A, Hill AT. Systolic blood pressure is superior to other haemodynamic predictors of outcome in community acquired pneumonia. Thorax. 2008;63:698702.
    • (2008) Thorax , vol.63 , pp. 698702
    • Chalmers, J.D.1    Singanayagam, A.2    Hill, A.T.3
  • 21
    • 0038554228 scopus 로고    scopus 로고
    • Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study
    • Lim WS, Van Der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003;58:377382.
    • (2003) Thorax , vol.58 , pp. 377382
    • Lim, W.S.1    Van Der-Eerden, M.M.2    Laing, R.3
  • 22
    • 30744456545 scopus 로고    scopus 로고
    • Validation of a predictive rule for the management of communityacquired pneumonia
    • Capelastegui A, España PP, Quintana JM, et al. Validation of a predictive rule for the management of communityacquired pneumonia. Eur Respir J. 2006;27:151-157.
    • (2006) Eur Respir J. , vol.27 , pp. 151-157
    • Capelastegui, A.1    España, P.P.2    Quintana, J.M.3
  • 23
    • 33745177635 scopus 로고    scopus 로고
    • CRB65 predicts death from community-acquired pneumonia
    • Bauer TT, Ewig S, Marre R, et al. CRB65 predicts death from community-acquired pneumonia. J Intern Med. 2006;260:93-101.
    • (2006) J Intern Med. , vol.260 , pp. 93-101
    • Bauer, T.T.1    Ewig, S.2    Marre, R.3
  • 24
    • 49149091451 scopus 로고    scopus 로고
    • CRB65 for the assessment of pneumonia severity: Who could ask for more?
    • Ewig S, Welte T. CRB65 for the assessment of pneumonia severity: who could ask for more? Thorax. 2008;63:665-666.
    • (2008) Thorax , vol.63 , pp. 665-666
    • Ewig, S.1    Welte, T.2
  • 25
    • 47149086953 scopus 로고    scopus 로고
    • Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia
    • Sep.
    • Shindo Y, Sato S, Maruyama E, et al. Comparison of severity scoring systems A-DROP and CURB-65 for community-acquired pneumonia. Respirology. 2008 Sep;13 (5):731-735. doi:10.1111/j.1440-1843.2008.01329.x.
    • (2008) Respirology , vol.13 , Issue.5 , pp. 731-735
    • Shindo, Y.1    Sato, S.2    Maruyama, E.3
  • 26
    • 77949524284 scopus 로고    scopus 로고
    • Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality
    • Restrepo MI, Mortensen EM, Rello J, et al. Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality. Chest. 2010;137:552-557.
    • (2010) Chest , vol.137 , pp. 552-557
    • Restrepo, M.I.1    Mortensen, E.M.2    Rello, J.3
  • 27
    • 33847155159 scopus 로고    scopus 로고
    • Infectious diseases society of america/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults
    • Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44:S27-72.
    • (2007) Clin Infect Dis. , vol.44 , pp. S27-S72
    • Mandell, L.A.1    Wunderink, R.G.2    Anzueto, A.3
  • 28
    • 0034959819 scopus 로고    scopus 로고
    • Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention
    • Niederman MS, Mandell LA, Anzueto A, et al. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med. 2001;163:1730-1754.
    • (2001) Am J Respir Crit Care Med. , vol.163 , pp. 1730-1754
    • Niederman, M.S.1    Mandell, L.A.2    Anzueto, A.3
  • 29
    • 47549084617 scopus 로고    scopus 로고
    • SMART-COP: A tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia
    • Charles PGP, Wolfe R, Whitby M, et al. SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect Dis. 2008;47:375-384.
    • (2008) Clin Infect Dis. , vol.47 , pp. 375-384
    • Charles, P.G.P.1    Wolfe, R.2    Whitby, M.3
  • 30
    • 56749166149 scopus 로고    scopus 로고
    • Predicting the need for mechanical ventilation and/or inotropic support for young adults admitted to the hospital with community-acquired pneumonia
    • Chalmers JD, Singanayagam A, Hill AT. Predicting the need for mechanical ventilation and/or inotropic support for young adults admitted to the hospital with community-acquired pneumonia. Clin Infect Dis. 2008;47:1571-1574.
    • (2008) Clin Infect Dis. , vol.47 , pp. 1571-1574
    • Chalmers, J.D.1    Singanayagam, A.2    Hill, A.T.3
  • 31
    • 73349140533 scopus 로고    scopus 로고
    • Validation of the infectious disease society of America/American thoracic society 2007 guidelines for severe community-acquired pneumonia
    • Brown SM, Jones BE, Jephson AR, et al. Validation of the infectious disease society of America/American thoracic society 2007 guidelines for severe community-acquired pneumonia. Crit Care Med. 2009;37:3010-3016.
    • (2009) Crit Care Med. , vol.37 , pp. 3010-3016
    • Brown, S.M.1    Jones, B.E.2    Jephson, A.R.3
  • 32
    • 33646569991 scopus 로고    scopus 로고
    • A prospective comparison of severity scores for identifying patients with severe community acquired pneumonia: Reconsidering what is meant by severe pneumonia
    • Buising KL, Thursky KA, Black JF, et al. A prospective comparison of severity scores for identifying patients with severe community acquired pneumonia: reconsidering what is meant by severe pneumonia. Thorax. 2006;61:419-224.
    • (2006) Thorax , vol.61 , pp. 224-419
    • Buising, K.L.1    Thursky, K.A.2    Black, J.F.3
  • 33
    • 80052233314 scopus 로고    scopus 로고
    • Validation of the infectious diseases society of America/American thoratic society minor criteria for intensive care unit admission in community-acquired pneumonia patients without major criteria or contraindications to intensive care unit care
    • Chalmers JD, Taylor JK, Mandal P, et al. Validation of the infectious diseases society of America/American thoratic society minor criteria for intensive care unit admission in community-acquired pneumonia patients without major criteria or contraindications to intensive care unit care. Clin Infect Dis. 2011;53:503-511.
    • (2011) Clin Infect Dis. , vol.53 , pp. 503-511
    • Chalmers, J.D.1    Taylor, J.K.2    Mandal, P.3
  • 34
    • 33845547409 scopus 로고    scopus 로고
    • Development and validation of a clinical prediction rule for severe community-acquired pneumonia
    • España PP, Capelastegui A, Gorordo I, et al. Development and validation of a clinical prediction rule for severe community-acquired pneumonia. Am J Resp Crit Care Med. 2006;174:1249-1256.
    • (2006) Am J Resp Crit Care Med. , vol.174 , pp. 1249-1256
    • España, P.P.1    Capelastegui, A.2    Gorordo, I.3
  • 35
    • 66649116260 scopus 로고    scopus 로고
    • Prospective comparison of severity scores for predicting clinically relevant outcomes for patients hospitalized with community-acquired pneumonia
    • Yandiola PP, Capelastegui A, Quintana J, et al. Prospective comparison of severity scores for predicting clinically relevant outcomes for patients hospitalized with community-acquired pneumonia. Chest. 2009;135:1572-1579.
    • (2009) Chest , vol.135 , pp. 1572-1579
    • Yandiola, P.P.1    Capelastegui, A.2    Quintana, J.3
  • 36
    • 67650266015 scopus 로고    scopus 로고
    • PIRO score for community-acquired pneumonia: A new prediction rule for assessment of severity in intensive care unit patients with community-acquired pneumonia
    • Rello J, Rodriguez A, Lisboa T, et al. PIRO score for community-acquired pneumonia: a new prediction rule for assessment of severity in intensive care unit patients with community-acquired pneumonia. Crit Care Med. 2009;37:456-462.
    • (2009) Crit Care Med. , vol.37 , pp. 456-462
    • Rello, J.1    Rodriguez, A.2    Lisboa, T.3
  • 37
    • 25444466936 scopus 로고    scopus 로고
    • B-type natriuretic peptide for risk stratification in community-acquired pneumonia
    • Mueller C, Laule-Kilian K, Scholer A, et al. B-type natriuretic peptide for risk stratification in community-acquired pneumonia. J Intern Med. 2005;258:391-393.
    • (2005) J Intern Med. , vol.258 , pp. 391-393
    • Mueller, C.1    Laule-Kilian, K.2    Scholer, A.3
  • 38
    • 44649099808 scopus 로고    scopus 로고
    • Use of B-type natriuretic peptide in the risk stratification of communityacquired pneumonia
    • Christ-Crain M, Breidthardt T, Stolz D, et al. Use of B-type natriuretic peptide in the risk stratification of communityacquired pneumonia. J Intern Med. 2008;264:166-176.
    • (2008) J Intern Med. , vol.264 , pp. 166-176
    • Christ-Crain, M.1    Breidthardt, T.2    Stolz, D.3
  • 39
    • 67650254329 scopus 로고    scopus 로고
    • Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia
    • Menendez R, Martínez R, Reyes S, et al. Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia. Thorax. 2009;64:587-591.
    • (2009) Thorax , vol.64 , pp. 587-591
    • Menendez, R.1    Martínez, R.2    Reyes, S.3
  • 40
    • 34248330207 scopus 로고    scopus 로고
    • Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia
    • Christ-Crain M, Morgenthaler NG, Stolz D, et al. Pro-adrenomedullin to predict severity and outcome in community-acquired pneumonia. Critical Care. 2006;10:R96-R103.
    • (2006) Critical Care , vol.10 , pp. R96-R103
    • Christ-Crain, M.1    Morgenthaler, N.G.2    Stolz, D.3
  • 41
    • 27144436156 scopus 로고    scopus 로고
    • Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index
    • Masia M, Gutierrez F, Shum C, et al. Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team Pneumonia Severity Index. Chest. 2005;128:2223-2229.
    • (2005) Chest , vol.128 , pp. 2223-2229
    • Masia, M.1    Gutierrez, F.2    Shum, C.3
  • 42
    • 40649128359 scopus 로고    scopus 로고
    • Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB65 classes
    • Kruger S, Ewig S, Marre R, et al. Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB65 classes. Eur Respir J. 2008;31:349-355.
    • (2008) Eur Respir J. , vol.31 , pp. 349-355
    • Kruger, S.1    Ewig, S.2    Marre, R.3
  • 43
    • 33947592780 scopus 로고    scopus 로고
    • Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    • Müller B, Harbarth S, Stolz D, et al. Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia. BMC Infect Dis. 2007;7:10.
    • (2007) BMC Infect Dis. , vol.7 , pp. 10
    • Müller, B.1    Harbarth, S.2    Stolz, D.3
  • 44
    • 79956348453 scopus 로고    scopus 로고
    • Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia
    • Lee JH, Kim J, Kim K, et al. Albumin and C-reactive protein have prognostic significance in patients with community-acquired pneumonia. J Crit Care. 2011;26:287-294.
    • (2011) J Crit Care , vol.26 , pp. 287-294
    • Lee, J.H.1    Kim, J.2    Kim, K.3
  • 45
    • 44949176523 scopus 로고    scopus 로고
    • Risk prediction with procalcitonin and clinical rules in communityacquired pneumonia
    • Huang D, Weissfeld LA, Kellum JA, et al. Risk prediction with procalcitonin and clinical rules in communityacquired pneumonia. Ann Emerg Med. 2008;52:48-58.
    • (2008) Ann Emerg Med. , vol.52 , pp. 48-58
    • Huang, D.1    Weissfeld, L.A.2    Kellum, J.A.3
  • 46
    • 6344281406 scopus 로고    scopus 로고
    • Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia
    • Almirall J, Bolíbar I, Toran P, et al. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest. 2004;125:1335-1342.
    • (2004) Chest , vol.125 , pp. 1335-1342
    • Almirall, J.1    Bolíbar, I.2    Toran, P.3
  • 47
    • 70449105200 scopus 로고    scopus 로고
    • Utility of C-reactive protein in assessing the disease severity and complications of community-acquired pneumonia
    • Hohenthal U, Hurme S, Helenius H, et al. Utility of C-reactive protein in assessing the disease severity and complications of community-acquired pneumonia. Clin Microbiol Infect. 2009;15:1026-1032.
    • (2009) Clin Microbiol Infect. , vol.15 , pp. 1026-1032
    • Hohenthal, U.1    Hurme, S.2    Helenius, H.3
  • 48
    • 33846117874 scopus 로고    scopus 로고
    • Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections
    • Müller B, Morgenthaler N, Stolz D, et al. Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Invest. 2007;37:145-152.
    • (2007) Eur J Clin Invest. , vol.37 , pp. 145-152
    • Müller, B.1    Morgenthaler, N.2    Stolz, D.3
  • 49
    • 36048932497 scopus 로고    scopus 로고
    • Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia
    • Christ-Crain M, Stolz D, Jutla S, et al. Free and total cortisol levels as predictors of severity and outcome in community-acquired pneumonia. Am J Respir Crit Care Med. 2007;176:913-920.
    • (2007) Am J Respir Crit Care Med. , vol.176 , pp. 913-920
    • Christ-Crain, M.1    Stolz, D.2    Jutla, S.3
  • 50
    • 33751084574 scopus 로고    scopus 로고
    • Circulating levels of pro-atrial natriuretic peptide in lower respiratory tract infections
    • Müller B, Süess E, Schuetz P, et al. Circulating levels of pro-atrial natriuretic peptide in lower respiratory tract infections. J Intern Med. 2006;260:568-576.
    • (2006) J Intern Med. , vol.260 , pp. 568-576
    • Müller, B.1    Süess, E.2    Schuetz, P.3
  • 51
    • 36448953900 scopus 로고    scopus 로고
    • Pro-atrial natriuretic peptide and pro-vasopressin to predict severity and prognosis in community-acquired pneumonia: Results from the German competence network CAPNETZ
    • Krüger S, Papassotiriou J, Marre R, et al. Pro-atrial natriuretic peptide and pro-vasopressin to predict severity and prognosis in community-acquired pneumonia: results from the German Competence Network CAPNETZ. Intensive Care Med. 2007;33:2069-2078.
    • (2007) Intensive Care Med. , vol.33 , pp. 2069-2078
    • Krüger, S.1    Papassotiriou, J.2    Marre, R.3
  • 52
    • 39849091058 scopus 로고    scopus 로고
    • C-reactive protein is an independent predictor of severity in communityacquired pneumonia
    • Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in communityacquired pneumonia. Am J Med. 2008;121:219-225.
    • (2008) Am J Med. , vol.121 , pp. 219-225
    • Chalmers, J.D.1    Singanayagam, A.2    Hill, A.T.3
  • 53
    • 6344277051 scopus 로고    scopus 로고
    • Plasma d-dimer levels correlate with outcomes in patients with community-acquired pneumonia
    • Querol-Ribelles JM, Tenias JM, Grau E, et al. Plasma d-dimer levels correlate with outcomes in patients with community-acquired pneumonia. Chest. 2004;126:1087-1092.
    • (2004) Chest , vol.126 , pp. 1087-1092
    • Querol-Ribelles, J.M.1    Tenias, J.M.2    Grau, E.3
  • 54
    • 64549090004 scopus 로고    scopus 로고
    • Admission D-dimer can identify low-risk patients with communityacquired pneumonia
    • Chalmers JD, Singanayagam A, Scally C, et al. Admission D-dimer can identify low-risk patients with communityacquired pneumonia. Ann Emerg Med. 2009;53:633-638.
    • (2009) Ann Emerg Med. , vol.53 , pp. 633-638
    • Chalmers, J.D.1    Singanayagam, A.2    Scally, C.3
  • 55
    • 49649108549 scopus 로고    scopus 로고
    • Adrenal function in patients with community-acquired pneumonia
    • Gotoh S, Nishimura N, Takahashi O, et al. Adrenal function in patients with community-acquired pneumonia. Eur Respir J. 2008;31:1268-1273.
    • (2008) Eur Respir J. , vol.31 , pp. 1268-1273
    • Gotoh, S.1    Nishimura, N.2    Takahashi, O.3
  • 56
    • 77956578386 scopus 로고    scopus 로고
    • Adrenal function is related to prognosis in moderate communityacquired pneumonia
    • Kolditz M, Halank M, Schulte-Hubbert B, et al. Adrenal function is related to prognosis in moderate communityacquired pneumonia. Eur Respir J. 2010;36:615-621.
    • (2010) Eur Respir J. , vol.36 , pp. 615-621
    • Kolditz, M.1    Halank, M.2    Schulte-Hubbert, B.3
  • 57
    • 0029887956 scopus 로고    scopus 로고
    • Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis
    • Hirata Y, Mitaka C, Sato K, et al. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab. 1996;81:1449-1453.
    • (1996) J Clin Endocrinol Metab. , vol.81 , pp. 1449-1453
    • Hirata, Y.1    Mitaka, C.2    Sato, K.3
  • 58
    • 84862861074 scopus 로고    scopus 로고
    • Proadrenomedullin in emergency department patients with communityacquired pneumonia
    • Huang DT, Angus DC, Pugh NA, et al. Proadrenomedullin in emergency department patients with communityacquired pneumonia. Ann Emerg Med. 2008;52(Suppl 4):S41.
    • (2008) Ann Emerg Med. , vol.52 , pp. S41
    • Huang, D.T.1    Angus, D.C.2    Pugh, N.A.3
  • 59
    • 77953126410 scopus 로고    scopus 로고
    • Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    • Schuetz P, Wolbers M, Christ-Crain M, et al. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care. 2010;14(3):R106. doi:10.1186/cc9055.
    • (2010) Crit Care , vol.14 , Issue.3 , pp. R106
    • Schuetz, P.1    Wolbers, M.2    Christ-Crain, M.3
  • 60
    • 35348971859 scopus 로고    scopus 로고
    • Midregional proatrial natriuretic peptide as a prognostic marker in pneumonia
    • Prat C, Lacoma A, Dominguez J, et al. Midregional proatrial natriuretic peptide as a prognostic marker in pneumonia. J Infect. 2007;55:400-407.
    • (2007) J Infect. , vol.55 , pp. 400-407
    • Prat, C.1    Lacoma, A.2    Dominguez, J.3
  • 61
    • 36649016435 scopus 로고    scopus 로고
    • Midregional pro-A-type natriuretic peptide and carboxyterminal provasopressin may predict prognosis in community-acquired pneumonia
    • Masia M, Papassotiriou J, Morgenthaler NG, et al. Midregional pro-A-type natriuretic peptide and carboxyterminal provasopressin may predict prognosis in community-acquired pneumonia. Clin Chem. 2007;53:2193-2201.
    • (2007) Clin Chem. , vol.53 , pp. 2193-2201
    • Masia, M.1    Papassotiriou, J.2    Morgenthaler, N.G.3
  • 62
    • 77951207947 scopus 로고    scopus 로고
    • Accuracy of C-reactive protein, procalcitonin and mid-regional proatrial natriuretic peptide to guide site of care of community-acquired pneumonia
    • Claessens Y-E, Mathevon T, Kierzek G, et al. Accuracy of C-reactive protein, procalcitonin and mid-regional proatrial natriuretic peptide to guide site of care of community-acquired pneumonia. Intensive Care Med. 2010;36:799-809.
    • (2010) Intensive Care Med. , vol.36 , pp. 799-809
    • Claessens, Y.-E.1    Mathevon, T.2    Kierzek, G.3
  • 63
    • 33646243227 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts is a marker of type I cell injury in acute lung injury
    • Uchida T, Shirasawa M, Ware LB, et al. Receptor for advanced glycation endproducts is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006;173:1008-1015.
    • (2006) Am J Respir Crit Care Med. , vol.173 , pp. 1008-1015
    • Uchida, T.1    Shirasawa, M.2    Ware, L.B.3
  • 64
    • 34247128758 scopus 로고    scopus 로고
    • Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    • Angus DC, Yang L, Kong L, et al. Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med. 2007;35:1061-1067.
    • (2007) Crit Care Med. , vol.35 , pp. 1061-1067
    • Angus, D.C.1    Yang, L.2    Kong, L.3
  • 65
    • 1642499233 scopus 로고    scopus 로고
    • Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia
    • Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451-458.
    • (2004) N Engl J Med. , vol.350 , pp. 451-458
    • Gibot, S.1    Cravoisy, A.2    Levy, B.3
  • 66
    • 84894231691 scopus 로고    scopus 로고
    • Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load
    • Oshansky CM, Gartland AJ, Wong-S-S, et al. Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load. Am J Respir Crit Care Med. 2014;189:449-462.
    • (2014) Am J Respir Crit Care Med. , vol.189 , pp. 449-462
    • Oshansky, C.M.1    Gartland, A.J.2    Wong, S.-S.3
  • 67
    • 40449127290 scopus 로고
    • Bacteriaemia and prognosis in lobar pneumonia: The results of quantitative blood culture in pneumococcus pneumonia
    • Landsman JB. Bacteriaemia and prognosis in lobar pneumonia: the results of quantitative blood culture in pneumococcus pneumonia. Glasgow Med J. 1952;33:33-45.
    • (1952) Glasgow Med J. , vol.33 , pp. 33-45
    • Landsman, J.B.1
  • 68
    • 50249205095 scopus 로고
    • Bacteraemia in lobar pneumonia
    • Christie IM. Bacteraemia in lobar pneumonia. The Lancet. 1933;222:804-805.
    • (1933) The Lancet , vol.222 , pp. 804-805
    • Christie, I.M.1
  • 69
    • 34249072240 scopus 로고    scopus 로고
    • High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease
    • Carrol ED, Guiver M, Nkhoma S, et al. High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease. Pediatr Infect Dis J. 2007;26:416-422.
    • (2007) Pediatr Infect Dis J. , vol.26 , pp. 416-422
    • Carrol, E.D.1    Guiver, M.2    Nkhoma, S.3
  • 70
    • 36348992639 scopus 로고    scopus 로고
    • Quantitative detection of Staphylococcus aureus and Enterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit
    • Peters RP, Van Agtmael MA, Gierveld S, et al. Quantitative detection of Staphylococcus aureus and Enterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit. J Clin Microbiol. 2007;45:3641-3646.
    • (2007) J Clin Microbiol. , vol.45 , pp. 3641-3646
    • Peters, R.P.1    Van Agtmael, M.A.2    Gierveld, S.3
  • 71
    • 66149087199 scopus 로고    scopus 로고
    • High levels of mecA DNA detected by a quantitative realtime PCR assay are associated with mortality in patients with methicillinresistant Staphylococcus aureus bacteremia
    • Ho Y-C, Chang S-C, Lin S-R, et al. High levels of mecA DNA detected by a quantitative realtime PCR assay are associated with mortality in patients with methicillinresistant Staphylococcus aureus bacteremia. J Clin Microbio. 2009;47:1443-1451.
    • (2009) J Clin Microbio. , vol.47 , pp. 1443-1451
    • Ho, Y.-C.1    Chang, S.-C.2    Lin, S.-R.3
  • 72
    • 70349640059 scopus 로고    scopus 로고
    • Streptococcus pneumoniae DNA load in blood as a marker of infection in patients with community-acquired pneumonia
    • Peters RP, De Boer RF, Schuurman T, et al. Streptococcus pneumoniae DNA load in blood as a marker of infection in patients with community-acquired pneumonia. J Clin Microbiol. 2009;47:3308-3312.
    • (2009) J Clin Microbiol. , vol.47 , pp. 3308-3312
    • Peters, R.P.1    De Boer, R.F.2    Schuurman, T.3
  • 73
    • 78649798530 scopus 로고    scopus 로고
    • High and increasing oxa-51 DNA load predict mortality in acinetobacter baumannii bacteremia: Implication for pathogenesis and evaluation of therapy
    • Chuang YC, Chang SC, Wang WK. High and Increasing Oxa-51 DNA load predict mortality in Acinetobacter baumannii bacteremia: implication for pathogenesis and evaluation of therapy. PLoS One. 2010;5(11):e14133.
    • (2010) PLoS One , vol.5 , Issue.11 , pp. e14133
    • Chuang, Y.C.1    Chang, S.C.2    Wang, W.K.3
  • 74
    • 79951727406 scopus 로고    scopus 로고
    • DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema
    • Munoz-Almagro GS, Selva L, et al. DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema. Eur J Clin Microbiol Infect Dis. 2011;30:327-335.
    • (2011) Eur J Clin Microbiol Infect Dis. , vol.30 , pp. 327-335
    • Munoz-Almagro, G.S.1    Selva, L.2
  • 75
    • 78650903911 scopus 로고    scopus 로고
    • Vibrio vulnificus DNA load and mortality
    • Kim DM, Jung SI, Jang HC, et al. Vibrio vulnificus DNA load and mortality. J Clin Microbiol. 2011;49:413-415.
    • (2011) J Clin Microbiol. , vol.49 , pp. 413-415
    • Kim, D.M.1    Jung, S.I.2    Jang, H.C.3
  • 76
    • 69249158125 scopus 로고    scopus 로고
    • Severity of pneumococcal pneumonia associated with genomic bacterial load
    • Rello J, Lisboa T, Lujan M, et al. Severity of pneumococcal pneumonia associated with genomic bacterial load. Chest. 2009;136:832-840.
    • (2009) Chest , vol.136 , pp. 832-840
    • Rello, J.1    Lisboa, T.2    Lujan, M.3
  • 77
    • 70350463588 scopus 로고    scopus 로고
    • Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study
    • Ferrer R, Artigas A, Suarez D, et al. Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med. 2009;180:861-866.
    • (2009) Am J Respir Crit Care Med. , vol.180 , pp. 861-866
    • Ferrer, R.1    Artigas, A.2    Suarez, D.3
  • 78
    • 33744527833 scopus 로고    scopus 로고
    • Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
    • Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589-1596.
    • (2006) Crit Care Med. , vol.34 , pp. 1589-1596
    • Kumar, A.1    Roberts, D.2    Wood, K.E.3
  • 79
    • 0031472414 scopus 로고    scopus 로고
    • Quality of care, process, and outcomes in elderly patients with pneumonia
    • Meehan TP, Fine MJ, Krumeholtz HM, et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA. 1997;278:2080-2084.
    • (1997) JAMA , vol.278 , pp. 2080-2084
    • Meehan, T.P.1    Fine, M.J.2    Krumeholtz, H.M.3
  • 80
    • 1642286527 scopus 로고    scopus 로고
    • Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia
    • Houck PM, Bratzler DW, Nsa W, et al. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med. 2004;164:637-644.
    • (2004) Arch Intern Med. , vol.164 , pp. 637-644
    • Houck, P.M.1    Bratzler, D.W.2    Nsa, W.3
  • 81
    • 84855410035 scopus 로고    scopus 로고
    • Initial management of pneumonia and sepsis. Factors associated with improved outcome
    • Menendez R, Torres A, Reyes S, et al. Initial management of pneumonia and sepsis. Factors associated with improved outcome. Eur Respir J. 2012;39(1):156-162. doi:10.1183/09031936.00188710
    • (2012) Eur Respir J. , vol.39 , Issue.1 , pp. 156-162
    • Menendez, R.1    Torres, A.2    Reyes, S.3
  • 82
    • 19044378448 scopus 로고    scopus 로고
    • Factors influencing in-hospital mortality in community-acquired pneumonia: A prospective study of patients not initially admitted to the ICU
    • Marrie TJ, Wu L. Factors influencing in-hospital mortality in community-acquired pneumonia: a prospective study of patients not initially admitted to the ICU. Chest. 2005;127:1260-1270.
    • (2005) Chest , vol.127 , pp. 1260-1270
    • Marrie, T.J.1    Wu, L.2
  • 83
    • 0033453983 scopus 로고    scopus 로고
    • Effects of a pneumonia clinical pathway on time to antibiotic treatment, length of stay, and mortality
    • Benenson R, Magalski A, Cavanaugh S, et al. Effects of a pneumonia clinical pathway on time to antibiotic treatment, length of stay, and mortality. Acad Emerg Med. 1999;6:1243-1248.
    • (1999) Acad Emerg Med. , vol.6 , pp. 1243-1248
    • Benenson, R.1    Magalski, A.2    Cavanaugh, S.3
  • 84
    • 0242636978 scopus 로고    scopus 로고
    • Early administration of antibiotics does not shorten time to clinical stability in patients with moderate-to-severe community-acquired pneumonia
    • Silber SH, Garret C, Singh R, et al. Early administration of antibiotics does not shorten time to clinical stability in patients with moderate-to-severe community-acquired pneumonia. Chest. 2003;124:1798-1804.
    • (2003) Chest , vol.124 , pp. 1798-1804
    • Silber, S.H.1    Garret, C.2    Singh, R.3
  • 85
    • 0037170578 scopus 로고    scopus 로고
    • Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with communityacquired pneumonia: Link between quality of care and resource utilization
    • Battleman DS, Callahan M, Thaler HT. Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with communityacquired pneumonia: link between quality of care and resource utilization. Arch Intern Med. 2002;162:682.
    • (2002) Arch Intern Med. , vol.162 , pp. 682
    • Battleman, D.S.1    Callahan, M.2    Thaler, H.T.3
  • 86
    • 0142196875 scopus 로고    scopus 로고
    • Community-acquired pneumonia: Compliance with centers for Medicare and Medicaid services, national guidelines, and factors associated with outcome
    • Ziss DR, Stowers A, Feild C. Community-acquired pneumonia: compliance with centers for Medicare and Medicaid services, national guidelines, and factors associated with outcome. South Med J. 2003;96:949-959.
    • (2003) South Med J. , vol.96 , pp. 949-959
    • Ziss, D.R.1    Stowers, A.2    Feild, C.3
  • 87
    • 80053284682 scopus 로고    scopus 로고
    • Guidelines for the management of adult lower respiratory tract infections
    • Woodhead M, Blasi F, Ewig S, et al. Guidelines for the management of adult lower respiratory tract infections. Clin Microbiol Infect. 2011;17(Suppl. 6):E1-E59.
    • (2011) Clin Microbiol Infect , vol.17 , pp. E1-E59
    • Woodhead, M.1    Blasi, F.2    Ewig, S.3
  • 88
    • 0033606799 scopus 로고    scopus 로고
    • Bacteremic pneumococcal pneumonia in one American city: A 20-year longitudinal study, 1978-1997
    • Mufson MA, Stanek RJ. Bacteremic pneumococcal pneumonia in one American city: a 20-year longitudinal study, 1978-1997. Am J Med. 1999;107:34S-43S.
    • (1999) Am J Med. , vol.107 , pp. 34-43
    • Mufson, M.A.1    Stanek, R.J.2
  • 89
    • 4544244010 scopus 로고    scopus 로고
    • Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia
    • Baddour LM, Yu VL, Klugman KP, et al. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med. 2004;170:440-444.
    • (2004) Am J Respir Crit Care Med. , vol.170 , pp. 440-444
    • Baddour, L.M.1    Yu, V.L.2    Klugman, K.P.3
  • 90
    • 0034890569 scopus 로고    scopus 로고
    • Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia
    • Waterer GW, Somes GW, Wunderink RG. Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia. Arch Intern Med. 2001;161:1837-1842.
    • (2001) Arch Intern Med. , vol.161 , pp. 1837-1842
    • Waterer, G.W.1    Somes, G.W.2    Wunderink, R.G.3
  • 91
    • 0037442372 scopus 로고    scopus 로고
    • Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia
    • Martinez JA, Horcajada JP, Almela M, et al. Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin Infect Dis. 2003;36:389-395.
    • (2003) Clin Infect Dis. , vol.36 , pp. 389-395
    • Martinez, J.A.1    Horcajada, J.P.2    Almela, M.3
  • 92
    • 19944429796 scopus 로고    scopus 로고
    • Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults
    • Weiss K, Low DE, Cortes L, et al. Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults. Can Respir J. 2004;11:589-593.
    • (2004) Can Respir J. , vol.11 , pp. 589-593
    • Weiss, K.1    Low, D.E.2    Cortes, L.3
  • 93
    • 0025668010 scopus 로고
    • Aetiology, outcome and prognostic factors in community-acquired pneumonia requiring hospitalization
    • Ortqvist A, Hedlund J, Grillner L, et al. Aetiology, outcome and prognostic factors in community-acquired pneumonia requiring hospitalization. Eur Respir J. 1990;3:1105-1113.
    • (1990) Eur Respir J. , vol.3 , pp. 1105-1113
    • Ortqvist, A.1    Hedlund, J.2    Grillner, L.3
  • 94
    • 9044221374 scopus 로고    scopus 로고
    • Multiple pathogens in adult patients admitted with communityacquired pneumonia: A one year prospective study of 346 consecutive patients
    • Lieberman D, Schlaeffer F, Boldur I, et al. Multiple pathogens in adult patients admitted with communityacquired pneumonia: a one year prospective study of 346 consecutive patients. Thorax. 1996;51:179-184.
    • (1996) Thorax , vol.51 , pp. 179-184
    • Lieberman, D.1    Schlaeffer, F.2    Boldur, I.3
  • 95
    • 0035059902 scopus 로고    scopus 로고
    • Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: Implications for management guidelines
    • Lim WS, Macfarlane JT, Boswell TC, et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax. 2001;56:296-301.
    • (2001) Thorax , vol.56 , pp. 296-301
    • Lim, W.S.1    Macfarlane, J.T.2    Boswell, T.C.3
  • 96
    • 0035871188 scopus 로고    scopus 로고
    • Microbial etiology of community-acquired pneumonia in the adult population of 4 municipalities in eastern Finland
    • Jokinen C, Heiskanen L, Juvonen H, et al. Microbial etiology of community-acquired pneumonia in the adult population of 4 municipalities in eastern Finland. Clin Infect Dis. 2001;32:1141-1154.
    • (2001) Clin Infect Dis. , vol.32 , pp. 1141-1154
    • Jokinen, C.1    Heiskanen, L.2    Juvonen, H.3
  • 97
    • 34248363207 scopus 로고    scopus 로고
    • A worldwide perspective of atypical pathogens in communityacquired pneumonia
    • Arnold FW, Summersgill JT, La Joie AS, et al. A worldwide perspective of atypical pathogens in communityacquired pneumonia. Am J Respir Crit Care Med. 2007;175:1086-1093.
    • (2007) Am J Respir Crit Care Med. , vol.175 , pp. 1086-1093
    • Arnold, F.W.1    Summersgill, J.T.2    La Joie, A.S.3
  • 98
    • 33847173420 scopus 로고    scopus 로고
    • Antibiotics for bacteremic pneumonia: Improved outcomes with macrolides but not fluoroquinolones
    • Metersky ML, Ma A, Houck PM, et al. Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones. Chest. 2007;131:466-473.
    • (2007) Chest , vol.131 , pp. 466-473
    • Metersky, M.L.1    Ma, A.2    Houck, P.M.3
  • 99
    • 77951209165 scopus 로고    scopus 로고
    • Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia
    • Martin-Loeches I, Lisboa T, Rodriguez A, et al. Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med. 2010;36:612-620.
    • (2010) Intensive Care Med. , vol.36 , pp. 612-620
    • Martin-Loeches, I.1    Lisboa, T.2    Rodriguez, A.3
  • 100
    • 84926321601 scopus 로고    scopus 로고
    • Antibiotic treatment strategies for community-acquired pneumonia in adults
    • Postma DF, Van Werkhoven CH, Van Elden LH, et al. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med. 2015;372:1312-1323.
    • (2015) N Engl J Med. , vol.372 , pp. 1312-1323
    • Postma, D.F.1    Van Werkhoven, C.H.2    Van Elden, L.H.3
  • 101
    • 53849142125 scopus 로고    scopus 로고
    • Immunomodulatory therapies for sepsis: Unexpected effects with macrolides
    • Giamarellos-Bourboulis EJ. Immunomodulatory therapies for sepsis: unexpected effects with macrolides. Int J Antimicrob Agents. 2008;32(Suppl 1):S39-43.
    • (2008) Int J Antimicrob Agents. , vol.32 , pp. S39-S43
    • Giamarellos-Bourboulis, E.J.1
  • 102
    • 12344261855 scopus 로고    scopus 로고
    • Clarithromycin coadministered with amikacin attenuates systemic inflammation in experimental sepsis with Escherichia coli
    • Giamarellos-Bourboulis EJ, Baziaka F, Antonopoulou A, et al. Clarithromycin coadministered with amikacin attenuates systemic inflammation in experimental sepsis with Escherichia coli. Int J Antimicrob Agents. 2005;25:168-172.
    • (2005) Int J Antimicrob Agents. , vol.25 , pp. 168-172
    • Giamarellos-Bourboulis, E.J.1    Baziaka, F.2    Antonopoulou, A.3
  • 103
    • 70349197594 scopus 로고    scopus 로고
    • Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathway
    • Ikegaya S, Inai K, Iwasaki H, et al. Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathway. J Chemother. 2009;21:396-402.
    • (2009) J Chemother. , vol.21 , pp. 396-402
    • Ikegaya, S.1    Inai, K.2    Iwasaki, H.3
  • 104
    • 75749143379 scopus 로고    scopus 로고
    • Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes
    • Gao X, Ray R, Xiao Y, et al. Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes. Pulm Pharmacol Ther. 2010;23:97-106.
    • (2010) Pulm Pharmacol Ther. , vol.23 , pp. 97-106
    • Gao, X.1    Ray, R.2    Xiao, Y.3
  • 105
    • 33947509104 scopus 로고    scopus 로고
    • J Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolideresistant strains of Streptococcus pneumoniae
    • Anderson R, Steel HC, Cockeran R, et al. J Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolideresistant strains of Streptococcus pneumoniae. J Antimicrob Chemother. 2007;59:224-229.
    • (2007) J Antimicrob Chemother. , vol.59 , pp. 224-229
    • Anderson, R.1    Steel, H.C.2    Cockeran, R.3
  • 106
    • 0033901506 scopus 로고    scopus 로고
    • Effect of macrolides as part of initial empiric therapy on medical outcomes for hospitalized patients with community acquired pneumonia
    • Burgess DS, Lewis JS. Effect of macrolides as part of initial empiric therapy on medical outcomes for hospitalized patients with community acquired pneumonia. Clin Ther. 2000;22:872878.
    • (2000) Clin Ther. , vol.22 , pp. 872878
    • Burgess, D.S.1    Lewis, J.S.2
  • 107
    • 37149051175 scopus 로고    scopus 로고
    • The need for macrolides in hospitalised community-acquired pneumonia: Propensity analysis
    • Paul M, Nielsen AD, Gafter-Gvili A, et al The need for macrolides in hospitalised community-acquired pneumonia: propensity analysis. Eur Respir J. 2007;30:525-531.
    • (2007) Eur Respir J. , vol.30 , pp. 525-531
    • Paul, M.1    Nielsen, A.D.2    Gafter-Gvili, A.3
  • 108
    • 33747346508 scopus 로고    scopus 로고
    • Addition of amacrolide to a ss-lactam in bacteremic pneumococcal pneumonia
    • Dwyer R, Ortqvist A, Aufwerber E, et al. Addition of amacrolide to a ss-lactam in bacteremic pneumococcal pneumonia. Eur J Clin Microbiol Infect Dis. 2006;25:518-521.
    • (2006) Eur J Clin Microbiol Infect Dis. , vol.25 , pp. 518-521
    • Dwyer, R.1    Ortqvist, A.2    Aufwerber, E.3
  • 109
    • 22644444626 scopus 로고    scopus 로고
    • Addition of macrolide in treating adult hospitalized community-acquired pneumonia
    • Loh L-C, Quah S-Y, Khoo S-K, et al. Addition of macrolide in treating adult hospitalized community-acquired pneumonia. Respirology. 2005;10:371-377.
    • (2005) Respirology , vol.10 , pp. 371-377
    • Loh, L.-C.1    Quah, S.-Y.2    Khoo, S.-K.3
  • 110
    • 0038778661 scopus 로고    scopus 로고
    • Legionnaire's disease: A rational approach to therapy
    • Roig J, Rello J. Legionnaire's disease: a rational approach to therapy. J Antimicrob Chemother. 2003;51:1119-1129.
    • (2003) J Antimicrob Chemother. , vol.51 , pp. 1119-1129
    • Roig, J.1    Rello, J.2
  • 111
    • 0345119082 scopus 로고    scopus 로고
    • Azithromycin in the treatment of Legionella pneumonia requiring hospitalization
    • Plouffe JF, Breiman RF, Fields BS, et al. Azithromycin in the treatment of Legionella pneumonia requiring hospitalization. Clin Infect Dis. 2003;37:1475-1480.
    • (2003) Clin Infect Dis. , vol.37 , pp. 1475-1480
    • Plouffe, J.F.1    Breiman, R.F.2    Fields, B.S.3
  • 112
    • 24944476483 scopus 로고    scopus 로고
    • Fluoroquinolones vs macrolides in the treatment of Legionnaires disease
    • Sabria M, Pedro-Botet ML, Gomez J, et al. Fluoroquinolones vs macrolides in the treatment of Legionnaires disease. Chest. 2005;128:1401-1405.
    • (2005) Chest , vol.128 , pp. 1401-1405
    • Sabria, M.1    Pedro-Botet, M.L.2    Gomez, J.3
  • 113
    • 2942726091 scopus 로고    scopus 로고
    • Levofloxacin efficacy in the treatment of community-acquired legionellosis
    • Yu VL, Greenberg RN, Zadeikis N, et al. Levofloxacin efficacy in the treatment of community-acquired legionellosis. Chest. 2004;125:2135-2139.
    • (2004) Chest , vol.125 , pp. 2135-2139
    • Yu, V.L.1    Greenberg, R.N.2    Zadeikis, N.3
  • 114
    • 0035870683 scopus 로고    scopus 로고
    • Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia
    • Dean NC, Silver MP, Bateman KA, et al. Decreased mortality after implementation of a treatment guideline for community-acquired pneumonia. Am J Med. 2001;110:451-457.
    • (2001) Am J Med. , vol.110 , pp. 451-457
    • Dean, N.C.1    Silver, M.P.2    Bateman, K.A.3
  • 115
    • 17744376776 scopus 로고    scopus 로고
    • Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a betalactam agent alone
    • Garcia Vazquez E, Mensa J, Martinez JA, et al. Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a betalactam agent alone. Eur J Clin Microbiol Infect Dis. 2005;24:190-195.
    • (2005) Eur J Clin Microbiol Infect Dis. , vol.24 , pp. 190-195
    • Garcia Vazquez, E.1    Mensa, J.2    Martinez, J.A.3
  • 116
    • 8344262268 scopus 로고    scopus 로고
    • Effects of guideline-concordant antimicrobial therapy on mortality among patients with community-acquired pneumonia
    • Mortensen EM, Restrepo M, Anzueto A, et al. Effects of guideline-concordant antimicrobial therapy on mortality among patients with community-acquired pneumonia. Am J Med. 2004;117:726-731.
    • (2004) Am J Med. , vol.117 , pp. 726-731
    • Mortensen, E.M.1    Restrepo, M.2    Anzueto, A.3
  • 117
    • 15744377189 scopus 로고    scopus 로고
    • Mortality in monotherapy versus combination therapy in severe community-acquired pneumonia: A systematic review
    • Restrepo MI, Mortensen EM, Anzueto A, et al. Mortality in monotherapy versus combination therapy in severe community-acquired pneumonia: a systematic review. Chest. 2003;124(4S):190S.
    • (2003) Chest , vol.124 , Issue.4 S , pp. 190
    • Restrepo, M.I.1    Mortensen, E.M.2    Anzueto, A.3
  • 118
    • 22544435383 scopus 로고    scopus 로고
    • Guidelines for the treatment of community-acquired pneumonia: Predictors of adherence and outcome
    • Menendez R, Torres A, Zalacain R, et al. Guidelines for the treatment of community-acquired pneumonia: predictors of adherence and outcome. Am J Respir Crit Care Med. 2005;172:757-762.
    • (2005) Am J Respir Crit Care Med. , vol.172 , pp. 757-762
    • Menendez, R.1    Torres, A.2    Zalacain, R.3
  • 119
    • 70349264521 scopus 로고    scopus 로고
    • Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-acquired pneumonia organization international cohort study results
    • Arnold FW, La Joie AS, Brock GN, et al. Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: community-acquired pneumonia organization international cohort study results. Arch Intern Med. 2009;169 (16):1515.
    • (2009) Arch Intern Med. , vol.169 , Issue.16 , pp. 1515
    • Arnold, F.W.1    La Joie, A.S.2    Brock, G.N.3
  • 120
    • 33746339224 scopus 로고    scopus 로고
    • Impact of antibiotic guideline compliance on duration of mechanical ventilation in critically ill patients with community-acquired pneumonia
    • Shorr AF, Bodi M, Rodriguez A, et al. Impact of antibiotic guideline compliance on duration of mechanical ventilation in critically ill patients with community-acquired pneumonia. Chest. 2006;130:93-100.
    • (2006) Chest , vol.130 , pp. 93-100
    • Shorr, A.F.1    Bodi, M.2    Rodriguez, A.3
  • 121
    • 0029017307 scopus 로고
    • Patterns of cytokine expression in community-acquired pneumonia
    • Puren AJ, Feldman C, Savage N, et al. Patterns of cytokine expression in community-acquired pneumonia. Chest. 1995;107:1342-1349.
    • (1995) Chest , vol.107 , pp. 1342-1349
    • Puren, A.J.1    Feldman, C.2    Savage, N.3
  • 122
    • 0032863149 scopus 로고    scopus 로고
    • Role of glucocorticoids on inflammatory response in nonimmunosuppressed patients with pneumonia: A pilot study
    • Monton C, Ewig S, Torres A, et al. Role of glucocorticoids on inflammatory response in nonimmunosuppressed patients with pneumonia: a pilot study. Eur Respir J. 1999;14:218-220.
    • (1999) Eur Respir J. , vol.14 , pp. 218-220
    • Monton, C.1    Ewig, S.2    Torres, A.3
  • 123
    • 0141563840 scopus 로고    scopus 로고
    • Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia
    • Fernandez-Serrano S, Dorca J, Coromines M, et al. Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia. Clin Diagn Lab Immunol. 2003;10:813-820.
    • (2003) Clin Diagn Lab Immunol. , vol.10 , pp. 813-820
    • Fernandez-Serrano, S.1    Dorca, J.2    Coromines, M.3
  • 124
    • 19944430688 scopus 로고    scopus 로고
    • Hydrocortisone infusion for severe communityacquired pneumonia: A preliminary randomized study
    • Confalonieri M, Urbino R, Potena A, et al. Hydrocortisone infusion for severe communityacquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med. 2005;171:242248.
    • (2005) Am J Respir Crit Care Med. , vol.171 , pp. 242248
    • Confalonieri, M.1    Urbino, R.2    Potena, A.3
  • 125
    • 84941368693 scopus 로고    scopus 로고
    • Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: A systematic review and meta-analysis
    • Siemieniuk RA, Meade MO, Alonso Coello P, et al. Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: a systematic review and meta-analysis. Ann Intern Med. 2015;163:519-528.
    • (2015) Ann Intern Med. , vol.163 , pp. 519-528
    • Siemieniuk, R.A.1    Meade, M.O.2    Alonso Coello, P.3
  • 126
    • 84954148193 scopus 로고    scopus 로고
    • Efficacy and safety of corticosteroids for community-acquired pneumonia: A systematic review and meta-analysis
    • Wan YD, Sun TW, Liu ZQ, et al. Efficacy and safety of corticosteroids for community-acquired pneumonia: A systematic review and meta-analysis. Chest. 2016;149 (1):209-219. doi:10.1378/chest.15-1733
    • (2016) Chest , vol.149 , Issue.1 , pp. 209-219
    • Wan, Y.D.1    Sun, T.W.2    Liu, Z.Q.3
  • 127
    • 34548569037 scopus 로고    scopus 로고
    • Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization
    • Mikami M, Suzuki M, Kitagawa H, et al. Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization. Lung. 2007;185:249-255.
    • (2007) Lung , vol.185 , pp. 249-255
    • Mikami, M.1    Suzuki, M.2    Kitagawa, H.3
  • 128
    • 38849127566 scopus 로고    scopus 로고
    • Effects of systemic steroids in patients with severe communityacquired pneumonia
    • Garcia-Vidal C, Calbo E, Pascual V, et al. Effects of systemic steroids in patients with severe communityacquired pneumonia. Eur Respir J. 2007;30:951-956.
    • (2007) Eur Respir J. , vol.30 , pp. 951-956
    • Garcia-Vidal, C.1    Calbo, E.2    Pascual, V.3
  • 129
    • 84941795682 scopus 로고    scopus 로고
    • Adjunctive systemic corticosteroids for hospitalized community-acquired pneumonia: Systematic review and meta-analysis 2015 update
    • Horita N, et al Adjunctive systemic corticosteroids for hospitalized community-acquired pneumonia: systematic review and meta-analysis 2015 update. Sci Rep. 2015;5:14061.
    • (2015) Sci Rep. , vol.5 , pp. 14061
    • Horita, N.1
  • 130
    • 79952561515 scopus 로고    scopus 로고
    • Effects of corticosteroids on the clinical course of communityacquired pneumonia: A randomized controlled trial
    • Fernandez-Serrano S, Dorca J, Garcia-Vidal C, et al. Effects of corticosteroids on the clinical course of communityacquired pneumonia: a randomized controlled trial. Critical Care. 2011;15:R96.
    • (2011) Critical Care , vol.15 , pp. R96
    • Fernandez-Serrano, S.1    Dorca, J.2    Garcia-Vidal, C.3
  • 131
    • 42949123466 scopus 로고    scopus 로고
    • Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia
    • Mortensen EM, Pugh MJ, Copeland LA, et al. Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia. Eur Respir J. 2008;31:611-617.
    • (2008) Eur Respir J. , vol.31 , pp. 611-617
    • Mortensen, E.M.1    Pugh, M.J.2    Copeland, L.A.3
  • 132
    • 33847321185 scopus 로고    scopus 로고
    • Statins and the risk of pneumonia: A populationbased, nested case-control study
    • Schlienger RG, Fedson DS, Jick SS, et al. Statins and the risk of pneumonia: a populationbased, nested case-control study. Pharmacotherapy. 2007;27:325-332.
    • (2007) Pharmacotherapy , vol.27 , pp. 325-332
    • Schlienger, R.G.1    Fedson, D.S.2    Jick, S.S.3
  • 133
    • 33750958903 scopus 로고    scopus 로고
    • Statins and outcomes in patients admitted to hospital with community acquired pneumonia: Population based prospective cohort study
    • Majumdar SR, McAlister FA, Eurich DT, et al. Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study. BMJ. 2006;333:999.
    • (2006) BMJ , vol.333 , pp. 999
    • Majumdar, S.R.1    McAlister, F.A.2    Eurich, D.T.3
  • 134
    • 63149094677 scopus 로고    scopus 로고
    • A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe communityacquired pneumonia
    • Laterre P-F, Opal SM, Abraham E, et al. A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe communityacquired pneumonia. Crit Care. 2009;13:R36.
    • (2009) Crit Care , vol.13 , pp. R36
    • Laterre, P.-F.1    Opal, S.M.2    Abraham, E.3
  • 135
    • 70349469854 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor to reverse sepsisassociated immunosuppression: A double-blind, randomized, placebo-controlled multicenter trial
    • Meisel C, Schefold JC, Pschowski R, et al. Granulocyte macrophage colony-stimulating factor to reverse sepsisassociated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009;180:640-648.
    • (2009) Am J Respir Crit Care Med. , vol.180 , pp. 640-648
    • Meisel, C.1    Schefold, J.C.2    Pschowski, R.3
  • 136
    • 0032698105 scopus 로고    scopus 로고
    • Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation
    • Confalonieri M, Potena A, Carbone G, et al. Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med. 1999;160:1585-1591.
    • (1999) Am J Respir Crit Care Med. , vol.160 , pp. 1585-1591
    • Confalonieri, M.1    Potena, A.2    Carbone, G.3
  • 137
    • 0347362531 scopus 로고    scopus 로고
    • Noninvasive ventilation in severe hypoxemic respiratory failure: A randomized clinical trial
    • Ferrer M, Esquinas A, Leon M, et al., et al. Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med. 2003;168:1438-1444.
    • (2003) Am J Respir Crit Care Med. , vol.168 , pp. 1438-1444
    • Ferrer, M.1    Esquinas, A.2    Leon, M.3
  • 138
    • 33845940692 scopus 로고    scopus 로고
    • A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome
    • Antonelli M, Conti G, Esquinas A, et al. A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med. 2007;35:18-25.
    • (2007) Crit Care Med. , vol.35 , pp. 18-25
    • Antonelli, M.1    Conti, G.2    Esquinas, A.3
  • 139
    • 72249119414 scopus 로고    scopus 로고
    • Antibiotic usage and resistance: Gaining or losing ground on infections in critically ill patients?
    • Opal SM, Calandra T. Antibiotic usage and resistance: gaining or losing ground on infections in critically ill patients? JAMA. 2009;302:2367-2368.
    • (2009) JAMA , vol.302 , pp. 2367-2368
    • Opal, S.M.1    Calandra, T.2
  • 140
    • 84885071058 scopus 로고    scopus 로고
    • Septic shock: Desperately seeking treatment
    • Huet O, Chin-Dusting JP. Septic shock: desperately seeking treatment. Clin Sci (Lond). 2014;126:31-39.
    • (2014) Clin Sci (Lond) , vol.126 , pp. 31-39
    • Huet, O.1    Chin-Dusting, J.P.2
  • 141
    • 84907045288 scopus 로고    scopus 로고
    • Immunomodulatory adjuvant therapy in severe community-acquired pneumonia
    • Morton B, Pennington SH, Gordon SB. Immunomodulatory adjuvant therapy in severe community-acquired pneumonia. Expert Rev Respir Med. 2014;8:587-596.
    • (2014) Expert Rev Respir Med. , vol.8 , pp. 587-596
    • Morton, B.1    Pennington, S.H.2    Gordon, S.B.3
  • 142
    • 84896367599 scopus 로고    scopus 로고
    • Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease
    • Steel HC, Cockeran R, Anderson R, et al. Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease. Mediators Inflamm. 2013;2013:490346. doi:10.1155/2013/490346.
    • (2013) Mediators Inflamm. , vol.2013 , pp. 490346
    • Steel, H.C.1    Cockeran, R.2    Anderson, R.3
  • 143
    • 84869423294 scopus 로고    scopus 로고
    • Magic bullets for the 21st century: The reemergence of immunotherapy for multiand pan-resistant microbes
    • Roux D, Pier GB, Skurnik D. Magic bullets for the 21st century: the reemergence of immunotherapy for multiand pan-resistant microbes. J Antimicrob Chemother. 2012;67:27852787.
    • (2012) J Antimicrob Chemother. , vol.67 , pp. 27852787
    • Roux, D.1    Pier, G.B.2    Skurnik, D.3
  • 144
    • 0043269792 scopus 로고    scopus 로고
    • An international prospective study of pneumococcal bacteremia: Correlation with in vitro resistance, antibiotics administered, and clinical outcome
    • Yu VL, Chiou CC, Feldman C, et al. An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis. 2003;37:230-237.
    • (2003) Clin Infect Dis. , vol.37 , pp. 230-237
    • Yu, V.L.1    Chiou, C.C.2    Feldman, C.3
  • 145
    • 84862589039 scopus 로고    scopus 로고
    • Bacteria and their toxins tamed for immunotherapy
    • Adkins I, Holubova J, Kosova M, et al. Bacteria and their toxins tamed for immunotherapy. Curr Pharm Biotechnol. 2012;13:1446-1473.
    • (2012) Curr Pharm Biotechnol. , vol.13 , pp. 1446-1473
    • Adkins, I.1    Holubova, J.2    Kosova, M.3
  • 146
    • 84878253590 scopus 로고    scopus 로고
    • Role of pore-forming toxins in bacterial infectious diseases
    • Los FC, Randis TM, Aroian RV, et al. Role of pore-forming toxins in bacterial infectious diseases. Microbiol Mol Biol Rev. 2013;77:173-207.
    • (2013) Microbiol Mol Biol Rev. , vol.77 , pp. 173-207
    • Los, F.C.1    Randis, T.M.2    Aroian, R.V.3
  • 147
    • 53149104367 scopus 로고    scopus 로고
    • Pneumolysin: A double-edged sword during the hostpathogen interaction
    • Marriott HM, Mitchell TJ, Dockrell DH. Pneumolysin: a double-edged sword during the hostpathogen interaction. Curr Mol Med. 2008;8:497-509.
    • (2008) Curr Mol Med. , vol.8 , pp. 497-509
    • Marriott, H.M.1    Mitchell, T.J.2    Dockrell, D.H.3
  • 148
    • 84890878773 scopus 로고    scopus 로고
    • Towards clinical applications of anti-endotoxin antibodies; A re-appraisal of the disconnect
    • Hurley JC. Towards clinical applications of anti-endotoxin antibodies; a re-appraisal of the disconnect. Toxins (Basel). 2013;5:2589-2620.
    • (2013) Toxins (Basel). , vol.5 , pp. 2589-2620
    • Hurley, J.C.1
  • 149
    • 77952616726 scopus 로고    scopus 로고
    • Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11
    • Horn MP, Zuercher AW, Imboden MA, et al. Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11. Antimicrob Agents Chemother. 2010;54:2338-2344.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 2338-2344
    • Horn, M.P.1    Zuercher, A.W.2    Imboden, M.A.3
  • 150
    • 84911004081 scopus 로고    scopus 로고
    • Assessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumonia
    • Que Y-A, Lazar H, Wolff M, et al. Assessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumonia. Eur J Clin Microbiol Infect Dis. 2014;33:1861-1867.
    • (2014) Eur J Clin Microbiol Infect Dis. , vol.33 , pp. 1861-1867
    • Que, Y.-A.1    Lazar, H.2    Wolff, M.3
  • 151
    • 84864289317 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized, double-blind, placebo-controlled trial
    • François B, Luyt C-E, Dugard A, et al. Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: a randomized, double-blind, placebo-controlled trial. Crit Care Med. 2012;40(8):2320-2326.
    • (2012) Crit Care Med. , vol.40 , Issue.8 , pp. 2320-2326
    • François, B.1    Luyt, C.-E.2    Dugard, A.3
  • 152
    • 84903381980 scopus 로고    scopus 로고
    • Anti-PcrV antibody in cystic fibrosis: A novel approach targeting Pseudomonas aeruginosa airway infection
    • Milla CE, Chmiel JF, Accurso FJ, et al. Anti-PcrV antibody in cystic fibrosis: a novel approach targeting Pseudomonas aeruginosa airway infection. Pediatr Pulmonol. 2014;49:650-658.
    • (2014) Pediatr Pulmonol. , vol.49 , pp. 650-658
    • Milla, C.E.1    Chmiel, J.F.2    Accurso, F.J.3
  • 153
    • 0038350759 scopus 로고    scopus 로고
    • Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: A phase I feasibility study
    • Kollberg H, Carlander D, Olesen H, et al. Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study. Pediatr Pulmonol. 2003;35:433-440.
    • (2003) Pediatr Pulmonol. , vol.35 , pp. 433-440
    • Kollberg, H.1    Carlander, D.2    Olesen, H.3
  • 154
    • 0030692764 scopus 로고    scopus 로고
    • Pharmacokinetics, tolerability, and preliminary efficacy of human anti-Pseudomonas aeruginosa monoclonal antibodies in pneumonia and burn infection patients
    • Harrison FJ, Rohm D, Kohzuki T, et al. Pharmacokinetics, tolerability, and preliminary efficacy of human anti-Pseudomonas aeruginosa monoclonal antibodies in pneumonia and burn infection patients. Hybridoma. 1997;16:413-420.
    • (1997) Hybridoma. , vol.16 , pp. 413-420
    • Harrison, F.J.1    Rohm, D.2    Kohzuki, T.3
  • 155
    • 79954586417 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of panobacumab: Specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia
    • Lu Q, Rouby J-J, Laterre P-F, et al. Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumonia. J Antimicrob Chemother. 2011;66:1110-1116.
    • (2011) J Antimicrob Chemother. , vol.66 , pp. 1110-1116
    • Lu, Q.1    Rouby, J.-J.2    Laterre, P.-F.3
  • 156
    • 84908178834 scopus 로고    scopus 로고
    • Mechanisms of neutralization of a human anti-α-toxin antibody
    • Oganesyan V, Peng L, Damschroder MM, et al. Mechanisms of neutralization of a human anti-α-toxin antibody. J Biol Chem. 2014;289:29874-29880.
    • (2014) J Biol Chem. , vol.289 , pp. 29874-29880
    • Oganesyan, V.1    Peng, L.2    Damschroder, M.M.3
  • 157
    • 84978018775 scopus 로고    scopus 로고
    • https://www.clinicaltrials.gov/ct2/show/NCT01589185? term=aridis&rank=2
  • 158
    • 84906673077 scopus 로고    scopus 로고
    • New perspectives in the management of Pseudomonas aeruginosa infections
    • Savoia D. New perspectives in the management of Pseudomonas aeruginosa infections. Future Microbiol. 2014;9:917-928.
    • (2014) Future Microbiol. , vol.9 , pp. 917-928
    • Savoia, D.1
  • 159
    • 84977978649 scopus 로고    scopus 로고
    • https://www.clinicaltrials.gov/ct2/show/NCT01455675? term=igy&rank=1
  • 160
    • 85028612144 scopus 로고    scopus 로고
    • A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
    • Di Giandomenico A, Keller AE, Gao C, et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014;6:262ra155.
    • (2014) Sci Transl Med. , vol.6 , pp. 262ra155
    • Di Giandomenico, A.1    Keller, A.E.2    Gao, C.3
  • 161
    • 84978018778 scopus 로고    scopus 로고
    • http://www.drugdevelopment-technology.com/news/newsaridis-begins-phase-i-trial-of-aerucinmonoclonalantibody-to-treat-acute-pneumonia-4541705
  • 162
    • 84921376947 scopus 로고    scopus 로고
    • Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody
    • Rouha H, Badarau A, Visram ZC, et al. Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. MAbs. 2015;7(1):243-254. doi:10.4161/19420862.2014.985132.
    • (2015) MAbs , vol.7 , Issue.1 , pp. 243-254
    • Rouha, H.1    Badarau, A.2    Visram, Z.C.3
  • 163
    • 84949131641 scopus 로고    scopus 로고
    • Vaccination against respiratory Pseudomonas aeruginosa infection
    • Grimwood K, Kyd JM, Owen SJ, et al. Vaccination against respiratory Pseudomonas aeruginosa infection. Hum Vaccin Immunother. 2015;11:14-20.
    • (2015) Hum Vaccin Immunother. , vol.11 , pp. 14-20
    • Grimwood, K.1    Kyd, J.M.2    Owen, S.J.3
  • 164
    • 84900323437 scopus 로고    scopus 로고
    • Vaccine development and passive immunization for Pseudomonas aeruginosa in critically ill patients: A clinical update
    • Vincent J-L. Vaccine development and passive immunization for Pseudomonas aeruginosa in critically ill patients: a clinical update. Future Microbiol. 2014;9:457-463.
    • (2014) Future Microbiol. , vol.9 , pp. 457-463
    • Vincent, J.-L.1
  • 165
    • 79551526450 scopus 로고    scopus 로고
    • Bacteraemic pneumococcal pneumonia: Current therapeutic options
    • Feldman CL, Anderson R. Bacteraemic pneumococcal pneumonia: current therapeutic options. Drugs. 2011;71:131-153.
    • (2011) Drugs , vol.71 , pp. 131-153
    • Feldman, C.L.1    Anderson, R.2
  • 166
    • 84856638259 scopus 로고    scopus 로고
    • Clinical development of liposomebased drugs: Formulation, characterization, and therapeutic efficacy
    • Chang H-I, Yeh M-K. Clinical development of liposomebased drugs: formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012;7:49-60.
    • (2012) Int J NanoMedicine , vol.7 , pp. 49-60
    • Chang, H.-I.1    Yeh, M.-K.2
  • 167
    • 84927674621 scopus 로고    scopus 로고
    • Liposomes as novel antiinfectives targeting bacterial virulence factors?
    • Azeredo Da Silveira S, Perez A. Liposomes as novel antiinfectives targeting bacterial virulence factors? Expert Rev Anti Infect Ther. 2015;13:531-533.
    • (2015) Expert Rev Anti Infect Ther. , vol.13 , pp. 531-533
    • Azeredo Da Silveira, S.1    Perez, A.2
  • 168
    • 84964285801 scopus 로고    scopus 로고
    • Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
    • Henry BD, Neill DR, Becker KA, et al. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015;33:81-88.
    • (2015) Nat Biotechnol. , vol.33 , pp. 81-88
    • Henry, B.D.1    Neill, D.R.2    Becker, K.A.3
  • 169
    • 84938821329 scopus 로고    scopus 로고
    • Mesenchymal stem cells as a therapeutic tool to treat sepsis
    • Lombardo E, Van Der Poll T, Dela Rosa O, et al. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells. 2015;7:368-379.
    • (2015) World J Stem Cells. , vol.7 , pp. 368-379
    • Lombardo, E.1    Van Der-Poll, T.2    Dela Rosa, O.3
  • 170
    • 84863165443 scopus 로고    scopus 로고
    • Novel therapeutic targets for sepsis: Regulation of exaggerated inflammatory responses
    • Matsuda A, Jacob A, Wu R, et al. Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses. J Nippon Med Sch. 2012;79:4-18.
    • (2012) J Nippon Med Sch. , vol.79 , pp. 4-18
    • Matsuda, A.1    Jacob, A.2    Wu, R.3
  • 171
    • 84879363528 scopus 로고    scopus 로고
    • Adult stem cells for acute lung injury: Remaining questions and concerns
    • Zhu Y-G, Hao Q, Monsel A, et al. Adult stem cells for acute lung injury: remaining questions and concerns. Respirology. 2013;18:744-756.
    • (2013) Respirology , vol.18 , pp. 744-756
    • Zhu, Y.-G.1    Hao, Q.2    Monsel, A.3
  • 172
    • 84891713097 scopus 로고    scopus 로고
    • A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens
    • Wittebole X, De Roock S, Opal SM. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5:226-235.
    • (2014) Virulence , vol.5 , pp. 226-235
    • Wittebole, X.1    De Roock, S.2    Opal, S.M.3
  • 173
    • 84960107295 scopus 로고    scopus 로고
    • Influenza infection in the intensive care unit. Four years after the pandemic
    • May
    • Pérez-Carrasco M, Lagunes L, Antón A, et al. Influenza infection in the intensive care unit. Four years after the pandemic. Enferm Infecc Microbiol Clin. 2015 May 26;pii:S0213005X(15)00151-2. doi:10.1016/j.eimc.2015.04.004.
    • (2015) Enferm Infecc Microbiol Clin. , vol.26
    • Pérez-Carrasco, M.1    Lagunes, L.2    Antón, A.3
  • 174
    • 84894305348 scopus 로고    scopus 로고
    • Impact of pandemic influenza 2009 H1N1pandemic on invasive pneumococcal infection in adults
    • Pedro-Botet ML, Burgos J, Lunan M, et al. Impact of pandemic influenza 2009 H1N1pandemic on invasive pneumococcal infection in adults. Eur J Clin Microbiol Infect Dis. 2014;46:185-192.
    • (2014) Eur J Clin Microbiol Infect Dis. , vol.46 , pp. 185-192
    • Pedro-Botet, M.L.1    Burgos, J.2    Lunan, M.3
  • 175
    • 84920392121 scopus 로고    scopus 로고
    • Clinical characteristics and outcomes of severe rhinovirusassociated pneumonia identified by bronchoscopic bronchoalveolar lavage in adults: Comparison with severe influenza virus-associated pneumonia
    • Epub 2014 Nov 15
    • Choi SH, Huh JW, Hong SB, et al. Clinical characteristics and outcomes of severe rhinovirusassociated pneumonia identified by bronchoscopic bronchoalveolar lavage in adults: comparison with severe influenza virus-associated pneumonia. J Clin Virol. 2015;62:41-47. Epub 2014 Nov 15 doi:10.1016/j.jcv.2014.11.010.
    • (2015) J Clin Virol. , vol.62 , pp. 41-47
    • Choi, S.H.1    Huh, J.W.2    Hong, S.B.3
  • 176
    • 69249135545 scopus 로고    scopus 로고
    • Severe communityacquired pneumonia and PIRO: A new paradigm of management
    • Rello J, Lisboa T, Wunderink RG. Severe communityacquired pneumonia and PIRO: a new paradigm of management. Curr Infect Dis Rep. 2009;11:343-348.
    • (2009) Curr Infect Dis Rep. , vol.11 , pp. 343-348
    • Rello, J.1    Lisboa, T.2    Wunderink, R.G.3


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